PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24879320-1	2014	The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear.	Lipid A	57-64	toll like receptor 4	Equus caballus	134-138	
25563849-0	2015	Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection.	Lipid A	99-106	toll like receptor 4	Equus caballus	35-39	
25563849-3	2015	In this study, molecular dynamics simulation (25 ns) was performed to elucidate the differential behavior of TLR4/MD2 complex in response to Rhodobacter sphaeroides lipid A (RsLA).	Lipid A	165-172	toll like receptor 4	Equus caballus	109-113	
24879320-2	2014	Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism.	Lipid A	78-85	toll like receptor 4	Equus caballus	47-51	
24879320-6	2014	Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA) within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex.	Lipid A	75-82	toll like receptor 4	Equus caballus	127-131	
24688739-0	2013	Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian LPS sensor system.	Lipid A	154-161	toll like receptor 4	Equus caballus	90-94	
24688705-0	2013	Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa.	Lipid A	160-167	toll like receptor 4	Equus caballus	74-78