PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27903965-3 2017 Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. Hyaluronic Acid 100-115 hyaluronan synthase 2 Homo sapiens 155-168 27903965-3 2017 Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. Hyaluronic Acid 117-119 hyaluronan synthase 2 Homo sapiens 155-168 27903965-3 2017 Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. Hyaluronic Acid 117-119 hyaluronan synthase 2 Homo sapiens 170-174 26992562-4 2016 Treatment with BMP4, BMP6, BMP7 or BMP15 induced differing levels of noncanonical SMAD2/3, but equal levels of canonical SMAD1/5/8, phosphorylation which were mirrored by differing levels of HAS2 up-regulation and hyaluronan production. Hyaluronic Acid 214-224 hyaluronan synthase 2 Homo sapiens 191-195 28496038-3 2017 Our experimental results indicate that methylmercury induces the expression of hyaluronan in cultured human microvascular endothelial cells and pericytes through the induction of expressed UDP-glucose dehydrogenase and hyaluronan synthase 2, respectively. Hyaluronic Acid 79-89 hyaluronan synthase 2 Homo sapiens 219-240 27169756-1 2016 AIMS: The important role of hyaluronan synthase 2 (HAS2), an isozyme responsible for hyaluronan synthesis, in cancer has been increasingly recognised. Hyaluronic Acid 28-38 hyaluronan synthase 2 Homo sapiens 51-55 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 60-64 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 12-14 hyaluronan synthase 2 Homo sapiens 60-64 26887530-1 2016 The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. Hyaluronic Acid 33-48 hyaluronan synthase 2 Homo sapiens 4-25 26490312-5 2016 RESULTS: One such transcript was hyaluronic acid synthase 2 (HAS2), an enzyme responsible for hyaluronic acid (HA) synthesis. Hyaluronic Acid 33-48 hyaluronan synthase 2 Homo sapiens 61-65 26490312-5 2016 RESULTS: One such transcript was hyaluronic acid synthase 2 (HAS2), an enzyme responsible for hyaluronic acid (HA) synthesis. Hyaluronic Acid 61-63 hyaluronan synthase 2 Homo sapiens 33-59 26887530-1 2016 The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. Hyaluronic Acid 33-48 hyaluronan synthase 2 Homo sapiens 27-31 26887530-1 2016 The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. Hyaluronic Acid 27-29 hyaluronan synthase 2 Homo sapiens 4-25 25366928-12 2015 CONCLUSIONS: Hyaluronic acid could promote the expression of HAS2 and PRG4, but could not modulate HIF-1alpha and VEGF expression of TMJ osteoarthritic synovial cells in hypoxia. Hyaluronic Acid 13-28 hyaluronan synthase 2 Homo sapiens 61-65 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 161-165 24590928-5 2015 These findings indicate that the deficiency of hyaluronan in the aged dermis might result from the down-regulation in the potential of older human fibroblasts to secrete hyaluronan and that decrease in secretory potential is mainly associated with the down-regulated expression of hyaluronan synthases, especially hyaluronan synthase 2, but not with the expression levels of hyaluronidases. Hyaluronic Acid 47-57 hyaluronan synthase 2 Homo sapiens 314-335 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 12-14 hyaluronan synthase 2 Homo sapiens 161-165 25147816-6 2014 PEGPH20 had a weaker effect on HAS2-overexpressing tumors which grew more slowly and contained both extracellular and intracellular hyaluronan. Hyaluronic Acid 132-142 hyaluronan synthase 2 Homo sapiens 31-35 25549589-8 2015 Inhibition of hyaluronan synthesis in TGF-beta1-induced lung myofibroblasts over a 4day period with 4-methyl umbelliferone (4-MU) further enhanced myofibroblast morphology, caused increased deposition of fibronectin and type I collagen in the ECM, and increased expression of alpha-smooth muscle actin and hyaluronan synthase 2 (HAS2) mRNA. Hyaluronic Acid 14-24 hyaluronan synthase 2 Homo sapiens 306-327 25549589-8 2015 Inhibition of hyaluronan synthesis in TGF-beta1-induced lung myofibroblasts over a 4day period with 4-methyl umbelliferone (4-MU) further enhanced myofibroblast morphology, caused increased deposition of fibronectin and type I collagen in the ECM, and increased expression of alpha-smooth muscle actin and hyaluronan synthase 2 (HAS2) mRNA. Hyaluronic Acid 14-24 hyaluronan synthase 2 Homo sapiens 329-333 24527698-1 2014 AIMS: Hyaluronan synthase 2 (HAS2) is an enzyme in hyaluronan synthesis. Hyaluronic Acid 51-61 hyaluronan synthase 2 Homo sapiens 6-27 24527698-1 2014 AIMS: Hyaluronan synthase 2 (HAS2) is an enzyme in hyaluronan synthesis. Hyaluronic Acid 51-61 hyaluronan synthase 2 Homo sapiens 29-33 24513306-3 2014 SCOPE OF REVIEW: The review addresses the control of hyaluronan synthesis highlighting the critical role of hyaluronan synthase 2 in this context as well as discussing the recent findings related to covalent modifications which influence the enzyme activity. Hyaluronic Acid 53-63 hyaluronan synthase 2 Homo sapiens 108-129 24847057-2 2014 We found that small amounts of UDP-sugars were released from keratinocytes and that UDP-glucose (UDP-Glc) added into keratinocyte cultures induced a specific, rapid induction of hyaluronan synthase 2 (HAS2), and an increase of hyaluronan synthesis. Hyaluronic Acid 178-188 hyaluronan synthase 2 Homo sapiens 201-205 24406795-0 2014 Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Hyaluronic Acid 25-35 hyaluronan synthase 2 Homo sapiens 133-137 24558368-1 2014 As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Hyaluronic Acid 50-65 hyaluronan synthase 2 Homo sapiens 138-159 24558368-1 2014 As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Hyaluronic Acid 50-65 hyaluronan synthase 2 Homo sapiens 161-165 24558368-1 2014 As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Hyaluronic Acid 67-69 hyaluronan synthase 2 Homo sapiens 138-159 24558368-1 2014 As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Hyaluronic Acid 67-69 hyaluronan synthase 2 Homo sapiens 161-165 24197137-4 2014 Furthermore, FGFR-mediated hyaluronan accumulation requires activation of the STAT3 pathway, which regulates expression of hyaluronan synthase 2 (HAS2) and subsequent hyaluronan synthesis. Hyaluronic Acid 27-37 hyaluronan synthase 2 Homo sapiens 123-144 24197137-4 2014 Furthermore, FGFR-mediated hyaluronan accumulation requires activation of the STAT3 pathway, which regulates expression of hyaluronan synthase 2 (HAS2) and subsequent hyaluronan synthesis. Hyaluronic Acid 27-37 hyaluronan synthase 2 Homo sapiens 146-150 24197137-4 2014 Furthermore, FGFR-mediated hyaluronan accumulation requires activation of the STAT3 pathway, which regulates expression of hyaluronan synthase 2 (HAS2) and subsequent hyaluronan synthesis. Hyaluronic Acid 123-133 hyaluronan synthase 2 Homo sapiens 146-150 25795779-12 2015 Interestingly, HAS1 transfection reduced the synthesis of hyaluronan obtained by HAS2 and HAS3, suggesting functional cooperation between the isoenzymes. Hyaluronic Acid 58-68 hyaluronan synthase 2 Homo sapiens 81-85 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 127-131 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 12-14 hyaluronan synthase 2 Homo sapiens 127-131 25081531-2 2014 Increased levels of hyaluronan due to deregulation of hyaluronan-synthesizing enzymes, like HAS2, and expression of CD44, the key receptor for hyaluronan, are correlated to poor outcome of patients with basal-like breast cancer. Hyaluronic Acid 20-30 hyaluronan synthase 2 Homo sapiens 92-96 25081531-2 2014 Increased levels of hyaluronan due to deregulation of hyaluronan-synthesizing enzymes, like HAS2, and expression of CD44, the key receptor for hyaluronan, are correlated to poor outcome of patients with basal-like breast cancer. Hyaluronic Acid 54-64 hyaluronan synthase 2 Homo sapiens 92-96 22825838-0 2012 Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling. Hyaluronic Acid 40-50 hyaluronan synthase 2 Homo sapiens 99-103 24057227-7 2014 The staining of HAS2 was most widespread, both spatially and temporally, correlating with hyaluronan staining especially in early mesenchymal tissues and heart. Hyaluronic Acid 90-100 hyaluronan synthase 2 Homo sapiens 16-20 23493399-7 2013 Depletion of Has2 inhibited differentiation and caused a loss of cell-associated hyaluronan and the hyaluronan-dependent pericellular matrix. Hyaluronic Acid 81-91 hyaluronan synthase 2 Homo sapiens 13-17 23493399-7 2013 Depletion of Has2 inhibited differentiation and caused a loss of cell-associated hyaluronan and the hyaluronan-dependent pericellular matrix. Hyaluronic Acid 100-110 hyaluronan synthase 2 Homo sapiens 13-17 23295082-5 2013 MicroRNA-dependent degradation of Has2 is required to control extracellular hyaluronan levels and thereby the size of the endocardial cushions. Hyaluronic Acid 76-86 hyaluronan synthase 2 Homo sapiens 34-38 23303191-5 2013 Hyaluronan synthesis driven by HAS2 was less affected by glucosamine addition, and HAS3 was not affected at all. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 31-35 22825838-5 2012 Knock-down of Has2 expression with siRNA showed that Has2 was responsible for the increased hyaluronan synthesis induced by the melanoma cell CM. Hyaluronic Acid 92-102 hyaluronan synthase 2 Homo sapiens 14-18 22825838-5 2012 Knock-down of Has2 expression with siRNA showed that Has2 was responsible for the increased hyaluronan synthesis induced by the melanoma cell CM. Hyaluronic Acid 92-102 hyaluronan synthase 2 Homo sapiens 53-57 22298898-8 2012 One such gene, hyaluronan synthase 2 (HAS2), synthesizes hyaluronan, a core component of the extracellular matrix. Hyaluronic Acid 15-25 hyaluronan synthase 2 Homo sapiens 38-42 21887686-2 2012 The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). Hyaluronic Acid 4-19 hyaluronan synthase 2 Homo sapiens 61-65 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 2 Homo sapiens 99-103 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 2 Homo sapiens 26-30 21743962-0 2011 Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane. Hyaluronic Acid 11-21 hyaluronan synthase 2 Homo sapiens 84-88 22024046-3 2011 Adiponectin promoted hyaluronan synthesis along with an increase in the mRNA levels of hyaluronan synthase 2 (HAS2), which plays a primary role in hyaluronan synthesis. Hyaluronic Acid 87-97 hyaluronan synthase 2 Homo sapiens 110-114 22162480-2 2012 Excess adipogenesis and hyaluronan (HA) overproduction [HA synthase 2 (HAS2) is the major source] expand the orbital contents causing GO. Hyaluronic Acid 24-34 hyaluronan synthase 2 Homo sapiens 56-69 22162480-2 2012 Excess adipogenesis and hyaluronan (HA) overproduction [HA synthase 2 (HAS2) is the major source] expand the orbital contents causing GO. Hyaluronic Acid 24-34 hyaluronan synthase 2 Homo sapiens 71-75 22016393-4 2011 The metastatic to bone tumor cells exhibited a 7-fold higher hyaluronan-synthesizing capacity compared with MDA-MB-231 cells predominately due to an increased expression of hyaluronan synthase 2 (HAS2). Hyaluronic Acid 61-71 hyaluronan synthase 2 Homo sapiens 173-194 22016393-4 2011 The metastatic to bone tumor cells exhibited a 7-fold higher hyaluronan-synthesizing capacity compared with MDA-MB-231 cells predominately due to an increased expression of hyaluronan synthase 2 (HAS2). Hyaluronic Acid 61-71 hyaluronan synthase 2 Homo sapiens 196-200 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 55-59 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 12-14 hyaluronan synthase 2 Homo sapiens 55-59 20501660-0 2010 Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt. Hyaluronic Acid 36-46 hyaluronan synthase 2 Homo sapiens 79-100 21228273-0 2011 Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 112-116 21795679-3 2011 In this study, we show that the cellular level of UDP-HexNAc also controls hyaluronan synthesis by modulating the expression of HAS2 (hyaluronan synthase 2). Hyaluronic Acid 75-85 hyaluronan synthase 2 Homo sapiens 128-132 21795679-3 2011 In this study, we show that the cellular level of UDP-HexNAc also controls hyaluronan synthesis by modulating the expression of HAS2 (hyaluronan synthase 2). Hyaluronic Acid 75-85 hyaluronan synthase 2 Homo sapiens 134-155 21551265-4 2011 This study was undertaken to reveal whether endothelial hyaluronan synthesis via hyaluronan synthase 2 (HAS2) can be changed by different shear stress conditions in vitro, especially in regard to an undisturbed, arterial-like pulsatile flow profile. Hyaluronic Acid 56-66 hyaluronan synthase 2 Homo sapiens 81-102 21551265-4 2011 This study was undertaken to reveal whether endothelial hyaluronan synthesis via hyaluronan synthase 2 (HAS2) can be changed by different shear stress conditions in vitro, especially in regard to an undisturbed, arterial-like pulsatile flow profile. Hyaluronic Acid 56-66 hyaluronan synthase 2 Homo sapiens 104-108 20820878-2 2011 The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 60-64 20820878-2 2011 The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 66-87 20820878-2 2011 The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 112-116 20522558-0 2010 Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway. Hyaluronic Acid 33-43 hyaluronan synthase 2 Homo sapiens 111-132 20522558-0 2010 Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway. Hyaluronic Acid 33-43 hyaluronan synthase 2 Homo sapiens 134-138 19416972-1 2009 The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making hyaluronan, altered concentrations of which are associated with many pathological situations including wounding, several inflammatory conditions, and malignant tumors. Hyaluronic Acid 10-20 hyaluronan synthase 2 Homo sapiens 33-37 19332174-14 2009 GlcNAc-accelerated hyaluronan synthesis is associated with upregulation of hyaluronan synthase-2. Hyaluronic Acid 19-29 hyaluronan synthase 2 Homo sapiens 75-96 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 109-119 hyaluronan synthase 2 Homo sapiens 184-188 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 121-123 hyaluronan synthase 2 Homo sapiens 184-188 20507402-8 2010 These results suggest that Pro-Hyp stimulates both cell mitotic activity and hyaluronic acid synthesis, which is mediated by activation of HAS2 transcription. Hyaluronic Acid 77-92 hyaluronan synthase 2 Homo sapiens 139-143 19285976-0 2009 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Hyaluronic Acid 31-41 hyaluronan synthase 2 Homo sapiens 119-146 19231585-1 2009 INTRODUCTION: Hyaluronan (HA) and its biosynthetic enzymes hyaluronan synthases (HAS2 and HAS3) mediate Matrigel invasion by SW620 colon carcinoma cells. Hyaluronic Acid 14-24 hyaluronan synthase 2 Homo sapiens 81-85 19231585-1 2009 INTRODUCTION: Hyaluronan (HA) and its biosynthetic enzymes hyaluronan synthases (HAS2 and HAS3) mediate Matrigel invasion by SW620 colon carcinoma cells. Hyaluronic Acid 26-28 hyaluronan synthase 2 Homo sapiens 81-85 16522194-2 2006 Hyaluronan is synthesized by three homologous hyaluronan synthases designated HAS1, HAS2 and HAS3 that differ in their tissue distribution, regulation and enzymatic characteristics. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 84-88 18953425-5 2008 Consistent with the significantly reduced transcript levels of hyaluronan synthase 2, an enzyme responsible for the total level of hyaluronan secreted by these cells, COX-2 silencing resulted in lower hyaluronan levels secreted in culture medium. Hyaluronic Acid 131-141 hyaluronan synthase 2 Homo sapiens 63-84 18158910-4 2008 Increased accumulation of hyaluronan in the culture medium mirrored the UVB-induced increase in the mRNA levels of HAS3 and HAS2. Hyaluronic Acid 26-36 hyaluronan synthase 2 Homo sapiens 124-128 18158910-8 2008 UVB-irradiated cells may enhance hyaluronan production to maintain homeostasis through up-regulation of HAS3 and HAS2 genes via cytokine response mechanism. Hyaluronic Acid 33-43 hyaluronan synthase 2 Homo sapiens 113-117 17315194-6 2007 siRNA-mediated knock down of HAS2 in Hs578T breast tumor cells led to an up-regulation of HAS1, HAS3 and HYAL1 mRNAs, resulting in only a 50% decrease in the net hyaluronan production; however, the synthesized hyaluronan was of lower size and more polydisparse compared to control siRNA-treated cells. Hyaluronic Acid 162-172 hyaluronan synthase 2 Homo sapiens 29-33 17315194-6 2007 siRNA-mediated knock down of HAS2 in Hs578T breast tumor cells led to an up-regulation of HAS1, HAS3 and HYAL1 mRNAs, resulting in only a 50% decrease in the net hyaluronan production; however, the synthesized hyaluronan was of lower size and more polydisparse compared to control siRNA-treated cells. Hyaluronic Acid 210-220 hyaluronan synthase 2 Homo sapiens 29-33 17872502-0 2007 Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 51-55 12134143-5 2002 We show that hyaluronan-deficient AVC explants from Has2(-/-) embryos, which normally lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of ErbB2 and ErbB3. Hyaluronic Acid 13-23 hyaluronan synthase 2 Homo sapiens 52-56 15843373-12 2005 Collectively, our data suggest that natural antisense mRNAs of HAS2 are able to regulate HAS2 mRNA levels and hyaluronan biosynthesis in a cell culture model system and may have an important and novel regulatory role in the control of HAS2, HA biosynthesis, and HA-dependent cell functions in vivo. Hyaluronic Acid 110-120 hyaluronan synthase 2 Homo sapiens 63-67 15922739-8 2005 The selective inhibition of HAS-2 mRNA in MG-63 cells by antisense phosphorothioate oligonucleotides resulted in reduced hyaluronan accumulation by these cells. Hyaluronic Acid 121-131 hyaluronan synthase 2 Homo sapiens 28-33 15922739-11 2005 These data suggest that hyaluronan synthesized by HAS-2 in MG-63 plays a crucial role in osteosarcoma cell proliferation, motility, and invasion. Hyaluronic Acid 24-34 hyaluronan synthase 2 Homo sapiens 50-55 15632176-5 2005 On the other hand, increasing hyaluronan production by overexpression of hyaluronan synthase 2 or emmprin causes elevated ErbB2 phosphorylation in MCF-7 mammary carcinoma cells, which normally exhibit low levels of ErbB2 activity. Hyaluronic Acid 30-40 hyaluronan synthase 2 Homo sapiens 73-94 12757764-1 2003 The glycosaminoglycan (GAG) hyaluronan (HA) is a key component of the vertebrate extracellular matrix (ECM) and is synthesised by the HA synthase (HAS) enzymes HAS1, HAS2 and HAS3 at the plasma membrane. Hyaluronic Acid 40-42 hyaluronan synthase 2 Homo sapiens 166-170 12186949-2 2002 We probed the importance of hyaluronan synthesis in keratinocytes by establishing cell lines carrying the exogenous hyaluronan synthase 2 (Has2) gene in sense and antisense orientations to increase and decrease their hyaluronan synthesis, respectively. Hyaluronic Acid 116-126 hyaluronan synthase 2 Homo sapiens 139-143 12186949-5 2002 The decrease of hyaluronan on the undersurface of Has2 antisense cells was associated with an increased area of adhesion plaques containing vinculin. Hyaluronic Acid 16-26 hyaluronan synthase 2 Homo sapiens 50-54 12186949-8 2002 The results suggest that the dynamic synthesis of hyaluronan directed by Has2, rather than the abundance of pericellular hyaluronan, controls keratinocyte migration, a cell function vital for the repair of squamous epithelia following wounding. Hyaluronic Acid 50-60 hyaluronan synthase 2 Homo sapiens 73-77 15677552-8 2005 IL-1beta induction of hyaluronan expression was inhibited in cells transfected with short interfering RNA corresponding to HAS2 transcripts. Hyaluronic Acid 22-32 hyaluronan synthase 2 Homo sapiens 123-127 15677552-10 2005 These results suggest that IL-1beta induction of HAS2 expression involves multiple signaling pathways that act in concert, thus leading to an increase in expression of hyaluronan by jejunum-derived mesenchymal cells. Hyaluronic Acid 168-178 hyaluronan synthase 2 Homo sapiens 49-53 12767932-5 2003 Modulating hyaluronan levels by transfection of PROb carcinoma cells with hyaluronan synthase-2 revealed no correlation between hyaluronan content and TIFP. Hyaluronic Acid 11-21 hyaluronan synthase 2 Homo sapiens 74-95 12134143-7 2002 We show further that ErbB3 is activated during hyaluronan treatment of Has2(-/-) explants. Hyaluronic Acid 47-57 hyaluronan synthase 2 Homo sapiens 71-75 11506502-4 2001 HAS2-transfected cells with the ability to synthesize about 520 ng hyaluronan/5 x 10(4)cells/24 h exhibited about a 2-fold increase in the expression of the cell surface hyaluronan receptor CD44 and their locomotion increased compared to that of mock-transfected Mero-25 cells. Hyaluronic Acid 67-77 hyaluronan synthase 2 Homo sapiens 0-4 11566024-5 2001 This increase was accompanied by a transient increase in hyaluronan synthase 2 (HAS2) expression and an increase in hyaluronan synthesis and polymer length. Hyaluronic Acid 57-67 hyaluronan synthase 2 Homo sapiens 80-84 11327061-7 2001 Hyaluronan synthesis was probed by identifying the isotypes of hyaluronan synthase (HAS) expressed in periodontal fibroblasts as HAS-2 and HAS-3 and the effect of EMD on the levels of mRNA for each enzyme was monitored by reverse transcription polymerase chain reaction (RTPCR). Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 129-134 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 2 Homo sapiens 140-144 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 2 Homo sapiens 293-297 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 2 Homo sapiens 140-144 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 2 Homo sapiens 293-297 11453924-6 2001 The results suggest that accumulation of hyaluronan in REM may be related to populations of FXIIIa+/HAS2+ dermal dendrocytes rather than to dermal fibroblasts. Hyaluronic Acid 41-51 hyaluronan synthase 2 Homo sapiens 100-104 10070975-0 1999 Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity. Hyaluronic Acid 18-28 hyaluronan synthase 2 Homo sapiens 70-74 34504153-0 2021 Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2. Hyaluronic Acid 27-42 hyaluronan synthase 2 Homo sapiens 95-116 8798477-8 1996 When the Has2 cDNA was transfected into human 293 and Chinese hamster ovary cells, the production of hyaluronan in the transfected cells increased up to 34- and 9-fold, respectively. Hyaluronic Acid 101-111 hyaluronan synthase 2 Homo sapiens 9-13 32795674-11 2020 CONCLUSIONS: Targeting LDHA using its specific suppressant GSK2837808A impeded lactate secretion and contributed to HAS2 and HA synthesis in TMJOA SFs, providing the vital role of LDHA associated with TMJOA pathogenesis and a novel therapeutic approach for TMJOA. Hyaluronic Acid 25-27 hyaluronan synthase 2 Homo sapiens 116-120 35403677-1 2022 Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Hyaluronic Acid 143-153 hyaluronan synthase 2 Homo sapiens 73-94 35593963-7 2022 Accumulation of hyaluronan induced by HIS-mediated HAS2 upregulation is a substantial basis for clinical manifestations of COVID-19, especially in lymphocytopenia and pulmonary ground-glass opacity. Hyaluronic Acid 16-26 hyaluronan synthase 2 Homo sapiens 51-55 35395768-8 2022 RESULTS: Our results showed that BMP2 treatment significantly increased the production of hyaluronan by upregulating the expression of hyaluronan synthase 2 (HAS2). Hyaluronic Acid 90-100 hyaluronan synthase 2 Homo sapiens 135-156 35395768-8 2022 RESULTS: Our results showed that BMP2 treatment significantly increased the production of hyaluronan by upregulating the expression of hyaluronan synthase 2 (HAS2). Hyaluronic Acid 90-100 hyaluronan synthase 2 Homo sapiens 158-162 35403677-1 2022 Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Hyaluronic Acid 143-153 hyaluronan synthase 2 Homo sapiens 96-100 35403677-5 2022 Using primary and immortalized human granulosa-lutein (hGL) cells as study models, we provide the first data showing that activin A increased the production of hyaluronan by upregulating the expression of HAS2 in these cells. Hyaluronic Acid 160-170 hyaluronan synthase 2 Homo sapiens 205-209 31437481-0 2019 TGF-beta1 promotes hyaluronan synthesis by upregulating hyaluronan synthase 2 expression in human granulosa-lutein cells. Hyaluronic Acid 19-29 hyaluronan synthase 2 Homo sapiens 56-77 32551924-4 2021 OBJECTIVE: We sought to determine the effect of PGD2 on the mRNA expression of three isoforms of membrane-bound hyaluronic acid synthase (HAS1, HAS2 and HAS3) in fibroblasts, the major source of hyaluronan production, derived from CRS patients. Hyaluronic Acid 112-127 hyaluronan synthase 2 Homo sapiens 144-148 32084457-2 2020 Of the three transmembrane hyaluronan synthases, HAS2 is the main pro-angiogenic enzyme responsible for excessive hyaluronan production. Hyaluronic Acid 27-37 hyaluronan synthase 2 Homo sapiens 49-53 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 78-82 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 190-194 31826652-6 2020 Hyaluronan production by HAS2 was shown to be further driven by availability of the hyaluronan substrates UDP-glucosamine and UDP-glucuronic acid. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 25-29 31437481-5 2019 Using both primary and immortalized hGL cells as study models, we provide the first data showing that TGF-beta1 significantly promoted the synthesis of hyaluronan by upregulating the expression of hyaluronan synthase 2 in these cells. Hyaluronic Acid 152-162 hyaluronan synthase 2 Homo sapiens 197-218 30935974-6 2019 Silencing HAS2 and CD44 partly inhibited the inflammatory response, suggesting that hyaluronan coat is involved in the process. Hyaluronic Acid 84-94 hyaluronan synthase 2 Homo sapiens 10-14 28533273-5 2017 The HAS2 product hyaluronan further stimulated CD44s-mediated Akt signaling, creating a feed-forward signaling circuit that promoted tumor cell survival. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 4-8 31075987-5 2019 alpha-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Hyaluronic Acid 171-186 hyaluronan synthase 2 Homo sapiens 153-157 30456933-7 2019 Using gas-phase electrophoretic molecular mobility analysis, we uncover a shift towards high molecular mass hyaluronan in pancreatic cancer tissue compared to normal pancreas and at a transcriptional level, we find that hyaluronan synthesising HAS2 correlates positively with CD44. Hyaluronic Acid 220-230 hyaluronan synthase 2 Homo sapiens 244-248 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 18-33 hyaluronan synthase 2 Homo sapiens 125-129 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 35-37 hyaluronan synthase 2 Homo sapiens 125-129 29425696-4 2019 In this review, details of hyaluronan synthesis are discussed including how HAS2 production of hyaluronan is necessary for normal chondrocyte development and matrix assembly, how an abundance or deficit of pericellular hyaluronan alters chondrocyte metabolism, and whether hyaluronan size matters or changes with aging or disease. Hyaluronic Acid 27-37 hyaluronan synthase 2 Homo sapiens 76-80 29425696-4 2019 In this review, details of hyaluronan synthesis are discussed including how HAS2 production of hyaluronan is necessary for normal chondrocyte development and matrix assembly, how an abundance or deficit of pericellular hyaluronan alters chondrocyte metabolism, and whether hyaluronan size matters or changes with aging or disease. Hyaluronic Acid 95-105 hyaluronan synthase 2 Homo sapiens 76-80 29425696-4 2019 In this review, details of hyaluronan synthesis are discussed including how HAS2 production of hyaluronan is necessary for normal chondrocyte development and matrix assembly, how an abundance or deficit of pericellular hyaluronan alters chondrocyte metabolism, and whether hyaluronan size matters or changes with aging or disease. Hyaluronic Acid 95-105 hyaluronan synthase 2 Homo sapiens 76-80 29673760-5 2019 This decrease in hyaluronan was accompanied by suppression of Hyaluronan Synthase 2 (HAS2), the major enzyme responsible for the synthesis of hyaluronan, and by induction of hyaluronidases (HYALs) -1 and -2. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 62-83 29673760-5 2019 This decrease in hyaluronan was accompanied by suppression of Hyaluronan Synthase 2 (HAS2), the major enzyme responsible for the synthesis of hyaluronan, and by induction of hyaluronidases (HYALs) -1 and -2. Hyaluronic Acid 17-27 hyaluronan synthase 2 Homo sapiens 85-89 29673760-5 2019 This decrease in hyaluronan was accompanied by suppression of Hyaluronan Synthase 2 (HAS2), the major enzyme responsible for the synthesis of hyaluronan, and by induction of hyaluronidases (HYALs) -1 and -2. Hyaluronic Acid 142-152 hyaluronan synthase 2 Homo sapiens 85-89 30456933-7 2019 Using gas-phase electrophoretic molecular mobility analysis, we uncover a shift towards high molecular mass hyaluronan in pancreatic cancer tissue compared to normal pancreas and at a transcriptional level, we find that hyaluronan synthesising HAS2 correlates positively with CD44. Hyaluronic Acid 108-118 hyaluronan synthase 2 Homo sapiens 244-248 30819231-2 2019 Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process. Hyaluronic Acid 56-71 hyaluronan synthase 2 Homo sapiens 0-21 30819231-2 2019 Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process. Hyaluronic Acid 56-71 hyaluronan synthase 2 Homo sapiens 23-27 30237745-8 2018 The key ECM genes selected were collagen type I, elastin and hyaluronan synthase type 2 (HAS2), which is the cellular enzyme responsible for high-molecular weight hyaluronic acid (HA) production. Hyaluronic Acid 163-178 hyaluronan synthase 2 Homo sapiens 61-87 30237745-8 2018 The key ECM genes selected were collagen type I, elastin and hyaluronan synthase type 2 (HAS2), which is the cellular enzyme responsible for high-molecular weight hyaluronic acid (HA) production. Hyaluronic Acid 163-178 hyaluronan synthase 2 Homo sapiens 89-93 30237745-8 2018 The key ECM genes selected were collagen type I, elastin and hyaluronan synthase type 2 (HAS2), which is the cellular enzyme responsible for high-molecular weight hyaluronic acid (HA) production. Hyaluronic Acid 89-91 hyaluronan synthase 2 Homo sapiens 61-87 29682180-5 2018 We further establish that an increase in hyaluronic acid (HA) synthesis driven by Hyaluronic Acid Synthase 2 (HAS2) is critical for anchorage independent growth of NSCLC cells with AGL loss. Hyaluronic Acid 41-56 hyaluronan synthase 2 Homo sapiens 82-108 29682180-5 2018 We further establish that an increase in hyaluronic acid (HA) synthesis driven by Hyaluronic Acid Synthase 2 (HAS2) is critical for anchorage independent growth of NSCLC cells with AGL loss. Hyaluronic Acid 41-56 hyaluronan synthase 2 Homo sapiens 110-114 29682180-5 2018 We further establish that an increase in hyaluronic acid (HA) synthesis driven by Hyaluronic Acid Synthase 2 (HAS2) is critical for anchorage independent growth of NSCLC cells with AGL loss. Hyaluronic Acid 58-60 hyaluronan synthase 2 Homo sapiens 82-108 29682180-5 2018 We further establish that an increase in hyaluronic acid (HA) synthesis driven by Hyaluronic Acid Synthase 2 (HAS2) is critical for anchorage independent growth of NSCLC cells with AGL loss. Hyaluronic Acid 58-60 hyaluronan synthase 2 Homo sapiens 110-114 28168629-3 2017 Based on our recent study on cDNA microarray data of breast cancer patients, we hypothesized that two enzymes involved in the hyaluronan metabolism, namely, hyaluronan synthase 2 (HAS2) and hyaluronidase 1 (HYAL1) are associated with brain metastases formation. Hyaluronic Acid 126-136 hyaluronan synthase 2 Homo sapiens 157-178 28389562-10 2017 Furthermore, we identified that HAS2-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1/EGR1 signaling. Hyaluronic Acid 46-56 hyaluronan synthase 2 Homo sapiens 32-36 28604766-2 2017 Hyaluronan accumulates in rapidly remodeling tissues, such as breast cancer, due to deregulated expression of the HAS2 gene and/or alterations of HAS2 activity. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 114-118 28604766-2 2017 Hyaluronan accumulates in rapidly remodeling tissues, such as breast cancer, due to deregulated expression of the HAS2 gene and/or alterations of HAS2 activity. Hyaluronic Acid 0-10 hyaluronan synthase 2 Homo sapiens 146-150 27744520-6 2017 Importantly, these changes were associated with a decreased expression of syndecan-1, decreased signalling response to HGF and an increase in the synthesis of hyaluronan, due to an upregulation of the hyaluronan synthases HAS2 and HAS3. Hyaluronic Acid 159-169 hyaluronan synthase 2 Homo sapiens 222-226 28168629-3 2017 Based on our recent study on cDNA microarray data of breast cancer patients, we hypothesized that two enzymes involved in the hyaluronan metabolism, namely, hyaluronan synthase 2 (HAS2) and hyaluronidase 1 (HYAL1) are associated with brain metastases formation. Hyaluronic Acid 126-136 hyaluronan synthase 2 Homo sapiens 180-184 28188289-9 2017 The present data reveal a selective up-regulation of HAS2 expression by extracellular UTP, which is likely to contribute to the previously reported rapid activation of hyaluronan metabolism in response to tissue trauma or ultraviolet radiation. Hyaluronic Acid 168-178 hyaluronan synthase 2 Homo sapiens 53-57