PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2566318-7 1989 The results indicate that concerning IMP and GMP, human RBC contain very active futile cycles, nucleotide----nucleoside----base----nucleotide, catalyzed by 5"-nucleotidase, PNP, and HGPRT. Inosine Monophosphate 37-40 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 182-187 2617949-2 1989 However, some differences were detected in thermolability and inhibition of HGPRT by purine metabolites: IMP, GMP and inosine. Inosine Monophosphate 105-108 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 76-81 2543233-1 1989 Hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyzes the conversion of hypoxanthine and guanine to IMP and GMP, respectively, in the presence of 5-phosphoribosyl-1-pyrophosphate. Inosine Monophosphate 110-113 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-46 2543233-1 1989 Hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyzes the conversion of hypoxanthine and guanine to IMP and GMP, respectively, in the presence of 5-phosphoribosyl-1-pyrophosphate. Inosine Monophosphate 110-113 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-52 2437821-2 1987 Inosinic acid formed from the enzyme-catalyzed reaction of hypoxanthine and PP-ribose-P using partially purified hypoxanthine-guanine phosphoribosyltransferase is measured after chromatography on an ion-exchange column (Partisil 10 SAX). Inosine Monophosphate 0-13 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 113-159 3436062-2 1987 Both enzyme reactions of APRT and HPRT in lysates treated with a charcoal-dextran were simultaneously carried out in the same reaction tube and the enzyme activities were determined by measuring the increases in absorbance at 260 nm of adenosine and inosine converted from adenosine-5"-monophosphate and inosine-5"-monophosphate with alkaline phosphatase. Inosine Monophosphate 304-328 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 34-38 3936863-5 1985 The enzyme activities were calculated by measurement of the decrease in the PNPase substrate, inosine, and the increase in the HGPRTase product, inosine-5"-monophosphate. Inosine Monophosphate 145-169 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 127-135 26968365-1 2016 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) reversibly catalyzes the transfer of the 5-phophoribosyl group from 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP) to hypoxanthine or guanine to form inosine monophosphate (IMP) or guanosine monophosphate (GMP) in the purine salvage pathway. Inosine Monophosphate 217-238 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-53 6717466-5 1984 This mutant phenotype was associated with a more than 10-fold reduction in hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity relative to that of the parental P3 cell line, which was shown to catalyze the formation of 4.6 pmoles inosine-5"-monophosphate (IMP)/min/microgram protein. Inosine Monophosphate 243-267 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 75-122 6717466-5 1984 This mutant phenotype was associated with a more than 10-fold reduction in hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity relative to that of the parental P3 cell line, which was shown to catalyze the formation of 4.6 pmoles inosine-5"-monophosphate (IMP)/min/microgram protein. Inosine Monophosphate 243-267 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 124-129 6717466-5 1984 This mutant phenotype was associated with a more than 10-fold reduction in hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity relative to that of the parental P3 cell line, which was shown to catalyze the formation of 4.6 pmoles inosine-5"-monophosphate (IMP)/min/microgram protein. Inosine Monophosphate 269-272 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 75-122 6717466-5 1984 This mutant phenotype was associated with a more than 10-fold reduction in hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity relative to that of the parental P3 cell line, which was shown to catalyze the formation of 4.6 pmoles inosine-5"-monophosphate (IMP)/min/microgram protein. Inosine Monophosphate 269-272 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 124-129 6258915-5 1980 In HGPRT-containing cells, salvage IMP synthesis from preformed and exogenously supplied hypoxanthine is the main source for IMP production. Inosine Monophosphate 35-38 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 3-8 6258915-5 1980 In HGPRT-containing cells, salvage IMP synthesis from preformed and exogenously supplied hypoxanthine is the main source for IMP production. Inosine Monophosphate 125-128 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 3-8 5256231-2 1969 The patients are deficient in hypoxanthine-guanine phosphoribosyltransferase, which converts hypoxanthine to inosinic acid, a major precursor of adenine and guanine nucleotides. Inosine Monophosphate 109-122 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 30-76 26968365-1 2016 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) reversibly catalyzes the transfer of the 5-phophoribosyl group from 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP) to hypoxanthine or guanine to form inosine monophosphate (IMP) or guanosine monophosphate (GMP) in the purine salvage pathway. Inosine Monophosphate 240-243 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-53 15990111-1 2005 Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyses the synthesis of the purine nucleoside monophosphates, IMP and GMP, by the addition of a 6-oxopurine base, either hypoxanthine or guanine, to the 1-beta-position of 5-phospho-alpha-d-ribosyl-1-pyrophosphate (PRib-PP). Inosine Monophosphate 126-129 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 6-52 21486037-7 2011 We used ultraviolet resonance Raman spectroscopy to study the complexes of HGPRT with products (IMP, GMP, and XMP), in both organisms, in resonance with the purine nucleobase electronic absorption. Inosine Monophosphate 96-99 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 75-80 16358551-3 2005 Inosine monophosphate (IMP), the product of HGPRT (used as the index of activity), was measured in peripheral blood mononuclear cells using high-performance liquid chromatography. Inosine Monophosphate 0-21 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 44-49 16358551-3 2005 Inosine monophosphate (IMP), the product of HGPRT (used as the index of activity), was measured in peripheral blood mononuclear cells using high-performance liquid chromatography. Inosine Monophosphate 23-26 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 44-49 15990111-1 2005 Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyses the synthesis of the purine nucleoside monophosphates, IMP and GMP, by the addition of a 6-oxopurine base, either hypoxanthine or guanine, to the 1-beta-position of 5-phospho-alpha-d-ribosyl-1-pyrophosphate (PRib-PP). Inosine Monophosphate 126-129 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 54-59 1583701-3 1992 The proportion of hypoxanthine converted to IMP by hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) is markedly greater than that degraded to xanthine and uric acid by xanthine oxidase (EC 1.3.2.3). Inosine Monophosphate 44-47 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 51-97 12689826-2 2003 The total PP(i) is determined by a reaction with inosine 5"-monophosphate, catalyzed by hypoxanthine-guanine phosphoribosyl transferase, yielding hypoxanthine and phosphoribosyl pyrophosphate. Inosine Monophosphate 49-73 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 88-135 11307586-2 2001 The enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyzes the reutilization of hypoxanthine and guanine to the purine nucleotides IMP and GMP, respectively. Inosine Monophosphate 147-150 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 11-57 11307586-2 2001 The enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyzes the reutilization of hypoxanthine and guanine to the purine nucleotides IMP and GMP, respectively. Inosine Monophosphate 147-150 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 59-63 10833458-1 2000 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxanthine and guanine by transferring the phosphoribosyl moiety from phosphoribosylpyrophosphate (PRPP) on to N9 in the purine base, resulting in the formation of inosine monophosphate (IMP) and guanosine monophosphate (GMP). Inosine Monophosphate 258-279 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-46 10833458-1 2000 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxanthine and guanine by transferring the phosphoribosyl moiety from phosphoribosylpyrophosphate (PRPP) on to N9 in the purine base, resulting in the formation of inosine monophosphate (IMP) and guanosine monophosphate (GMP). Inosine Monophosphate 258-279 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-53 10833458-1 2000 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxanthine and guanine by transferring the phosphoribosyl moiety from phosphoribosylpyrophosphate (PRPP) on to N9 in the purine base, resulting in the formation of inosine monophosphate (IMP) and guanosine monophosphate (GMP). Inosine Monophosphate 281-284 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-46 10833458-1 2000 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxanthine and guanine by transferring the phosphoribosyl moiety from phosphoribosylpyrophosphate (PRPP) on to N9 in the purine base, resulting in the formation of inosine monophosphate (IMP) and guanosine monophosphate (GMP). Inosine Monophosphate 281-284 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-53 9521733-1 1998 Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyzes the reversible formation of IMP and GMP from their respective bases hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP). Inosine Monophosphate 96-99 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-46 9521733-1 1998 Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyzes the reversible formation of IMP and GMP from their respective bases hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP). Inosine Monophosphate 96-99 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 48-56 8976093-1 1996 The purine salvage enzyme hypoxanthine guanine phosphoribosyl transferase (HPRT) catalyzes the transfer of phosphoribose from PRPP to the 9-position of hypoxanthine or guanine, yielding IMP or GMP, respectively. Inosine Monophosphate 186-189 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 26-73 8976093-1 1996 The purine salvage enzyme hypoxanthine guanine phosphoribosyl transferase (HPRT) catalyzes the transfer of phosphoribose from PRPP to the 9-position of hypoxanthine or guanine, yielding IMP or GMP, respectively. Inosine Monophosphate 186-189 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 75-79 1311306-4 1992 Insufficient generation of IMP (and ultimately guanylates) to support growth of lymphoblasts lacking HGPRT activity and blocked in purine synthesis de novo best explained these findings, implying that a major route of interconversion of AMP to IMP involves the reaction sequence: AMP----Ado----Ino----Hyp----IMP. Inosine Monophosphate 27-30 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 101-106 8128888-5 1993 The higher activity of HPRT with training suggests an improved potential for rephosphorylation of intracellular hypoxanthine to inosine monophosphate (IMP) in the trained muscle. Inosine Monophosphate 128-149 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 23-27 8128888-5 1993 The higher activity of HPRT with training suggests an improved potential for rephosphorylation of intracellular hypoxanthine to inosine monophosphate (IMP) in the trained muscle. Inosine Monophosphate 151-154 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 23-27 35114018-0 2022 Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP. Inosine Monophosphate 107-110 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-46 2071157-1 1991 Hypoxanthine--guanine phosphoribosyltransferase (HPRT) is a purine salvage enzyme that catalyzes the conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. Inosine Monophosphate 131-152 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-47 2071157-1 1991 Hypoxanthine--guanine phosphoribosyltransferase (HPRT) is a purine salvage enzyme that catalyzes the conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. Inosine Monophosphate 131-152 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 49-53 1703446-2 1991 Hprt-RNA was determined by quantitative solution hybridization and enzyme activity by measuring the rate of conversion of [14C]hypoxanthine to inosine 5"-monophosphate. Inosine Monophosphate 143-167 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-4 35114018-2 2022 Here, the reverse reaction of HGPRT from the thermophilic bacterium Hungateiclostridium thermocellum was studied in the presence of IMP and pyrophosphate. Inosine Monophosphate 132-135 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 30-35