PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27632566-12 2016 Furthermore, hydroxyapatite crystals, a component of dental calculus, induced IL-1beta in mouse macrophages, and baked calculus induced IL-1beta in lipid A-primed human PMNs and PBMCs. Lipid A 148-155 interleukin 1 beta Mus musculus 136-144 29438662-0 2018 Alendronate augments lipid A-induced IL-1beta release and Smad3/NLRP3/ASC-dependent cell death. Lipid A 21-28 interleukin 1 beta Mus musculus 37-45 29438662-4 2018 Pretreatment of J774.1 cells with ALN increased lipid A-induced IL-1beta production and cell death, but not IL-6 and TNF-alpha production. Lipid A 48-55 interleukin 1 beta Mus musculus 64-72 29438662-5 2018 Ac-YVAD-CHO, a caspase-1 inhibitor, inhibited ALN-augmented IL-1beta production induced by lipid A, although it did not affect ALN-induced cell death. Lipid A 91-98 interleukin 1 beta Mus musculus 60-68 23620183-3 2013 A maximum level of NF-kappaB activation, which is involved in IL-1beta gene transcription, was also induced to a similar level by these four lipid A compounds, while the maximum level of IFN-beta promoter activity induced during MyD88-independent signaling was also less than 50% for lipid IVa stimulation compared with other lipid A compounds. Lipid A 141-148 interleukin 1 beta Mus musculus 62-70 26778788-0 2016 Pre-treatment of C57BL6/J mice with the TLR4 agonist monophosphoryl lipid A prevents LPS-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1beta, independent of interleukin-4 expression. Lipid A 68-75 interleukin 1 beta Mus musculus 153-170 10683464-1 2000 Porphyromonas gingivalis strain 381 lipid A showed lower activity in inducing interleukin (IL)-1alpha and IL-1beta production and cytokine mRNA expression than synthetic Escherichia coli lipid A (compound 506) in alveolar macrophages of C57BL/6 mice. Lipid A 36-43 interleukin 1 beta Mus musculus 106-114 11067935-5 2000 Treatment of a mouse macrophage cell line with LPS, synthetic lipid A, IL-2, IL-15, IL-1beta, IFN-gamma, or TNF-alpha significantly increased TLR2 mRNA expression, whereas TLR4 mRNA expression remained constant. Lipid A 62-69 interleukin 1 beta Mus musculus 84-92 10683464-3 2000 A calmodulin (CaM) antagonist, W-7, inhibited IL-1beta production and its mRNA expression induced by P. gingivalis lipid A but not compound 506 in alveolar macrophages. Lipid A 115-122 interleukin 1 beta Mus musculus 46-54