PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33272572-3 2021 The transcript levels of some of the genes regulated by the IRE1-XBP1 and PERK-ATF4 pathways were upregulated in Optn-deficient cells, in comparison with normal cells, upon treatment with tunicamycin, and also in the brain cortex and liver of tunicamycin treated Optn-deficient mice. Tunicamycin 188-199 X-box binding protein 1 Mus musculus 65-69 34759791-8 2021 Additionally, TM treatment resulted in markedly increased PERK, GRP78, ATF6, XBP1, and CHOP protein expression levels. Tunicamycin 14-16 X-box binding protein 1 Mus musculus 77-81 34759791-9 2021 On the contrary, the expression of PERK, GRP78, XBP1, and CHOP was obviously reduced in TM-induced bEnd.3 cells after ESC treatment. Tunicamycin 88-90 X-box binding protein 1 Mus musculus 48-52 33272572-3 2021 The transcript levels of some of the genes regulated by the IRE1-XBP1 and PERK-ATF4 pathways were upregulated in Optn-deficient cells, in comparison with normal cells, upon treatment with tunicamycin, and also in the brain cortex and liver of tunicamycin treated Optn-deficient mice. Tunicamycin 243-254 X-box binding protein 1 Mus musculus 65-69 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Tunicamycin 30-41 X-box binding protein 1 Mus musculus 173-196 31834612-4 2020 IRE1alpha deficiency prevented almost all spliced XBP1 (sXBP1) protein expression by treatment with thapsigargin (Tg) and tunicamycin (Tm); these phenomena paralleled the values measured by our two Nanoluciferase-based IRE1 assays. Tunicamycin 122-133 X-box binding protein 1 Mus musculus 50-54 31834612-4 2020 IRE1alpha deficiency prevented almost all spliced XBP1 (sXBP1) protein expression by treatment with thapsigargin (Tg) and tunicamycin (Tm); these phenomena paralleled the values measured by our two Nanoluciferase-based IRE1 assays. Tunicamycin 135-137 X-box binding protein 1 Mus musculus 50-54 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Tunicamycin 30-41 X-box binding protein 1 Mus musculus 198-202 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Tunicamycin 30-41 X-box binding protein 1 Mus musculus 272-276 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Tunicamycin 369-380 X-box binding protein 1 Mus musculus 198-202 26740650-5 2016 We evoked mild endoplasmic reticulum (ER) stress with tunicamycin (Tu), producing modest increases in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein. Tunicamycin 67-69 X-box binding protein 1 Mus musculus 189-193 26599511-8 2015 Additionally, this compound demoted the induction of ER chaperones such as GRP78 and HSP70 and the splicing of XBP-1 mRNA by tunicamycin. Tunicamycin 125-136 X-box binding protein 1 Mus musculus 111-116 16645094-3 2006 DKO mice responded abnormally to tunicamycin-induced ER stress in the liver, with extensive tissue damage and decreased expression of the IRE1 substrate X-box-binding protein 1 and its target genes. Tunicamycin 33-44 X-box binding protein 1 Mus musculus 153-176 26079879-5 2015 Consistently, ERS gene markers, including binding immunoglobulin protein (BIP)/glucose regulated protein 78 (GRP78) expression and the splicing of X box binding protein 1 (XBP-1), were activated by tunicamycin time-dependently. Tunicamycin 198-209 X-box binding protein 1 Mus musculus 147-170 26079879-5 2015 Consistently, ERS gene markers, including binding immunoglobulin protein (BIP)/glucose regulated protein 78 (GRP78) expression and the splicing of X box binding protein 1 (XBP-1), were activated by tunicamycin time-dependently. Tunicamycin 198-209 X-box binding protein 1 Mus musculus 172-177 23711292-0 2013 Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages. Tunicamycin 46-57 X-box binding protein 1 Mus musculus 14-37 23711292-5 2013 Reduced gene expression of x-box binding protein 1 (XBP1), a downstream effector of IRE1alpha, enhanced p-IRE1alpha levels and reduced apoptosis in aged, but not young macrophages treated with tunicamycin. Tunicamycin 193-204 X-box binding protein 1 Mus musculus 27-50 23711292-5 2013 Reduced gene expression of x-box binding protein 1 (XBP1), a downstream effector of IRE1alpha, enhanced p-IRE1alpha levels and reduced apoptosis in aged, but not young macrophages treated with tunicamycin. Tunicamycin 193-204 X-box binding protein 1 Mus musculus 52-56 22808162-7 2012 Tunicamycin (TM), an ER stress inducer used as a positive control, promoted an increase in the density of nuclear XBP-1 at the one-cell and two-cell stages. Tunicamycin 0-11 X-box binding protein 1 Mus musculus 114-119 22808162-9 2012 Conversely, high concentrations of TM or sorbitol led to reduced nuclear XBP-1 density and significant ER stress-induced apoptosis. Tunicamycin 35-37 X-box binding protein 1 Mus musculus 73-78 17438523-8 2007 In flatmounted retinas of ERAI mice, the fluorescence intensity arising from the XBP-1-venus fusion protein, indicating ER-stress activation, was increased at 24 h after tunicamycin, NMDA, or IOP elevation. Tunicamycin 170-181 X-box binding protein 1 Mus musculus 81-86 22893028-11 2012 In contrast, tunicamycin activated a balanced adaptive UPR in association with the maintenance of Xbp1 splicing. Tunicamycin 13-24 X-box binding protein 1 Mus musculus 98-102 21321189-5 2011 The tunicamycin-induced splicing of X-box binding protein-1 and expression of GRP78 and CHOP were reduced by resveratrol in cultured cells in a SIRT1-dependent manner. Tunicamycin 4-15 X-box binding protein 1 Mus musculus 36-59 15178695-5 2004 In mouse primary cultured glial cells, edaravone attenuated ER stress as evidenced by inhibition of the induction of glucose regulated protein 78 and CHOP and XBP-1 splicing under treatment with tunicamycin (Tm), which induces ER stress. Tunicamycin 195-206 X-box binding protein 1 Mus musculus 159-164 15178695-5 2004 In mouse primary cultured glial cells, edaravone attenuated ER stress as evidenced by inhibition of the induction of glucose regulated protein 78 and CHOP and XBP-1 splicing under treatment with tunicamycin (Tm), which induces ER stress. Tunicamycin 208-210 X-box binding protein 1 Mus musculus 159-164