PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 195585-4 1977 During the development of tumour-cell resistance to 5-fluorouracil or 5-fluorouridine in vivo there was an early differential increase in the activity of a low-affinity (high-Km) uridine kinase isoenzyme, as measured in cell extracts, and a 7-fold increase in the Km values for the uptake of both uridine and 5-fluorouridine into the intact resistant cells. 5-fluorouridine 70-85 uridine-cytidine kinase 2 Homo sapiens 179-193 195585-4 1977 During the development of tumour-cell resistance to 5-fluorouracil or 5-fluorouridine in vivo there was an early differential increase in the activity of a low-affinity (high-Km) uridine kinase isoenzyme, as measured in cell extracts, and a 7-fold increase in the Km values for the uptake of both uridine and 5-fluorouridine into the intact resistant cells. 5-fluorouridine 309-324 uridine-cytidine kinase 2 Homo sapiens 179-193 11137707-6 2001 The lower FUR and FdUR nucleotide levels in the resistant cells were a result of reduced cellular transport and uridine kinase (UR kinase) and thymidine kinase (TK) activities. 5-fluorouridine 10-13 uridine-cytidine kinase 2 Homo sapiens 112-126 11137707-6 2001 The lower FUR and FdUR nucleotide levels in the resistant cells were a result of reduced cellular transport and uridine kinase (UR kinase) and thymidine kinase (TK) activities. 5-fluorouridine 10-13 uridine-cytidine kinase 2 Homo sapiens 128-137