PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34717917-0	2022	Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1alpha and STAT3 in KRAS mutant human colon cancer cells.	Digitoxin	0-9	signal transducer and activator of transcription 3	Homo sapiens	97-102	
34717917-8	2022	Digitoxin inhibited the expression and activation of STAT3 through upregulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN), SHP1 and protein inhibitors of activated STAT3 (PIAS3) and direct binding to STAT3.	Digitoxin	0-9	signal transducer and activator of transcription 3	Homo sapiens	53-58	
34717917-8	2022	Digitoxin inhibited the expression and activation of STAT3 through upregulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN), SHP1 and protein inhibitors of activated STAT3 (PIAS3) and direct binding to STAT3.	Digitoxin	0-9	signal transducer and activator of transcription 3	Homo sapiens	189-194	
34717917-8	2022	Digitoxin inhibited the expression and activation of STAT3 through upregulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN), SHP1 and protein inhibitors of activated STAT3 (PIAS3) and direct binding to STAT3.	Digitoxin	0-9	signal transducer and activator of transcription 3	Homo sapiens	225-230	
34717917-9	2022	Meanwhile, digitoxin inhibited HIF-1alpha in STAT3-independent manner in KRAS mutant colon cancer cells.	Digitoxin	11-20	signal transducer and activator of transcription 3	Homo sapiens	45-50	
34717917-10	2022	Moreover, digitoxin promoted apoptosis and inhibited proliferation and migration, which was potentially mediated by suppression of HIF-1alpha and STAT3.	Digitoxin	10-19	signal transducer and activator of transcription 3	Homo sapiens	146-151	
34717917-5	2022	Our result demonstrated that digitoxin but not cetuximab markedly decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), signal transducer and activator of transcription 3 (STAT3) and p-STAT3 protein in KRAS mutant colon cancer cells.	Digitoxin	29-38	signal transducer and activator of transcription 3	Homo sapiens	140-190	
34717917-5	2022	Our result demonstrated that digitoxin but not cetuximab markedly decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), signal transducer and activator of transcription 3 (STAT3) and p-STAT3 protein in KRAS mutant colon cancer cells.	Digitoxin	29-38	signal transducer and activator of transcription 3	Homo sapiens	192-197	
34717917-5	2022	Our result demonstrated that digitoxin but not cetuximab markedly decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), signal transducer and activator of transcription 3 (STAT3) and p-STAT3 protein in KRAS mutant colon cancer cells.	Digitoxin	29-38	signal transducer and activator of transcription 3	Homo sapiens	205-210