PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17785433-7 2007 This study reports the previously unsuspected collaboration between HIF-1 and dysregulated MYC and thereby provides additional insights into the regulation of VEGF and the Warburg effect, which describes the propensity for cancer cells to convert glucose to lactate. Lactic Acid 258-265 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-94 22225880-2 2012 Using [U-(13)C]-glucose as the tracer, both glucose consumption and lactate production were increased by MYC expression and hypoxia. Lactic Acid 68-75 MYC proto-oncogene, bHLH transcription factor Homo sapiens 105-108 21969607-3 2011 LDH-A gene expression is believed to be upregulated by both HIF and Myc in cancer cells to achieve increased lactate production. Lactic Acid 109-116 MYC proto-oncogene, bHLH transcription factor Homo sapiens 68-71 20018866-7 2010 Activation of either Akt or c-Myc leads to the Warburg effect as indicated by increased cellular glucose uptake, glycolysis, and lactate generation. Lactic Acid 129-136 MYC proto-oncogene, bHLH transcription factor Homo sapiens 28-33 20133848-1 2010 As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). Lactic Acid 110-117 MYC proto-oncogene, bHLH transcription factor Homo sapiens 195-200 18811052-3 2007 When MYC-dependent tumors grow, the hypoxic tumor microenvironment elevates the levels of HIF, such that oncogenic MYC and HIF collaborate to enhance the cancer cell"s metabolic needs through increased uptake of glucose and its conversion to lactate. Lactic Acid 242-249 MYC proto-oncogene, bHLH transcription factor Homo sapiens 5-8 18811052-3 2007 When MYC-dependent tumors grow, the hypoxic tumor microenvironment elevates the levels of HIF, such that oncogenic MYC and HIF collaborate to enhance the cancer cell"s metabolic needs through increased uptake of glucose and its conversion to lactate. Lactic Acid 242-249 MYC proto-oncogene, bHLH transcription factor Homo sapiens 115-118 9192621-4 1997 Stably transfected Rat1a fibroblasts that overexpress LDH-A alone or those transformed by c-Myc overproduce lactic acid. Lactic Acid 108-119 MYC proto-oncogene, bHLH transcription factor Homo sapiens 90-95 10823814-2 2000 We previously observed that the c-Myc oncogenic transcription factor regulates lactate dehydrogenase A and induces lactate overproduction. Lactic Acid 79-86 MYC proto-oncogene, bHLH transcription factor Homo sapiens 32-37 10100870-0 1999 Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression. Lactic Acid 10-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 32-35 10100870-1 1999 As a result of Myc-dependent transcription of the LDH-A gene, Myc-transformed cells (Rat1-Myc) exhibit increased lactate production rates (LPR) even under aerobic conditions (the Warburg effect). Lactic Acid 113-120 MYC proto-oncogene, bHLH transcription factor Homo sapiens 15-18 10100870-1 1999 As a result of Myc-dependent transcription of the LDH-A gene, Myc-transformed cells (Rat1-Myc) exhibit increased lactate production rates (LPR) even under aerobic conditions (the Warburg effect). Lactic Acid 113-120 MYC proto-oncogene, bHLH transcription factor Homo sapiens 62-65 10100870-1 1999 As a result of Myc-dependent transcription of the LDH-A gene, Myc-transformed cells (Rat1-Myc) exhibit increased lactate production rates (LPR) even under aerobic conditions (the Warburg effect). Lactic Acid 113-120 MYC proto-oncogene, bHLH transcription factor Homo sapiens 62-65 10100870-3 1999 In this report we demonstrate that the overexpression of the anti-apoptotic protein Bcl-2 in Rat1-Myc cells (Rat1-Myc-Bcl-2) reduces the molar ratio of lactate production to glucose consumption (Y(L/G)). Lactic Acid 152-159 MYC proto-oncogene, bHLH transcription factor Homo sapiens 98-101 10100870-3 1999 In this report we demonstrate that the overexpression of the anti-apoptotic protein Bcl-2 in Rat1-Myc cells (Rat1-Myc-Bcl-2) reduces the molar ratio of lactate production to glucose consumption (Y(L/G)). Lactic Acid 152-159 MYC proto-oncogene, bHLH transcription factor Homo sapiens 114-117 9192621-8 1997 Our studies have linked c-Myc to the induction of LDH-A, whose expression increases lactate production and is necessary for c-Myc-mediated transformation. Lactic Acid 84-91 MYC proto-oncogene, bHLH transcription factor Homo sapiens 24-29 34133930-4 2021 Ablation of MYC decreases lactate production by regulating lactate dehydrogenase (LDH) activity and causes increased inflammatory cytokines by regulating interferon regulatory factor 4 (IRF4) in response to lipopolysaccharide. Lactic Acid 26-33 MYC proto-oncogene, bHLH transcription factor Homo sapiens 12-15 33894159-7 2021 Thus, NAAG, lactate, and GABA can play important roles as storage molecules for glutamate, glucose, and succinate carbon in oncogenic MYC-transformed P493 lymphoma B cells (MYC-ON cells) but not in non-oncogenic MYC-OFF cells. Lactic Acid 12-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 134-137 35096062-12 2022 The inhibition of c-Myc reverses the effects of FOXC1 overexpression and leads to reduced cell proliferation, aerobic glycolysis, and lactic acid content. Lactic Acid 134-145 MYC proto-oncogene, bHLH transcription factor Homo sapiens 18-23 35096062-16 2022 These findings provided the first evidence that the exosome-mediated delivery of miR-4792 could play an important role in bladder cancer development through the downregulation of FOXC1 and c-Myc, which further inhibited aerobic glycolysis and lactic acid content. Lactic Acid 243-254 MYC proto-oncogene, bHLH transcription factor Homo sapiens 189-194 31555797-7 2019 Overexpression of c-Myc, but not constitutively active Akt, conferred protection against SFN-mediated downregulation of HKII and LDHA protein expression and suppression of lactate levels. Lactic Acid 172-179 MYC proto-oncogene, bHLH transcription factor Homo sapiens 18-23 32433492-9 2020 Interestingly, we found that lactate preconditioning results in increased transcript abundance of MYC and SNAI1, key facilitators of early somatic cell reprogramming. Lactic Acid 29-36 MYC proto-oncogene, bHLH transcription factor Homo sapiens 98-101 32010625-5 2019 We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 < p < 0.05 for all genes). Lactic Acid 47-54 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 32010625-5 2019 We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 < p < 0.05 for all genes). Lactic Acid 70-77 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 31804603-5 2019 C-Myc downregulation decreased the expression of lactate dehydrogenase A, the enzyme catalyzing the conversion of pyruvate to lactate. Lactic Acid 49-56 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 29932015-8 2019 With the inhibition of STAT3/c-Myc signaling, meanwhile, the upregulation of both cell glucose uptake and lactate production by IL-6 pretreatment was reduced simultaneously. Lactic Acid 106-113 MYC proto-oncogene, bHLH transcription factor Homo sapiens 29-34 29545400-5 2018 Analysis of the RNA-Seq data from The Cancer Genome Atlas indicated a significant positive association between Myc expression and gene expression of many glycolysis-related genes, including hexokinase II and lactate dehydrogenase A Expression of these enzyme proteins and lactate levels were decreased upon PEITC treatment in prostate cancer cells, and these effects were significantly attenuated by ectopic expression of c-Myc. Lactic Acid 208-215 MYC proto-oncogene, bHLH transcription factor Homo sapiens 422-427 30054337-7 2018 Increased lactate labeling in tumors correlated with c-Myc-driven expression of hexokinase 2, lactate dehydrogenase A, and the monocarboxylate transporters and was accompanied by increased radioresistance. Lactic Acid 10-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 53-58 28812580-6 2017 Finally, we identify small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle. Lactic Acid 51-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 85-88 28822229-9 2018 The activation of the Wnt/beta-catenin pathway induces, via the Wnt target genes c-Myc and cyclin D1 or via HIF-1alpha, gene transactivation encoding aerobic glycolysis enzymes, such as glucose transporter, hexokinase 2, pyruvate kinase M2, pyruvate dehydrogenase kinase 1 and lactate dehydrogenase-A, leading to lactate production, as the primary alternative of ATP, at all oxygen levels, even in normoxic conditions. Lactic Acid 277-284 MYC proto-oncogene, bHLH transcription factor Homo sapiens 81-86 28749470-5 2017 Mechanistically, miR-181d stabilized c-myc through directly targeting the 3"-UTRs of CRY2 and FBXL3, which subsequently increased the glucose consumption and the lactate production. Lactic Acid 162-169 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-42 26636483-8 2016 Consequently, lactate-induced c-Myc activation triggers the expression of glutamine transporter ASCT2 and of glutaminase 1 (GLS1), resulting in improved glutamine uptake and catabolism. Lactic Acid 14-21 MYC proto-oncogene, bHLH transcription factor Homo sapiens 30-35 24285728-0 2014 Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Lactic Acid 9-16 MYC proto-oncogene, bHLH transcription factor Homo sapiens 42-45 26021472-6 2015 Knockdown of c-Myc reduced the protein expression of LDHA, lactate production and glucose consumption, and silencing of LDHA mimicked this effect. Lactic Acid 59-66 MYC proto-oncogene, bHLH transcription factor Homo sapiens 13-18 24285728-1 2014 Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate. Lactic Acid 68-75 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 23897900-6 2013 The MYC-induced metabolic signature is characterized by enhanced glucose and glutamine uptake, increased lactate production, and altered amino acid metabolism. Lactic Acid 105-112 MYC proto-oncogene, bHLH transcription factor Homo sapiens 4-7 23296385-6 2013 We found that P493-6 cells with High Myc expression increased their specific uptake of glutamine, arginine, serine, lysine, and branched-chain amino acids by two- to threefold in comparison to low Myc cells, but exhibited only modest increases in glucose uptake and lactate excretion. Lactic Acid 266-273 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 23639941-7 2013 The reduction in extracellular lactate in BRAF-driven melanoma cells was time-dependent and associated with reduced expression of hexokinase-II driven by c-Myc depletion. Lactic Acid 31-38 MYC proto-oncogene, bHLH transcription factor Homo sapiens 154-159