PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34042266-0 2021 Eriodictyol attenuates TNBS-induced ulcerative colitis through repressing TLR4/NF-kB signaling pathway in rats. Trinitrobenzenesulfonic Acid 23-27 toll-like receptor 4 Rattus norvegicus 74-78 34042266-13 2021 Moreover, EDT regulated TNBS-induced TLR4/NF-kappaB pathway activation, therefore inhibiting the progression of UC. Trinitrobenzenesulfonic Acid 24-28 toll-like receptor 4 Rattus norvegicus 37-41 26218952-20 2015 Furthermore, TSN IIA, but not the neutralizing anti-HMGB1 antibody, significantly inhibited TNBS-induced spinal TLR4 and GFAP expression. Trinitrobenzenesulfonic Acid 92-96 toll-like receptor 4 Rattus norvegicus 112-116 30901719-7 2019 Furthermore, the activation of TLR4/NF-kappaB signaling pathway was significantly inhibited by AZA and BJOE treatment when compared with that of TNBS-treated rats. Trinitrobenzenesulfonic Acid 145-149 toll-like receptor 4 Rattus norvegicus 31-35 27038922-1 2016 AIM: The aim of the present study is to explore whether atorvastatin improves intestinal inflammation through the inhibition of the TLR4/NFkB signaling pathway in TNBS-induced rat colitis. Trinitrobenzenesulfonic Acid 163-167 toll-like receptor 4 Rattus norvegicus 132-136 27038922-9 2016 Furthermore, they inhibited the TNBS-induced expression of TLR4, MyD88 and NF-kappaB p65 proteins. Trinitrobenzenesulfonic Acid 32-36 toll-like receptor 4 Rattus norvegicus 59-63 27038922-10 2016 CONCLUSIONS: It is suggested that the anti-inflammatory effect of atorvastatin on TNBS-induced rat colitis may involve the inhibition of the TLR4/NFkB signaling pathway. Trinitrobenzenesulfonic Acid 82-86 toll-like receptor 4 Rattus norvegicus 141-145 32996043-10 2021 ASE 100 mg/kg significantly reduced TNBS-induced expression of the TLR4, COX-2 and NF-kappaB p65. Trinitrobenzenesulfonic Acid 36-40 toll-like receptor 4 Rattus norvegicus 67-71 32396274-8 2020 TNBS could activate toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappaB) signaling pathway, while PCSK9 inhibition suppressed activation of TLR4/NF-kappaB in TNBS-induced rats. Trinitrobenzenesulfonic Acid 0-4 toll-like receptor 4 Rattus norvegicus 20-40 32396274-8 2020 TNBS could activate toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappaB) signaling pathway, while PCSK9 inhibition suppressed activation of TLR4/NF-kappaB in TNBS-induced rats. Trinitrobenzenesulfonic Acid 0-4 toll-like receptor 4 Rattus norvegicus 42-46 32396274-8 2020 TNBS could activate toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappaB) signaling pathway, while PCSK9 inhibition suppressed activation of TLR4/NF-kappaB in TNBS-induced rats. Trinitrobenzenesulfonic Acid 168-172 toll-like receptor 4 Rattus norvegicus 150-154 32396274-9 2020 In conclusion, PCSK9 inhibition attenuated TNBS-induced rat colitis through anti-inflammatory effect under inactivation of TLR4/NF-kappaB, suggesting potential therapeutic strategy in IBD. Trinitrobenzenesulfonic Acid 43-47 toll-like receptor 4 Rattus norvegicus 123-127 30143913-0 2019 Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-kappaB signalling pathway. Trinitrobenzenesulfonic Acid 22-26 toll-like receptor 4 Rattus norvegicus 99-103 30143913-1 2019 AIM: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signalling pathway and activation of melatonin receptor. Trinitrobenzenesulfonic Acid 97-126 toll-like receptor 4 Rattus norvegicus 180-200 30143913-1 2019 AIM: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signalling pathway and activation of melatonin receptor. Trinitrobenzenesulfonic Acid 97-126 toll-like receptor 4 Rattus norvegicus 202-206 30143913-1 2019 AIM: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signalling pathway and activation of melatonin receptor. Trinitrobenzenesulfonic Acid 128-132 toll-like receptor 4 Rattus norvegicus 180-200 30143913-1 2019 AIM: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signalling pathway and activation of melatonin receptor. Trinitrobenzenesulfonic Acid 128-132 toll-like receptor 4 Rattus norvegicus 202-206 30143913-12 2019 In addition, melatonin decreased TNBS-induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins. Trinitrobenzenesulfonic Acid 33-37 toll-like receptor 4 Rattus norvegicus 63-67 30143913-14 2019 CONCLUSIONS: It seems that the inhibition of TLR4/NF-kappaB signalling pathway may mediate the anti-inflammatory effects of melatonin in TNBS-induced rat colitis. Trinitrobenzenesulfonic Acid 137-141 toll-like receptor 4 Rattus norvegicus 45-49 27107073-12 2016 BSQW or Mesalazin significantly inhibited TNBS-induced expression of the TLR4, MyD88 and NF-kappaB P65 genes. Trinitrobenzenesulfonic Acid 42-46 toll-like receptor 4 Rattus norvegicus 73-77 23250811-0 2013 Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-kappaB signaling pathway. Trinitrobenzenesulfonic Acid 18-22 toll-like receptor 4 Rattus norvegicus 86-90 24142717-2 2013 This study aimed to investigate the impact of probiotics (Lactobacillus, Bifidobacterium) on the expression of TLR4 and tumor necrosis factor-alpha (TNF-alpha) in the colon mucosa of rat experimental ulcerative colitis model induced by trinitrobenzene sulfonic acid (TNBS)/ethanol and immune complexes. Trinitrobenzenesulfonic Acid 236-265 toll-like receptor 4 Rattus norvegicus 111-115 19002562-3 2009 In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS). Trinitrobenzenesulfonic Acid 222-250 toll-like receptor 4 Rattus norvegicus 76-81