PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24919440-5 2014 RESULTS: By using integrated two datasets, we discovered that the biomarkers involved in the glycolysis pathway are highly enriched, including 4 genes (ENO1, TPI1, PKG1 and LDHC) and 2 metabolites (lactate and pyruvate). Lactic Acid 198-205 enolase 1 Homo sapiens 152-156 26097998-8 2015 Functionally, we found that FBXW7 suppresses the ENO1-induced gene expression, lactate production, cell proliferation and migration. Lactic Acid 79-86 enolase 1 Homo sapiens 49-53 35443744-0 2022 Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1alpha pathway and does not affect their drug sensitivities. Lactic Acid 0-7 enolase 1 Homo sapiens 97-101 35443744-9 2022 The HIF1alpha/ENO1/AKT/PI3K pathway was also activated by lactate. Lactic Acid 58-65 enolase 1 Homo sapiens 14-18 29180328-4 2017 RESULTS: Transfection of U251 cells with siRNA-ENO1 markedly reduced glucose uptake (P=0.023) and lactate generation (P=0.007) in the cells and resulted in significant suppression of cell proliferation (*P<0.05) since the second day following the transfection. Lactic Acid 98-105 enolase 1 Homo sapiens 47-51