PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32597970-10	2020	The TNBS-induced UC mice exhibited colonic damage and inflammation, accompanied by decreased RNF8 expression, impaired autophagy, and increased phosphorylation levels of AKT and mTOR in the colon.	Trinitrobenzenesulfonic Acid	4-8	mechanistic target of rapamycin kinase	Mus musculus	178-182	
32597970-13	2020	Collectively, RNF8 overexpression protects against TNBS-induced UC, which might be due to its enhancement of autophagy by suppressing the AKT/mTOR signaling via AKT1 ubiquitination.	Trinitrobenzenesulfonic Acid	51-55	mechanistic target of rapamycin kinase	Mus musculus	142-146	
27852394-12	2016	Conclusion: ALA may improve the TNBS-induced colitis in mice by inhibiting the phosphorylation of mTOR to promote autophagy.	Trinitrobenzenesulfonic Acid	32-36	mechanistic target of rapamycin kinase	Mus musculus	98-102	
24441193-3	2013	The present study evaluated the expression of TGFbeta, Smad3, alphavbeta6 integrin, mTOR and PPARgamma in 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced colorectal fibrosis in Smad3 wild-type (WT) and null mice.	Trinitrobenzenesulfonic Acid	106-141	mechanistic target of rapamycin kinase	Mus musculus	84-88	
24441193-3	2013	The present study evaluated the expression of TGFbeta, Smad3, alphavbeta6 integrin, mTOR and PPARgamma in 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced colorectal fibrosis in Smad3 wild-type (WT) and null mice.	Trinitrobenzenesulfonic Acid	143-147	mechanistic target of rapamycin kinase	Mus musculus	84-88	
24441193-4	2013	Smad3 WT mice treated with TNBS developed a marked colorectal fibrosis and showed a concomitant up-regulation of TGFbeta, Smad3, alphavbeta6 and mTOR and a reduction of PPARgamma expression.	Trinitrobenzenesulfonic Acid	27-31	mechanistic target of rapamycin kinase	Mus musculus	145-149	
24441193-5	2013	On the other hand, Smad3 Null mice similarly treated with TNBS did not develop fibrosis and showed a very low or even absent expression of TGFbeta, Smad3, alphavbeta6 and mTOR and a marked over-expression of PPARgamma.	Trinitrobenzenesulfonic Acid	58-62	mechanistic target of rapamycin kinase	Mus musculus	171-175	
30765845-3	2019	In this report, we found that mTOR inhibitor rapamycin or mTOR deletion in CX3Cr1+ mononuclear phagocytes inhibits expression of interleukin (IL)-23, accompanied by reduced intestinal production of IL-22 and ameliorated fibrosis in the TNBS-induced fibrosis mouse model.	Trinitrobenzenesulfonic Acid	236-240	mechanistic target of rapamycin kinase	Mus musculus	30-34	
30765845-3	2019	In this report, we found that mTOR inhibitor rapamycin or mTOR deletion in CX3Cr1+ mononuclear phagocytes inhibits expression of interleukin (IL)-23, accompanied by reduced intestinal production of IL-22 and ameliorated fibrosis in the TNBS-induced fibrosis mouse model.	Trinitrobenzenesulfonic Acid	236-240	mechanistic target of rapamycin kinase	Mus musculus	58-62