PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19633173-0 2009 Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Hyaluronic Acid 60-70 hyaluronan synthase 2 Mus musculus 28-32 17915907-4 2007 Hyaluronan synthesis was enhanced by 13- and 24-fold, most likely due to increased expression of hyaluronan synthase-2. Hyaluronic Acid 0-10 hyaluronan synthase 2 Mus musculus 97-118 17322391-3 2007 In expressing Cre recombinase under the control of the MMTV promoter, the bigenic mice bearing Has2 and neu transgenes exhibited a deposition of hyaluronan matrix and aggressive growth of Neu-initiated mammary tumors. Hyaluronic Acid 145-155 hyaluronan synthase 2 Mus musculus 95-99 15854028-3 2005 Hyaluronan increased in the epidermis when keratinocytes started to stratify on day E15, remained high until birth, and then rapidly declined, with corresponding changes in the mRNA levels of has2 and has3. Hyaluronic Acid 0-10 hyaluronan synthase 2 Mus musculus 192-196 16931798-3 2006 Targeted deletion of the hyaluronan synthase-2 (Has2) gene in mice results in an absence of hyaluronan (HA), cardiac jelly, and endocardial cushions, a loss of vascular integrity, and death at embryonic day 9.5. Hyaluronic Acid 25-35 hyaluronan synthase 2 Mus musculus 48-52 16816377-1 2006 Aggressive cells in prostate cancer secrete extracellular hyaluronan (HA) as a result of up-regulated HA synthase enzymes HAS2 and HAS3. Hyaluronic Acid 58-68 hyaluronan synthase 2 Mus musculus 122-126 15522760-1 2005 We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Hyaluronic Acid 32-47 hyaluronan synthase 2 Mus musculus 206-227 15522760-1 2005 We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Hyaluronic Acid 32-47 hyaluronan synthase 2 Mus musculus 229-233 15854028-6 2005 The hyaluronan response was associated with a strong induction of has2 and has3 mRNA, slightly higher CD44 expression, and considerable epidermal hyperplasia. Hyaluronic Acid 4-14 hyaluronan synthase 2 Mus musculus 66-70 15854028-7 2005 The data show that the pre- and postnatal fluctuations in epidermal hyaluronan content correlate with the expression levels of has2 and has3. Hyaluronic Acid 68-78 hyaluronan synthase 2 Mus musculus 127-131 12975613-8 2002 This review focuses on recent studies utilizing hyaluronan-deficient, gene targeted mice with null alleles for the principal source of hyaluronan during mid-gestation, hyaluronan synthase-2 (has-2). Hyaluronic Acid 48-58 hyaluronan synthase 2 Mus musculus 168-189 12975613-8 2002 This review focuses on recent studies utilizing hyaluronan-deficient, gene targeted mice with null alleles for the principal source of hyaluronan during mid-gestation, hyaluronan synthase-2 (has-2). Hyaluronic Acid 48-58 hyaluronan synthase 2 Mus musculus 191-196 10571120-3 1999 In the hypertrophic cells, cytoplasmic hyaluronan was stained with the biotinylated hyaluronan-binding region (b-HABR) of aggrecan, and mRNAs of hyaluronan synthase (Has 1, Has 2 and Has 3) were detected by in situ hybridization. Hyaluronic Acid 39-49 hyaluronan synthase 2 Mus musculus 173-178 34200222-9 2021 The expression of hyaluronic acid synthase 2 and hyaluronidase 1 by UV-B was remarkably ameliorated with increased production of hyaluronic acid by treating fsCH to photoaged mice. Hyaluronic Acid 129-144 hyaluronan synthase 2 Mus musculus 18-44 9442026-7 1998 Expression of mouse Has2, Has3, and Xenopus Has1 (DG42) led to hyaluronan biosynthesis in transfected mammalian cells. Hyaluronic Acid 63-73 hyaluronan synthase 2 Mus musculus 20-24 9442026-8 1998 However, only mouse Has2 and Has3 expressing cells formed significant hyaluronan-dependent pericellular coats in culture, implying both functional similarities and differences among vertebrate HAS enzymes. Hyaluronic Acid 70-80 hyaluronan synthase 2 Mus musculus 20-24 8798545-8 1996 Transfection experiments demonstrated that mouse Has2 could direct hyaluronan coat biosynthesis in transfected COS cells, as evidenced by a classical particle exclusion assay. Hyaluronic Acid 67-77 hyaluronan synthase 2 Mus musculus 49-53 32360595-3 2020 We have previously reported that 1,25D inhibits hyaluronic acid synthase 2 (HAS2) expression and hyaluronic acid (HA) synthesis in murine TNBC cells. Hyaluronic Acid 48-63 hyaluronan synthase 2 Mus musculus 76-80 35608281-6 2022 Conditional Gdf5Cre-driven ablation of Has2 -responsible for production of the joint polysaccharide lubricant hyaluronic acid (HA)- delayed the cavitation process. Hyaluronic Acid 110-125 hyaluronan synthase 2 Mus musculus 39-43 35608281-6 2022 Conditional Gdf5Cre-driven ablation of Has2 -responsible for production of the joint polysaccharide lubricant hyaluronic acid (HA)- delayed the cavitation process. Hyaluronic Acid 127-129 hyaluronan synthase 2 Mus musculus 39-43 26427019-4 2015 Furthermore, on analyzing the mice skin, orally administered hyaluronan with a molecular weight of less than 10k increased the levels of the HAS2 gene expression in the skin. Hyaluronic Acid 61-71 hyaluronan synthase 2 Mus musculus 141-145 27318148-12 2016 We identified hyaluronan synthase 2 (Has2) as another novel downstream factor of Etv1; that may mediate ETV1"s significant expansion of hyaluronic acid in PDAC stroma. Hyaluronic Acid 136-151 hyaluronan synthase 2 Mus musculus 14-35 27318148-12 2016 We identified hyaluronan synthase 2 (Has2) as another novel downstream factor of Etv1; that may mediate ETV1"s significant expansion of hyaluronic acid in PDAC stroma. Hyaluronic Acid 136-151 hyaluronan synthase 2 Mus musculus 37-41 25163516-0 2014 Spatially restricted hyaluronan production by Has2 drives epithelial tubulogenesis in vitro. Hyaluronic Acid 21-31 hyaluronan synthase 2 Mus musculus 46-50 24469446-6 2014 Comparing PN-null to WT mice also revealed that expression of hyaluronan (HA) and activation of hyaluronan synthase-2 (Has2) are also enhanced upon PN/INTEGRIN/focal adhesion kinase-mediated activation of PI3K and/or ERK, an effect confirmed by the reduction of HA synthase-2 in PN-null mice. Hyaluronic Acid 62-72 hyaluronan synthase 2 Mus musculus 262-275 25077968-4 2014 Our previous studies using a hyaluronan synthase 2 (Has2) transgenic mouse model demonstrated that hyaluronan overproduction caused rapid development of aggressive breast carcinoma at a high incidence. Hyaluronic Acid 29-39 hyaluronan synthase 2 Mus musculus 52-56 21224752-0 2011 The role of hyaluronan produced by Has2 gene expression in development of the spine. Hyaluronic Acid 12-22 hyaluronan synthase 2 Mus musculus 35-39 23108409-3 2013 We demonstrate that TGFbeta potently stimulates hyaluronan synthesis via upregulation of hyaluronan synthase 2 (HAS2) in NMuMG mammary epithelial cells. Hyaluronic Acid 48-58 hyaluronan synthase 2 Mus musculus 89-110 23108409-3 2013 We demonstrate that TGFbeta potently stimulates hyaluronan synthesis via upregulation of hyaluronan synthase 2 (HAS2) in NMuMG mammary epithelial cells. Hyaluronic Acid 48-58 hyaluronan synthase 2 Mus musculus 112-116 23313125-2 2013 Through analysis of the early limb bud transcriptome, we identified a posteriorly-enriched gene, Hyaluronic Acid Synthase 2 (Has2), which encodes a key enzyme for the synthesis of hyaluronan (HA), as a direct target of Gli transcriptional regulation during early mouse limb development. Hyaluronic Acid 180-190 hyaluronan synthase 2 Mus musculus 97-123 23313125-2 2013 Through analysis of the early limb bud transcriptome, we identified a posteriorly-enriched gene, Hyaluronic Acid Synthase 2 (Has2), which encodes a key enzyme for the synthesis of hyaluronan (HA), as a direct target of Gli transcriptional regulation during early mouse limb development. Hyaluronic Acid 180-190 hyaluronan synthase 2 Mus musculus 125-129 22382329-4 2012 Hyaluronan synthesis was found to be mediated by hyaluronan synthase 2 (HAS2) expressed in Swiss 3T3 cells. Hyaluronic Acid 0-10 hyaluronan synthase 2 Mus musculus 49-70 22382329-4 2012 Hyaluronan synthesis was found to be mediated by hyaluronan synthase 2 (HAS2) expressed in Swiss 3T3 cells. Hyaluronic Acid 0-10 hyaluronan synthase 2 Mus musculus 72-76 22382329-5 2012 A decreases in the amount of hyaluronan, which was achieved by retroviral expression of short hairpin RNA for Has2 or by addition of hyaluronidase, significantly enhanced the proliferation of the cultured mast cells without any obvious effects on their maturation. Hyaluronic Acid 29-39 hyaluronan synthase 2 Mus musculus 110-114 21224752-2 2011 OBJECTIVE: To evaluate the role hyaluronan produced by hyaluronan synthase-2 (Has2) in spine development. Hyaluronic Acid 32-42 hyaluronan synthase 2 Mus musculus 55-76 21224752-2 2011 OBJECTIVE: To evaluate the role hyaluronan produced by hyaluronan synthase-2 (Has2) in spine development. Hyaluronic Acid 32-42 hyaluronan synthase 2 Mus musculus 78-82 21224752-3 2011 SUMMARY OF BACKGROUND DATA: The Has2 gene is responsible for most hyaluronan production throughout the body, including the skeleton. Hyaluronic Acid 66-76 hyaluronan synthase 2 Mus musculus 32-36 21224752-15 2011 CONCLUSION: Hyaluronan production by Has2 is essential for normal vertebral and intervertebral disc development within the spine, and the absence of this synthase impairs the organization of both soft and hard tissue elements. Hyaluronic Acid 12-22 hyaluronan synthase 2 Mus musculus 37-41 21246657-0 2011 Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Hyaluronic Acid 0-10 hyaluronan synthase 2 Mus musculus 34-38