PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26362177-0 2015 Hyaluronan-induced VEGF-C promotes fibrosis-induced lymphangiogenesis via Toll-like receptor 4-dependent signal pathway. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 74-94 27301359-3 2016 Herein, we show that hyaluronan (HA) oligomer, HA tetrasaccharide (HA4), could suppress the expression of proinflammatory cytokine IL-1beta when stimulated with both TLR2- and TLR4-specific agonists in primary hippocampal neurons. Hyaluronic Acid 21-31 toll-like receptor 4 Mus musculus 176-180 26505972-0 2015 CD44 and TLR4 mediate hyaluronic acid regulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal growth in postnatal and adult mice. Hyaluronic Acid 22-37 toll-like receptor 4 Mus musculus 9-13 26505972-1 2015 Hyaluronic acid, a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 84-104 26505972-1 2015 Hyaluronic acid, a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 106-110 26505972-7 2015 These studies demonstrated that signaling through both CD44 and TLR4 were important in mediating the effects of hyaluronic acid on growth in the small intestine and colon. Hyaluronic Acid 112-127 toll-like receptor 4 Mus musculus 64-68 26505972-10 2015 These studies indicate that endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 and TLR4. Hyaluronic Acid 39-54 toll-like receptor 4 Mus musculus 207-211 31484704-0 2019 Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 27-31 21037098-1 2010 Hyaluronan is a high-molecular mass component of pulmonary extracelluar matrix, and lung injury can generate a low-molecular mass hyaluronan (HA) fragment that functions as endogenous ligand to cell surface receptors CD44 and TLR4. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 226-230 25673209-2 2015 Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation. Hyaluronic Acid 108-118 toll-like receptor 4 Mus musculus 161-181 25673209-2 2015 Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation. Hyaluronic Acid 108-118 toll-like receptor 4 Mus musculus 183-188 25673209-2 2015 Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation. Hyaluronic Acid 120-122 toll-like receptor 4 Mus musculus 161-181 25673209-2 2015 Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation. Hyaluronic Acid 120-122 toll-like receptor 4 Mus musculus 183-188 25318610-2 2015 Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear factor kappaB (NF-kB) that in turn stimulates the inflammation response. Hyaluronic Acid 6-16 toll-like receptor 4 Mus musculus 99-119 25318610-2 2015 Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear factor kappaB (NF-kB) that in turn stimulates the inflammation response. Hyaluronic Acid 6-16 toll-like receptor 4 Mus musculus 121-126 25318610-2 2015 Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear factor kappaB (NF-kB) that in turn stimulates the inflammation response. Hyaluronic Acid 18-20 toll-like receptor 4 Mus musculus 99-119 25318610-2 2015 Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear factor kappaB (NF-kB) that in turn stimulates the inflammation response. Hyaluronic Acid 18-20 toll-like receptor 4 Mus musculus 121-126 24252748-6 2014 TGF-beta production from macrophages stimulated by hyaluronan, a ligand for TLR2 and TLR4, was evaluated by real-time PCR. Hyaluronic Acid 51-61 toll-like receptor 4 Mus musculus 85-89 24252748-9 2014 Moreover, TGF-beta production from macrophages induced by hyaluronan stimulation in vitro was significantly decreased in the absence of TLRs, especially TLR4. Hyaluronic Acid 58-68 toll-like receptor 4 Mus musculus 153-157 22796382-3 2012 Hyaluronan (HA) fragments act to prime inflammation via CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 69-89 22796382-3 2012 Hyaluronan (HA) fragments act to prime inflammation via CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 91-96 22234777-1 2012 Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 197-217 22234777-1 2012 Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 219-224 22234777-1 2012 Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 197-217 22234777-1 2012 Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll-like receptor 4 (TLR-4). Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 219-224 22038822-0 2012 Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 62-66 22197458-1 2012 Hyaluronan (HA) fragments are able to induce inflammation by stimulating both CD44 and toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 87-107 22197458-1 2012 Hyaluronan (HA) fragments are able to induce inflammation by stimulating both CD44 and toll-like receptor 4 (TLR-4). Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 109-114 22197458-1 2012 Hyaluronan (HA) fragments are able to induce inflammation by stimulating both CD44 and toll-like receptor 4 (TLR-4). Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 87-107 22197458-1 2012 Hyaluronan (HA) fragments are able to induce inflammation by stimulating both CD44 and toll-like receptor 4 (TLR-4). Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 109-114 22287316-0 2012 Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 33-38 21887846-0 2011 Hyaluronic acid as a rescue therapy for trinitrobenzene sulfonic acid-induced colitis through Cox-2 and PGE2 in a Toll-like receptor 4-dependent way. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 114-134 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Hyaluronic Acid 73-88 toll-like receptor 4 Mus musculus 172-192 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Hyaluronic Acid 73-88 toll-like receptor 4 Mus musculus 194-198 26321117-0 2015 Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 23-26 26321117-3 2015 Increasing evidence demonstrates that hyaluronan (HA) can modulate TLR4 activation and has shown early promise as a therapeutic agent in ALI. Hyaluronic Acid 38-48 toll-like receptor 4 Mus musculus 67-71 26321117-3 2015 Increasing evidence demonstrates that hyaluronan (HA) can modulate TLR4 activation and has shown early promise as a therapeutic agent in ALI. Hyaluronic Acid 50-52 toll-like receptor 4 Mus musculus 67-71 26371821-0 2015 Expression of Concern: TLR4 Is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness after Ozone Inhalation; c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice. Hyaluronic Acid 45-55 toll-like receptor 4 Mus musculus 23-27 25537799-0 2015 Treatment with the hyaluronic Acid synthesis inhibitor 4-methylumbelliferone suppresses LPS-induced lung inflammation. Hyaluronic Acid 19-34 toll-like receptor 4 Mus musculus 88-91 25537799-3 2015 In the current study, we investigated the potential use of the hyaluronic acid (HA) synthesis inhibitor 4-methylumbelliferone (4-MU) on LPS-induced acute lung inflammation. Hyaluronic Acid 63-78 toll-like receptor 4 Mus musculus 136-139 25537799-3 2015 In the current study, we investigated the potential use of the hyaluronic acid (HA) synthesis inhibitor 4-methylumbelliferone (4-MU) on LPS-induced acute lung inflammation. Hyaluronic Acid 80-82 toll-like receptor 4 Mus musculus 136-139 24058413-3 2013 Conversely, release of endogenous fragments of hyaluronic acid (HA) after injury has been proposed to inhibit LPS induced inflammation driven by TLR4. Hyaluronic Acid 47-62 toll-like receptor 4 Mus musculus 145-149 24058413-3 2013 Conversely, release of endogenous fragments of hyaluronic acid (HA) after injury has been proposed to inhibit LPS induced inflammation driven by TLR4. Hyaluronic Acid 64-66 toll-like receptor 4 Mus musculus 145-149 23721397-0 2013 Hyaluronan fragments induce IFNbeta via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 48-52 23298137-1 2013 4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). Hyaluronic Acid 6-16 toll-like receptor 4 Mus musculus 127-147 23298137-1 2013 4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). Hyaluronic Acid 6-16 toll-like receptor 4 Mus musculus 149-162 23298137-1 2013 4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). Hyaluronic Acid 18-20 toll-like receptor 4 Mus musculus 127-147 23298137-1 2013 4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). Hyaluronic Acid 18-20 toll-like receptor 4 Mus musculus 149-162 21957979-0 2012 Superoxide dismutase 3 suppresses hyaluronic acid fragments mediated skin inflammation by inhibition of toll-like receptor 4 signaling pathway: superoxide dismutase 3 inhibits reactive oxygen species-induced trafficking of toll-like receptor 4 to lipid rafts. Hyaluronic Acid 34-49 toll-like receptor 4 Mus musculus 104-124 21957979-0 2012 Superoxide dismutase 3 suppresses hyaluronic acid fragments mediated skin inflammation by inhibition of toll-like receptor 4 signaling pathway: superoxide dismutase 3 inhibits reactive oxygen species-induced trafficking of toll-like receptor 4 to lipid rafts. Hyaluronic Acid 34-49 toll-like receptor 4 Mus musculus 223-243 21723389-0 2011 Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 82-87 21098223-0 2011 TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. Hyaluronic Acid 50-60 toll-like receptor 4 Mus musculus 0-4 21098223-1 2011 Intratracheal administration of low molecular mass (LMM) hyaluronan (200 kDa) results in greater neutrophil infiltration in the lungs of TLR4(-/-) mice compared with that in wild-type mice. Hyaluronic Acid 57-67 toll-like receptor 4 Mus musculus 137-141 22073274-0 2011 Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 63-67 19781786-0 2009 Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS. Hyaluronic Acid 22-32 toll-like receptor 4 Mus musculus 44-48 20007931-0 2010 TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Hyaluronic Acid 22-32 toll-like receptor 4 Mus musculus 0-4 20007931-4 2010 However, the relation between TLR4 and hyaluronan in the airway response to ozone remains unexplored. Hyaluronic Acid 39-49 toll-like receptor 4 Mus musculus 30-34 19879319-0 2010 Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes. Hyaluronic Acid 15-25 toll-like receptor 4 Mus musculus 48-68 20506365-2 2010 We undertook the present study to assess whether the endogenous TLR-2/TLR-4 ligands low molecular weight hyaluronan (LMW-HA) and high mobility group box chromosomal protein 1 (HMGB-1), which are increased in osteoarthritic (OA) joints, drive procatabolic chondrocyte responses dependent on TLR-2 and TLR-4 signaling through the cytosolic adaptor myeloid differentiation factor 88 (MyD88). Hyaluronic Acid 105-115 toll-like receptor 4 Mus musculus 70-75 20506365-2 2010 We undertook the present study to assess whether the endogenous TLR-2/TLR-4 ligands low molecular weight hyaluronan (LMW-HA) and high mobility group box chromosomal protein 1 (HMGB-1), which are increased in osteoarthritic (OA) joints, drive procatabolic chondrocyte responses dependent on TLR-2 and TLR-4 signaling through the cytosolic adaptor myeloid differentiation factor 88 (MyD88). Hyaluronic Acid 105-115 toll-like receptor 4 Mus musculus 300-305 19732774-2 2009 TLR4 ligands include bacterial lipopolysaccharide and hyaluronic acid, a component of the extracellular matrix. Hyaluronic Acid 54-69 toll-like receptor 4 Mus musculus 0-4 19781786-1 2009 Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with CD44. Hyaluronic Acid 13-23 toll-like receptor 4 Mus musculus 64-68 19781786-2 2009 Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters lipopolysaccharide (LPS) responsiveness and thus could alter the septic response. Hyaluronic Acid 43-53 toll-like receptor 4 Mus musculus 66-70 19781786-6 2009 Investigation of the mechanism responsible for inhibition of LPS activation showed hyaluronan treatment resulted in an increase in peritoneal macrophage A20 mRNA expression, and that this was significantly reduced in macrophages from Cd44(-/-) mice and Tlr4(-/-) mice. Hyaluronic Acid 83-93 toll-like receptor 4 Mus musculus 253-257 19781786-8 2009 Therefore, our results show that hyaluronan acts through TLR4, CD44 and A20 to stimulate a unique cellular response that can protect against the septic response to LPS. Hyaluronic Acid 33-43 toll-like receptor 4 Mus musculus 57-61 19574428-0 2009 CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. Hyaluronic Acid 77-87 toll-like receptor 4 Mus musculus 96-100 19800307-2 2009 As previous data reported that hyaluronan (HA) and heparan sulfate (HS) may interact with TLR-4, the aim of this study was to investigate whether glycosaminoglycans (GAGs) may modulate the TLR-4 receptor in a model of LPS-induced inflammatory cytokines in mouse chondrocytes. Hyaluronic Acid 31-41 toll-like receptor 4 Mus musculus 90-95 19800307-2 2009 As previous data reported that hyaluronan (HA) and heparan sulfate (HS) may interact with TLR-4, the aim of this study was to investigate whether glycosaminoglycans (GAGs) may modulate the TLR-4 receptor in a model of LPS-induced inflammatory cytokines in mouse chondrocytes. Hyaluronic Acid 31-41 toll-like receptor 4 Mus musculus 189-194 19800307-2 2009 As previous data reported that hyaluronan (HA) and heparan sulfate (HS) may interact with TLR-4, the aim of this study was to investigate whether glycosaminoglycans (GAGs) may modulate the TLR-4 receptor in a model of LPS-induced inflammatory cytokines in mouse chondrocytes. Hyaluronic Acid 43-45 toll-like receptor 4 Mus musculus 90-95 19574428-6 2009 Hyaluronan (HA), an endogenous ligand for toll-like receptor (TLR)-4, stimulated B cells, which infiltrates into wounds to produce interleukin-6 and transforming growth factor-beta through TLR4 in a CD19-dependent manner. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 42-68 19574428-6 2009 Hyaluronan (HA), an endogenous ligand for toll-like receptor (TLR)-4, stimulated B cells, which infiltrates into wounds to produce interleukin-6 and transforming growth factor-beta through TLR4 in a CD19-dependent manner. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 189-193 19574428-6 2009 Hyaluronan (HA), an endogenous ligand for toll-like receptor (TLR)-4, stimulated B cells, which infiltrates into wounds to produce interleukin-6 and transforming growth factor-beta through TLR4 in a CD19-dependent manner. Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 42-68 19574428-6 2009 Hyaluronan (HA), an endogenous ligand for toll-like receptor (TLR)-4, stimulated B cells, which infiltrates into wounds to produce interleukin-6 and transforming growth factor-beta through TLR4 in a CD19-dependent manner. Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 189-193 19277526-0 2009 Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 50-54 18641349-0 2008 Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4. Hyaluronic Acid 21-36 toll-like receptor 4 Mus musculus 128-132 18854367-7 2009 Finally, mononuclear cells from CD44-null and toll-like receptor 4 (TLR4) mutant mice were both stimulated with lower molecular weight hyaluronan. Hyaluronic Acid 135-145 toll-like receptor 4 Mus musculus 46-66 18854367-7 2009 Finally, mononuclear cells from CD44-null and toll-like receptor 4 (TLR4) mutant mice were both stimulated with lower molecular weight hyaluronan. Hyaluronic Acid 135-145 toll-like receptor 4 Mus musculus 68-72 18854367-12 2009 In both TLR4 mutant and CD44-null mice, the induction of IL-6 by lower molecular weight hyaluronan stimulation was decreased. Hyaluronic Acid 88-98 toll-like receptor 4 Mus musculus 8-12 18768846-2 2008 Small fragment hyaluronan (HA) is released following injury, and is an endogenous ligand for TLR4 as well as CD44. Hyaluronic Acid 15-25 toll-like receptor 4 Mus musculus 93-97 18768846-2 2008 Small fragment hyaluronan (HA) is released following injury, and is an endogenous ligand for TLR4 as well as CD44. Hyaluronic Acid 27-29 toll-like receptor 4 Mus musculus 93-97 18467694-6 2008 Addition of hyaluronan, an endogenous ligand for Toll-like receptor (TLR) 2 and TLR4, stimulated B cells to produce various cytokines, primarily through TLR4; CD19 deficiency suppressed this stimulation. Hyaluronic Acid 12-22 toll-like receptor 4 Mus musculus 80-84 18467694-6 2008 Addition of hyaluronan, an endogenous ligand for Toll-like receptor (TLR) 2 and TLR4, stimulated B cells to produce various cytokines, primarily through TLR4; CD19 deficiency suppressed this stimulation. Hyaluronic Acid 12-22 toll-like receptor 4 Mus musculus 153-157 14764599-0 2004 Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 73-77 17400552-0 2007 Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. Hyaluronic Acid 15-25 toll-like receptor 4 Mus musculus 101-121 17400552-3 2007 The response of cultured monocytes to hyaluronan was different than the response to lipopolysaccharide (LPS) despite both being dependent on Toll-like receptor 4 (TLR4). Hyaluronic Acid 38-48 toll-like receptor 4 Mus musculus 141-161 17400552-3 2007 The response of cultured monocytes to hyaluronan was different than the response to lipopolysaccharide (LPS) despite both being dependent on Toll-like receptor 4 (TLR4). Hyaluronic Acid 38-48 toll-like receptor 4 Mus musculus 163-167 17400552-5 2007 These factors were not induced by LPS despite the mutual dependence of both hyaluronan and LPS on TLR4. Hyaluronic Acid 76-86 toll-like receptor 4 Mus musculus 98-102 17400552-6 2007 Explanation for the unique response to hyaluronan was provided by observations that a lack of TLR4 or CD44 in mice diminished the response to sterile injury, and together with MD-2, was required for responsiveness to hyaluronan in vitro. Hyaluronic Acid 39-49 toll-like receptor 4 Mus musculus 94-98 17400552-6 2007 Explanation for the unique response to hyaluronan was provided by observations that a lack of TLR4 or CD44 in mice diminished the response to sterile injury, and together with MD-2, was required for responsiveness to hyaluronan in vitro. Hyaluronic Acid 217-227 toll-like receptor 4 Mus musculus 94-98 17400552-7 2007 Thus, a unique complex of TLR4, MD-2, and CD44 recognizes hyaluronan. Hyaluronic Acid 58-68 toll-like receptor 4 Mus musculus 26-30 17164294-0 2007 Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 51-71 16244651-4 2005 Hyaluronan fragments isolated from serum of individuals with acute lung injury stimulated macrophage chemokine production in a TLR4- and TLR2-dependent manner. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 127-131 18434414-0 2008 Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 120-124 18434414-3 2008 Based on reports that hyaluronan fragments can activate TLR2 and TLR4 in macrophages, and that ovulated COCs are characterized by a hyaluronan-rich matrix, we cultured ovulated mouse COCs with purified hyaluronan fragments, treated them with purified hyaluronidase or exposed them to sperm as a physiologically relevant source of hyaluronidase. Hyaluronic Acid 22-32 toll-like receptor 4 Mus musculus 65-69 18434414-5 2008 Anti-TLR2 and anti-TLR4 neutralizing antibodies significantly suppressed hyaluronan fragment- and hyaluronidase-induced activation of the NFkappaB pathway and the expression of these genes. Hyaluronic Acid 73-83 toll-like receptor 4 Mus musculus 19-23 14764599-7 2004 Activation was TLR4-dependent, as shown by use of TLR4 blocking antibody and TLR4-deficient mice, but not due to the presence of undetected contaminants as shown by inactivation following digestion with the hyaluronan-degrading enzyme chondroitinase ABC or incubation with the hyaluronan-specific blocking peptide Pep-1. Hyaluronic Acid 207-217 toll-like receptor 4 Mus musculus 15-19 14764599-7 2004 Activation was TLR4-dependent, as shown by use of TLR4 blocking antibody and TLR4-deficient mice, but not due to the presence of undetected contaminants as shown by inactivation following digestion with the hyaluronan-degrading enzyme chondroitinase ABC or incubation with the hyaluronan-specific blocking peptide Pep-1. Hyaluronic Acid 277-287 toll-like receptor 4 Mus musculus 15-19 33552081-10 2020 In this model, TLR2 and TLR4 in pericryptal macrophages are activated by microbial products or by host hyaluronic acid, resulting in production of CXCL12, a chemokine. Hyaluronic Acid 103-118 toll-like receptor 4 Mus musculus 24-28 33552081-13 2020 Several TLR2 and TLR4 agonists, including hyaluronic acid, are radioprotective in the intestine through the inhibition of radiation-induced apoptosis in LGR5+ epithelial stem cells. Hyaluronic Acid 42-57 toll-like receptor 4 Mus musculus 17-21 32538139-0 2020 Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 81-85 33486695-1 2021 Hyaluronan (HA) as a glycosaminoglycan can bind to cell-surface receptors, such as TLR4, to regulate inflammation, tissue injury, repair, and fibrosis. Hyaluronic Acid 0-10 toll-like receptor 4 Mus musculus 83-87 33486695-1 2021 Hyaluronan (HA) as a glycosaminoglycan can bind to cell-surface receptors, such as TLR4, to regulate inflammation, tissue injury, repair, and fibrosis. Hyaluronic Acid 12-14 toll-like receptor 4 Mus musculus 83-87 33552081-3 2020 In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. Hyaluronic Acid 39-54 toll-like receptor 4 Mus musculus 24-28 33552081-4 2020 In neonatal mice endogenous hyaluronic acid binding to TLR4 drives normal intestinal growth. Hyaluronic Acid 28-43 toll-like receptor 4 Mus musculus 55-59 33552081-5 2020 Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE2 production, which transactivates EGFR in LGR5+ crypt epithelial stem cells leading to increased proliferation. Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 27-31 32538139-1 2020 Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 89-109 32538139-1 2020 Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 0-15 toll-like receptor 4 Mus musculus 111-115 32538139-1 2020 Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 17-19 toll-like receptor 4 Mus musculus 89-109 32538139-1 2020 Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). Hyaluronic Acid 17-19 toll-like receptor 4 Mus musculus 111-115 32538139-12 2020 In this pathway, endogenous extracellular hyaluronic acid binds to Toll-like receptor 4 on pericryptal macrophages releasing PGE2 which binds to epidermal growth factor receptor on Lgr5+ stem cells resulting in proliferation. Hyaluronic Acid 42-57 toll-like receptor 4 Mus musculus 67-87