PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11067935-5	2000	Treatment of a mouse macrophage cell line with LPS, synthetic lipid A, IL-2, IL-15, IL-1beta, IFN-gamma, or TNF-alpha significantly increased TLR2 mRNA expression, whereas TLR4 mRNA expression remained constant.	Lipid A	62-69	interleukin 1 beta	Mus musculus	84-92	
10683464-1	2000	Porphyromonas gingivalis strain 381 lipid A showed lower activity in inducing interleukin (IL)-1alpha and IL-1beta production and cytokine mRNA expression than synthetic Escherichia coli lipid A (compound 506) in alveolar macrophages of C57BL/6 mice.	Lipid A	36-43	interleukin 1 beta	Mus musculus	106-114	
10683464-3	2000	A calmodulin (CaM) antagonist, W-7, inhibited IL-1beta production and its mRNA expression induced by P. gingivalis lipid A but not compound 506 in alveolar macrophages.	Lipid A	115-122	interleukin 1 beta	Mus musculus	46-54	
29438662-5	2018	Ac-YVAD-CHO, a caspase-1 inhibitor, inhibited ALN-augmented IL-1beta production induced by lipid A, although it did not affect ALN-induced cell death.	Lipid A	91-98	interleukin 1 beta	Mus musculus	60-68	
27632566-12	2016	Furthermore, hydroxyapatite crystals, a component of dental calculus, induced IL-1beta in mouse macrophages, and baked calculus induced IL-1beta in lipid A-primed human PMNs and PBMCs.	Lipid A	148-155	interleukin 1 beta	Mus musculus	136-144	
29438662-0	2018	Alendronate augments lipid A-induced IL-1beta release and Smad3/NLRP3/ASC-dependent cell death.	Lipid A	21-28	interleukin 1 beta	Mus musculus	37-45	
29438662-4	2018	Pretreatment of J774.1 cells with ALN increased lipid A-induced IL-1beta production and cell death, but not IL-6 and TNF-alpha production.	Lipid A	48-55	interleukin 1 beta	Mus musculus	64-72	
26778788-0	2016	Pre-treatment of C57BL6/J mice with the TLR4 agonist monophosphoryl lipid A prevents LPS-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1beta, independent of interleukin-4 expression.	Lipid A	68-75	interleukin 1 beta	Mus musculus	153-170	
23620183-3	2013	A maximum level of NF-kappaB activation, which is involved in IL-1beta gene transcription, was also induced to a similar level by these four lipid A compounds, while the maximum level of IFN-beta promoter activity induced during MyD88-independent signaling was also less than 50% for lipid IVa stimulation compared with other lipid A compounds.	Lipid A	141-148	interleukin 1 beta	Mus musculus	62-70