PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32727671-0 2021 Synovial fluid levels of VEGF and FGF-2 before and after intra-articular injection of hyaluronic acid in patients with temporomandibular disorders: a short-term study. Hyaluronic Acid 86-101 fibroblast growth factor 2 Homo sapiens 34-39 2543365-4 1989 Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-beta 1 also stimulated hyaluronan synthesis; their effects were less than that of PDGF-BB, but combinations of factors produced potent stimulatory effects on hyaluronan synthesis. Hyaluronic Acid 129-139 fibroblast growth factor 2 Homo sapiens 63-67 2543365-4 1989 Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-beta 1 also stimulated hyaluronan synthesis; their effects were less than that of PDGF-BB, but combinations of factors produced potent stimulatory effects on hyaluronan synthesis. Hyaluronic Acid 264-274 fibroblast growth factor 2 Homo sapiens 63-67 31439376-0 2019 Highly sulfated hyaluronic acid maintains human induced pluripotent stem cells under feeder-free and bFGF-free conditions. Hyaluronic Acid 16-31 fibroblast growth factor 2 Homo sapiens 101-105 33456301-8 2020 Only bFGF was able to promote cell growth and hyaluronic acid production. Hyaluronic Acid 46-61 fibroblast growth factor 2 Homo sapiens 5-9 22915482-2 2012 To mimic the structure and function of native extracellular matrix (ECM), a derivative of hyaluronic acid (HA), HA-GRGDSP, was synthesized, Arg-Gly-Asp (RGD)-containing collagen (Col)/HA multilayer polyelectrolyte films (MPFs) coating was fabricated on titanium (Ti) through alternate deposition of Col and HA-GRGDSP with 4.5 assembly cycles; moreover, bioactive molecule, basic fibroblast growth factor (bFGF), was also incorporated into such coating. Hyaluronic Acid 90-105 fibroblast growth factor 2 Homo sapiens 373-403 27267669-3 2016 We found that bFGF stimulated proliferation and hyaluronan production, but not IL-6 production by orbital fibroblasts, while VEGF hardly affected orbital fibroblast activity. Hyaluronic Acid 48-58 fibroblast growth factor 2 Homo sapiens 14-18 27267669-4 2016 Remarkably, co-stimulation of orbital fibroblasts with bFGF and PDGF-BB synergistically enhanced IL-6 and hyaluronan production and displayed an additive effect on proliferation compared to either bFGF or PDGF-BB stimulation. Hyaluronic Acid 106-116 fibroblast growth factor 2 Homo sapiens 55-59 27267669-5 2016 Nintedanib, a FGF- and PDGF-receptor targeting drug, more efficiently blocked bFGF + PDGF-BB-induced IL-6 and hyaluronan production than dasatinib that only targets PDGF-receptor. Hyaluronic Acid 110-120 fibroblast growth factor 2 Homo sapiens 78-82 24083250-9 2013 Growth factors, including PDGF-BB, TGFbeta2, and FGF-2, enhanced hyaluronan deposition to ECM and modulated HA-receptor expression in fibrosarcoma cells. Hyaluronic Acid 65-75 fibroblast growth factor 2 Homo sapiens 49-54 24083250-10 2013 Indeed, FGF-2 through upregulation of specific HAS isoforms and hyaluronan synthesis regulated secretion and net hyaluronan deposition to the fibrosarcoma pericellular matrix modulating these cells" migration capability. Hyaluronic Acid 113-123 fibroblast growth factor 2 Homo sapiens 8-13 30841964-0 2019 bFGF-Sodium Hyaluronate Collagen Scaffolds Enable the Formation of Nascent Neural Networks After Adult Spinal Cord Injury. Hyaluronic Acid 5-23 fibroblast growth factor 2 Homo sapiens 0-4 30841964-3 2019 Here, we designed a bFGF controlled releasing system (bFGF-CRS) by loading bFGF onto the sodium hyaluronate collagen scaffolds to modify the hostile microenvironment. Hyaluronic Acid 89-107 fibroblast growth factor 2 Homo sapiens 20-24 30841964-3 2019 Here, we designed a bFGF controlled releasing system (bFGF-CRS) by loading bFGF onto the sodium hyaluronate collagen scaffolds to modify the hostile microenvironment. Hyaluronic Acid 89-107 fibroblast growth factor 2 Homo sapiens 54-58 30841964-3 2019 Here, we designed a bFGF controlled releasing system (bFGF-CRS) by loading bFGF onto the sodium hyaluronate collagen scaffolds to modify the hostile microenvironment. Hyaluronic Acid 89-107 fibroblast growth factor 2 Homo sapiens 54-58 33405624-2 2019 Herein, we present a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) mixture hydrogel dispersed with polycaprolactone (PCL) microspheres that can enhance simultaneous regeneration of VF muscle and lamina propria, as well as have a bulking effect on atrophied VF. Hyaluronic Acid 90-105 fibroblast growth factor 2 Homo sapiens 40-44 33405624-2 2019 Herein, we present a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) mixture hydrogel dispersed with polycaprolactone (PCL) microspheres that can enhance simultaneous regeneration of VF muscle and lamina propria, as well as have a bulking effect on atrophied VF. Hyaluronic Acid 107-109 fibroblast growth factor 2 Homo sapiens 40-44 29595848-4 2018 In this study, we generated multivalent conjugates (MVCs) of basic fibroblast growth factor (bFGF), a key growth factor involved in angiogenesis and wound healing, to hyaluronic acid (HyA) polymer chains. Hyaluronic Acid 167-182 fibroblast growth factor 2 Homo sapiens 61-91 29595848-4 2018 In this study, we generated multivalent conjugates (MVCs) of basic fibroblast growth factor (bFGF), a key growth factor involved in angiogenesis and wound healing, to hyaluronic acid (HyA) polymer chains. Hyaluronic Acid 167-182 fibroblast growth factor 2 Homo sapiens 93-97 29595848-4 2018 In this study, we generated multivalent conjugates (MVCs) of basic fibroblast growth factor (bFGF), a key growth factor involved in angiogenesis and wound healing, to hyaluronic acid (HyA) polymer chains. Hyaluronic Acid 184-187 fibroblast growth factor 2 Homo sapiens 61-91 29595848-4 2018 In this study, we generated multivalent conjugates (MVCs) of basic fibroblast growth factor (bFGF), a key growth factor involved in angiogenesis and wound healing, to hyaluronic acid (HyA) polymer chains. Hyaluronic Acid 184-187 fibroblast growth factor 2 Homo sapiens 93-97 27075110-3 2016 We reported that basic fibroblast growth factor (bFGF) stimulates fibroblasts to produce extracellular matrices such as hyaluronic acid in the lamina propria, leading to a regeneration of pliable vocal folds in animal models. Hyaluronic Acid 120-135 fibroblast growth factor 2 Homo sapiens 17-47 27075110-3 2016 We reported that basic fibroblast growth factor (bFGF) stimulates fibroblasts to produce extracellular matrices such as hyaluronic acid in the lamina propria, leading to a regeneration of pliable vocal folds in animal models. Hyaluronic Acid 120-135 fibroblast growth factor 2 Homo sapiens 49-53 22915482-2 2012 To mimic the structure and function of native extracellular matrix (ECM), a derivative of hyaluronic acid (HA), HA-GRGDSP, was synthesized, Arg-Gly-Asp (RGD)-containing collagen (Col)/HA multilayer polyelectrolyte films (MPFs) coating was fabricated on titanium (Ti) through alternate deposition of Col and HA-GRGDSP with 4.5 assembly cycles; moreover, bioactive molecule, basic fibroblast growth factor (bFGF), was also incorporated into such coating. Hyaluronic Acid 90-105 fibroblast growth factor 2 Homo sapiens 405-409 17587060-0 2007 FGF2 and dexamethasone increase the production of hyaluronan in two-dimensional culture of elastic cartilage-derived cells: in vitro analyses and in vivo cartilage formation. Hyaluronic Acid 50-60 fibroblast growth factor 2 Homo sapiens 0-4 22563650-6 2012 In our present study, we demonstrated that when FGF2 was added to elastic chondrocytes, the cell count increased and the level of hyaluronic acid, which is a major extracellular matrix (ECM) component, increased. Hyaluronic Acid 130-145 fibroblast growth factor 2 Homo sapiens 48-52 20854186-0 2010 Neovascularization by bFGF releasing hyaluronic acid-gelatin microspheres: in vitro and in vivo studies. Hyaluronic Acid 37-52 fibroblast growth factor 2 Homo sapiens 22-26 18462788-6 2008 Sulfation of hyaluronan, as well, resulted in strong binding of basic FGF to hyaluronan-sulfate, but not to hyaluronan. Hyaluronic Acid 13-23 fibroblast growth factor 2 Homo sapiens 70-73 18462788-6 2008 Sulfation of hyaluronan, as well, resulted in strong binding of basic FGF to hyaluronan-sulfate, but not to hyaluronan. Hyaluronic Acid 77-87 fibroblast growth factor 2 Homo sapiens 70-73 16249723-0 2005 Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells. Hyaluronic Acid 38-48 fibroblast growth factor 2 Homo sapiens 0-26 16806456-0 2006 Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Hyaluronic Acid 98-108 fibroblast growth factor 2 Homo sapiens 139-143 9839475-6 1998 Basic fibroblast growth factor bFGF-induced proliferation, however, was best on hyaluronan-coated plastic. Hyaluronic Acid 80-90 fibroblast growth factor 2 Homo sapiens 0-35 11378333-5 2001 bFGF also increased hyaluronan production. Hyaluronic Acid 20-30 fibroblast growth factor 2 Homo sapiens 0-4 11378333-7 2001 Our results suggest that up-regulation of the HAS genes by bFGF and IGF-1 is closely associated with the stimulation of hyaluronan synthesis, and that effects of growth factors on HAS gene expression may have important implications for tissue remodeling, such as in development and wound healing. Hyaluronic Acid 120-130 fibroblast growth factor 2 Homo sapiens 59-63 15573376-0 2005 Fibroblast growth factor-2 regulates the synthesis of hyaluronan by human periodontal ligament cells. Hyaluronic Acid 54-64 fibroblast growth factor 2 Homo sapiens 0-26 15573376-2 2005 In this study, we examined the effect of FGF-2 on the production of hyaluronan (HA), an extracellular matrix playing important roles in homeostasis and inflammatory/wound healing responses, by human periodontal ligament (HPDL) cells. Hyaluronic Acid 68-78 fibroblast growth factor 2 Homo sapiens 41-46 15762960-5 2005 Hyaluronan and its receptor CD44 were prominently expressed in IVL when compared to leiomyomas and associated with an elevation in bFGF expression. Hyaluronic Acid 0-10 fibroblast growth factor 2 Homo sapiens 131-135 12167228-0 2002 Increase in gap junctional intercellular communication by high molecular weight hyaluronic acid associated with fibroblast growth factor 2 and keratinocyte growth factor production in normal human dermal fibroblasts. Hyaluronic Acid 80-95 fibroblast growth factor 2 Homo sapiens 112-138 9310181-1 1997 The effects and the mechanisms of action of transforming (TGF-beta 2) and basic fibroblast (bFGF) growth factors on the synthesis of hyaluronan and proteoglycans (PGs) in human malignant mesothelioma cells have been studied. Hyaluronic Acid 133-143 fibroblast growth factor 2 Homo sapiens 92-96 9310181-8 1997 bFGF showed stimulatory effects for the synthesis of hyaluronan and cell associated GalAGPGs in STAV-FCS, whereas no significant enhancement was recorded for HSPGs. Hyaluronic Acid 53-63 fibroblast growth factor 2 Homo sapiens 0-4 9310181-12 1997 Incubation of both cell lines with this isoflavonoid inhibited the enhanced synthesis of hyaluronan and all PGs induced by TGF-beta 2 and bFGF. Hyaluronic Acid 89-99 fibroblast growth factor 2 Homo sapiens 138-142 8864853-11 1996 Instead, EGF and bFGF stimulated hyaluronic acid synthesis in the culture. Hyaluronic Acid 33-48 fibroblast growth factor 2 Homo sapiens 17-21 8508806-7 1993 The capacity of different GAGs to protect bFGF from proteolytic cleavage decreases in the following order: heparin > heparan sulfate > dermatan sulfate = chondroitin sulfates A and C > hyaluronic acid = K5 polysaccharide, indicating that both the degree of sulfation and the backbone structure of GAG modulate its interaction with bFGF. Hyaluronic Acid 194-209 fibroblast growth factor 2 Homo sapiens 42-46