PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15601821-6	2004	Furthermore, mice lacking GADD34-directed eIF2alpha dephosphorylation, like CHOP(-/-) mice, are resistant to renal toxicity of the ER stress-inducing drug tunicamycin.	Tunicamycin	155-166	eukaryotic translation initiation factor 2A	Mus musculus	42-51	
31548168-7	2020	RESULTS: Tunicamycin or d-galactosamine significantly induced ER stress and necroptosis, as well as eIF2alpha phosphorylation, in mice and LO2 cells (p<0.05).	Tunicamycin	9-20	eukaryotic translation initiation factor 2A	Mus musculus	100-109	
12824288-6	2003	The phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha) at Ser51 induced by thapsigargin or DTT was prolonged in GADD34-/- MEF, although following treatment with tunicamycin, the eIF2alpha phosphorylation level did not change in either GADD34+/+ or GADD34-/- cells.	Tunicamycin	190-201	eukaryotic translation initiation factor 2A	Mus musculus	23-71	
12824288-6	2003	The phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha) at Ser51 induced by thapsigargin or DTT was prolonged in GADD34-/- MEF, although following treatment with tunicamycin, the eIF2alpha phosphorylation level did not change in either GADD34+/+ or GADD34-/- cells.	Tunicamycin	190-201	eukaryotic translation initiation factor 2A	Mus musculus	73-82	
12824288-6	2003	The phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha) at Ser51 induced by thapsigargin or DTT was prolonged in GADD34-/- MEF, although following treatment with tunicamycin, the eIF2alpha phosphorylation level did not change in either GADD34+/+ or GADD34-/- cells.	Tunicamycin	190-201	eukaryotic translation initiation factor 2A	Mus musculus	207-216	
32718038-9	2020	We compared TM-induced ER stress in wild type, Lcn2-/-, and Chop null (Chop-/-) primary hepatocytes and found Chop-/- hepatocytes to attenuate ER stress responses and resist ER stress-induced hepatocyte apoptosis through canonical eIF2alpha/GADD34 signaling, inhibiting protein synthesis.	Tunicamycin	12-14	eukaryotic translation initiation factor 2A	Mus musculus	231-240	
33430288-6	2021	Renal unfolded protein response (UPR) gene expression markers, the lipogenic transcription factor SREBP1 and the phosphorylation of eIF2alpha increased 8 h after tunicamycin administration.	Tunicamycin	162-173	eukaryotic translation initiation factor 2A	Mus musculus	132-141	
29845243-4	2018	Notably, tunicamycin treatment, an endoplasmic reticulum (ER) stress inducer, induced the phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha), but decreased ATF4 protein levels in the mouse liver.	Tunicamycin	9-20	eukaryotic translation initiation factor 2A	Mus musculus	109-156	
29845243-4	2018	Notably, tunicamycin treatment, an endoplasmic reticulum (ER) stress inducer, induced the phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha), but decreased ATF4 protein levels in the mouse liver.	Tunicamycin	9-20	eukaryotic translation initiation factor 2A	Mus musculus	158-167	
21216966-6	2011	PTP1B overexpression or TCPTP knockdown in MIN6 cells mitigated palmitate- or tunicamycin-induced PERK/eIF2alpha ER stress signaling, whereas PTP1B deficiency enhanced ER stress.	Tunicamycin	78-89	eukaryotic translation initiation factor 2A	Mus musculus	103-112	
28383761-9	2017	Meanwhile, in mouse liver phosphorylation of eIF2alpha, a factor that regulates NMD, was increased by both tunicamycin and nutritional interventions.	Tunicamycin	107-118	eukaryotic translation initiation factor 2A	Mus musculus	45-54	
17438523-6	2007	RESULTS: Treatment with tunicamycin induced apoptotic cell death in RGC-5 and also induced production of ER stress-related proteins (BiP, the phosphorylated form of eIF2alpha, and CHOP protein).	Tunicamycin	24-35	eukaryotic translation initiation factor 2A	Mus musculus	165-174	
21150875-9	2011	Finally, treatment of proximal tubule cells isolated from TNFR1-/- mice with an inhibitor of eIF2alpha phosphatase increased the levels of phosphorylated eIF2alpha and substantially reduced tunicamycin-induced cell death.	Tunicamycin	190-201	eukaryotic translation initiation factor 2A	Mus musculus	93-102	
17418825-4	2007	ER stress, induced by Thapsigargin and tunicamycin, elevated a phosphorylated form of eIF2alpha and ATF4, but the cellular fate depended on treatment duration.	Tunicamycin	39-50	eukaryotic translation initiation factor 2A	Mus musculus	86-95