PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11248085-0 2001 The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Lithocholic Acid 30-46 nuclear receptor subfamily 1 group I member 2 Homo sapiens 21-24 11248085-2 2001 In this study, we demonstrate that PXR is activated by the toxic bile acid lithocholic acid (LCA) and its 3-keto metabolite. Lithocholic Acid 75-91 nuclear receptor subfamily 1 group I member 2 Homo sapiens 35-38 11248085-2 2001 In this study, we demonstrate that PXR is activated by the toxic bile acid lithocholic acid (LCA) and its 3-keto metabolite. Lithocholic Acid 93-96 nuclear receptor subfamily 1 group I member 2 Homo sapiens 35-38 11248085-4 2001 Finally, we demonstrate that activation of PXR protects against severe liver damage induced by LCA. Lithocholic Acid 95-98 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-46 11248085-5 2001 Based on these data, we propose that PXR serves as a physiological sensor of LCA, and coordinately regulates gene expression to reduce the concentrations of this toxic bile acid. Lithocholic Acid 77-80 nuclear receptor subfamily 1 group I member 2 Homo sapiens 37-40 11248086-4 2001 By using combinations of knockout and transgenic animals, we show that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine. Lithocholic Acid 187-190 nuclear receptor subfamily 1 group I member 2 Homo sapiens 85-88 11248086-4 2001 By using combinations of knockout and transgenic animals, we show that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine. Lithocholic Acid 187-190 nuclear receptor subfamily 1 group I member 2 Homo sapiens 89-92 21977915-9 2011 In cell lines, stimulation with lithocholic acid did not increase PXR mRNA levels, but did induce nuclear translocation of PXR protein. Lithocholic Acid 32-48 nuclear receptor subfamily 1 group I member 2 Homo sapiens 123-126 31336134-0 2019 Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice. Lithocholic Acid 53-69 nuclear receptor subfamily 1 group I member 2 Homo sapiens 93-112 31336134-19 2019 CONCLUSION: These results clearly demonstrated the lignans from Schisandra sphenanthera exert hepatoprotective effects against LCA-induced cholestasis by activation of PXR. Lithocholic Acid 127-130 nuclear receptor subfamily 1 group I member 2 Homo sapiens 168-171 22561792-8 2012 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 287-306 22561792-8 2012 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 308-311 22561792-8 2012 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid 18-21 nuclear receptor subfamily 1 group I member 2 Homo sapiens 287-306 22561792-8 2012 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid 18-21 nuclear receptor subfamily 1 group I member 2 Homo sapiens 308-311 25808545-5 2015 We show that vitamin K2 and lithocholic acid, a by-product of intestinal flora, activate pregnane X receptor (PXR) and subsequent CYP3A4 and CYP2C9 expression in hPSC-derived and isolated fetal hepatocytes. Lithocholic Acid 28-44 nuclear receptor subfamily 1 group I member 2 Homo sapiens 89-108 25808545-5 2015 We show that vitamin K2 and lithocholic acid, a by-product of intestinal flora, activate pregnane X receptor (PXR) and subsequent CYP3A4 and CYP2C9 expression in hPSC-derived and isolated fetal hepatocytes. Lithocholic Acid 28-44 nuclear receptor subfamily 1 group I member 2 Homo sapiens 110-113 21977915-12 2011 Upon stimulation with lithocholic acid, PXR translocates to the nuclei of OE19 adenocarcinoma cells. Lithocholic Acid 22-38 nuclear receptor subfamily 1 group I member 2 Homo sapiens 40-43 20888898-8 2011 An examination of the effects of prototype VDR, PXR, GR and FXR ligands showed that these pathways are all intact in precision cut slices and that LCA exerted VDR, PXR and FXR effects. Lithocholic Acid 147-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 164-167 17327420-1 2007 The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol. Lithocholic Acid 164-181 nuclear receptor subfamily 1 group I member 2 Homo sapiens 18-37 17696253-1 2007 AIM: To study the effect of the toxic secondary bile acid lithocholic acid (LCA) on the expression of fibroblast growth factor 19 (FGF19) in intestinal cells and to characterize the pregnane-X-receptor (PXR) response of the FGF19 promoter region. Lithocholic Acid 76-79 nuclear receptor subfamily 1 group I member 2 Homo sapiens 203-206 17696253-7 2007 Using reporter gene assays with several deletion constructs we found that the LCA responsive element in the human FGF19 promoter maps to the proximal regulatory region containing two potential binding sites for PXR. Lithocholic Acid 78-81 nuclear receptor subfamily 1 group I member 2 Homo sapiens 211-214 17696253-8 2007 Overexpression of PXR and its dimerization partner retinoid X receptor (RXR) and stimulation with LCA or the potent PXR ligand rifampicin leads to a significant induction of FGF19 promoter activity in intestinal cells. Lithocholic Acid 98-101 nuclear receptor subfamily 1 group I member 2 Homo sapiens 18-21 17696253-9 2007 CONCLUSION: LCA induced feedback inhibition of bile acid synthesis in the liver is likely to be regulated by PXR inducing intestinal FGF19 expression. Lithocholic Acid 12-15 nuclear receptor subfamily 1 group I member 2 Homo sapiens 109-112 18800312-5 2008 Reporter assays were used to evaluate the function of all known hPXR variants in response to the secondary bile acid lithocholic acid and therapeutic agents rifampicin, ursodeoxycholic acid and dexamethasone. Lithocholic Acid 117-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 64-68 18537536-3 2008 Another decisive discovery pointed later that the pregnane X-receptor (PXR) is activated by the endogenous toxic lithocholic acid, as well as several xenobiotics and drugs. Lithocholic Acid 113-129 nuclear receptor subfamily 1 group I member 2 Homo sapiens 50-69 18537536-3 2008 Another decisive discovery pointed later that the pregnane X-receptor (PXR) is activated by the endogenous toxic lithocholic acid, as well as several xenobiotics and drugs. Lithocholic Acid 113-129 nuclear receptor subfamily 1 group I member 2 Homo sapiens 71-74 17696253-0 2007 Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR. Lithocholic Acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 84-87 17327420-1 2007 The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol. Lithocholic Acid 164-181 nuclear receptor subfamily 1 group I member 2 Homo sapiens 39-42 12370413-1 2002 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. Lithocholic Acid 117-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 21-24 15515100-2 2004 Lithocholic acid is a hydrophobic secondary bile acid that is a substrate of nuclear Pregnane X receptor (PXR). Lithocholic Acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 85-104 15515100-2 2004 Lithocholic acid is a hydrophobic secondary bile acid that is a substrate of nuclear Pregnane X receptor (PXR). Lithocholic Acid 0-16 nuclear receptor subfamily 1 group I member 2 Homo sapiens 106-109 17491508-6 2007 In human liver the presence of LCA is sensed by the pregnane X receptor (PXR) which has the potential to switch on all the genes required for safe metabolism and elimination of LCA from the body. Lithocholic Acid 31-34 nuclear receptor subfamily 1 group I member 2 Homo sapiens 52-71 17491508-6 2007 In human liver the presence of LCA is sensed by the pregnane X receptor (PXR) which has the potential to switch on all the genes required for safe metabolism and elimination of LCA from the body. Lithocholic Acid 31-34 nuclear receptor subfamily 1 group I member 2 Homo sapiens 73-76 17491508-6 2007 In human liver the presence of LCA is sensed by the pregnane X receptor (PXR) which has the potential to switch on all the genes required for safe metabolism and elimination of LCA from the body. Lithocholic Acid 177-180 nuclear receptor subfamily 1 group I member 2 Homo sapiens 52-71 17491508-6 2007 In human liver the presence of LCA is sensed by the pregnane X receptor (PXR) which has the potential to switch on all the genes required for safe metabolism and elimination of LCA from the body. Lithocholic Acid 177-180 nuclear receptor subfamily 1 group I member 2 Homo sapiens 73-76 17491508-8 2007 Similarly, PXR exposure to LCA produces up-regulated expression of the membrane transporters MDR1 and MRP2 which excrete metabolites of LCA. Lithocholic Acid 27-30 nuclear receptor subfamily 1 group I member 2 Homo sapiens 11-14 17491508-8 2007 Similarly, PXR exposure to LCA produces up-regulated expression of the membrane transporters MDR1 and MRP2 which excrete metabolites of LCA. Lithocholic Acid 136-139 nuclear receptor subfamily 1 group I member 2 Homo sapiens 11-14 15883047-8 2005 The expression of ABCA1 and SR-BI was inhibited by the PXR activators rifampicin and lithocholic acid (LCA) in HepG2 cells and pregnenolone 16alpha-carbonitrile (PCN) in primary rat hepatocytes. Lithocholic Acid 103-106 nuclear receptor subfamily 1 group I member 2 Homo sapiens 55-58 14525957-3 2004 To identify structural determinants required for VDR activation by 1alpha,25(OH)2D3 and LCA, we generated VDR mutants predicted to modulate ligand response based on sequence homology to pregnane X receptor, another bile acid-responsive nuclear receptor. Lithocholic Acid 88-91 nuclear receptor subfamily 1 group I member 2 Homo sapiens 186-205 12370413-1 2002 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. Lithocholic Acid 117-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 26-45 12370413-1 2002 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. Lithocholic Acid 135-138 nuclear receptor subfamily 1 group I member 2 Homo sapiens 21-24 12370413-1 2002 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. Lithocholic Acid 135-138 nuclear receptor subfamily 1 group I member 2 Homo sapiens 26-45 12370413-2 2002 We found that activation of PXR also increases the activity and gene expression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD) known to sulfate LCA to facilitate its elimination. Lithocholic Acid 178-181 nuclear receptor subfamily 1 group I member 2 Homo sapiens 28-31 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 70-86 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-46 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 70-86 nuclear receptor subfamily 1 group I member 2 Homo sapiens 102-105 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 70-86 nuclear receptor subfamily 1 group I member 2 Homo sapiens 102-105 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 228-244 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-46 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 228-244 nuclear receptor subfamily 1 group I member 2 Homo sapiens 102-105 11893771-3 2002 Among the chemicals that bind and activate PXR is the toxic bile acid lithocholic acid; activation of PXR, in turn, protects against the severe liver damage caused by this bile acid.Thus, PXR serves as a physiological sensor of lithocholic acid and perhaps other bile acids and coordinately regulates genes involved in their detoxification. Lithocholic Acid 228-244 nuclear receptor subfamily 1 group I member 2 Homo sapiens 102-105