PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32124197-7 2020 A recent study has demonstrated that the treatment with anti-IL-17 antibody significantly alleviated 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colorectal fibrosis in mice by down-regulating the expression of collagen 3 and several pro-fibrogenic cytokines. Trinitrobenzenesulfonic Acid 101-136 interleukin 17A Mus musculus 61-66 33100902-11 2020 Moreover, the expression of Ang II, ACE2, Ang (1-7), IL-17A, and IL-10 in the TNBS group increased compared to that in the control group. Trinitrobenzenesulfonic Acid 78-82 interleukin 17A Mus musculus 53-59 32124197-7 2020 A recent study has demonstrated that the treatment with anti-IL-17 antibody significantly alleviated 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colorectal fibrosis in mice by down-regulating the expression of collagen 3 and several pro-fibrogenic cytokines. Trinitrobenzenesulfonic Acid 138-142 interleukin 17A Mus musculus 61-66 29620246-5 2018 Compared with the control group, TNBS-treated mice had significantly higher secretion of IL-17, higher DAI scores, a lower ratio of Treg, reduced colon lengths and higher histological scores for colon inflammation. Trinitrobenzenesulfonic Acid 33-37 interleukin 17A Mus musculus 89-94 29113905-8 2018 TRIM21-/- mice had more severe colitis after administration of trinitrobenzene sulfonic acid compared with wild-type mice, which was characterized by increased expression of IFN-gamma, TNF-alpha, and IL-17A in the colon. Trinitrobenzenesulfonic Acid 63-92 interleukin 17A Mus musculus 200-206 31941937-7 2020 Acute intestinal inflammation due to DSS and TNBS was attenuated in IL-17A knockout mice, whereas chronic colitis was not relieved by T cell transfer from Il17a-/- mice (% of original body weight: wild-type mice vs. Il17a-/- mice, 81.9% vs. 82.2%; P = 0.922). Trinitrobenzenesulfonic Acid 45-49 interleukin 17A Mus musculus 68-74 29545894-6 2018 In TNBS mice receiving AdTGF-2, the increase in IFN-gamma, tumor necrosis factor-alpha, IL-6, IL-17 and IL-23 was significantly prevented by dexamethasone treatment. Trinitrobenzenesulfonic Acid 3-7 interleukin 17A Mus musculus 94-99 28582593-9 2018 RESULTS: Trinitrobenzene sulfonic acid exposure significantly reduced bodyweight and increased mucosal inflammation, leukocyte infiltration, and Il17a mRNA expression in WT relative to SPARC KO mice. Trinitrobenzenesulfonic Acid 9-38 interleukin 17A Mus musculus 145-150 26926174-10 2016 In addition, neomangiferin inhibited TNBS-induced expression of tumor necrosis factor-alpha, IL-17, IL-6, and IL-1beta, and increased IL-10 expression. Trinitrobenzenesulfonic Acid 37-41 interleukin 17A Mus musculus 93-98 30518233-9 2018 FRG most potently suppressed TNBS-induced colon shortening, NF- kappa B activation and TNF- alpha and IL-17 expression and increased IL-10 expression. Trinitrobenzenesulfonic Acid 29-33 interleukin 17A Mus musculus 102-107 26971225-5 2016 They also suppressed TNBS-induced Th17 cell differentiation and IL-17 expression, but increased TNBS-suppressed Treg cell differentiation and IL-10 expression. Trinitrobenzenesulfonic Acid 21-25 interleukin 17A Mus musculus 64-69 28713999-7 2017 Expression of IL-17 in the plasma, colon and spleen was increased in TNBS-induced mice. Trinitrobenzenesulfonic Acid 69-73 interleukin 17A Mus musculus 14-19 26338824-10 2016 Furthermore, intracolonical administration of antisense miR-301a in TNBS-induced mouse colitis model significantly decreased numbers of interleukin (IL)-17A+ cells and amounts of pro-inflammatory cytokines (eg, IL-17A, TNF-alpha) in inflamed colon. Trinitrobenzenesulfonic Acid 68-72 interleukin 17A Mus musculus 211-217 27761147-8 2016 Furthermore, these inhibited TNBS-induced T-bet, RORgammat, TNF-alpha, and IL-17 expression but increased TNBS-suppressed Foxp3 and IL-10 expression. Trinitrobenzenesulfonic Acid 29-33 interleukin 17A Mus musculus 75-80 26054809-6 2015 Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis. Trinitrobenzenesulfonic Acid 77-112 interleukin 17A Mus musculus 200-205 26054809-6 2015 Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis. Trinitrobenzenesulfonic Acid 114-118 interleukin 17A Mus musculus 200-205 23030668-4 2012 We assessed the inflammation scores of TNBS-induced acute colitis in wild-type (WT), IL-17 knockout (KO), and IFN-gamma KO mice and measured the levels of inflammatory cytokines using real-time PCR and ELISAs. Trinitrobenzenesulfonic Acid 39-43 interleukin 17A Mus musculus 85-90 23030668-6 2012 Intraperitoneal injection of anti-IL-17 monoclonal antibody confirmed a specific role for IL-17 in TNBS-induced acute colitis in the 3 strains of mice. Trinitrobenzenesulfonic Acid 99-103 interleukin 17A Mus musculus 34-39 23030668-6 2012 Intraperitoneal injection of anti-IL-17 monoclonal antibody confirmed a specific role for IL-17 in TNBS-induced acute colitis in the 3 strains of mice. Trinitrobenzenesulfonic Acid 99-103 interleukin 17A Mus musculus 90-95 16670527-6 2006 RESULTS: Using a model of acute trinitrobenzenesulfonic acid (TNBS)-induced colitis, we found that IL-17 was produced in colon tissue at 24 and 48 hours and that IL-17R knockout mice were significantly protected against TNBS-induced weight loss, IL-6 production, colonic inflammation, and local macrophage inflammatory protein-2 induction. Trinitrobenzenesulfonic Acid 32-60 interleukin 17A Mus musculus 99-104 23027085-5 2012 The Th17 cytokine, IL-17, and the Th1 cytokine, IFN-gamma, were expressed at high levels in the TNBS-induced colitic mice. Trinitrobenzenesulfonic Acid 96-100 interleukin 17A Mus musculus 19-24 21424108-8 2011 After administrations of TNBS, vaccinated mice had significantly less body weight loss and a significant decrease of inflammatory scores, collagen deposition and expression of p40, IL-12, IL-23, IL-17, TNF, iNOS and Bcl-2 in colon tissues, compared with carrier and saline groups. Trinitrobenzenesulfonic Acid 25-29 interleukin 17A Mus musculus 195-200 16670527-6 2006 RESULTS: Using a model of acute trinitrobenzenesulfonic acid (TNBS)-induced colitis, we found that IL-17 was produced in colon tissue at 24 and 48 hours and that IL-17R knockout mice were significantly protected against TNBS-induced weight loss, IL-6 production, colonic inflammation, and local macrophage inflammatory protein-2 induction. Trinitrobenzenesulfonic Acid 62-66 interleukin 17A Mus musculus 99-104 16670527-6 2006 RESULTS: Using a model of acute trinitrobenzenesulfonic acid (TNBS)-induced colitis, we found that IL-17 was produced in colon tissue at 24 and 48 hours and that IL-17R knockout mice were significantly protected against TNBS-induced weight loss, IL-6 production, colonic inflammation, and local macrophage inflammatory protein-2 induction. Trinitrobenzenesulfonic Acid 220-224 interleukin 17A Mus musculus 99-104