PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10616194-5 1999 Briefly, we found that (a) rheumatoid synovial cells highly expressed CD44; (b) crosslinking of CD44 augmented IL-6 production and its mRNA transcription; (c) hyaluronan, especially when fragmented, also increased IL-6 production; and (d) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein. Hyaluronic Acid 159-169 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 279-298