PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35441471-0 2022 The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/beta-catenin signalling pathway. Lithocholic Acid 46-62 catenin beta 1 Homo sapiens 132-144 35441471-10 2022 Specifically, LCA supplementation caused higher levels of FITC-labelled dextran in serum, reduced PCNA expression and inhibited the activity of Wnt/beta-catenin pathway in enterocytes. Lithocholic Acid 14-17 catenin beta 1 Homo sapiens 148-160 27908290-10 2016 CONCLUSIONS: Our results suggest that bile acids, specifically DCA and LCA, induce cancer stemness in colonic epithelial cells by modulating M3R and Wnt/beta-catenin signaling and thus could be considered promoters of colon cancer. Lithocholic Acid 71-74 catenin beta 1 Homo sapiens 153-165 20043299-5 2010 Using Caco-2 colorectal cancer (CRC) cells, it was observed that VDR ligands, 1,25D and LCA, both suppress beta-catenin transcriptional activity, though 1,25D exhibited significantly greater inhibition. Lithocholic Acid 88-91 catenin beta 1 Homo sapiens 107-119 35441471-12 2022 CONCLUSION: LCA exacerbates NEC by inhibiting intestinal cell proliferation through downregulating the Wnt/beta-catenin pathway. Lithocholic Acid 12-15 catenin beta 1 Homo sapiens 107-119