PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34158867-10 2021 LDHB downregulation skewed TAMs to function as a lactate and sterol/oxysterol source for the proliferation of tumor cells. Lactic Acid 49-56 lactate dehydrogenase B Homo sapiens 0-4 34606041-4 2022 Cancer cells absorb lactate by mono-carboxylate transporter 1 (MCT1) and convert lactate to pyruvate via intracellular lactate dehydrogenase B (LDH-B) to maintain their growth and metabolism. Lactic Acid 81-88 lactate dehydrogenase B Homo sapiens 119-142 34606041-4 2022 Cancer cells absorb lactate by mono-carboxylate transporter 1 (MCT1) and convert lactate to pyruvate via intracellular lactate dehydrogenase B (LDH-B) to maintain their growth and metabolism. Lactic Acid 81-88 lactate dehydrogenase B Homo sapiens 144-149 33248168-6 2021 RESULTS: Hyperacetylation of lactate dehydrogenase B (LDHB) was found to be associated with lactate accumulation in NAFL and NASH livers in human and mouse. Lactic Acid 29-36 lactate dehydrogenase B Homo sapiens 54-58 35406740-4 2022 BACH1 suppresses the transcriptional expression of monocarboxylate transporter 1 (MCT1) and lactate dehydrogenase B, inhibiting lactate-mediated mitochondrial metabolism. Lactic Acid 128-135 lactate dehydrogenase B Homo sapiens 92-115 34020698-10 2021 AF tissue highly expresses MCT1, LDH-H, an enzyme that preferentially converts lactate to pyruvate, and PDH, an enzyme that converts pyruvate to acetyl-coA. Lactic Acid 79-86 lactate dehydrogenase B Homo sapiens 33-38 34069745-7 2021 Changes in LDHA and LDHB gene expression were correlated with the increase in lactate concentration in the culture media of treated MCF-7 cells. Lactic Acid 78-85 lactate dehydrogenase B Homo sapiens 20-24 35075123-4 2022 MRI-derived tumour (1-13C)lactate labelling correlated with epithelial mRNA expression of the enzyme lactate dehydrogenase (LDHA and LDHB combined), and the ratio of lactate transporter expression between the epithelial and stromal compartments (epithelium-to-stroma MCT4). Lactic Acid 26-33 lactate dehydrogenase B Homo sapiens 133-137 32391634-4 2020 Lactate dehydrogenase B (LDHB) is the key glycolytic enzyme that catalyses the interconversion between pyruvate and lactate. Lactic Acid 116-123 lactate dehydrogenase B Homo sapiens 0-23 33353120-6 2020 We show that higher lactate concentration in cancer tissue is concomitant with a shift in isozyme pattern towards the "muscle-type" LDH and corresponding LDHA and LDHB protein expression changes. Lactic Acid 20-27 lactate dehydrogenase B Homo sapiens 163-167 32821126-10 2020 Furthermore, the conditioned medium of activated HSCs enhanced the lactate metabolism of hypoxic tumor cells by activating the IL-6/STAT3 pathway and upregulating the downstream MCT1 and LDHB, in order to confer the resistance of SN38, which is the active metabolite of irinotecan. Lactic Acid 67-74 lactate dehydrogenase B Homo sapiens 187-191 32391634-4 2020 Lactate dehydrogenase B (LDHB) is the key glycolytic enzyme that catalyses the interconversion between pyruvate and lactate. Lactic Acid 116-123 lactate dehydrogenase B Homo sapiens 25-29 32416791-3 2020 We hypothesized that the expression levels of the major signaling molecules that control lactate metabolism, including lactate dehydrogenases (LDHA and LDHB) and monocarboxylate transporters (MCT1 and MCT4), were altered in WB. Lactic Acid 89-96 lactate dehydrogenase B Homo sapiens 152-156 32416791-15 2020 Our current findings suggest the potential roles of LDHB and MCT4 on lactate metabolism and provide a unique molecular elucidation for altered lactate homeostasis in WB muscles of broilers. Lactic Acid 69-76 lactate dehydrogenase B Homo sapiens 52-56 31035592-3 2019 LDHA has a higher affinity for pyruvate, preferentially converting pyruvate to lactate, and NADH to NAD+ in anaerobic conditions, whereas LDHB possess a higher affinity for lactate, preferentially converting lactate to pyruvate, and NAD+ to NADH, when oxygen is abundant. Lactic Acid 173-180 lactate dehydrogenase B Homo sapiens 138-142 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Lactic Acid 73-80 lactate dehydrogenase B Homo sapiens 98-102 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Lactic Acid 73-80 lactate dehydrogenase B Homo sapiens 98-101 31804482-3 2019 Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. Lactic Acid 114-121 lactate dehydrogenase B Homo sapiens 37-41 31804482-3 2019 Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. Lactic Acid 186-193 lactate dehydrogenase B Homo sapiens 37-41 31804482-4 2019 Mechanistically, LDHB serine 162 phosphorylation relieves its substrate inhibition effect by pyruvate, resulting in remarkable elevation in the conversions of pyruvate and NADH to lactate and NAD+. Lactic Acid 180-187 lactate dehydrogenase B Homo sapiens 17-21 30923124-5 2019 We also observed that LDHB knockdown increases inhibitory phosphorylation of pyruvate dehydrogenase (PDH) via lactate-mediated PDH kinase (PDK) activation and thereby attenuates oxidative phosphorylation activity. Lactic Acid 110-117 lactate dehydrogenase B Homo sapiens 22-26 30923124-9 2019 These results suggest that LDHB suppression is a key mechanism that enhances glycolysis and is critically involved in the maintenance and propagation of mitochondrial dysfunction via lactate release in liver cancer progression. Lactic Acid 183-190 lactate dehydrogenase B Homo sapiens 27-31 28582845-2 2017 Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A and LDH-B, reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate. Lactic Acid 139-146 lactate dehydrogenase B Homo sapiens 81-86 31035592-2 2019 Among the enzymes mediating this plasticity through bidirectional conversion of pyruvate and lactate, the lactate dehydrogenase A (LDHA) and lactate dehydrogenase B (LDHB), are indicated. Lactic Acid 93-100 lactate dehydrogenase B Homo sapiens 141-164 31035592-2 2019 Among the enzymes mediating this plasticity through bidirectional conversion of pyruvate and lactate, the lactate dehydrogenase A (LDHA) and lactate dehydrogenase B (LDHB), are indicated. Lactic Acid 93-100 lactate dehydrogenase B Homo sapiens 166-170 31035592-3 2019 LDHA has a higher affinity for pyruvate, preferentially converting pyruvate to lactate, and NADH to NAD+ in anaerobic conditions, whereas LDHB possess a higher affinity for lactate, preferentially converting lactate to pyruvate, and NAD+ to NADH, when oxygen is abundant. Lactic Acid 173-180 lactate dehydrogenase B Homo sapiens 138-142 30443978-1 2019 Lactate dehydrogenase B (LDHB) is a glycolytic enzyme that catalyses the conversion of lactate and NAD+ to pyruvate, NADH and H+ . Lactic Acid 87-94 lactate dehydrogenase B Homo sapiens 0-23 30443978-1 2019 Lactate dehydrogenase B (LDHB) is a glycolytic enzyme that catalyses the conversion of lactate and NAD+ to pyruvate, NADH and H+ . Lactic Acid 87-94 lactate dehydrogenase B Homo sapiens 25-29 28846077-9 2017 Incubation of MRC5 fibroblasts with lactate resulted in an increase of LDHB and of PDH expression. Lactic Acid 36-43 lactate dehydrogenase B Homo sapiens 71-75 28536031-4 2017 This osteoblast differentiation-inducing effect of lactate can be inhibited by blocking its entry into cells with MCT1 siRNA or inhibitors, and by interfering with its metabolism by using specific siRNAs for LDHB and PDH. Lactic Acid 51-58 lactate dehydrogenase B Homo sapiens 208-212 28582845-2 2017 Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A and LDH-B, reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate. Lactic Acid 150-157 lactate dehydrogenase B Homo sapiens 81-86 27738103-3 2016 Here we show that Ldhb expression is induced by exercise in human muscle and negatively correlated with changes in intramuscular pH levels, a marker of lactate production, during isometric exercise. Lactic Acid 152-159 lactate dehydrogenase B Homo sapiens 18-22 27622334-5 2016 In cancer cells preferentially to normal cells, lactate dehydrogenase B (LDHB), catalyzing the conversion of lactate and NAD(+) to pyruvate, NADH and H(+), controls lysosomal acidification, vesicle maturation, and intracellular proteolysis. Lactic Acid 48-55 lactate dehydrogenase B Homo sapiens 73-77 23281225-5 2013 Lactate dehydrogenase B downregulation has been already related to an increased anaerobic utilization of glucose by tumor cells; accordingly, we verified that Cetuximab-resistant cells have a significantly higher production of lactate. Lactic Acid 227-234 lactate dehydrogenase B Homo sapiens 0-23 26032856-7 2015 In agreement with this, we found that the addition of exogenous lactic acid to growth media was sufficient to induce cell death that could be inhibited by the expression of LDHB. Lactic Acid 64-75 lactate dehydrogenase B Homo sapiens 173-177 25807933-1 2015 Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. Lactic Acid 109-116 lactate dehydrogenase B Homo sapiens 0-23 25807933-1 2015 Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. Lactic Acid 109-116 lactate dehydrogenase B Homo sapiens 25-29 24280423-11 2013 Consistent with selective inhibition of LDHA, the most sensitive breast cancer cell lines to lactate inhibition in hypoxic conditions were cells with low expression of LDHB. Lactic Acid 93-100 lactate dehydrogenase B Homo sapiens 168-172 26126931-6 2015 In contrast, the human LDHB did not complement the yeast pdc null mutant, although LDHB did generate lactate in yeast cells. Lactic Acid 101-108 lactate dehydrogenase B Homo sapiens 23-27 26126931-6 2015 In contrast, the human LDHB did not complement the yeast pdc null mutant, although LDHB did generate lactate in yeast cells. Lactic Acid 101-108 lactate dehydrogenase B Homo sapiens 83-87 25973606-4 2015 This study investigated the role of lactate dehydrogenase B (LDHB), a key glycolytic enzyme catalyzing the inter-conversion between pyruvate and lactate, in determining chemotherapy response and prognosis in OSCC patients. Lactic Acid 36-43 lactate dehydrogenase B Homo sapiens 61-65 23139210-10 2012 These findings suggest that targeting LDHB or other components of lactate metabolism would be of clinical benefit in triple-negative breast cancer. Lactic Acid 66-73 lactate dehydrogenase B Homo sapiens 38-42 21356207-6 2011 Unexpectedly, the increased lactate production was due to LDH isozyme shifts to LDH5 by LDHB down-expression rather than LDHA induction, implying the importance of LDHB modulation. Lactic Acid 28-35 lactate dehydrogenase B Homo sapiens 88-92 21356207-6 2011 Unexpectedly, the increased lactate production was due to LDH isozyme shifts to LDH5 by LDHB down-expression rather than LDHA induction, implying the importance of LDHB modulation. Lactic Acid 28-35 lactate dehydrogenase B Homo sapiens 164-168 16193382-9 2005 In the latter case, LDH-B would be expected to be essential for the use of extracellular lactate to fuel cell activities. Lactic Acid 89-96 lactate dehydrogenase B Homo sapiens 20-25