PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21576248-9 2011 Targeting Sp1 and UGDH with specific siRNAs also lowered hyaluronan synthase-1 (HAS-1) and HAS-2 levels and reduced hyaluronan accumulation in orbital fibroblasts. Hyaluronic Acid 57-67 hyaluronan synthase 1 Homo sapiens 80-85 20875124-0 2010 Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. Hyaluronic Acid 82-92 hyaluronan synthase 1 Homo sapiens 22-28 20960509-0 2011 Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis. Hyaluronic Acid 15-30 hyaluronan synthase 1 Homo sapiens 47-51 20501660-1 2010 Hyaluronan synthases (HAS1-3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes. Hyaluronic Acid 84-94 hyaluronan synthase 1 Homo sapiens 22-28 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 109-119 hyaluronan synthase 1 Homo sapiens 178-182 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 121-123 hyaluronan synthase 1 Homo sapiens 178-182 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 44-59 hyaluronan synthase 1 Homo sapiens 119-145 21977277-1 2009 The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular matrix molecule. Hyaluronic Acid 4-14 hyaluronan synthase 1 Homo sapiens 27-32 19435493-0 2009 Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. Hyaluronic Acid 14-24 hyaluronan synthase 1 Homo sapiens 36-42 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 61-63 hyaluronan synthase 1 Homo sapiens 119-145 18768572-8 2008 The results demonstrate an increased hyaluronic acid content in idiopathic pulmonary arterial hypertension lungs, associated with increased hyaluronan synthase 1 and decreased hyaluronoglucosaminidase 1 gene expression. Hyaluronic Acid 37-52 hyaluronan synthase 1 Homo sapiens 140-161 16603733-1 2006 The linear glycosaminoglycan hyaluronan (HA) is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2, and -3 and performs multiple functions as part of the vertebrate extracellular matrix. Hyaluronic Acid 41-43 hyaluronan synthase 1 Homo sapiens 116-132 18400745-0 2008 Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 76-80 15870928-9 2005 Serum hyaluronan levels were higher in the HAS1-positive group than in the HAS1-negative group, but the expression of HAS2 and HAS3 was unrelated to serum hyaluronan levels. Hyaluronic Acid 6-16 hyaluronan synthase 1 Homo sapiens 43-47 15731173-4 2005 MM cells expressing one or more HAS1 variants synthesize extracellular and/or intracellular hyaluronan (HA). Hyaluronic Acid 92-102 hyaluronan synthase 1 Homo sapiens 32-36 16522194-2 2006 Hyaluronan is synthesized by three homologous hyaluronan synthases designated HAS1, HAS2 and HAS3 that differ in their tissue distribution, regulation and enzymatic characteristics. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 78-82 15794859-1 2005 The hyaluronan synthase 1 (HAS1) gene encodes a plasma membrane protein that synthesizes hyaluronan, an extracellular matrix molecule. Hyaluronic Acid 4-14 hyaluronan synthase 1 Homo sapiens 27-31 14988410-1 2004 Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 161-176 15231668-1 2004 Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, and 3) are thought to participate in cancer progression. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 60-74 15231668-1 2004 Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, and 3) are thought to participate in cancer progression. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 60-74 14988410-1 2004 Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 161-176 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 1 Homo sapiens 134-138 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 1 Homo sapiens 134-138 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 1 Homo sapiens 287-291 12757764-1 2003 The glycosaminoglycan (GAG) hyaluronan (HA) is a key component of the vertebrate extracellular matrix (ECM) and is synthesised by the HA synthase (HAS) enzymes HAS1, HAS2 and HAS3 at the plasma membrane. Hyaluronic Acid 40-42 hyaluronan synthase 1 Homo sapiens 160-164 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 1 Homo sapiens 287-291 35106474-7 2022 Hyaluronan synthase 1, a critical enzyme in the synthetic pathway for hyaluronic acid, was knocked down in SN12L1 cells and in vitro experiments revealed inhibition of interstitial flow induced migration. Hyaluronic Acid 70-85 hyaluronan synthase 1 Homo sapiens 0-21 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 28-38 hyaluronan synthase 1 Homo sapiens 111-115 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 135-145 hyaluronan synthase 1 Homo sapiens 111-115 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 135-145 hyaluronan synthase 1 Homo sapiens 111-115 32551924-4 2021 OBJECTIVE: We sought to determine the effect of PGD2 on the mRNA expression of three isoforms of membrane-bound hyaluronic acid synthase (HAS1, HAS2 and HAS3) in fibroblasts, the major source of hyaluronan production, derived from CRS patients. Hyaluronic Acid 112-127 hyaluronan synthase 1 Homo sapiens 138-142 31075987-5 2019 alpha-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Hyaluronic Acid 171-186 hyaluronan synthase 1 Homo sapiens 144-148 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 72-76 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 97-101 29709595-3 2019 Increased expression of the genes of hyaluronan synthases (HAS1-3) are infrequent in human tumors, while posttranslational modifications that activate the HAS enzymes, and glucose shunted to the UDP-sugar substrates HASs, can have crucial contributions to tumor hyaluronan synthesis. Hyaluronic Acid 37-47 hyaluronan synthase 1 Homo sapiens 59-65 29063508-4 2018 In this study, we measured the mRNA expression of hyaluronic acid-related proteins: hyaluronan synthase (HAS) 1-3, hyaluronidase-1, -2, and hyaluronic acid-binding protein (versican). Hyaluronic Acid 50-65 hyaluronan synthase 1 Homo sapiens 84-113 30507579-2 2019 Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. Hyaluronic Acid 25-35 hyaluronan synthase 1 Homo sapiens 90-112 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Hyaluronic Acid 16-26 hyaluronan synthase 1 Homo sapiens 101-124 28604766-1 2017 The levels of hyaluronan, a ubiquitous glycosaminoglycan prominent in the extracellular matrix, is balanced through the actions of hyaluronan-synthesizing enzymes (HAS1, 2 and 3) and degrading hyaluronidases (Hyal 1, 2, 3 and PH20). Hyaluronic Acid 14-24 hyaluronan synthase 1 Homo sapiens 164-177 26883802-2 2016 Hyaluronan synthesis requires the transport of hyaluronan synthases (HAS1-3) from Golgi to plasma membrane (PM), where the enzymes are activated. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 69-75 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 54-58 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 54-58 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 155-159 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 155-159 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 18-33 hyaluronan synthase 1 Homo sapiens 119-123 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 35-37 hyaluronan synthase 1 Homo sapiens 119-123 24590928-4 2015 The relative secretion levels of hyaluronan by the different human fibroblasts tested were attributable to the relative expression of hyaluronan synthases 1, 2, 3 but not hyaluronidases 1, 2 enzymes at the gene and protein levels among those fibroblasts. Hyaluronic Acid 33-43 hyaluronan synthase 1 Homo sapiens 134-162 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Hyaluronic Acid 16-26 hyaluronan synthase 1 Homo sapiens 126-132 25795779-12 2015 Interestingly, HAS1 transfection reduced the synthesis of hyaluronan obtained by HAS2 and HAS3, suggesting functional cooperation between the isoenzymes. Hyaluronic Acid 58-68 hyaluronan synthase 1 Homo sapiens 15-19 24658508-0 2014 Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 98-126 25699059-1 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Hyaluronic Acid 81-91 hyaluronan synthase 1 Homo sapiens 0-21 25699059-1 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Hyaluronic Acid 81-91 hyaluronan synthase 1 Homo sapiens 23-27 25699059-2 2015 Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity. Hyaluronic Acid 54-64 hyaluronan synthase 1 Homo sapiens 12-16 26448759-1 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 92-106 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 121-125 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 121-125 24668563-2 2014 Hyaluronan (HA) is a high molecular weight polyanionic carbohydrate produced by synthases (HAS1 through HAS3) and fragmented by oxidative/nitrosative stress and hyaluronidases (HYAL1 through HYAL4, SPAM1) common in PCa microenvironments. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 91-95 23303191-4 2013 This failure of HAS1 to synthesize hyaluronan was compensated by increasing the cellular content of UDP-N-acetyl glucosamine by ~10-fold with 1 mm glucosamine in the growth medium. Hyaluronic Acid 35-45 hyaluronan synthase 1 Homo sapiens 16-20 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 1 Homo sapiens 17-21 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 1 Homo sapiens 90-94 22270036-9 2012 The skin-physiological improvement was accompanied by a significant increase in the mRNA expression of hyaluronic acid synthase-1 (HAS-1), an enzyme critically involved in the synthesis of hyaluronic acid, and a noticeable increase in gene expression involved in collagen de novo synthesis. Hyaluronic Acid 103-118 hyaluronan synthase 1 Homo sapiens 131-136 24509846-1 2014 Hyaluronan synthases (HAS1-3) are unique in that they are active only when located in the plasma membrane, where they extrude the growing hyaluronan (HA) directly into cell surface and extracellular space. Hyaluronic Acid 138-148 hyaluronan synthase 1 Homo sapiens 22-28 24406795-0 2014 Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Hyaluronic Acid 25-35 hyaluronan synthase 1 Homo sapiens 127-131 24099991-2 2014 In mammals, three hyaluronan synthase isoenzymes (HAS1-3) inserted in the plasma membrane produce hyaluronan directly on cell surface. Hyaluronic Acid 18-28 hyaluronan synthase 1 Homo sapiens 50-54 24099991-5 2014 When cultured in 5 mM glucose, HAS1-transfected MCF-7 cells show very little cell surface hyaluronan, detected with a fluorescent hyaluronan binding probe. Hyaluronic Acid 90-100 hyaluronan synthase 1 Homo sapiens 31-35 24099991-5 2014 When cultured in 5 mM glucose, HAS1-transfected MCF-7 cells show very little cell surface hyaluronan, detected with a fluorescent hyaluronan binding probe. Hyaluronic Acid 130-140 hyaluronan synthase 1 Homo sapiens 31-35 23303191-7 2013 The results indicate that HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. Hyaluronic Acid 145-155 hyaluronan synthase 1 Homo sapiens 26-30 21887686-2 2012 The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). Hyaluronic Acid 4-19 hyaluronan synthase 1 Homo sapiens 55-59 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 34-53 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 34-53