PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30070319-9 2018 Effects of TGF-beta1 on lactate production, glucose uptake, and ATP production were detected by lactate assay, glucose uptake assay, and ATP assay. Lactic Acid 24-31 transforming growth factor beta 1 Homo sapiens 11-20 33097055-10 2020 Mechanistically, lactic acid coordinates TGF-beta1/Snail and TAZ/AP-1 pathway to induce formation of Snail/TAZ/AP-1 complex at the MRP1/ABCC1 promoter. Lactic Acid 17-28 transforming growth factor beta 1 Homo sapiens 41-50 33097055-17 2020 The secreted lactic acid coordinates TGF-beta1/Snail and TAZ/AP-1 pathway to activate the expression of MRP1/ABCC1 protein, thus contributing to chemoresistance in NSCLC. Lactic Acid 13-24 transforming growth factor beta 1 Homo sapiens 37-46 31770555-0 2020 Lactic acid-mediated endothelial to Mesenchymal transition through TGF-beta1 contributes to in-stent stenosis in poly-L-lactic acid stent. Lactic Acid 0-11 transforming growth factor beta 1 Homo sapiens 67-76 30799198-13 2019 Moreover, lactate derived from hypoxic CAFs, acting as a metabolic coupling between CAFs and breast cancer cells, promotes breast cancer cell invasion by activating the TGFbeta1/p38 MAPK/MMP2/9 signaling axis and fueling the mitochondrial activity in cancer cells. Lactic Acid 10-17 transforming growth factor beta 1 Homo sapiens 169-177 30070319-9 2018 Effects of TGF-beta1 on lactate production, glucose uptake, and ATP production were detected by lactate assay, glucose uptake assay, and ATP assay. Lactic Acid 96-103 transforming growth factor beta 1 Homo sapiens 11-20 30070319-15 2018 TGF-beta1 overexpression increased lactate production, glucose uptake and ATP production in hepatocellular carcinoma. Lactic Acid 35-42 transforming growth factor beta 1 Homo sapiens 0-9 29482580-6 2018 The level of TGF-beta1 in culture supernatant of cells was measured by ELISA for its correlation with extracellular levels of lactate. Lactic Acid 126-133 transforming growth factor beta 1 Homo sapiens 13-22 29482580-12 2018 Mechanistically, lactate exerts its central function in induction of snail and EMT by directly remodeling ECM and releasing activated TGF-beta1. Lactic Acid 17-24 transforming growth factor beta 1 Homo sapiens 134-143 28834297-7 2017 We demonstrate that TGF-beta1 upregulates PFKFB3 mRNA and protein expression resulting in an increase in fructose 2,6-bisphosphate concentration, glucose uptake, glycolytic flux and lactate production. Lactic Acid 182-189 transforming growth factor beta 1 Homo sapiens 20-29 27385728-3 2016 WHAT IS KNOWN ALREADY: TGF-beta1 induces the metabolic conversion of glucose to lactate via aerobic glycolysis (the "Warburg effect") in the peritoneum of women with endometriosis, through increased expression of the transcription factor hypoxia inducible factor alpha (HIF-1alpha). Lactic Acid 80-87 transforming growth factor beta 1 Homo sapiens 23-32 28611673-3 2017 We discuss how EGFR signaling downregulates tumor antigen presentation, upregulates suppressive checkpoint receptor ligand programmed death ligand (PD-L1), induces secretion of inhibitory molecules such as transforming growth factor beta (TGFbeta) and reprograms the metabolic pathways in cancer cells to upregulate aerobic glycolysis and lactate secretion that ultimately lead to impaired cellular immunity mediated by natural killer (NK) cell and cytotoxic T lymphocytes (CTL). Lactic Acid 339-346 transforming growth factor beta 1 Homo sapiens 206-237 28611673-3 2017 We discuss how EGFR signaling downregulates tumor antigen presentation, upregulates suppressive checkpoint receptor ligand programmed death ligand (PD-L1), induces secretion of inhibitory molecules such as transforming growth factor beta (TGFbeta) and reprograms the metabolic pathways in cancer cells to upregulate aerobic glycolysis and lactate secretion that ultimately lead to impaired cellular immunity mediated by natural killer (NK) cell and cytotoxic T lymphocytes (CTL). Lactic Acid 339-346 transforming growth factor beta 1 Homo sapiens 239-246 22923663-7 2012 Physiologic concentrations of lactic acid induced myofibroblast differentiation via activation of TGF-beta. Lactic Acid 30-41 transforming growth factor beta 1 Homo sapiens 98-106 24796928-2 2014 In tumors, TGF-beta induces the metabolic conversion of glucose to lactate via glycolysis, a process referred to as the "Warburg effect." Lactic Acid 67-74 transforming growth factor beta 1 Homo sapiens 11-19 24796928-12 2014 RESULTS: Concentrations of lactate in peritoneal fluid paralleled those of TGF-beta1, being significantly higher in women with endometriosis compared to women without (P < .05). Lactic Acid 27-34 transforming growth factor beta 1 Homo sapiens 75-84 24796928-14 2014 Exposure of mesothelial cells to TGF-beta1 increased production of lactate (P < .05), increased HIF1A mRNA (P < .05), and protein, and increased concentrations of mRNAs encoded by glycolysis-associated genes (LDHA, PDK1, SLC2A1; P < .05). Lactic Acid 67-74 transforming growth factor beta 1 Homo sapiens 33-42 22923663-11 2012 CONCLUSIONS: We have identified the metabolite lactic acid as an important mediator of myofibroblast differentiation via a pH-dependent activation of TGF-beta. Lactic Acid 47-58 transforming growth factor beta 1 Homo sapiens 150-158 1370796-8 1992 The inhibitory effect of TGF beta 1 was not limited to the action of FSH on aromatase activity but also extended to the gonadotropin action (mediated by cAMP) on lactate production. Lactic Acid 162-169 transforming growth factor beta 1 Homo sapiens 25-35 21934447-5 2011 Only TGF-beta production was marginally enhanced (49%) by addition of lactic acid alone. Lactic Acid 70-81 transforming growth factor beta 1 Homo sapiens 5-13 17574548-0 2007 Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1. Lactic Acid 0-7 transforming growth factor beta 1 Homo sapiens 110-119 17574548-9 2007 Treatment with 10 mM lactate was accompanied by enhanced mRNA expression and release of TGF-beta1, which also shows anti-angiogenic activity in the model. Lactic Acid 21-28 transforming growth factor beta 1 Homo sapiens 88-97 17574548-11 2007 The lactate response on the EC network was diminished by TGF-beta1 neutralization, indicating a causal relationship between lactate and TGF-beta1 in the finely tuned processes of vessel formation and maturation which may also occur in vivo within tumor tissue. Lactic Acid 4-11 transforming growth factor beta 1 Homo sapiens 57-66 17574548-11 2007 The lactate response on the EC network was diminished by TGF-beta1 neutralization, indicating a causal relationship between lactate and TGF-beta1 in the finely tuned processes of vessel formation and maturation which may also occur in vivo within tumor tissue. Lactic Acid 4-11 transforming growth factor beta 1 Homo sapiens 136-145 17574548-11 2007 The lactate response on the EC network was diminished by TGF-beta1 neutralization, indicating a causal relationship between lactate and TGF-beta1 in the finely tuned processes of vessel formation and maturation which may also occur in vivo within tumor tissue. Lactic Acid 124-131 transforming growth factor beta 1 Homo sapiens 57-66 10076187-7 1999 However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner. Lactic Acid 95-102 transforming growth factor beta 1 Homo sapiens 25-33 8612316-5 1996 Treatment of non-tumor-bearing animals with the anti-TGF-beta regimen did not alter blood ATP or serum glucose level but did decrease serum lactate levels. Lactic Acid 140-147 transforming growth factor beta 1 Homo sapiens 53-61 8612316-7 1996 Animals bearing the EMT-6/CTX and EMT-6/CDDP tumors had higher serum lactate levels than normal or EMT-6/Parent tumor-bearing animals; these were decreased by the anti-TGF-beta regimen. Lactic Acid 69-76 transforming growth factor beta 1 Homo sapiens 168-176 1370796-9 1992 As for the inhibitory effect of TGF beta 1 on FSH-induced aromatase activity, the inhibitory effect of the growth factor on FSH-stimulated lactate production was dose and time dependent with a maximal decrease (about 30%) observed in the picomolar range (1 ng/ml, 40 pM) after 48 h treatment with TGF beta 1. Lactic Acid 139-146 transforming growth factor beta 1 Homo sapiens 32-42 1370796-9 1992 As for the inhibitory effect of TGF beta 1 on FSH-induced aromatase activity, the inhibitory effect of the growth factor on FSH-stimulated lactate production was dose and time dependent with a maximal decrease (about 30%) observed in the picomolar range (1 ng/ml, 40 pM) after 48 h treatment with TGF beta 1. Lactic Acid 139-146 transforming growth factor beta 1 Homo sapiens 297-307 34459125-8 2021 Subsequently, TNF-alpha, IL-1beta, and lactate activated CAFs, and facilitated the secretion of IL-6, IL-7, IL-8, CCL5, and transforming growth factor-beta1 from CAFs. Lactic Acid 39-46 transforming growth factor beta 1 Homo sapiens 124-156