PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27247778-7	2016	Plasma levels of HMGB-1 on day 1 correlated with prognostic parameters (estimated interval to return of spontaneous circulation, lactate, and NH3), tissue damage, systemic inflammation, and disease severity.	Lactic Acid	129-136	high mobility group box 1	Homo sapiens	17-23	
17525840-8	2007	A positive correlation was observed between HMGB1 and SOFA score and lactate, and procalcitonin concentrations.	Lactic Acid	69-76	high mobility group box 1	Homo sapiens	44-49	
33658363-5	2021	Further characterizing HMGB1 as a sialic acid-binding lectin, we found that optimal binding takes place at normal blood pH and is markedly reduced when pH is adjusted with lactic acid to levels found in sepsis.	Lactic Acid	172-183	high mobility group box 1	Homo sapiens	23-28	
34363018-0	2022	Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.	Lactic Acid	0-7	high mobility group box 1	Homo sapiens	28-33	
34363018-2	2022	However, it is unclear whether lactate could promote HMGB1 release during sepsis.	Lactic Acid	31-38	high mobility group box 1	Homo sapiens	53-58	
34363018-3	2022	The present study demonstrated a novel role of lactate in HMGB1 lactylation and acetylation in macrophages during polymicrobial sepsis.	Lactic Acid	47-54	high mobility group box 1	Homo sapiens	58-63	
34363018-4	2022	We found that macrophages can uptake extracellular lactate via monocarboxylate transporters (MCTs) to promote HMGB1 lactylation via a p300/CBP-dependent mechanism.	Lactic Acid	51-58	high mobility group box 1	Homo sapiens	110-115	
34363018-5	2022	We also observed that lactate stimulates HMGB1 acetylation by Hippo/YAP-mediated suppression of deacetylase SIRT1 and beta-arrestin2-mediated recruitment of acetylases p300/CBP to the nucleus via G protein-coupled receptor 81 (GPR81).	Lactic Acid	22-29	high mobility group box 1	Homo sapiens	41-46	
34363018-7	2022	In vivo reduction of lactate production and/or inhibition of GPR81-mediated signaling decreases circulating exosomal HMGB1 levels and improves survival outcome in polymicrobial sepsis.	Lactic Acid	21-28	high mobility group box 1	Homo sapiens	117-122	
34916197-0	2021	(Aloin inhibits lactate-induced proliferation and migration of gastric cancer cells by downregulating HMGB1 expression).	Lactic Acid	16-23	high mobility group box 1	Homo sapiens	102-107	
34916197-5	2021	HMGB1 expression was knocked down in BGC-823 cells using RNA interference technique, and the effects of HMGB1 knockdown on proliferation and migration of the cells stimulated with lactate for 24 h were examined using EdU and wound healing assays.	Lactic Acid	180-187	high mobility group box 1	Homo sapiens	104-109	
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	Lactic Acid	15-22	high mobility group box 1	Homo sapiens	122-127	
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	Lactic Acid	15-22	high mobility group box 1	Homo sapiens	255-260	
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	Lactic Acid	264-271	high mobility group box 1	Homo sapiens	255-260	
34916197-8	2021	BGC-823 cells with HMGB1 knockdown, as compared with the cells transfected with the negative control plasmid, showed significantly lowered proliferation and migration abilities following lactate treatment.	Lactic Acid	187-194	high mobility group box 1	Homo sapiens	19-24	
34916197-9	2021	CONCLUSION: Aloin inhibits lactate-induced proliferation and migration of gastric cancer cells by down-regulating the expression and release of HMGB1 and the expressions of proliferation- and migration-related proteins.	Lactic Acid	27-34	high mobility group box 1	Homo sapiens	144-149	
33030958-10	2021	We identified that HMGB1 secreted by breast cancer cells promotes fibroblast activation via RAGE/aerobic glycolysis, and activated fibroblasts enhance breast cancer cell metastasis through increased lactate.	Lactic Acid	199-206	high mobility group box 1	Homo sapiens	19-24