PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22605928-0 2012 Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. Hyaluronic Acid 0-15 matrix metallopeptidase 2 Homo sapiens 26-31 20211062-12 2010 The invasiveness of the cells and the activity of MMP-2 and MMP-9 were clearly activated by hyaluronic acid (HA) treatment and blocked by CD44 neutralizing antibody. Hyaluronic Acid 92-107 matrix metallopeptidase 2 Homo sapiens 50-55 19932571-8 2010 Some of these age-dependent modifications mediated by hyaluronan will be reviewed and commented, especially the upregulation of matrix degrading enzymes as MMP-2 and MMP-9. Hyaluronic Acid 54-64 matrix metallopeptidase 2 Homo sapiens 156-161 20211062-12 2010 The invasiveness of the cells and the activity of MMP-2 and MMP-9 were clearly activated by hyaluronic acid (HA) treatment and blocked by CD44 neutralizing antibody. Hyaluronic Acid 109-111 matrix metallopeptidase 2 Homo sapiens 50-55 18577517-0 2008 CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. Hyaluronic Acid 59-74 matrix metallopeptidase 2 Homo sapiens 218-223 30894640-4 2019 Here, we investigated the molecular interplay of MMP2 with different GAG (chondroitin sulfate, hyaluronan (HA), sulfated hyaluronan (SH) and heparin (HE)) and the impact of GAG on MMP2/TIMP3 complex formation using in vitro-experiments with human bone marrow stromal cells, in silico docking and molecular dynamics simulations. Hyaluronic Acid 107-109 matrix metallopeptidase 2 Homo sapiens 49-53 17217338-6 2007 Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective. Hyaluronic Acid 208-218 matrix metallopeptidase 2 Homo sapiens 18-23 12124327-0 2002 Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90. Hyaluronic Acid 0-10 matrix metallopeptidase 2 Homo sapiens 37-63 12124327-1 2002 We investigated the production of matrix metalloproteinase (MMP) by hyaluronan(HA) stimulation in a human cancer cell line, QG90, that expresses a large amount of CD44s, a HA receptor. Hyaluronic Acid 68-78 matrix metallopeptidase 2 Homo sapiens 60-63 16355613-1 2005 OBJECTIVE: To observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C). Hyaluronic Acid 257-272 matrix metallopeptidase 2 Homo sapiens 69-95 16355613-1 2005 OBJECTIVE: To observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C). Hyaluronic Acid 274-276 matrix metallopeptidase 2 Homo sapiens 69-95 33714187-3 2021 The HA-AuNR/M-M2pep NP is composed of hyaluronic acid modified gold nanorod (HA-AuNR) surface-modified with matrix metalloproteinase-2 (MMP2)-responsive M2pep fusion peptides (M-M2pep). Hyaluronic Acid 38-53 matrix metallopeptidase 2 Homo sapiens 136-140 31534794-7 2019 Increasing MMP-2 activity over time was positively correlated with levels of syndecan-1 (r = 0.886; p=0.03) and hyaluronan (r = 0.943; p=0.02). Hyaluronic Acid 112-122 matrix metallopeptidase 2 Homo sapiens 11-16 30894640-4 2019 Here, we investigated the molecular interplay of MMP2 with different GAG (chondroitin sulfate, hyaluronan (HA), sulfated hyaluronan (SH) and heparin (HE)) and the impact of GAG on MMP2/TIMP3 complex formation using in vitro-experiments with human bone marrow stromal cells, in silico docking and molecular dynamics simulations. Hyaluronic Acid 121-131 matrix metallopeptidase 2 Homo sapiens 49-53 33435105-3 2018 The covalently conjugated ECM biomacromolecules, hyaluronic acid and collagen I, can not only enhance the biocompatibility of the particles and avoid early drug leakage, but also allow selective biodegradation triggered by hyaluronidase (HAase) and Matrix metalloproteinases 2 (MMP-2), which are overexpressed enzymes in some tumor tissues. Hyaluronic Acid 49-64 matrix metallopeptidase 2 Homo sapiens 249-283 29143522-2 2017 Herein, we propose a size-shrinkable drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction. Hyaluronic Acid 239-254 matrix metallopeptidase 2 Homo sapiens 325-351 29143522-2 2017 Herein, we propose a size-shrinkable drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction. Hyaluronic Acid 239-254 matrix metallopeptidase 2 Homo sapiens 353-358 26981446-5 2016 RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P < 0.001), IL-6 (rho = 0.46, P < 0.001), and hyaluronan (rho = 0.27, P < 0.001), but not CA125 (rho = 0.13, P = 0.051). Hyaluronic Acid 225-235 matrix metallopeptidase 2 Homo sapiens 154-159 30485523-9 2018 The effects of sulfated hyaluronic acid were predominantly linked to an alteration in the composition of the extracellular matrix, affecting the synthesis, secretion, and/or activity of fibrillary (fibronectin and thrombospondin-2) and nonfibrillary (transglutaminase-2, periostin, and lysyloxidase) extracellular matrix components, including proteases and their inhibitors (matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-3). Hyaluronic Acid 24-39 matrix metallopeptidase 2 Homo sapiens 375-442