PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26096886-0	2015	Fumaric acid esters prevent the NLRP3 inflammasome-mediated and ATP-triggered pyroptosis of differentiated THP-1 cells.	Fumarates	0-19	NLR family pyrin domain containing 3	Homo sapiens	32-37	
35137954-0	2022	Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages.	Fumarates	14-22	NLR family pyrin domain containing 3	Homo sapiens	83-88	
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	Fumarates	45-53	NLR family pyrin domain containing 3	Homo sapiens	190-195	
35137954-5	2022	DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1beta release.	Fumarates	53-61	NLR family pyrin domain containing 3	Homo sapiens	121-126	
35137954-9	2022	Furthermore, we highlight itaconate and fumarate derivatives as potential therapeutic options in NLRP3- and IL-1alpha-driven diseases, including in the brain.	Fumarates	40-48	NLR family pyrin domain containing 3	Homo sapiens	97-102