PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12821717-4 2003 Here, we show that RANKL mRNA induction and ERK activation, when treated with synthetic lipid A (an active center of LPS), were markedly reduced in mouse osteoblasts lacking Cot/Tpl2, which was recently recognized as an essential kinase for the induction of TNF-alpha by LPS in macrophages. Lipid A 88-95 mitogen-activated protein kinase 1 Mus musculus 44-47 17496062-12 2007 MPO was also comparable in vehicle-treated or C3H/HeJ mice treated with LPS or lipid A at 6 and 24 h. Phospho-ERK activation was pronounced at 6 and 24 h after lipid A but not LPS treatment. Lipid A 160-167 mitogen-activated protein kinase 1 Mus musculus 110-113 17496062-13 2007 In vitro studies confirmed the relationship between phospho-ERK activation and cytokine expression in macrophage stimulated with either LPS or lipid A. Lipid A 143-150 mitogen-activated protein kinase 1 Mus musculus 60-63 17496062-14 2007 Compared with whole LPS, the lipid A fraction is associated with amplified whole lung MPO and ERK activation 6 h after intratracheal instillation in mice. Lipid A 29-36 mitogen-activated protein kinase 1 Mus musculus 94-97 31241993-2 2019 Pretreatment with the nontoxic immunomodulator monophosphoryl lipid A (MPLA) prevents inhibition by LPS through activation of a TLR4-TIR-domain-containing adaptor-inducing interferon-beta (TRIF)-phosphatidylinositol 3-kinase (PI3K) pathway that prevents LPS-induced ERK activation. Lipid A 62-69 mitogen-activated protein kinase 1 Mus musculus 266-269 10354505-9 1999 Although a monosaccharide lipid A analog, GLA-58, was able to stimulate macrophages to activate ERK proteins without cytokine production, pretreatment of macrophages with this compound suppressed both LPS-stimulated activation of ERK and cytokine production. Lipid A 26-33 mitogen-activated protein kinase 1 Mus musculus 96-99