PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
501928-7	1979	Serum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin.	Digitoxin	6-15	albumin	Homo sapiens	72-79	
2004463-0	1991	Preparation of specific antiserum to digitoxin by using digitoxin hemisuccinate-bovine serum albumin conjugate at the digitoxose C-3" position.	Digitoxin	37-46	albumin	Homo sapiens	87-100	
22484270-7	2012	In addition, with the aid of site markers (such as, phenylbutazone, ibuprofen and digitoxin), TMPZ primarily bound to tryptophan residues of BSA/HSA within site I (sub-domain II A).	Digitoxin	82-91	albumin	Homo sapiens	141-144	
10604823-1	1999	Digitoxin is very strongly bound to serum albumin.	Digitoxin	0-9	albumin	Homo sapiens	36-49	
10202961-0	1999	Characterisation of the binding of digitoxin and acetyldigitoxin to human serum albumin by high-performance affinity chromatography.	Digitoxin	35-44	albumin	Homo sapiens	74-87	
10202961-1	1999	Zonal elution and high-performance affinity chromatography were used to examine interactions of the drugs digitoxin and acetyldigitoxin with the protein human serum albumin (HSA).	Digitoxin	106-115	albumin	Homo sapiens	159-172	
8372053-0	1993	The affinity of human serum albumin for [3H]-digitoxin is dependent on albumin concentration.	Digitoxin	45-54	albumin	Homo sapiens	28-35	
8372053-0	1993	The affinity of human serum albumin for [3H]-digitoxin is dependent on albumin concentration.	Digitoxin	45-54	albumin	Homo sapiens	71-78	
8372053-1	1993	Binding of [3H]-digitoxin to human serum albumin and human serum was investigated in order to characterize the relationship between binding and albumin concentration.	Digitoxin	16-25	albumin	Homo sapiens	41-48	
8372053-1	1993	Binding of [3H]-digitoxin to human serum albumin and human serum was investigated in order to characterize the relationship between binding and albumin concentration.	Digitoxin	16-25	albumin	Homo sapiens	144-151	
8372053-4	1993	[3H]-Digitoxin binding both to purified albumin and to normal serum was markedly pH-dependent, the bound/unbound ratio being highly significantly (P < 0.001) inversely correlated to pH in the range 6-8.5.	Digitoxin	5-14	albumin	Homo sapiens	40-47	
8372053-5	1993	When albumin concentration was increased within the physiological range, the ratio bound/unbound [3H]-digitoxin increased much less than expected from predictions using the law of mass action.	Digitoxin	102-111	albumin	Homo sapiens	5-12	
8372053-6	1993	Binding saturation experiments revealed that the equilibrium dissociation constant for [3H]-digitoxin was increased at higher albumin concentrations without any decrease in the number of binding sites per albumin molecule.	Digitoxin	92-101	albumin	Homo sapiens	126-133	
8372053-7	1993	In conclusion, the results strongly indicate that binding estimates in therapeutic monitoring of digitoxin in patients with elevated or reduced albumin concentration should not be based on the law of mass action but on empiric relationships between albumin concentration and binding.	Digitoxin	97-106	albumin	Homo sapiens	144-151	
8372053-7	1993	In conclusion, the results strongly indicate that binding estimates in therapeutic monitoring of digitoxin in patients with elevated or reduced albumin concentration should not be based on the law of mass action but on empiric relationships between albumin concentration and binding.	Digitoxin	97-106	albumin	Homo sapiens	249-256	
501928-7	1979	Serum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin.	Digitoxin	6-15	albumin	Homo sapiens	159-166	
501928-7	1979	Serum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin.	Digitoxin	106-115	albumin	Homo sapiens	72-79	
501928-7	1979	Serum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin.	Digitoxin	106-115	albumin	Homo sapiens	159-166	
501928-8	1979	Minimal effective level, 10 ng/ml, was however obtained with higher daily dose of digitoxin in patients with lower serum albumin.	Digitoxin	82-91	albumin	Homo sapiens	121-128	
891591-1	1977	The binding of semi-synthetic (16alpha-gitoxin and its 16-acetate) and naturally occurring cardioactive glycosides (digitoxin, ouabain) to human serum albumin was studied using equilibrium dialysis, ultracentrifugation and gel filtration.	Digitoxin	116-125	albumin	Homo sapiens	145-158	
26688208-5	2016	The binding site of dimethyl fumarate on bovine serum albumin was determined by displacement studies, using the site probes viz., warfarin, ibuprofen and digitoxin.	Digitoxin	154-163	albumin	Homo sapiens	48-61