PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35543351-1 2022 Cell migration inducing hyaluronidase 1 (CEMIP) mediates catabolism of hyaluronan, and participates in the cell metastasis, invasion, and motility. Hyaluronic Acid 71-81 hyaluronidase 1 Homo sapiens 24-39 30990018-1 2019 Hyaluronidase has two cruical isoforms, hyaluronidase-1 (Hyal-1) and hyaluronidase-2 (Hyal-2), which are essential for cellular hyaluronic acid (HA) catabolism to generate different-sized oligosaccharide fragments for performing different physiological functions. Hyaluronic Acid 128-143 hyaluronidase 1 Homo sapiens 40-55 32363767-0 2020 Hyaluronic acid presentation at the surface of self-assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor. Hyaluronic Acid 0-15 hyaluronidase 1 Homo sapiens 103-108 32363767-1 2020 In this study, an original method of macromolecular design was used to develop a hyaluronidase-1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). Hyaluronic Acid 145-160 hyaluronidase 1 Homo sapiens 81-96 32363767-1 2020 In this study, an original method of macromolecular design was used to develop a hyaluronidase-1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). Hyaluronic Acid 145-160 hyaluronidase 1 Homo sapiens 98-103 32363767-1 2020 In this study, an original method of macromolecular design was used to develop a hyaluronidase-1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). Hyaluronic Acid 162-164 hyaluronidase 1 Homo sapiens 81-96 32363767-1 2020 In this study, an original method of macromolecular design was used to develop a hyaluronidase-1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). Hyaluronic Acid 162-164 hyaluronidase 1 Homo sapiens 98-103 32441104-1 2020 Hyaluronidase 1 (Hyal-1) is an important enzyme involved in intracellular hyaluronic acid (HA) catabolism for performing various physiological functions, and its aberrant level is closely associated with many malignant diseases. Hyaluronic Acid 74-89 hyaluronidase 1 Homo sapiens 0-15 32441104-1 2020 Hyaluronidase 1 (Hyal-1) is an important enzyme involved in intracellular hyaluronic acid (HA) catabolism for performing various physiological functions, and its aberrant level is closely associated with many malignant diseases. Hyaluronic Acid 74-89 hyaluronidase 1 Homo sapiens 17-23 32441104-1 2020 Hyaluronidase 1 (Hyal-1) is an important enzyme involved in intracellular hyaluronic acid (HA) catabolism for performing various physiological functions, and its aberrant level is closely associated with many malignant diseases. Hyaluronic Acid 91-93 hyaluronidase 1 Homo sapiens 0-15 32441104-1 2020 Hyaluronidase 1 (Hyal-1) is an important enzyme involved in intracellular hyaluronic acid (HA) catabolism for performing various physiological functions, and its aberrant level is closely associated with many malignant diseases. Hyaluronic Acid 91-93 hyaluronidase 1 Homo sapiens 17-23 30990018-1 2019 Hyaluronidase has two cruical isoforms, hyaluronidase-1 (Hyal-1) and hyaluronidase-2 (Hyal-2), which are essential for cellular hyaluronic acid (HA) catabolism to generate different-sized oligosaccharide fragments for performing different physiological functions. Hyaluronic Acid 145-147 hyaluronidase 1 Homo sapiens 40-55 30990018-1 2019 Hyaluronidase has two cruical isoforms, hyaluronidase-1 (Hyal-1) and hyaluronidase-2 (Hyal-2), which are essential for cellular hyaluronic acid (HA) catabolism to generate different-sized oligosaccharide fragments for performing different physiological functions. Hyaluronic Acid 145-147 hyaluronidase 1 Homo sapiens 57-63 30990018-1 2019 Hyaluronidase has two cruical isoforms, hyaluronidase-1 (Hyal-1) and hyaluronidase-2 (Hyal-2), which are essential for cellular hyaluronic acid (HA) catabolism to generate different-sized oligosaccharide fragments for performing different physiological functions. Hyaluronic Acid 128-143 hyaluronidase 1 Homo sapiens 57-63 29673760-5 2019 This decrease in hyaluronan was accompanied by suppression of Hyaluronan Synthase 2 (HAS2), the major enzyme responsible for the synthesis of hyaluronan, and by induction of hyaluronidases (HYALs) -1 and -2. Hyaluronic Acid 17-27 hyaluronidase 1 Homo sapiens 174-206 30176279-1 2018 Human hyaluronidase-1 (Hyal-1) is one of the main enzymes in the homeostasis of hyaluronic acid (HA), the main polysaccharide of extracellular matrix. Hyaluronic Acid 80-95 hyaluronidase 1 Homo sapiens 6-21 30705130-1 2019 Hyaluronic acid (HA) and its degradation products play an important role in lung pathophysiology and airway remodelling in chronic obstructive pulmonary disease (COPD).We investigated if HA and its degrading enzyme hyaluronidase (HYAL)-1 are associated with COPD severity and outcome.Serum HA was assessed in a discovery cohort of 80 COPD patients at stable state and exacerbations. Hyaluronic Acid 0-15 hyaluronidase 1 Homo sapiens 215-237 30176279-1 2018 Human hyaluronidase-1 (Hyal-1) is one of the main enzymes in the homeostasis of hyaluronic acid (HA), the main polysaccharide of extracellular matrix. Hyaluronic Acid 97-99 hyaluronidase 1 Homo sapiens 6-21 24820161-3 2014 Hyaluronidase 1 (HYAL1), degrading hyaluronic acid (HA), has two predicted C-mannosylation sites at Trp130 and Trp321. Hyaluronic Acid 35-50 hyaluronidase 1 Homo sapiens 0-15 29063508-4 2018 In this study, we measured the mRNA expression of hyaluronic acid-related proteins: hyaluronan synthase (HAS) 1-3, hyaluronidase-1, -2, and hyaluronic acid-binding protein (versican). Hyaluronic Acid 50-65 hyaluronidase 1 Homo sapiens 115-130 28604766-1 2017 The levels of hyaluronan, a ubiquitous glycosaminoglycan prominent in the extracellular matrix, is balanced through the actions of hyaluronan-synthesizing enzymes (HAS1, 2 and 3) and degrading hyaluronidases (Hyal 1, 2, 3 and PH20). Hyaluronic Acid 14-24 hyaluronidase 1 Homo sapiens 209-221 27419371-1 2017 Tumor cell-derived hyaluronidase HYAL-1 degrades hyaluronic acid (HA) into angiogenic fragments (AGF: 10-12 disaccharides). Hyaluronic Acid 49-64 hyaluronidase 1 Homo sapiens 33-39 27419371-1 2017 Tumor cell-derived hyaluronidase HYAL-1 degrades hyaluronic acid (HA) into angiogenic fragments (AGF: 10-12 disaccharides). Hyaluronic Acid 66-68 hyaluronidase 1 Homo sapiens 33-39 24668563-2 2014 Hyaluronan (HA) is a high molecular weight polyanionic carbohydrate produced by synthases (HAS1 through HAS3) and fragmented by oxidative/nitrosative stress and hyaluronidases (HYAL1 through HYAL4, SPAM1) common in PCa microenvironments. Hyaluronic Acid 0-10 hyaluronidase 1 Homo sapiens 177-182 28888002-6 2017 To minimize the premature release, hyaluronic acid (HA) was further coating on the outer surface of pSiO2, which would be degraded by over-expressed hyaluronidase (Hyal-1) in the tumor microenvironment. Hyaluronic Acid 35-50 hyaluronidase 1 Homo sapiens 149-170 28888002-6 2017 To minimize the premature release, hyaluronic acid (HA) was further coating on the outer surface of pSiO2, which would be degraded by over-expressed hyaluronidase (Hyal-1) in the tumor microenvironment. Hyaluronic Acid 52-54 hyaluronidase 1 Homo sapiens 149-170 28168629-3 2017 Based on our recent study on cDNA microarray data of breast cancer patients, we hypothesized that two enzymes involved in the hyaluronan metabolism, namely, hyaluronan synthase 2 (HAS2) and hyaluronidase 1 (HYAL1) are associated with brain metastases formation. Hyaluronic Acid 126-136 hyaluronidase 1 Homo sapiens 190-205 28168629-3 2017 Based on our recent study on cDNA microarray data of breast cancer patients, we hypothesized that two enzymes involved in the hyaluronan metabolism, namely, hyaluronan synthase 2 (HAS2) and hyaluronidase 1 (HYAL1) are associated with brain metastases formation. Hyaluronic Acid 126-136 hyaluronidase 1 Homo sapiens 207-212 27764788-2 2016 Genes encoded in the 3p21.3 cluster include HYAL1, HYAL2 and HYAL3 members of hyaluronidases involved in the breakdown of hyaluronan, an abundant component of the vertebrate extracellular matrix. Hyaluronic Acid 122-132 hyaluronidase 1 Homo sapiens 44-49 25009769-1 2014 Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350). Hyaluronic Acid 60-75 hyaluronidase 1 Homo sapiens 0-14 25009769-1 2014 Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350). Hyaluronic Acid 60-75 hyaluronidase 1 Homo sapiens 16-21 24820161-3 2014 Hyaluronidase 1 (HYAL1), degrading hyaluronic acid (HA), has two predicted C-mannosylation sites at Trp130 and Trp321. Hyaluronic Acid 35-50 hyaluronidase 1 Homo sapiens 17-22 24820161-3 2014 Hyaluronidase 1 (HYAL1), degrading hyaluronic acid (HA), has two predicted C-mannosylation sites at Trp130 and Trp321. Hyaluronic Acid 52-54 hyaluronidase 1 Homo sapiens 0-15 24820161-3 2014 Hyaluronidase 1 (HYAL1), degrading hyaluronic acid (HA), has two predicted C-mannosylation sites at Trp130 and Trp321. Hyaluronic Acid 52-54 hyaluronidase 1 Homo sapiens 17-22 20875124-0 2010 Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. Hyaluronic Acid 82-92 hyaluronidase 1 Homo sapiens 50-55 23377816-9 2013 Laboratory analysis suggested that degradation of hyaluronan occurred through the action of three hyaluronidase isoforms: Hyal-1, Hyal-2 and PH-20. Hyaluronic Acid 50-60 hyaluronidase 1 Homo sapiens 122-128 24970149-4 2012 Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent. Hyaluronic Acid 97-99 hyaluronidase 1 Homo sapiens 15-30 24970149-4 2012 Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent. Hyaluronic Acid 97-99 hyaluronidase 1 Homo sapiens 32-37 21887686-2 2012 The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). Hyaluronic Acid 4-19 hyaluronidase 1 Homo sapiens 90-96 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 0-10 hyaluronidase 1 Homo sapiens 86-108 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 12-14 hyaluronidase 1 Homo sapiens 86-108 20960509-0 2011 Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis. Hyaluronic Acid 15-30 hyaluronidase 1 Homo sapiens 63-69 21555367-1 2011 The tumor cell-derived hyaluronidase (HAase) HYAL-1 degrades hyaluronic acid (HA) into proangiogenic fragments that support tumor progression. Hyaluronic Acid 61-76 hyaluronidase 1 Homo sapiens 45-51 21555367-1 2011 The tumor cell-derived hyaluronidase (HAase) HYAL-1 degrades hyaluronic acid (HA) into proangiogenic fragments that support tumor progression. Hyaluronic Acid 38-40 hyaluronidase 1 Homo sapiens 45-51 20558613-7 2010 The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing genetic evidence to link these pathways. Hyaluronic Acid 41-51 hyaluronidase 1 Homo sapiens 82-108 20558613-7 2010 The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing genetic evidence to link these pathways. Hyaluronic Acid 41-51 hyaluronidase 1 Homo sapiens 110-115 20875124-8 2010 There was an inverse correlation between HYAL1 mRNA and the epithelial hyaluronan staining intensity (r = -0.6; P = 0.001). Hyaluronic Acid 71-81 hyaluronidase 1 Homo sapiens 41-46 20875124-9 2010 CONCLUSION: The results indicated that HYAL1 and HYAL2 were coexpressed and significantly downregulated in endometrioid endometrial cancer and correlated with the accumulation of hyaluronan. Hyaluronic Acid 179-189 hyaluronidase 1 Homo sapiens 39-44 19478093-4 2009 Here we report the design of a HYAL1 variant that degrades hyaluronan up to pH 5.9. Hyaluronic Acid 59-69 hyaluronidase 1 Homo sapiens 31-36 19889881-2 2010 However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS. Hyaluronic Acid 59-69 hyaluronidase 1 Homo sapiens 15-30 19889881-2 2010 However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS. Hyaluronic Acid 71-73 hyaluronidase 1 Homo sapiens 15-30 19889881-2 2010 However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS. Hyaluronic Acid 107-109 hyaluronidase 1 Homo sapiens 15-30 19435493-7 2009 An inverse correlation was noted between HYAL1 mRNA and the intensity of hyaluronan staining of the corresponding tissue sections (r = -0.4; P = 0.025). Hyaluronic Acid 73-83 hyaluronidase 1 Homo sapiens 41-46 19435493-8 2009 CONCLUSION: The results indicate that in serous epithelial ovarian malignancies HAS expression is not consistently elevated but HYAL1 expression is significantly reduced and correlates with the accumulation of hyaluronan. Hyaluronic Acid 210-220 hyaluronidase 1 Homo sapiens 128-133 19408825-4 2009 METHODS: In the present study we used plasma hyaluronidase measurement as an indicator of hyaluronan metabolism and activity. Hyaluronic Acid 90-100 hyaluronidase 1 Homo sapiens 38-58 19218337-1 2009 Accumulation of extracellular hyaluronan (HA) and its processing enzyme, the hyaluronidase Hyal1, predicts invasive, metastatic progression of human prostate cancer. Hyaluronic Acid 30-40 hyaluronidase 1 Homo sapiens 91-96 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 44-59 hyaluronidase 1 Homo sapiens 160-186 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 61-63 hyaluronidase 1 Homo sapiens 160-186 17170110-0 2007 CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2. Hyaluronic Acid 61-76 hyaluronidase 1 Homo sapiens 80-102 18718911-2 2008 HYAL-1 (hyaluronoglucosaminidase-1) belongs to the hyaluronidase family of enzymes that degrade hyaluronic acid. Hyaluronic Acid 96-111 hyaluronidase 1 Homo sapiens 0-6 18718911-2 2008 HYAL-1 (hyaluronoglucosaminidase-1) belongs to the hyaluronidase family of enzymes that degrade hyaluronic acid. Hyaluronic Acid 96-111 hyaluronidase 1 Homo sapiens 8-34 17503783-2 2007 In addition to its function in normal cellular hyaluronan turnover, human hyaluronidase-1 is implicated in cancer proliferation, angiogenesis, and inflammatory diseases; its expression is up-regulated in advanced stages of bladder cancer, whereas the expression of the alternative splice-variants is down-regulated. Hyaluronic Acid 47-57 hyaluronidase 1 Homo sapiens 74-89 16104017-1 2005 Human hyaluronidases (Hyals) are a group of five endo-beta-acetyl-hexosaminidase enzymes, Hyal-1, -2, -3, -4, and PH-20, which degrade hyaluronan using a hydrolytic mechanism of action. Hyaluronic Acid 135-145 hyaluronidase 1 Homo sapiens 90-108 11731267-7 2001 A model is proposed suggesting that Hyal-2 and Hyal-1 are the major mammalian hyaluronidases in somatic tissues, and that they act in concert to degrade high molecular weight hyaluronan to the tetrasaccharide. Hyaluronic Acid 175-185 hyaluronidase 1 Homo sapiens 47-53 11731267-8 2001 Twenty-kDa hyaluronan fragments are generated at the cell surface in unique endocytic vesicles resulting from digestion by the glycosylphosphatidyl-inositol-anchored Hyal-2, transported intracellularly by an unknown process, and then further digested by Hyal-1. Hyaluronic Acid 11-21 hyaluronidase 1 Homo sapiens 254-260 17145867-1 2006 Tumor cells express HYAL1 hyaluronidase, which degrades hyaluronic acid. Hyaluronic Acid 56-71 hyaluronidase 1 Homo sapiens 20-25 15781637-10 2005 HYAL1-S and vector tumors expressed significantly higher amounts of HYAL1 (in tumor cells) and hyaluronic acid (in tumor-associated stroma) than HYAL1-AS tumors. Hyaluronic Acid 95-110 hyaluronidase 1 Homo sapiens 0-5