PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18826950-3 2008 In the current study, surface TLR4 expression were similar but TLR4 activation (lipid A, 10 microg/ml) resulted in lower TNF-alpha release by HIV+ human macrophages compared with healthy cells. Lipid A 80-87 tumor necrosis factor Homo sapiens 121-130 19531474-0 2009 Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes. Lipid A 40-47 tumor necrosis factor Homo sapiens 109-136 18283493-5 2008 Using protein and gene expression assays, we show that TNF-alpha and CXCL10 represent DC-restricted molecular signatures of TLR2/TLR4 and TLR3 activation, respectively, in sharp contrast to IL-6 produced by monocytes upon stimulation with P(3)CSK(4) and Lipid A. Lipid A 254-261 tumor necrosis factor Homo sapiens 55-64 22025552-2 2011 In this study we assessed in these macrophages if the blunted increase in TLR-4-mediated TNF-alpha release induced by lipid A (LA) is associated with PI3K-induced upregulation of mammalian target of rapamycin (mTOR) activity. Lipid A 118-125 tumor necrosis factor Homo sapiens 89-98 18440300-7 2008 The lipid A-induced cytokine production in human mononuclear cells shows that the ability of the two peptides to inhibit a tumor necrosis factor-alpha production correlates with characteristic changes of the biophysical parameters. Lipid A 4-11 tumor necrosis factor Homo sapiens 123-150 16725239-4 2006 The ability to induce tumor necrosis factor-alpha (TNF-alpha) release in human whole blood cells was significantly lower for the LPS devoid of lipid A than for its parent form. Lipid A 143-150 tumor necrosis factor Homo sapiens 22-49 18827361-4 2008 In contrast, macrophages stimulated with OL or lipid A sonically dissolved in ethanol or dimethyl sulfoxide (DMSO) secreted much TNF-alpha, but very little IL-1beta. Lipid A 47-54 tumor necrosis factor Homo sapiens 129-138 17513113-2 2007 This structurally unusual lipid A can antagonize TNF-alpha production by human monocytes induced by Escherichia coli LPS. Lipid A 26-33 tumor necrosis factor Homo sapiens 49-58 16725239-4 2006 The ability to induce tumor necrosis factor-alpha (TNF-alpha) release in human whole blood cells was significantly lower for the LPS devoid of lipid A than for its parent form. Lipid A 143-150 tumor necrosis factor Homo sapiens 51-60 12117916-5 2002 In both cell lines the LPS and the lipid A from bacteria grown at 27 degrees C were stronger inducers of TNF-alpha than those from bacteria grown at 37 degrees C. However, the difference in activity was more prominent in human macrophage cells. Lipid A 35-42 tumor necrosis factor Homo sapiens 105-114 16109884-2 2005 Recognizing the critical role of Toll-like receptor (TLR) signaling in host defense, this study showed that human U937 macrophage stimulation by the TLR4-specific ligand, lipid A (biologically active component of bacterial LPS), promoted TNF-alpha release through extracellular regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase phosphorylation. Lipid A 171-178 tumor necrosis factor Homo sapiens 238-247 16109884-7 2005 Furthermore, targeted gene silencing of MKP-1 partially restored lipid A-mediated TNF-alpha release in HIV+ U1 cells. Lipid A 65-72 tumor necrosis factor Homo sapiens 82-91 11083772-3 2000 In the human monocytic cell line, THP-1, combining SP-A with lipid A or rough LPS further enhanced lipid A- or rough LPS-stimulated tumor necrosis factor alpha (TNF-alpha) mRNA levels, while SP-A-elicited increases in TNF-alpha mRNA levels were partially neutralized. Lipid A 61-68 tumor necrosis factor Homo sapiens 132-159 12542852-5 2002 Lactoferrin binds with high affinity to lipid A, the toxic moiety of the lipopolysaccharide, or endotoxin from Gram-negative bacteria Lipopolysacchride interaction with monocytes/ma phages results in the production and release of TNF-alpha, that plays an important role in inducing septic shock In this respect, it has recently been demonstrated that lactoferrin inhibits the lipopolysaccharide interaction with CD14 on monocytes/macrophages by competition with the lipopolysaccharide binding protein. Lipid A 40-47 tumor necrosis factor Homo sapiens 230-239 11133766-4 2001 The results show induction of TNF-alpha and ECP-release by LPS and lipid A in a dose-dependent manner. Lipid A 67-74 tumor necrosis factor Homo sapiens 30-39 11083772-3 2000 In the human monocytic cell line, THP-1, combining SP-A with lipid A or rough LPS further enhanced lipid A- or rough LPS-stimulated tumor necrosis factor alpha (TNF-alpha) mRNA levels, while SP-A-elicited increases in TNF-alpha mRNA levels were partially neutralized. Lipid A 61-68 tumor necrosis factor Homo sapiens 161-170 11083772-3 2000 In the human monocytic cell line, THP-1, combining SP-A with lipid A or rough LPS further enhanced lipid A- or rough LPS-stimulated tumor necrosis factor alpha (TNF-alpha) mRNA levels, while SP-A-elicited increases in TNF-alpha mRNA levels were partially neutralized. Lipid A 99-106 tumor necrosis factor Homo sapiens 132-159 11083772-3 2000 In the human monocytic cell line, THP-1, combining SP-A with lipid A or rough LPS further enhanced lipid A- or rough LPS-stimulated tumor necrosis factor alpha (TNF-alpha) mRNA levels, while SP-A-elicited increases in TNF-alpha mRNA levels were partially neutralized. Lipid A 99-106 tumor necrosis factor Homo sapiens 161-170 8119492-6 1994 The biological lipid A effects are mediated by macrophage-derived bioactive peptides such as tumor necrosis factor alpha (TNF). Lipid A 15-22 tumor necrosis factor Homo sapiens 93-120 10690516-1 2000 ONO-4007 is a synthetic analogue of the lipid A moiety of bacterial lipopolysaccharide, which exhibits antitumor activity by the induction of intratumoral tumor necrosis factor alpha, the potentiation of tumor-infiltrating macrophages, and the inhibition of angiogenesis. Lipid A 40-47 tumor necrosis factor Homo sapiens 155-182 11521054-1 2000 E5531, a synthetic lipid A analog, has been shown to inhibit endotoxin (lipopolysaccharide, LPS)-induced tumor necrosis factor-alpha (TNF-alpha) production by human monocytes and murine macrophages. Lipid A 19-26 tumor necrosis factor Homo sapiens 105-132 11521054-1 2000 E5531, a synthetic lipid A analog, has been shown to inhibit endotoxin (lipopolysaccharide, LPS)-induced tumor necrosis factor-alpha (TNF-alpha) production by human monocytes and murine macrophages. Lipid A 19-26 tumor necrosis factor Homo sapiens 134-143 9435177-1 1998 ONO-4007 is a synthetic lipid A analog that exhibits strong antitumor activity in several animal models via intratumoral production of tumor necrosis factor (TNF). Lipid A 24-31 tumor necrosis factor Homo sapiens 135-156 9435177-1 1998 ONO-4007 is a synthetic lipid A analog that exhibits strong antitumor activity in several animal models via intratumoral production of tumor necrosis factor (TNF). Lipid A 24-31 tumor necrosis factor Homo sapiens 158-161 8830332-0 1996 Effects of a new synthetic lipid A on endogenous tumor necrosis factor production and antitumor activity against human pancreatic cancer cells. Lipid A 27-34 tumor necrosis factor Homo sapiens 49-70 8830332-1 1996 The effects of a synthetic lipid A on tumor necrosis factor (TNF) production and antitumor activity against human pancreatic cancer cells were investigated. Lipid A 27-34 tumor necrosis factor Homo sapiens 38-59 8830332-7 1996 Synthetic lipid A induces TNF production and has antitumor activity against transplanted pancreatic cancer cells. Lipid A 10-17 tumor necrosis factor Homo sapiens 26-29 7525728-0 1994 Acyclic analogue of lipid A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway. Lipid A 20-27 tumor necrosis factor Homo sapiens 39-48 7525728-6 1994 Co-incubation of PBMC with the specific LPS inhibitor Rhodobacter sphaeroides lipid A inhibited SDZ 280.961-mediated stimulation of TNF-alpha release, indicating that this analogue signals mononuclear cells via a LPS-activated signaling pathway. Lipid A 78-85 tumor necrosis factor Homo sapiens 132-141 10706705-1 2000 The stimulation of both THP-1 and U937 human-derived cells by Salmonella lipid A preparations from various strains, as assessed by TNF-alpha induction and NF-kappaB activation, was found to be very low (almost inactive) compared with Escherichia coli lipid A, but all of the lipid As exerted strong activity on mouse cells and on Limulus gelation activity. Lipid A 73-80 tumor necrosis factor Homo sapiens 131-140 10706705-8 2000 In addition, both 516 and lipid A from Salmonella were found to antagonize the 506 and E. coli LPS action that induced TNF-alpha release and NF-kappaB activation in THP-1 cells. Lipid A 26-33 tumor necrosis factor Homo sapiens 119-128 10569739-3 1999 We investigated a series of structurally related monosaccharide lipid A analogues for their potency to activate human macrophage U937 cells and peripheral blood mononuclear cells for production of tumor necrosis factor-alpha and interleukin-6 compared with their potency to activate murine macrophage RAW264.7 cells. Lipid A 64-71 tumor necrosis factor Homo sapiens 197-224 9435177-7 1998 In whole blood, ONO-4007 failed to induce TNF-alpha, whereas LPS and LA-15-PP (Escherichia coli-type lipid A) strongly induced TNF-alpha production. Lipid A 101-108 tumor necrosis factor Homo sapiens 127-136 9412657-0 1997 Antitumor effect of DT-5461, a lipid A derivative, against human tumor xenografts is mediated by intratumoral production of tumor necrosis factor and affected by host immunosuppressive factors in nude mice. Lipid A 31-38 tumor necrosis factor Homo sapiens 124-145 8001393-16 1995 Monophosphoryl lipid A-pretreated volunteers demonstrated significantly reduced concentrations of TNF-alpha after endotoxin challenge, as compared with subjects treated with vehicle control (84 +/- 76 vs. 244 +/- 128 pg/mL; p < .05). Lipid A 15-22 tumor necrosis factor Homo sapiens 98-107 8119492-6 1994 The biological lipid A effects are mediated by macrophage-derived bioactive peptides such as tumor necrosis factor alpha (TNF). Lipid A 15-22 tumor necrosis factor Homo sapiens 122-125 8119492-8 1994 Synthetic lipid A partial structures compete the specific binding of LPS or lipid A and antagonistically inhibit the production of LPS-induced TNF. Lipid A 10-17 tumor necrosis factor Homo sapiens 143-146 7831357-6 1994 The toxic effects of endotoxins or their lipid A component, respectively, are initiated by the specific interaction of lipid A with macrophages/monocytes resulting in the production of peptide or lipid mediators like tumor necrosis factor alpha (TNF), the leukotrienes, and oxygen radicals. Lipid A 41-48 tumor necrosis factor Homo sapiens 217-244 7831357-6 1994 The toxic effects of endotoxins or their lipid A component, respectively, are initiated by the specific interaction of lipid A with macrophages/monocytes resulting in the production of peptide or lipid mediators like tumor necrosis factor alpha (TNF), the leukotrienes, and oxygen radicals. Lipid A 41-48 tumor necrosis factor Homo sapiens 246-249 7687236-2 1993 In the presence of small and by itself rather inefficient concentrations of lipopolysaccharide (LPS) or free lipid A (1 to 10 ng/ml), TNF-alpha production of virus-infected macrophages was strongly potentiated. Lipid A 109-116 tumor necrosis factor Homo sapiens 134-143 8225388-0 1993 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production: evidence for a role of C1q in autocrine binding of TNF. Lipid A 65-72 tumor necrosis factor Homo sapiens 169-172 8225388-1 1993 Studies were designed to further define the modulatory role of complement subcomponent C1q in macrophage activation by Lipid A to mediate production of TNF and cytotoxic nitric oxide (NO). Lipid A 119-126 tumor necrosis factor Homo sapiens 152-155 8225388-3 1993 In contrast, DHP-pretreated macrophages displayed an increase in the release of TNF in response to Lipid A as compared to untreated controls. Lipid A 99-106 tumor necrosis factor Homo sapiens 80-83 8225388-4 1993 Time kinetic studies indicated that DHP-pretreated macrophages produced higher sustained levels of TNF activity during 1 to 24 h culture with Lipid A than did untreated control macrophages. Lipid A 142-149 tumor necrosis factor Homo sapiens 99-102 8225388-5 1993 This was confirmed by increased TNF mRNA expression in response to Lipid A by DHP-treated cells. Lipid A 67-74 tumor necrosis factor Homo sapiens 32-35 1576244-0 1992 Inhibition of endotoxin or lipid A-induced tumor necrosis factor production by synthetic lipid A partial structures in human peripheral blood mononuclear cells. Lipid A 27-34 tumor necrosis factor Homo sapiens 43-64 1508144-0 1992 [Effect of lipid A on the production of tumor necrosis factor (TNF) and antitumor activity against pancreatic cancer cells: preliminary report]. Lipid A 11-18 tumor necrosis factor Homo sapiens 40-61 1508144-0 1992 [Effect of lipid A on the production of tumor necrosis factor (TNF) and antitumor activity against pancreatic cancer cells: preliminary report]. Lipid A 11-18 tumor necrosis factor Homo sapiens 63-66 1576244-0 1992 Inhibition of endotoxin or lipid A-induced tumor necrosis factor production by synthetic lipid A partial structures in human peripheral blood mononuclear cells. Lipid A 89-96 tumor necrosis factor Homo sapiens 43-64 1576244-3 1992 In agreement with previous reports it was shown that LPS of Salmonella abortus equi and synthetic Escherichia coli-type lipid A (compound 506 or LA-15-PP) have potent TNF-inducing capacity. Lipid A 120-127 tumor necrosis factor Homo sapiens 167-170 1576244-4 1992 The maximum release of TNF was found after stimulation with 1 to 10 ng/ml of LPS or 10 to 1000 ng/ml of lipid A. Lipid A 104-111 tumor necrosis factor Homo sapiens 23-26 1576244-5 1992 Synthetic precursor Ia and lipid X failed to induce TNF release, but could inhibit LPS or lipid A-induced TNF release in a dose-dependent manner. Lipid A 90-97 tumor necrosis factor Homo sapiens 106-109 1547025-0 1992 Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A. Lipid A 140-147 tumor necrosis factor Homo sapiens 55-76 1547025-2 1992 In the present study we have investigated the modulation of LPS by the synthetic non-active tetraacylated precursor Ia of lipid A (compound 406) in the induction of tumor necrosis factor (TNF), interleukin 1 (IL-1) and interleukin 6 (IL-6) in human peripheral blood mononuclear cells (PBMC) and in human peripheral blood monocytes (PBMo). Lipid A 122-129 tumor necrosis factor Homo sapiens 165-186 1547025-2 1992 In the present study we have investigated the modulation of LPS by the synthetic non-active tetraacylated precursor Ia of lipid A (compound 406) in the induction of tumor necrosis factor (TNF), interleukin 1 (IL-1) and interleukin 6 (IL-6) in human peripheral blood mononuclear cells (PBMC) and in human peripheral blood monocytes (PBMo). Lipid A 122-129 tumor necrosis factor Homo sapiens 188-191 2193101-2 1990 We examined the capacities of rough mutant Salmonella typhimurium LPS (Rc) and LPS partial structures lipid A, monophosphoryl lipid A (MPLA), lipid IVA, and lipid X to induce production of TNF in whole blood. Lipid A 102-109 tumor necrosis factor Homo sapiens 189-192 2193101-2 1990 We examined the capacities of rough mutant Salmonella typhimurium LPS (Rc) and LPS partial structures lipid A, monophosphoryl lipid A (MPLA), lipid IVA, and lipid X to induce production of TNF in whole blood. Lipid A 126-133 tumor necrosis factor Homo sapiens 189-192 2193101-4 1990 Lipid A, MPLA, lipid IVA, and lipid X exhibited decreasing capacities to stimulate production of TNF in whole blood, respectively. Lipid A 0-7 tumor necrosis factor Homo sapiens 97-100 2193101-7 1990 Coincubation with lipid IVA inhibited TNF release induced by Rc LPS or lipid A, but not by phorbol ester. Lipid A 71-78 tumor necrosis factor Homo sapiens 38-41 2613271-6 1989 Lipid A also induced the production of TNF-alpha by monocytes/macrophages but was less active than wildtype LPS. Lipid A 0-7 tumor necrosis factor Homo sapiens 39-48 2613271-9 1989 The 1- and 4"-monodephospho partial structures (compounds 505 and 504) of E. coli lipid A were less active and represented the smallest structures tested that were able to induce TNF-alpha release by monocytes/macrophages. Lipid A 82-89 tumor necrosis factor Homo sapiens 179-188 6528335-0 1984 Role of lipid A in the production of tumor necrosis factor and differences in antitumor activity between tumor necrosis factor and lipopolysaccharide. Lipid A 8-15 tumor necrosis factor Homo sapiens 37-58 6528335-3 1984 Free lipid A and lipid A-mouse serum albumin complex, which were prepared from the acid hydrolyzate, effectively induced TNF. Lipid A 5-12 tumor necrosis factor Homo sapiens 121-124 6528335-3 1984 Free lipid A and lipid A-mouse serum albumin complex, which were prepared from the acid hydrolyzate, effectively induced TNF. Lipid A 17-24 tumor necrosis factor Homo sapiens 121-124 6528335-10 1984 Lipid A is largely responsible for the TNF-inducing activity of LPS, but is not essential for the antitumor activity of TNF. Lipid A 0-7 tumor necrosis factor Homo sapiens 39-42 1681579-5 1991 Lipid A triggers the release of mediators such as cachectin (tumor necrosis factor), thereby initiating a cascade of potentially lethal events. Lipid A 0-7 tumor necrosis factor Homo sapiens 50-59 2731990-4 1989 By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes. Lipid A 76-83 tumor necrosis factor Homo sapiens 18-27