PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30672380-3 2019 Since colocalization of Toll-like receptor 4 (TLR4) and TRPV1 has been observed in primary afferents including the trigeminal sensory neurons and the dorsal root ganglion neurons, we test the hypothesis that TLR4 might regulate the expression and function of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis using the TLR4-deficient and the wild-type C57 mice. Trinitrobenzenesulfonic Acid 327-331 toll-like receptor 4 Mus musculus 24-44 31112869-0 2019 Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population. Trinitrobenzenesulfonic Acid 36-70 toll-like receptor 4 Mus musculus 139-159 30672380-3 2019 Since colocalization of Toll-like receptor 4 (TLR4) and TRPV1 has been observed in primary afferents including the trigeminal sensory neurons and the dorsal root ganglion neurons, we test the hypothesis that TLR4 might regulate the expression and function of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis using the TLR4-deficient and the wild-type C57 mice. Trinitrobenzenesulfonic Acid 327-331 toll-like receptor 4 Mus musculus 46-50 30672380-3 2019 Since colocalization of Toll-like receptor 4 (TLR4) and TRPV1 has been observed in primary afferents including the trigeminal sensory neurons and the dorsal root ganglion neurons, we test the hypothesis that TLR4 might regulate the expression and function of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis using the TLR4-deficient and the wild-type C57 mice. Trinitrobenzenesulfonic Acid 327-331 toll-like receptor 4 Mus musculus 208-212 30672380-3 2019 Since colocalization of Toll-like receptor 4 (TLR4) and TRPV1 has been observed in primary afferents including the trigeminal sensory neurons and the dorsal root ganglion neurons, we test the hypothesis that TLR4 might regulate the expression and function of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis using the TLR4-deficient and the wild-type C57 mice. Trinitrobenzenesulfonic Acid 327-331 toll-like receptor 4 Mus musculus 208-212 28612842-3 2018 TNBS treatment increased fecal and blood levels of lipopolysaccharide (LPS) and the number of Enterobacteriaceae, particularly Escherichia coli (EC), in the gut microbiota composition, but significantly reduced the number of Lactobacillus johnsonii (LJ). Trinitrobenzenesulfonic Acid 0-4 toll-like receptor 4 Mus musculus 71-74 29543509-4 2018 Colitis in wild-type and IL-10-, Toll-like receptor 4 (TLR4)-, and myeloid differentiation primary response 88 (MyD88)-deficient mice was induced via the administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) into the colon. Trinitrobenzenesulfonic Acid 172-207 toll-like receptor 4 Mus musculus 33-53 29543509-4 2018 Colitis in wild-type and IL-10-, Toll-like receptor 4 (TLR4)-, and myeloid differentiation primary response 88 (MyD88)-deficient mice was induced via the administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) into the colon. Trinitrobenzenesulfonic Acid 172-207 toll-like receptor 4 Mus musculus 55-59 29180692-8 2017 Our study provided evidence for the first time that baicalein attenuated TNBS-induced colitis, at least in part, via inhibition of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 inflammasome. Trinitrobenzenesulfonic Acid 73-77 toll-like receptor 4 Mus musculus 131-135 29180692-0 2017 Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice. Trinitrobenzenesulfonic Acid 22-26 toll-like receptor 4 Mus musculus 58-62 20181058-4 2010 RESULTS: DSS and TNBS induced the protein expression of TLR-4 and activated transcription factor NF-kappaB. Trinitrobenzenesulfonic Acid 17-21 toll-like receptor 4 Mus musculus 56-61 20181058-12 2010 DISCUSSION: These findings suggest that DSS and TNBS may cause colitis by inducing lipid peroxidation and enterobacterial proliferation, which may deteriorate the colitis by regulating proinflammatory cytokines via TLR-4-linked NF-kappaB activation pathway. Trinitrobenzenesulfonic Acid 48-52 toll-like receptor 4 Mus musculus 215-220 20136961-12 2009 TLR4 expression was elevated after injected with TNBS and was downregulated in the eggs group. Trinitrobenzenesulfonic Acid 49-53 toll-like receptor 4 Mus musculus 0-4 19597321-5 2009 LAB also blocked activation of the transcription factor, NF-kappaB, and expression of TLR-4 induced by TNBS. Trinitrobenzenesulfonic Acid 103-107 toll-like receptor 4 Mus musculus 86-91 19050899-8 2009 Lactobacillus HY7801 inhibited the NF-kappaB activation and TLR-4 expression induced by TNBS, as well as the expression of cyclooxygenase 2. Trinitrobenzenesulfonic Acid 88-92 toll-like receptor 4 Mus musculus 60-65 17988539-6 2007 TLR4 expression of colon was up-regulated in mice of TNBS group and down-regulated in schistosome ova group which was still higher than that of normal controls (0.762 +/- 0.054 vs 0.325 +/- 0.029 vs 0.237 +/- 0.021, P < 0.01). Trinitrobenzenesulfonic Acid 53-57 toll-like receptor 4 Mus musculus 0-4 27494685-8 2016 In addition, kappa-carrageenan, together with TNBS, decreased the enzyme activity of SOD and GSH-px and up-regulated the expression of TLR4, NF-kappaB, p-ERK, p-JNK, p-Jun., IL-8 and MDA in the colonic mucosa. Trinitrobenzenesulfonic Acid 46-50 toll-like receptor 4 Mus musculus 135-139 27494685-9 2016 CONCLUSIONS: kappa-Carrageenan aggravated the TNBS-induced intestinal inflammation, and such an effect could be associated with the oxidative stress and activation of TLR4-NF-kappaB and MAPK/ERK1/2 pathway. Trinitrobenzenesulfonic Acid 46-50 toll-like receptor 4 Mus musculus 167-171 21887846-0 2011 Hyaluronic acid as a rescue therapy for trinitrobenzene sulfonic acid-induced colitis through Cox-2 and PGE2 in a Toll-like receptor 4-dependent way. Trinitrobenzenesulfonic Acid 40-69 toll-like receptor 4 Mus musculus 114-134 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Trinitrobenzenesulfonic Acid 111-140 toll-like receptor 4 Mus musculus 172-192 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Trinitrobenzenesulfonic Acid 111-140 toll-like receptor 4 Mus musculus 194-198 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Trinitrobenzenesulfonic Acid 142-146 toll-like receptor 4 Mus musculus 172-192 21887846-1 2011 We hypothesized whether systemic administration of high-molecular-weight hyaluronic acid (HMW HA) could rescue trinitrobenzene sulfonic acid (TNBS)-induced colitis through Toll-like receptor 4 (TLR4) signal. Trinitrobenzenesulfonic Acid 142-146 toll-like receptor 4 Mus musculus 194-198