PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31864360-8 2019 RESULTS: CF cells exposed to digitoxin exhibited significant suppression of both TNFalpha/NFkappaB signaling and downstream secretion of IL-8, IL-6 and GM-CSF, with or without co-treatment with VX drugs. Digitoxin 29-38 C-X-C motif chemokine ligand 8 Homo sapiens 137-141 28006108-5 2017 The primary objective was to measure the effects of digitoxin on IL-8 and neutrophil counts in induced sputum. Digitoxin 52-61 C-X-C motif chemokine ligand 8 Homo sapiens 65-69 15136726-0 2004 Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Digitoxin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 15136726-3 2004 We show here that digitoxin, at sub nM concentrations, can suppress hypersecretion of IL-8 from cultured CF lung epithelial cells. Digitoxin 18-27 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 15136726-11 2004 We therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as a candidate drug for suppressing IL-8-dependent lung inflammation in CF. Digitoxin 26-35 C-X-C motif chemokine ligand 8 Homo sapiens 135-139