PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7594555-2 1995 In the present study, these chemically detoxified synthetic lipid A precursors were found to antagonize the LPS action of inducing TNF-alpha in both murine peritoneal macrophages and in human monocyte-macrophage cell line THP-1. Lipid A 60-67 GLI family zinc finger 2 Homo sapiens 222-227 24943046-7 2014 A study for regioselective de-O-phosphorylation reaction was then performed to afford pure monophosphoryl lipid A with an attenuated endotoxic activity, as evaluated by cytokine production in human monocytic cell line THP-1 in vitro. Lipid A 106-113 GLI family zinc finger 2 Homo sapiens 218-223 20176798-5 2010 We found inactivated B. pertussis cells to be stronger inducers of proinflammatory cytokines in THP-1-derived macrophages when lipid A was modified. Lipid A 127-134 GLI family zinc finger 2 Homo sapiens 96-101 10706705-1 2000 The stimulation of both THP-1 and U937 human-derived cells by Salmonella lipid A preparations from various strains, as assessed by TNF-alpha induction and NF-kappaB activation, was found to be very low (almost inactive) compared with Escherichia coli lipid A, but all of the lipid As exerted strong activity on mouse cells and on Limulus gelation activity. Lipid A 73-80 GLI family zinc finger 2 Homo sapiens 24-29 10706705-1 2000 The stimulation of both THP-1 and U937 human-derived cells by Salmonella lipid A preparations from various strains, as assessed by TNF-alpha induction and NF-kappaB activation, was found to be very low (almost inactive) compared with Escherichia coli lipid A, but all of the lipid As exerted strong activity on mouse cells and on Limulus gelation activity. Lipid A 251-258 GLI family zinc finger 2 Homo sapiens 24-29 10706705-8 2000 In addition, both 516 and lipid A from Salmonella were found to antagonize the 506 and E. coli LPS action that induced TNF-alpha release and NF-kappaB activation in THP-1 cells. Lipid A 26-33 GLI family zinc finger 2 Homo sapiens 165-170 29938202-0 2018 Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells. Lipid A 0-7 GLI family zinc finger 2 Homo sapiens 84-89 29938202-13 2018 In conclusion, our data suggest that lipid A has significance for optimal development of Coxiella-containing vacuoles, and for robust multiplication of C. burnetii in macrophage-like THP-1 cells. Lipid A 37-44 GLI family zinc finger 2 Homo sapiens 183-188