PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17363466-8	2007	Levels of the proinflammatory cytokines TNF-alpha and IL-6 were markedly upregulated by trinitrobenzene sulfonic acid treatment.	Trinitrobenzenesulfonic Acid	88-117	interleukin 6	Rattus norvegicus	54-58	
18322307-7	2008	TNBS administration also significantly enhanced the serum and colonic mucosal cytokines (TNF-alpha and IL-6) and eicosanoids (LTB4 and PGE2) levels, which paralleled with the severity of colitis.	Trinitrobenzenesulfonic Acid	0-4	interleukin 6	Rattus norvegicus	103-107	
32525764-5	2020	Diosgenin significantly decreased (p < 0.05) TNBS-induced elevated colonic oxido-nitrosative damage, myeloperoxidase, hydroxyproline, mRNA expressions of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IFN-gamma) and inflammatory markers (iNOs and COX-2) induced by TNBS.	Trinitrobenzenesulfonic Acid	45-49	interleukin 6	Rattus norvegicus	202-206	
35239781-8	2022	The TNBS-induced colitis rats showed significant increases in disease activity scores, serum TNF-alpha, IL-2, and IL-6 levels, and colonic myeloperoxidase and malonaldehyde content.	Trinitrobenzenesulfonic Acid	4-8	interleukin 6	Rattus norvegicus	114-118	
30253332-6	2018	Then, we carried out flow cytometry, ELISA, qRT-PCR, and found that in TNBS+miR-155 inhibition group, the proportion of Th17 cells in spleens and mesenteric lymph nodes (MLNs) and the level of the Th17 cell-associated cytokines IL-6, IL-17A, IL-17F and IL-21 in colon tissues were significantly reduced (P &lt; 0.05), which revealed that miR-155 inhibition regulated the differentiation and function of Th17 cells.	Trinitrobenzenesulfonic Acid	71-75	interleukin 6	Rattus norvegicus	228-232	
30735453-8	2019	Chronic TNBS induced 1) a visceral hypersensitivity (P = 0.03), 2) an increased colon weight-to-length ratio (P = 0.01), 3) higher inflammatory and fibrosis scores (P = 0.0390 and P = 0.0016, respectively), and 4) a higher colonic IL-6 and IL-10 production (P = 0.008 and P = 0.005, respectively) compared with control rats.	Trinitrobenzenesulfonic Acid	8-12	interleukin 6	Rattus norvegicus	231-235	
26218952-18	2015	TNBS significantly increased the spinal expression of HMGB1 and proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6.	Trinitrobenzenesulfonic Acid	0-4	interleukin 6	Rattus norvegicus	115-119	
21042292-9	2011	TNBS-CysN group developed a less severe colitis compared with the TNBS group (macroscopic score 0.43+-0.78 vs 3.28+-0.95, microscopic score 6.62+-12.01 vs 19.25+-6.04, P&lt;0.05, respectively) associated with a decrease of TG activity, TG2 and isopeptide bond immunohistochemical expression, TNF-alpha and IL-6 levels.	Trinitrobenzenesulfonic Acid	0-4	interleukin 6	Rattus norvegicus	306-310