PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32647102-0 2020 Hyaluronic acid-coated gold nanorods enhancing BMP-2 peptide delivery for chondrogenesis. Hyaluronic Acid 0-15 bone morphogenetic protein 2 Homo sapiens 47-52 33028783-5 2020 ALP activity and OC expression were significantly increased when cells were cultured with collagen/hyaluronic acid+BMP2/7 heterodimer (p<0.05). Hyaluronic Acid 99-114 bone morphogenetic protein 2 Homo sapiens 115-121 32927087-0 2020 An injectable click-crosslinked hyaluronic acid hydrogel modified with a BMP-2 mimetic peptide as a bone tissue engineering scaffold. Hyaluronic Acid 32-47 bone morphogenetic protein 2 Homo sapiens 73-78 32647102-3 2020 We herein designed nanoparticles made from hyaluronic acid functionalized gold nanorods to conjugate with thiolated BMP-2 knuckle epitope peptide via a two-step reaction. Hyaluronic Acid 43-58 bone morphogenetic protein 2 Homo sapiens 116-121 32647102-8 2020 Moreover, in vitro cell viability showed that BMP-2 conjugated hyaluronic acid functionalized gold nanorods (B2HGR) were cytocompatible and did not cause cytotoxicity to fibroblast cells. Hyaluronic Acid 63-78 bone morphogenetic protein 2 Homo sapiens 46-51 31060227-0 2019 Chitosan-Based Hydrogels Embedded with Hyaluronic Acid Complex Nanoparticles for Controlled Delivery of Bone Morphogenetic Protein-2. Hyaluronic Acid 39-54 bone morphogenetic protein 2 Homo sapiens 104-132 31060227-2 2019 The selected CH-PDO with soluble characteristics in aqueous media was used together with hyaluronic acid (HA) to prepare HA/CH-PDO polyelectrolyte complex nanoparticles (NPs) via an ionotropic gelation technique, and such a type of HA/CH-PDO NPs was employed as a carrier for delivering bone morphogenetic protein-2 (BMP-2). Hyaluronic Acid 106-108 bone morphogenetic protein 2 Homo sapiens 287-315 31060227-2 2019 The selected CH-PDO with soluble characteristics in aqueous media was used together with hyaluronic acid (HA) to prepare HA/CH-PDO polyelectrolyte complex nanoparticles (NPs) via an ionotropic gelation technique, and such a type of HA/CH-PDO NPs was employed as a carrier for delivering bone morphogenetic protein-2 (BMP-2). Hyaluronic Acid 106-108 bone morphogenetic protein 2 Homo sapiens 317-322 26610690-1 2016 An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. Hyaluronic Acid 26-36 bone morphogenetic protein 2 Homo sapiens 119-147 32263647-3 2016 In this study, functional hyaluronan-alendronate/BMP-2 (HA-Aln/BMP-2) nanoparticles were embedded into the Gel/Chi multilayers on Ti6Al7Nb surfaces (namely Ti6Al7Nb/LBL/NP) to endow the Ti6Al7Nb-based implant with local anti-osteoporosis properties. Hyaluronic Acid 26-36 bone morphogenetic protein 2 Homo sapiens 49-54 26610690-1 2016 An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. Hyaluronic Acid 26-36 bone morphogenetic protein 2 Homo sapiens 149-154 22927307-0 2014 Characterization of recombinant human bone morphogenetic protein-2 delivery from injectable hyaluronan-based hydrogels by means of 125I-radiolabelling. Hyaluronic Acid 92-102 bone morphogenetic protein 2 Homo sapiens 38-66 26059079-0 2015 Synergistic Effects of SDF-1alpha and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair. Hyaluronic Acid 85-100 bone morphogenetic protein 2 Homo sapiens 38-43 25619298-2 2014 METHODS: By using plasmid of bone morphogenetic protein-2 (pBMP-2)-loaded lipopolysaccharide-amine nanopolymersomes (pLNP) as cationic polyelectrolytes and hyaluronic acid (HA) as anionic polyelectrolytes. Hyaluronic Acid 156-171 bone morphogenetic protein 2 Homo sapiens 29-57 25619298-2 2014 METHODS: By using plasmid of bone morphogenetic protein-2 (pBMP-2)-loaded lipopolysaccharide-amine nanopolymersomes (pLNP) as cationic polyelectrolytes and hyaluronic acid (HA) as anionic polyelectrolytes. Hyaluronic Acid 173-175 bone morphogenetic protein 2 Homo sapiens 29-57 25943094-0 2015 Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-beta1. Hyaluronic Acid 11-21 bone morphogenetic protein 2 Homo sapiens 99-104 22927307-1 2014 This study presents a thorough in vitro and in vivo characterization of the delivery of bone morphogenetic protein 2 (BMP-2) from a hyaluronan-based hydrogel system. Hyaluronic Acid 132-142 bone morphogenetic protein 2 Homo sapiens 88-116 22927307-1 2014 This study presents a thorough in vitro and in vivo characterization of the delivery of bone morphogenetic protein 2 (BMP-2) from a hyaluronan-based hydrogel system. Hyaluronic Acid 132-142 bone morphogenetic protein 2 Homo sapiens 118-123 19775743-0 2009 Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release. Hyaluronic Acid 30-45 bone morphogenetic protein 2 Homo sapiens 117-122 23947433-0 2013 Bisphosphonate-linked hyaluronic acid hydrogel sequesters and enzymatically releases active bone morphogenetic protein-2 for induction of osteogenic differentiation. Hyaluronic Acid 22-37 bone morphogenetic protein 2 Homo sapiens 92-120 23947433-4 2013 Herein we demonstrate that functionalization of a hyaluronan (HA) hydrogel with covalently linked bisphosphonate (BP) ligands provides efficient sequestering of BMP-2 in the resulting HA-BP hydrogel. Hyaluronic Acid 50-60 bone morphogenetic protein 2 Homo sapiens 161-166 23524688-2 2013 In this prospective randomized study, a hyaluronan-based hydrogel with BMP-2 was used to achieve bone healing in standardized critical-size cranial defects in humans after neurosurgery. Hyaluronic Acid 40-50 bone morphogenetic protein 2 Homo sapiens 71-76 20870047-5 2011 In the present study, the surface of a scaffold fabricated using MHDS was coated with a mixture of fibrin and hyaluronic acid (HA) and used as a vehicle for delivery of both bone morphogenetic protein-2 (BMP-2) and adipose-derived stromal cells (ASCs). Hyaluronic Acid 127-129 bone morphogenetic protein 2 Homo sapiens 174-202 23103154-0 2013 Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment. Hyaluronic Acid 49-64 bone morphogenetic protein 2 Homo sapiens 38-43 22967015-3 2012 We recently showed that PEM made of poly(l-lysine) and hyaluronan (PLL/HA) can retain high and tunable quantities of BMP-2 and can deliver it to cells to induce their differentiation in osteoblasts. Hyaluronic Acid 55-65 bone morphogenetic protein 2 Homo sapiens 117-122 20440158-0 2010 Bone morphogenetic protein-2 delivered by hyaluronan-based hydrogel induces massive bone formation and healing of cranial defects in minipigs. Hyaluronic Acid 42-52 bone morphogenetic protein 2 Homo sapiens 0-28 20440158-3 2010 The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nanoparticles, in the presence of BMP-2. Hyaluronic Acid 101-116 bone morphogenetic protein 2 Homo sapiens 211-216 18384163-9 2009 Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2. Hyaluronic Acid 131-146 bone morphogenetic protein 2 Homo sapiens 263-268 18384163-9 2009 Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2. Hyaluronic Acid 229-244 bone morphogenetic protein 2 Homo sapiens 263-268 17208295-0 2007 Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Hyaluronic Acid 24-39 bone morphogenetic protein 2 Homo sapiens 60-86 17208295-1 2007 Acrylated hyaluronic acid (HA) was used as a scaffold for bone morphogenic protein-2 (BMP-2) and human mesenchymal stem cells (hMSCs) for rat calvarial defect regeneration. Hyaluronic Acid 10-25 bone morphogenetic protein 2 Homo sapiens 58-84 17208295-1 2007 Acrylated hyaluronic acid (HA) was used as a scaffold for bone morphogenic protein-2 (BMP-2) and human mesenchymal stem cells (hMSCs) for rat calvarial defect regeneration. Hyaluronic Acid 10-25 bone morphogenetic protein 2 Homo sapiens 86-91 17208295-1 2007 Acrylated hyaluronic acid (HA) was used as a scaffold for bone morphogenic protein-2 (BMP-2) and human mesenchymal stem cells (hMSCs) for rat calvarial defect regeneration. Hyaluronic Acid 27-29 bone morphogenetic protein 2 Homo sapiens 58-84 17208295-1 2007 Acrylated hyaluronic acid (HA) was used as a scaffold for bone morphogenic protein-2 (BMP-2) and human mesenchymal stem cells (hMSCs) for rat calvarial defect regeneration. Hyaluronic Acid 27-29 bone morphogenetic protein 2 Homo sapiens 86-91 16771708-7 2006 In addition, the inhibitory action of TSG-6 and the in vitro interaction of TSG-6 with BMP-2 were abolished by the addition of hyaluronan. Hyaluronic Acid 127-137 bone morphogenetic protein 2 Homo sapiens 87-92 11774316-0 2002 Retention and activity of BMP-2 in hyaluronic acid-based scaffolds in vitro. Hyaluronic Acid 35-50 bone morphogenetic protein 2 Homo sapiens 26-31 11774316-2 2002 In this study, we examined in vitro the potential of a derivatized hyaluronic acid (Hyaff-11) scaffold as a delivery vehicle for recombinant human BMP-2 (rhBMP-2) in bone and cartilage repair therapies. Hyaluronic Acid 67-82 bone morphogenetic protein 2 Homo sapiens 147-152 15348249-1 2001 The present study was designed to evaluate the efficacy of high molecular weight hyaluronic acid (HA) used as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) adsorbed to a titanium fiber mesh implant (TFMI) in vivo. Hyaluronic Acid 81-96 bone morphogenetic protein 2 Homo sapiens 141-169 15348249-1 2001 The present study was designed to evaluate the efficacy of high molecular weight hyaluronic acid (HA) used as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) adsorbed to a titanium fiber mesh implant (TFMI) in vivo. Hyaluronic Acid 98-100 bone morphogenetic protein 2 Homo sapiens 141-169 35395768-0 2022 Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells. Hyaluronic Acid 90-100 bone morphogenetic protein 2 Homo sapiens 41-69 11394401-0 2001 Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. Hyaluronic Acid 0-10 bone morphogenetic protein 2 Homo sapiens 38-66 11394401-3 2001 The objective of this pilot study was to evaluate bone regeneration in mandibular, full-thickness, alveolar ridge, saddle-type defects following surgical implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a novel hyaluronan (HY) sponge carrier. Hyaluronic Acid 238-248 bone morphogenetic protein 2 Homo sapiens 188-216 35395768-3 2022 However, whether BMP2 can regulate the production of hyaluronan in human granulosa cells has never been elucidated. Hyaluronic Acid 53-63 bone morphogenetic protein 2 Homo sapiens 17-21 35395768-4 2022 METHODS: In the present study, we investigated the effect of BMP2 on the production of hyaluronan and the underlying molecular mechanism using both immortalized (SVOG) and primary human granulosa-lutein (hGL) cells. Hyaluronic Acid 87-97 bone morphogenetic protein 2 Homo sapiens 61-65 35395768-8 2022 RESULTS: Our results showed that BMP2 treatment significantly increased the production of hyaluronan by upregulating the expression of hyaluronan synthase 2 (HAS2). Hyaluronic Acid 90-100 bone morphogenetic protein 2 Homo sapiens 33-37 35395768-11 2022 CONCLUSIONS: Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells. Hyaluronic Acid 116-126 bone morphogenetic protein 2 Homo sapiens 84-88 35275488-3 2022 This bioactive coating consists of hyaluronic acid and poly(l-lysine) of controlled stiffness, loaded with fibronectin and bone morphogenic proteins 2 and 4 (BMP2 and BMP4) as matrix-bound proteins. Hyaluronic Acid 35-50 bone morphogenetic protein 2 Homo sapiens 158-162