PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10700381-4	2000	Controlled proteolysis of wild-type glucokinase by proteinase K revealed that the SH group oxidizing agent alloxan can induce the formation of multiple intramolecular disulfide bridges corresponding to a double-band pattern of glucokinase protein in nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Alloxan	107-114	glucokinase	Homo sapiens	36-47	
10700381-4	2000	Controlled proteolysis of wild-type glucokinase by proteinase K revealed that the SH group oxidizing agent alloxan can induce the formation of multiple intramolecular disulfide bridges corresponding to a double-band pattern of glucokinase protein in nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Alloxan	107-114	glucokinase	Homo sapiens	227-238	
3419426-0	1988	Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme.	Alloxan	29-36	glucokinase	Homo sapiens	14-25	
9048894-7	1997	The inhibition of glucokinase enzyme activity was reversed by dithiothreitol with an EC50 value of 9 microM for alloxan and of 50 microM for ninhydrin.	Alloxan	112-119	glucokinase	Homo sapiens	18-29	
9048894-9	1997	The enzyme inhibition by alloxan was accompanied by a change in the electrophoretic mobility with a second lower molecular 49 kDa glucokinase band which can be interpreted as a compact glucokinase molecule locked by disulfide bonds.	Alloxan	25-32	glucokinase	Homo sapiens	130-141	
9048894-9	1997	The enzyme inhibition by alloxan was accompanied by a change in the electrophoretic mobility with a second lower molecular 49 kDa glucokinase band which can be interpreted as a compact glucokinase molecule locked by disulfide bonds.	Alloxan	25-32	glucokinase	Homo sapiens	185-196	
3207996-0	1988	Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose for protection against inhibition.	Alloxan	27-34	glucokinase	Homo sapiens	53-64	
3207996-4	1988	With a half-maximal inhibitory concentration of 5 microM, alloxan was the most potent pyrimidine derivative inhibitor of glucokinase.	Alloxan	58-65	glucokinase	Homo sapiens	121-132	
3207996-12	1988	Only glucose derivatives with a sufficiently bulky substituent in position C-2, such as the glucokinase substrates glucose and mannose and the inhibitors mannoheptulose, glucosamine, and N-acetylglucosamine, protected glucokinase against inhibition by alloxan by binding to the active site of the enzyme.	Alloxan	252-259	glucokinase	Homo sapiens	92-103	
3207996-12	1988	Only glucose derivatives with a sufficiently bulky substituent in position C-2, such as the glucokinase substrates glucose and mannose and the inhibitors mannoheptulose, glucosamine, and N-acetylglucosamine, protected glucokinase against inhibition by alloxan by binding to the active site of the enzyme.	Alloxan	252-259	glucokinase	Homo sapiens	218-229	
3207996-15	1988	DTT (dithiothreitol) protected glucokinase against inhibition by alloxan and reversed the inhibition of the enzyme induced by alloxan.	Alloxan	65-72	glucokinase	Homo sapiens	31-42	
3207996-16	1988	Thus the mechanism of glucokinase inhibition by alloxan and other inhibitors, such as uramil and ninhydrin, is an oxidation of functionally essential SH groups of the enzyme, where the most reactive keto group of the inhibitor acts as the hydrogen acceptor.	Alloxan	48-55	glucokinase	Homo sapiens	22-33	
3419426-2	1988	The dithiol 1,4-dithiothreitol (1,4-DTT) protected against and reversed the inhibition of glucokinase by alloxan.	Alloxan	105-112	glucokinase	Homo sapiens	90-101	
3419426-4	1988	Only 1,3-dimercaptopropane, 1,4-dimercaptobutane, 1,4-dithioerythritol, and 1,4-DTT, with intermediate spacing between the SH groups, reversed the inhibition of glucokinase induced by alloxan.	Alloxan	184-191	glucokinase	Homo sapiens	161-172	
3419426-8	1988	Like alloxan, other dithiol reagents such as ninhydrin, N-ethylmaleimide, and maleimide inhibited glucokinase.	Alloxan	5-12	glucokinase	Homo sapiens	98-109