PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28703832-7 2017 iNOS, COX-2, NOX-1, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta) expressions were higher in the mesenteric arteries from TNBS-treated rats, without changes in both eNOS expression and eNOS-Ser1177 phosphorylation. Trinitrobenzenesulfonic Acid 147-151 tumor necrosis factor Rattus norvegicus 20-47 32525764-5 2020 Diosgenin significantly decreased (p < 0.05) TNBS-induced elevated colonic oxido-nitrosative damage, myeloperoxidase, hydroxyproline, mRNA expressions of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IFN-gamma) and inflammatory markers (iNOs and COX-2) induced by TNBS. Trinitrobenzenesulfonic Acid 45-49 tumor necrosis factor Rattus norvegicus 181-190 30386616-7 2018 Results: (1) Hp(2-20) accelerated healing of TNBS-induced colitis compared to controls consistently with the expression of FPRs in colonic mucosa; (2) TNBS upregulated mRNA mucosal expression of COX-2, TNF-alpha, TGF-beta, HB-EGF and t-TG and (3) this, with the exception of HB-EGF, was significantly counteracted by Hp(2-20). Trinitrobenzenesulfonic Acid 151-155 tumor necrosis factor Rattus norvegicus 202-211 29853790-7 2018 In addition, there was a downregulation of the TNBS-induced increase in the activity of iNOS and levels of Cox-2, TNF-alpha, and IL-1beta while the protein expression of NF-kappaB was significantly unregulated after administration of H-PHL. Trinitrobenzenesulfonic Acid 47-51 tumor necrosis factor Rattus norvegicus 114-123 28337639-15 2018 RESULTS: Rats in the TNBS group developed symptoms of colitis, including: body weight loss, colon mass index increase and damage of intestinal tissues with concomitant increase in TNF-alpha, IL-17, MDA levels and decreased SOD activity. Trinitrobenzenesulfonic Acid 21-25 tumor necrosis factor Rattus norvegicus 180-189 33062594-6 2020 Also, the IFN-gamma, IL-1beta, IL-6, Il-23, TNF-alpha, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Trinitrobenzenesulfonic Acid 187-191 tumor necrosis factor Rattus norvegicus 44-53 28703832-7 2017 iNOS, COX-2, NOX-1, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta) expressions were higher in the mesenteric arteries from TNBS-treated rats, without changes in both eNOS expression and eNOS-Ser1177 phosphorylation. Trinitrobenzenesulfonic Acid 147-151 tumor necrosis factor Rattus norvegicus 49-57 27822176-10 2016 Up-regulated mRNA expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOs, as well as down-regulated IL-10 mRNA expressions after TNBS administration, were significantly inhibited by FA (20 and 40 mg/kg) treatment. Trinitrobenzenesulfonic Acid 131-135 tumor necrosis factor Rattus norvegicus 32-41 25689466-7 2015 Survival rate, TNFalpha, and IL-1beta mRNA were improved in TNBS/Gln compared with TNBS/PBS (p < 0.05). Trinitrobenzenesulfonic Acid 60-64 tumor necrosis factor Rattus norvegicus 15-23 26218952-18 2015 TNBS significantly increased the spinal expression of HMGB1 and proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6. Trinitrobenzenesulfonic Acid 0-4 tumor necrosis factor Rattus norvegicus 100-109 24627565-3 2014 We investigated whether satellite glial cell (SGC) and tumor necrosis factor-alpha (TNF-alpha) activation in DRG participates in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced rat model of visceral hyperalgesia. Trinitrobenzenesulfonic Acid 168-172 tumor necrosis factor Rattus norvegicus 84-93 25821305-8 2015 Simvastatin or rosuvastatin counteracted the reduction in colon length, decreased colon weight, neutrophil accumulation, and tumor necrosis factor-alpha level in TNBS-induced colitis. Trinitrobenzenesulfonic Acid 162-166 tumor necrosis factor Rattus norvegicus 125-152 24627565-4 2014 In TNBS-treated rats, TNF-alpha expression increased in DRG and was colocalized to SGCs enveloping a given neuron. Trinitrobenzenesulfonic Acid 3-7 tumor necrosis factor Rattus norvegicus 22-31 24627565-6 2014 When nerves attached to DRG (L6-S1) were stimulated with a series of electrical stimulations, TNF-alpha were released from DRG in TNBS-treated animals compared with controls. Trinitrobenzenesulfonic Acid 130-134 tumor necrosis factor Rattus norvegicus 94-103 24142717-2 2013 This study aimed to investigate the impact of probiotics (Lactobacillus, Bifidobacterium) on the expression of TLR4 and tumor necrosis factor-alpha (TNF-alpha) in the colon mucosa of rat experimental ulcerative colitis model induced by trinitrobenzene sulfonic acid (TNBS)/ethanol and immune complexes. Trinitrobenzenesulfonic Acid 236-265 tumor necrosis factor Rattus norvegicus 149-158 24931258-21 2014 On day 7 the expressions of TNF-alpha and IL-1beta in the thalidomide treatment group were lower than in the TNBS model group. Trinitrobenzenesulfonic Acid 109-113 tumor necrosis factor Rattus norvegicus 28-37 22736915-4 2012 RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-alpha level. Trinitrobenzenesulfonic Acid 9-13 tumor necrosis factor Rattus norvegicus 85-94 22426941-10 2012 Our results suggest that down-regulation of TNF-alpha and COX-2 resulted in a decrease in inflammation caused by TNBS and thus provided some protection from the colonic damage caused by TNBS. Trinitrobenzenesulfonic Acid 113-117 tumor necrosis factor Rattus norvegicus 44-53 22426941-10 2012 Our results suggest that down-regulation of TNF-alpha and COX-2 resulted in a decrease in inflammation caused by TNBS and thus provided some protection from the colonic damage caused by TNBS. Trinitrobenzenesulfonic Acid 186-190 tumor necrosis factor Rattus norvegicus 44-53 22234755-5 2011 The relief of trinitrobenzene sulfonic acid-induced colitis was accompanied by significantly decreased production of tumor necrosis factor-alpha in both serum and intra-colon (p<0.05) and by significantly increased production of interleukin-10 in both serum and intra-colon (p<0.05). Trinitrobenzenesulfonic Acid 14-43 tumor necrosis factor Rattus norvegicus 117-144 21863329-4 2011 Thus, this study aimed to evaluate the effect of Etanercept (ETC), a tumour necrosis factor alpha (TNF-alpha) antagonist on the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis. Trinitrobenzenesulfonic Acid 128-163 tumor necrosis factor Rattus norvegicus 99-108 21863329-4 2011 Thus, this study aimed to evaluate the effect of Etanercept (ETC), a tumour necrosis factor alpha (TNF-alpha) antagonist on the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis. Trinitrobenzenesulfonic Acid 165-169 tumor necrosis factor Rattus norvegicus 99-108 21863329-7 2011 The gene expression of TNF-alpha mRNA, decreased significantly in this group compared to the TNBS non-treated group. Trinitrobenzenesulfonic Acid 93-97 tumor necrosis factor Rattus norvegicus 23-32 21863329-9 2011 Taken together, our results suggest that ETC attenuates intestinal colitis induced by TNBS in Wistar rats by TNF-alpha downregulation. Trinitrobenzenesulfonic Acid 86-90 tumor necrosis factor Rattus norvegicus 109-118 22234755-6 2011 CONCLUSIONS: Peifeikang can effectively ameliorate trinitrobenzene sulfonic acid-induced colitis in rats, the underlying mechanism of which may be attributed to the modulatory effects of Peifeikang on the production of tumor necrosis factor-alpha and interleukin-10. Trinitrobenzenesulfonic Acid 51-80 tumor necrosis factor Rattus norvegicus 219-246 21042292-9 2011 TNBS-CysN group developed a less severe colitis compared with the TNBS group (macroscopic score 0.43+-0.78 vs 3.28+-0.95, microscopic score 6.62+-12.01 vs 19.25+-6.04, P<0.05, respectively) associated with a decrease of TG activity, TG2 and isopeptide bond immunohistochemical expression, TNF-alpha and IL-6 levels. Trinitrobenzenesulfonic Acid 0-4 tumor necrosis factor Rattus norvegicus 292-301 19220658-8 2009 Trinitrobenzene sulfonic acid-induced expression of TNF-alpha and IL-1beta was reduced by muscovite and 5-ASA treatment. Trinitrobenzenesulfonic Acid 0-29 tumor necrosis factor Rattus norvegicus 52-61 17363466-8 2007 Levels of the proinflammatory cytokines TNF-alpha and IL-6 were markedly upregulated by trinitrobenzene sulfonic acid treatment. Trinitrobenzenesulfonic Acid 88-117 tumor necrosis factor Rattus norvegicus 40-49 18955701-8 2008 The TNBS-treated rats exhibited a marked, reversible inflammatory response within the hippocampus, characterized by microglial activation and increases in tumor necrosis factor alpha (TNFalpha) levels. Trinitrobenzenesulfonic Acid 4-8 tumor necrosis factor Rattus norvegicus 155-182 18955701-8 2008 The TNBS-treated rats exhibited a marked, reversible inflammatory response within the hippocampus, characterized by microglial activation and increases in tumor necrosis factor alpha (TNFalpha) levels. Trinitrobenzenesulfonic Acid 4-8 tumor necrosis factor Rattus norvegicus 184-192 18322307-7 2008 TNBS administration also significantly enhanced the serum and colonic mucosal cytokines (TNF-alpha and IL-6) and eicosanoids (LTB4 and PGE2) levels, which paralleled with the severity of colitis. Trinitrobenzenesulfonic Acid 0-4 tumor necrosis factor Rattus norvegicus 89-98 19196500-10 2009 The TNBS-induced increase in the TNFalpha-mRNA expression was suppressed by STW 5 but not by STW 6. Trinitrobenzenesulfonic Acid 4-8 tumor necrosis factor Rattus norvegicus 33-41 17324399-11 2007 Progesterone enhanced TNBS-induced MIF (P < .001) and TNF-alpha (P < .01) production, while EB decreased MIF (P < .01) and IL-beta levels (P < .01). Trinitrobenzenesulfonic Acid 22-26 tumor necrosis factor Rattus norvegicus 57-66 17343846-7 2007 Inflammation following TNBS induction was characterized by increased colonic wall thickness, edema, diffuse inflammatory cells infiltration, necrosis reaching an ulcer index (UI) of 9.66+/-0.66 cm(2) and increased MPO activity and TNF-alpha colonic levels. Trinitrobenzenesulfonic Acid 23-27 tumor necrosis factor Rattus norvegicus 231-240 16973935-8 2007 Four days after TNBS treatment, plasma corticosterone was unaltered in all groups; however, TNF-alpha was significantly increased in adult TNBS-treated rats that had LPS as neonates compared with all other groups. Trinitrobenzenesulfonic Acid 139-143 tumor necrosis factor Rattus norvegicus 92-101 16689657-4 2006 On day 7 after anal instillation of TNBS, SD and DA rats demonstrated massive lymphocyte infiltration with an interferon-gamma (IFN-gamma) mRNA upregulation, whereas Lewis, F344, and BN rats showed an intense submucosal neutrophil accumulation with high tumor necrosis factor-alpha (TNF-alpha) mRNA levels. Trinitrobenzenesulfonic Acid 36-40 tumor necrosis factor Rattus norvegicus 254-281 18174677-6 2007 RESULTS: TNBS induced severe colitis as evidenced by increased colonic edema, mucosal lesion area, histopathological score, MPO activity, and TNF-alpha level. Trinitrobenzenesulfonic Acid 9-13 tumor necrosis factor Rattus norvegicus 142-151 16689657-4 2006 On day 7 after anal instillation of TNBS, SD and DA rats demonstrated massive lymphocyte infiltration with an interferon-gamma (IFN-gamma) mRNA upregulation, whereas Lewis, F344, and BN rats showed an intense submucosal neutrophil accumulation with high tumor necrosis factor-alpha (TNF-alpha) mRNA levels. Trinitrobenzenesulfonic Acid 36-40 tumor necrosis factor Rattus norvegicus 283-292 16213481-4 2005 caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration. Trinitrobenzenesulfonic Acid 75-79 tumor necrosis factor Rattus norvegicus 165-174 12421838-0 2002 Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitic rats. Trinitrobenzenesulfonic Acid 96-124 tumor necrosis factor Rattus norvegicus 37-64 11884025-3 2001 The study was designed to investigate whether colitis induced by trinitrobenzene sulphonic acid (TNBS) in rats produces an increase in TACE activity and/or expression and whether its pharmacological inhibition reduces TNF-alpha levels, iNOS expression and colonic damage in this model. Trinitrobenzenesulfonic Acid 97-101 tumor necrosis factor Rattus norvegicus 218-227 12063094-4 2002 The effect of this compound was compared with that of methylprednisolone on the histological abnormalities and serum levels of tumor necrosis factor-alpha (TNF-alpha) in experimental colitis produced by 2,4,6-trinitrobenzenesulfonic acid (TNB). Trinitrobenzenesulfonic Acid 203-237 tumor necrosis factor Rattus norvegicus 127-154 12063094-4 2002 The effect of this compound was compared with that of methylprednisolone on the histological abnormalities and serum levels of tumor necrosis factor-alpha (TNF-alpha) in experimental colitis produced by 2,4,6-trinitrobenzenesulfonic acid (TNB). Trinitrobenzenesulfonic Acid 203-237 tumor necrosis factor Rattus norvegicus 156-165 11884025-7 2001 Instillation of TNBS caused an increase in TACE activity and expression and the release of TNF-alpha. Trinitrobenzenesulfonic Acid 16-20 tumor necrosis factor Rattus norvegicus 91-100 11884025-9 2001 BB1101 blocked TNBS-induced increase in TACE activity, TNF-alpha release and iNOS expression. Trinitrobenzenesulfonic Acid 15-19 tumor necrosis factor Rattus norvegicus 55-64 11884025-11 2001 TNBS causes TNF-alpha release by an increase in TACE activity and expression and this results in the expression of iNOS and subsequent inflammation, suggesting that TACE inhibition may prove useful as a therapeutic means in IBD. Trinitrobenzenesulfonic Acid 0-4 tumor necrosis factor Rattus norvegicus 12-21 9864264-3 1998 We tested the efficacy and safety of anti-TNFalpha therapy in experimental colitis induced by trinitrobenzenesulfonic acid. Trinitrobenzenesulfonic Acid 94-122 tumor necrosis factor Rattus norvegicus 42-50 11167873-11 2001 CONCLUSION: The systemic response to TNBS-induced colitis appears to be at least partially dependent on TNF. Trinitrobenzenesulfonic Acid 37-41 tumor necrosis factor Rattus norvegicus 104-107 9391247-11 1997 CONCLUSION: Prophylactic glutamine supplementation modulates the inflammatory activities of IL-8 and TNF-alpha in TNBS induced colitis. Trinitrobenzenesulfonic Acid 114-118 tumor necrosis factor Rattus norvegicus 101-110 35239781-8 2022 The TNBS-induced colitis rats showed significant increases in disease activity scores, serum TNF-alpha, IL-2, and IL-6 levels, and colonic myeloperoxidase and malonaldehyde content. Trinitrobenzenesulfonic Acid 4-8 tumor necrosis factor Rattus norvegicus 93-102