PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15699048-5 2005 We show that TSG-6 protein and hyaluronan, in a temperature-dependent fashion, form a stable complex that is resistant to dissociating agents. Hyaluronic Acid 31-41 tumor necrosis factor alpha induced protein 6 Mus musculus 13-18 16006654-12 2005 TSP1 enhances covalent modification of the inter-alpha-trypsin inhibitor by TSG-6 and transfer of its heavy chains to hyaluronan, suggesting a physiological function of TSP1 binding to TSG-6 in regulation of hyaluronan metabolism at sites of inflammation. Hyaluronic Acid 118-128 tumor necrosis factor alpha induced protein 6 Mus musculus 185-190 16006654-12 2005 TSP1 enhances covalent modification of the inter-alpha-trypsin inhibitor by TSG-6 and transfer of its heavy chains to hyaluronan, suggesting a physiological function of TSP1 binding to TSG-6 in regulation of hyaluronan metabolism at sites of inflammation. Hyaluronic Acid 208-218 tumor necrosis factor alpha induced protein 6 Mus musculus 76-81 16006654-12 2005 TSP1 enhances covalent modification of the inter-alpha-trypsin inhibitor by TSG-6 and transfer of its heavy chains to hyaluronan, suggesting a physiological function of TSP1 binding to TSG-6 in regulation of hyaluronan metabolism at sites of inflammation. Hyaluronic Acid 208-218 tumor necrosis factor alpha induced protein 6 Mus musculus 185-190 15836955-5 2005 Some of the hyaluronan binding factors that have been identified in the COC matrix are the serum derived factor inter-alpha trypsin inhibitor (IalphaI) and tumor necrosis factor stimulated gene-6 (TSG-6). Hyaluronic Acid 12-22 tumor necrosis factor alpha induced protein 6 Mus musculus 197-202 15699048-0 2005 TSG-6 protein binding to glycosaminoglycans: formation of stable complexes with hyaluronan and binding to chondroitin sulfates. Hyaluronic Acid 80-90 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 15699048-3 2005 TSG-6 protein is composed of the N-terminal link module that binds hyaluronan and a C-terminal CUB domain, present in a variety of proteins. Hyaluronic Acid 67-77 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 15699048-4 2005 Interactions between the isolated link module and hyaluronan have been studied extensively, but little is known about the binding of full-length TSG-6 protein to hyaluronan and other glycosaminoglycans. Hyaluronic Acid 162-172 tumor necrosis factor alpha induced protein 6 Mus musculus 145-150 15699048-6 2005 The formation of such stable complexes may underlie the activities of TSG-6 protein in inflammation and fertility, e.g. the TSG-6-dependent cross-linking of hyaluronan in the cumulus cell-oocyte complex during ovulation. Hyaluronic Acid 157-167 tumor necrosis factor alpha induced protein 6 Mus musculus 70-75 15699048-6 2005 The formation of such stable complexes may underlie the activities of TSG-6 protein in inflammation and fertility, e.g. the TSG-6-dependent cross-linking of hyaluronan in the cumulus cell-oocyte complex during ovulation. Hyaluronic Acid 157-167 tumor necrosis factor alpha induced protein 6 Mus musculus 124-129 15699048-8 2005 TSG-6 binding to immobilized hyaluronan did not interfere with subsequent adhesion of lymphoid cells. Hyaluronic Acid 29-39 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 15699048-9 2005 In addition to immobilized hyaluronan, full-length TSG-6 also binds free hyaluronan and all chondroitin sulfate isoforms under physiological conditions. Hyaluronic Acid 27-37 tumor necrosis factor alpha induced protein 6 Mus musculus 51-56 15699048-9 2005 In addition to immobilized hyaluronan, full-length TSG-6 also binds free hyaluronan and all chondroitin sulfate isoforms under physiological conditions. Hyaluronic Acid 73-83 tumor necrosis factor alpha induced protein 6 Mus musculus 51-56 30623115-1 2019 During inflammation, the covalent linking of the ubiquitous extracellular polysaccharide hyaluronan (HA) with the heavy chains (HC) of the serum protein inter alpha inhibitor (IalphaI) is exclusively mediated by the enzyme tumor necrosis factor alpha (TNFalpha)-stimulated-gene-6 (TSG-6). Hyaluronic Acid 89-99 tumor necrosis factor alpha induced protein 6 Mus musculus 281-286 14707130-4 2004 In this report, we characterize the specificity of TNFIP6-mediated HC transfer from IalphaI to hyaluronan. Hyaluronic Acid 95-105 tumor necrosis factor alpha induced protein 6 Mus musculus 51-57 12668637-8 2003 Recombinant TNFIP6 is able to catalyze the covalent transfer of heavy chains to hyaluronan in a cell-free system, restore the expansion of Tnfip6-null cumulus cell-oocyte complexes in vitro, and rescue the fertility in Tnfip6-null females. Hyaluronic Acid 80-90 tumor necrosis factor alpha induced protein 6 Mus musculus 12-18 12209527-13 2002 CONCLUSION: TSG-6 protein is known to form a complex with inter-alpha-inhibitor (IalphaI), a potent serine protease inhibitor, which may be immobilized via the hyaluronan (HA)-binding domain of TSG-6 protein in the HA-rich extracellular matrix of cartilage. Hyaluronic Acid 160-170 tumor necrosis factor alpha induced protein 6 Mus musculus 12-17 12209527-13 2002 CONCLUSION: TSG-6 protein is known to form a complex with inter-alpha-inhibitor (IalphaI), a potent serine protease inhibitor, which may be immobilized via the hyaluronan (HA)-binding domain of TSG-6 protein in the HA-rich extracellular matrix of cartilage. Hyaluronic Acid 160-170 tumor necrosis factor alpha induced protein 6 Mus musculus 194-199 31547322-0 2019 Hyaluronan Accelerates Intestinal Mucosal Healing through Interaction with TSG-6. Hyaluronic Acid 0-10 tumor necrosis factor alpha induced protein 6 Mus musculus 75-80 30373703-2 2019 Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-alpha-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tumour necrosis factor-stimulated gene 6 (TSG-6). Hyaluronic Acid 0-10 tumor necrosis factor alpha induced protein 6 Mus musculus 132-172 30373703-2 2019 Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-alpha-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tumour necrosis factor-stimulated gene 6 (TSG-6). Hyaluronic Acid 0-10 tumor necrosis factor alpha induced protein 6 Mus musculus 174-179 30373703-2 2019 Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-alpha-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tumour necrosis factor-stimulated gene 6 (TSG-6). Hyaluronic Acid 12-14 tumor necrosis factor alpha induced protein 6 Mus musculus 132-172 30373703-2 2019 Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-alpha-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tumour necrosis factor-stimulated gene 6 (TSG-6). Hyaluronic Acid 12-14 tumor necrosis factor alpha induced protein 6 Mus musculus 174-179 14707130-11 2004 Our data indicate that TNFIP6-mediated HC transfer to hyaluronan is a prerequisite for the correct cumulus matrix assembly and hyaluronan oligosaccharides and chondroitin interfere with this assembly by capturing the HCs of the IalphaI-related proteins. Hyaluronic Acid 54-64 tumor necrosis factor alpha induced protein 6 Mus musculus 23-29 11696432-2 2001 TSG-6 binds to hyaluronan in inflamed synovial tissue and forms a complex with a serine protease inter-alpha-trypsin inhibitor (IalphaI), increasing the protease inhibitory effect of IalphaI >100-fold. Hyaluronic Acid 15-25 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 9427551-7 1997 Since TSG-6 binds to hyaluronan and interacts with inter-alpha-trypsin inhibitor (IalphaI), molecules that are essential for matrix formation by COCs, this protein may have a structural role in the matrix or may enhance the antiproteolytic effect of IalphaI to protect the matrix from degradation. Hyaluronic Acid 21-31 tumor necrosis factor alpha induced protein 6 Mus musculus 6-11 8739346-2 1996 The purpose of this study was to gain insights into the role of TSG-6 and its functional interactions with hyaluronan in inflammation. Hyaluronic Acid 107-117 tumor necrosis factor alpha induced protein 6 Mus musculus 64-69 32422216-2 2020 TSG-6 has several known biological functions including enzymatic transfer of heavy chain proteins (HC) from inter-alpha-trypsin inhibitor to hyaluronan (HA) to form HC-HA complexes. Hyaluronic Acid 141-151 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 30623115-1 2019 During inflammation, the covalent linking of the ubiquitous extracellular polysaccharide hyaluronan (HA) with the heavy chains (HC) of the serum protein inter alpha inhibitor (IalphaI) is exclusively mediated by the enzyme tumor necrosis factor alpha (TNFalpha)-stimulated-gene-6 (TSG-6). Hyaluronic Acid 101-103 tumor necrosis factor alpha induced protein 6 Mus musculus 281-286 29122888-2 2017 TNF-stimulated gene 6 (TSG-6) is required to transfer inter-alpha-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor binding. Hyaluronic Acid 97-107 tumor necrosis factor alpha induced protein 6 Mus musculus 0-21 29122888-2 2017 TNF-stimulated gene 6 (TSG-6) is required to transfer inter-alpha-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor binding. Hyaluronic Acid 97-107 tumor necrosis factor alpha induced protein 6 Mus musculus 23-28 27435674-1 2016 Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can reorganize/stabilize its structure, also enhancing the binding of this glycosaminoglycan to its cell surface receptor, CD44. Hyaluronic Acid 63-73 tumor necrosis factor alpha induced protein 6 Mus musculus 47-52 23129777-0 2013 Tumor necrosis factor-stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells. Hyaluronic Acid 58-68 tumor necrosis factor alpha induced protein 6 Mus musculus 41-46 26468290-6 2015 In addition, we have found that the well characterized hyaluronan-binding site in the TSG-6 Link module is not used for recognition during transfer of HCs onto HA. Hyaluronic Acid 55-65 tumor necrosis factor alpha induced protein 6 Mus musculus 86-91 26986845-4 2016 It has been demonstrated that tumor necrosis factor alpha-induced protein 6 catalyzes the formation of heavy chains of (inter-alpha-trypsin inhibitor) -hyaluronan complexes and these are then cross-linked via PTX3. Hyaluronic Acid 152-162 tumor necrosis factor alpha induced protein 6 Mus musculus 30-75 26468290-2 2015 Hyaluronan is organized into a cross-linked network by the cooperative action of three proteins, inter-alpha-inhibitor (IalphaI), pentraxin-3, and TNF-stimulated gene-6 (TSG-6), driving the expansion of the COC and providing the cumulus matrix with its required viscoelastic properties. Hyaluronic Acid 0-10 tumor necrosis factor alpha induced protein 6 Mus musculus 147-168 26468290-2 2015 Hyaluronan is organized into a cross-linked network by the cooperative action of three proteins, inter-alpha-inhibitor (IalphaI), pentraxin-3, and TNF-stimulated gene-6 (TSG-6), driving the expansion of the COC and providing the cumulus matrix with its required viscoelastic properties. Hyaluronic Acid 0-10 tumor necrosis factor alpha induced protein 6 Mus musculus 170-175 26468290-3 2015 Although it is known that matrix stabilization involves the TSG-6-mediated transfer of IalphaI heavy chains (HCs) onto hyaluronan (to form covalent HC HA complexes that are cross-linked by pentraxin-3) and that this occurs via the formation of covalent HC TSG-6 intermediates, the underlying molecular mechanisms are not well understood. Hyaluronic Acid 119-129 tumor necrosis factor alpha induced protein 6 Mus musculus 60-65 23129777-1 2013 We tested the hypothesis that the artificial addition of heavy chains from inter-alpha-inhibitor to hyaluronan (HA), by adding recombinant TSG-6 (TNF-stimulated gene-6) to the culture medium of murine airway smooth muscle (MASM) cells, would enhance leukocyte binding to HA cables produced in response to poly(I:C). Hyaluronic Acid 100-110 tumor necrosis factor alpha induced protein 6 Mus musculus 139-144 23129777-1 2013 We tested the hypothesis that the artificial addition of heavy chains from inter-alpha-inhibitor to hyaluronan (HA), by adding recombinant TSG-6 (TNF-stimulated gene-6) to the culture medium of murine airway smooth muscle (MASM) cells, would enhance leukocyte binding to HA cables produced in response to poly(I:C). Hyaluronic Acid 100-110 tumor necrosis factor alpha induced protein 6 Mus musculus 146-167 19033448-0 2009 Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes. Hyaluronic Acid 50-60 tumor necrosis factor alpha induced protein 6 Mus musculus 90-95 19033448-0 2009 Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes. Hyaluronic Acid 79-89 tumor necrosis factor alpha induced protein 6 Mus musculus 90-95 19033448-3 2009 TSG-6-heavy chain complexes serve as intermediates in the transfer of heavy chains from inter-alpha-inhibitor to hyaluronan. Hyaluronic Acid 113-123 tumor necrosis factor alpha induced protein 6 Mus musculus 0-5 19033448-4 2009 In vivo, in addition to these complexes, stable ternary complexes of hyaluronan with both TSG-6 and heavy chains have been demonstrated in the ovulatory cumulus oophorus. Hyaluronic Acid 69-79 tumor necrosis factor alpha induced protein 6 Mus musculus 90-95 19033448-5 2009 In our ongoing efforts to characterize the multiple interactions between hyaluronan, TSG-6 and inter-alpha-inhibitor, we recently characterized the formation of highly stable complexes of TSG-6 with hyaluronan that had been tethered to a solid surface. Hyaluronic Acid 73-83 tumor necrosis factor alpha induced protein 6 Mus musculus 188-193 19033448-5 2009 In our ongoing efforts to characterize the multiple interactions between hyaluronan, TSG-6 and inter-alpha-inhibitor, we recently characterized the formation of highly stable complexes of TSG-6 with hyaluronan that had been tethered to a solid surface. Hyaluronic Acid 199-209 tumor necrosis factor alpha induced protein 6 Mus musculus 85-90 19033448-5 2009 In our ongoing efforts to characterize the multiple interactions between hyaluronan, TSG-6 and inter-alpha-inhibitor, we recently characterized the formation of highly stable complexes of TSG-6 with hyaluronan that had been tethered to a solid surface. Hyaluronic Acid 199-209 tumor necrosis factor alpha induced protein 6 Mus musculus 188-193 19033448-6 2009 Here we show that these hyaluronan-TSG-6 complexes are functionally active and transfer heavy chain subunits from inter-alpha-inhibitor to either free or surface-bound hyaluronan. Hyaluronic Acid 24-34 tumor necrosis factor alpha induced protein 6 Mus musculus 35-40 19033448-6 2009 Here we show that these hyaluronan-TSG-6 complexes are functionally active and transfer heavy chain subunits from inter-alpha-inhibitor to either free or surface-bound hyaluronan. Hyaluronic Acid 168-178 tumor necrosis factor alpha induced protein 6 Mus musculus 35-40 19033448-7 2009 Transitional hyaluronan-TSG-6-heavy chain complexes do not accumulate in vitro. Hyaluronic Acid 13-23 tumor necrosis factor alpha induced protein 6 Mus musculus 24-29 19033448-8 2009 Our data show the capability for heavy chain transfer by both free TSG-6 and preformed hyaluronan-TSG-6 complexes, suggesting that both might contribute to hyaluronan modification in vivo. Hyaluronic Acid 87-97 tumor necrosis factor alpha induced protein 6 Mus musculus 98-103