PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14653390-4 2003 RESULTS: The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion. Hyaluronic Acid 126-136 interleukin 6 Homo sapiens 33-37 14999424-9 2005 It can be concluded that hyaluronan considerably decreased IL-6 levels, which correlated with clinical improvement, but had no effect on IL-8 and TNF-alpha levels in synovial fluid. Hyaluronic Acid 25-35 interleukin 6 Homo sapiens 59-63 14733131-20 2003 Cultured human Muller cells expressed both VEGF and IL-6 mRNA and these expressions were augmented after the treatment of AGEs, while also acting as photosensitizers and accelerating the degradation of hyaluronic acid in vitro. Hyaluronic Acid 202-217 interleukin 6 Homo sapiens 52-56 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 261-276 interleukin 6 Homo sapiens 30-43 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 261-276 interleukin 6 Homo sapiens 45-49 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 278-288 interleukin 6 Homo sapiens 30-43 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 278-288 interleukin 6 Homo sapiens 45-49 11718104-3 2001 Stimulation with 1 ng/ml and 10 ng/ml IL-6 led to an increase in hyaluronic acid from 48% to 61% (-FCS) and from 77% to 90% (+10% FCS), respectively. Hyaluronic Acid 65-80 interleukin 6 Homo sapiens 38-42 11278272-0 2001 Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 85-98 10405161-2 1999 Hyaluronic acid with a molecular weight above 1.2 MDa (HMW-HA) inhibits the AGE-induced activation of the transcription factor NF-kappaB and the NF-kappaB-regulated cytokines interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 195-240 11215744-4 2000 Correlation analyses for TGF-beta and IL-6 indicated a strong dependence of the production of hyaluronan on cytokine levels and, to a lesser extent, on IL-1beta levels. Hyaluronic Acid 94-104 interleukin 6 Homo sapiens 38-42 11108572-5 2000 Among OA patients in whom remarkable improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the initial examination were relatively higher, and were markedly decreased after treatment with sodium hyaluronate (NaHA). Hyaluronic Acid 217-235 interleukin 6 Homo sapiens 96-100 10616194-4 1999 Using synovial cells from patients with rheumatoid arthritis (RA), we demonstrated that CD44 crosslinking and binding to hyaluronan augmented IL-6 production. Hyaluronic Acid 121-131 interleukin 6 Homo sapiens 142-146 10616194-5 1999 Briefly, we found that (a) rheumatoid synovial cells highly expressed CD44; (b) crosslinking of CD44 augmented IL-6 production and its mRNA transcription; (c) hyaluronan, especially when fragmented, also increased IL-6 production; and (d) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein. Hyaluronic Acid 159-169 interleukin 6 Homo sapiens 214-218 7881384-2 1994 At confluency of HSF cultures, hyaluronan increased the level of HSFEp in a time and dose-dependent fashion. Hyaluronic Acid 31-41 interleukin 6 Homo sapiens 17-20 9041915-11 1997 The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability. Hyaluronic Acid 244-259 interleukin 6 Homo sapiens 17-21 29162939-0 2017 Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. Hyaluronic Acid 33-51 interleukin 6 Homo sapiens 149-162 35573706-8 2022 Overall, our study indicates that HA-enriched ECM generated by co-cultures of activated CD4 T cells with FLS from human joints creates a pathogenic microenvironment by promoting adhesion of leukocytes and expression of inflammatory cytokines including IL6. Hyaluronic Acid 34-36 interleukin 6 Homo sapiens 252-255 32296689-2 2020 High molecular weight hyaluronan (hMwt HA) is one of the most abundant bioactive macromolecules of healthy synovial fluid (hSF) and it plays an important role in the protection of opposing articular cartilage surfaces within the synovial joint. Hyaluronic Acid 22-32 interleukin 6 Homo sapiens 123-126 31630264-10 2020 Additionally, the cross-linked hyaluronic acid gel could inhibit IL-6 secretion. Hyaluronic Acid 31-46 interleukin 6 Homo sapiens 65-69 31630264-11 2020 CONCLUSIONS: These results indicate that cross-linked hyaluronic acid gel can prevent epidural adhesion by inhibiting inflammatory factors, such as IL-6, and downregulating TGFbeta1 and COL1A1 mRNA expression. Hyaluronic Acid 54-69 interleukin 6 Homo sapiens 148-152 25126764-0 2014 Low molecular weight hyaluronan mediated CD44 dependent induction of IL-6 and chemokines in human dermal fibroblasts potentiates innate immune response. Hyaluronic Acid 21-31 interleukin 6 Homo sapiens 69-73 26690867-0 2015 Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. Hyaluronic Acid 12-22 interleukin 6 Homo sapiens 161-165 25818949-0 2015 Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 26-30 25442884-14 2014 Co-incubation of hyaluronan and histones caused formation of histone aggregates, decreased the cytotoxic effects of the histones, and blocked the increase in IL-6 (P<.01). Hyaluronic Acid 17-27 interleukin 6 Homo sapiens 158-162 21059338-0 2010 High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Hyaluronic Acid 22-37 interleukin 6 Homo sapiens 47-51 21059338-1 2010 To investigate the mechanism of the inhibitory action of high molecular weight hyaluronic acid (HA) on production of matrix metalloproteinases (MMPs) induced by IL-6 in human chondrocyte. Hyaluronic Acid 79-94 interleukin 6 Homo sapiens 161-165 21059338-1 2010 To investigate the mechanism of the inhibitory action of high molecular weight hyaluronic acid (HA) on production of matrix metalloproteinases (MMPs) induced by IL-6 in human chondrocyte. Hyaluronic Acid 96-98 interleukin 6 Homo sapiens 161-165 19296424-10 2009 RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation. Hyaluronic Acid 76-91 interleukin 6 Homo sapiens 42-46