PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26994069-1	2016	OBJECTIVE: To elucidate if TLR4-mediated MyD88 and TRIF signalling by the clinically applicable Lipopolysaccharide (LPS)-derivative monophosphoryl lipid A (MPLA) in primary human dendritic cells requires LPS cofactors LPS-binding protein (LBP) and CD14.	Lipid A	147-154	CD14 molecule	Homo sapiens	248-252	
25252784-6	2014	alphaGlcN(1 1)alphaMan-based Lipid A mimetics (alpha,alpha-GM-LAM) induced potent activation of NF-kappaB signaling in hTLR4/hMD-2/CD14-transfected HEK293 cells and robust LPS-like cytokines expression in macrophages and dendritic cells.	Lipid A	29-36	CD14 molecule	Homo sapiens	131-135	
19059378-0	2009	NMR spectral mapping of Lipid A molecular patterns affected by interaction with the innate immune receptor CD14.	Lipid A	24-31	CD14 molecule	Homo sapiens	107-111	
24380872-1	2014	TLR4/MD-2 senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes.	Lipid A	17-24	CD14 molecule	Homo sapiens	125-129	
22876888-7	2012	3) Antagonists of the interaction between endotoxins and the host receptors: LPS is recognised by the CD14 and the Toll-like receptor (TLR)-4/MD2 complex, where Lipid A is the crucial moiety in the interaction.	Lipid A	161-168	CD14 molecule	Homo sapiens	102-106	
20665199-2	2010	Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14.	Lipid A	88-95	CD14 molecule	Homo sapiens	101-105	
20665199-3	2010	The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation.	Lipid A	105-112	CD14 molecule	Homo sapiens	16-20	
15321997-4	2004	It is shown that an LPS preparation enriched for lipid A species at m/z 1,435 and 1,450 activates human and mouse TLR2, TLR2 plus TLR1, and TLR4 in transiently transfected HEK 293 cells coexpressing membrane-associated CD14.	Lipid A	49-56	CD14 molecule	Homo sapiens	219-223	
17621554-4	2007	The weak activity of the penta-acyl lipid A could be antagonized by the tetra-acyl derivative of Escherichia coli lipid A (compound 406) or the anti-CD14 monoclonal antibody MEM-18.	Lipid A	36-43	CD14 molecule	Homo sapiens	149-153	
12379680-8	2002	These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS-induced activation of NF-kappaB through human CD14/TLR4/MD-2.	Lipid A	75-82	CD14 molecule	Homo sapiens	172-176	
11891766-2	2002	Lipid A induces various transcription factors via intracellular signaling cascades initiated by their receptor CD14-TLR4.	Lipid A	0-7	CD14 molecule	Homo sapiens	111-115	
10084995-5	1999	S. sanguis and S. mutans LTAs at a 1,000-fold excess each completely inhibited the IL-8-inducing activities of both LPS and a synthetic lipid A on CD14(high) HGF.	Lipid A	136-143	CD14 molecule	Homo sapiens	147-151	
12542852-5	2002	Lactoferrin binds with high affinity to lipid A, the toxic moiety of the lipopolysaccharide, or endotoxin from Gram-negative bacteria Lipopolysacchride interaction with monocytes/ma phages results in the production and release of TNF-alpha, that plays an important role in inducing septic shock In this respect, it has recently been demonstrated that lactoferrin inhibits the lipopolysaccharide interaction with CD14 on monocytes/macrophages by competition with the lipopolysaccharide binding protein.	Lipid A	40-47	CD14 molecule	Homo sapiens	412-416	
11581570-10	2001	According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18.	Lipid A	83-90	CD14 molecule	Homo sapiens	213-217	
11545252-4	2001	METHODS: Cytokine release of interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha from human monocytes via soluble CD14 (sCD14) or membrane-associated (mCD14) receptor using anti-CD14 monoclonal antibody (MEM-18) or lipid A structure (compound 406) was measured in bioassays.	Lipid A	220-227	CD14 molecule	Homo sapiens	119-123	
10532583-5	1999	The lipid A moiety is responsible for LPS-induced activation of the non-CD14-bearing EC, and agents that bind to and neutralize this highly conserved portion of the LPS molecule can crossprotect against EC barrier dysfunction elicited by LPS derived from diverse species of Gram-negative bacteria.	Lipid A	4-11	CD14 molecule	Homo sapiens	72-76	
7540597-10	1995	The serum factors mediating the binding of lipid A to the 80-kDa membrane protein were identified as soluble CD14 and LPS-binding protein.	Lipid A	43-50	CD14 molecule	Homo sapiens	109-113	
9820516-0	1998	CD11/CD18 and CD14 share a common lipid A signaling pathway.	Lipid A	34-41	CD14 molecule	Homo sapiens	14-18	
9820516-10	1998	This supports the hypothesis that a receptor distinct from CD14 and CD11/CD18 is responsible for discriminating between the lipid A of LPS and the LPS antagonists.	Lipid A	124-131	CD14 molecule	Homo sapiens	59-63	
8805656-7	1996	We then tested the effects of lipid IVA and Rhodobacter sphaeroides lipid A, compounds that function as endotoxin inhibitors in human cells by interacting with a molecule thought to be a CD14-dependent LPS signal transducer.	Lipid A	68-75	CD14 molecule	Homo sapiens	187-191	
7693711-6	1993	Synthetic lipid A induces p38 phosphorylation in 70Z/3-hCD14 cells, whereas phorbol 12-myristate 13-acetate and interferon-gamma fail to induce tyrosine phosphorylation of p38.	Lipid A	10-17	CD14 molecule	Homo sapiens	55-60	
35481682-2	2022	In the TLR4/LPS pathway, LPS binding protein and CD14 enable lipid A of LPS to be recognized by the TLR4-MD2 receptor complex.	Lipid A	61-68	CD14 molecule	Homo sapiens	49-53	
7691750-13	1993	We conclude that monocytes do not absolutely require serum proteins to be stimulated by LPS and that CD14-independent LPS signaling pathways exist which are inhibitable by lipid IVa and R. sphaeroides lipid A.	Lipid A	201-208	CD14 molecule	Homo sapiens	101-105