PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11939620-5	2002	RESULTS: Insulin (1 nmol/L) increased cGMP production fivefold in VSMC with iNOS while raising the lactate-to-pyruvate ratio (LPR) from 3.1 +/- 0.5 to 10.0 +/- 1.6 (P < .05), indicating a rise in the ratio of reduced/oxidized nicotinamide adenine dinucleotide (NADH/NAD+) redox state of the cell.	Lactic Acid	99-106	insulin	Canis lupus familiaris	9-16	
8156929-1	1994	We have previously shown that in moderately hyperglycemic depancreatized dogs, a glucose-lowering infusion of insulin-like growth factor-I (IGF-I) increased glucose utilization and lactate more, and suppressed glucose production and lipolysis less, than an equipotent glucose-lowering dose of insulin.	Lactic Acid	181-188	insulin	Canis lupus familiaris	110-117	
9205542-9	1997	CONCLUSIONS: Insulin improves systolic and diastolic heart function during aerobic shock and accelerates in-vivo myocardial lactate oxidation.	Lactic Acid	124-131	insulin	Canis lupus familiaris	13-20	
8048587-5	1994	Lactate extraction increased from 0.18 +/- 0.05 to 0.62 +/- 0.11 mumol.min-1.g wet wt-1 during lactate infusion, whereas glucose extraction did not change significantly (0.15 +/- 0.05 mumol.min-1.g wet wt-1 at 45 min of insulin and glucose infusion to 0.09 +/- 0.02 mumol.min-1.g wet wt-1 at 45 min of the lactate infusion).	Lactic Acid	0-7	insulin	Canis lupus familiaris	220-227	
2496132-2	1989	The time-courses and the maximal stimulatory effects of FSH, insulin, and IGF-I on lactate production were virtually identical.	Lactic Acid	83-90	insulin	Canis lupus familiaris	61-68	
1616021-6	1992	Glucose uptake was increased by insulin during the control period (from 0.09 to 0.39 mumol.min-1.g-1), so that the combined extraction of glucose and lactate exceeded the requirement for oxidizable substrate calculated from oxygen consumption.	Lactic Acid	150-157	insulin	Canis lupus familiaris	32-39	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	185-192	insulin	Canis lupus familiaris	55-62	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	185-192	insulin	Canis lupus familiaris	100-107	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	185-192	insulin	Canis lupus familiaris	100-107	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	256-263	insulin	Canis lupus familiaris	55-62	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	256-263	insulin	Canis lupus familiaris	100-107	
1847858-4	1991	TGF beta 1 action was found closely related to that of insulin since 1) both TGF beta 1 (40 pM) and insulin (1 microgram/ml) induced the secretion of similar and nonadditive amounts of lactate; and 2) TGF beta 1 and insulin induced comparable increases in lactate production in FSH (1 microgram/ml)-treated Sertoli cells.	Lactic Acid	256-263	insulin	Canis lupus familiaris	100-107	
2496132-10	1989	It is concluded that FSH, insulin, and IGF-I stimulate lactate production by cultured Sertoli cells, but that only insulin and IGF-I stimulate hexose transport.	Lactic Acid	55-62	insulin	Canis lupus familiaris	26-33	
6349384-6	1983	With the preprogrammed insulin infusions used to normalize plasma glucose profiles to the intraduodenal glucose load, all hormonal and metabolic responses were normalized during intraportal infusion (IRI, 72.5 +/- 4.2 microU/ml; glucagon, 66 +/- 10 pg/ml; lactate, 1.06 +/- 0.10 mmol/liter; alanine, 0.251 +/- 0.042 mmol/liter; glycerol, 0.043 +/- 0.013 mmol/liter; NEFA, 0.24 +/- 0.03 mmol/liter; and 3-hydroxybutyrate, 0.012 +/- 0.007 mmol/liter) but marked hyperinsulinemia (103.2 +/- 6.1 microU/ml) and depressed glycerol, NEFA, and 3-hydroxybutyrate responses at 2 h (0.056 +/- 0.005, 0.52 +/- 0.10, and 0.019 +/- 0.010 mmol/liter, respectively) resulted during peripheral infusion.	Lactic Acid	256-263	insulin	Canis lupus familiaris	23-30	
3322904-7	1987	Indeed, 70% of the fall in hepatic glucose production and virtually 100% of the changes in lactate and alanine metabolism produced by basal insulin infusion were mediated by a fall in glucagon.	Lactic Acid	91-98	insulin	Canis lupus familiaris	140-147	
690190-5	1978	The conversion of alanine and lactate into glucose, on the other hand, increased throughout the period of insulin lack.	Lactic Acid	30-37	insulin	Canis lupus familiaris	106-113	
7044142-6	1982	These insulin infusion rates resulted in premeal fasting normoglycemia and in normal levels of insulin, glucagon, lactate, pyruvate, 3-hydroxybutyrate, nonesterified fatty acids, and 9 of 13 amino acids.	Lactic Acid	114-121	insulin	Canis lupus familiaris	6-13	
7452278-12	1980	The findings indicate that insulin-induced hypoglycemia in the newborn dog is associated with an increase in cerebral lactate utilization, supplementing glucose as the primary energy fuel and thereby preserving a normal CMRO2.	Lactic Acid	118-125	insulin	Canis lupus familiaris	27-34	
7152136-9	1982	The adjunction of 2 CP with insulin injections resulted in a fall in blood lactate and pyruvate levels and a progressive decrease of blood glucose concentrations.	Lactic Acid	75-82	insulin	Canis lupus familiaris	28-35	
6991314-4	1980	Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreaticoduodenal vein.	Lactic Acid	0-7	insulin	Canis lupus familiaris	77-84	
6991314-5	1980	To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose.	Lactic Acid	21-28	insulin	Canis lupus familiaris	40-47	
346182-7	1978	During insulin infusion, heart rates decreased (p less than 0.02) and myocardial lactate uptake increased (p less than 0.02), while oxygen uptake and coronary blood flow were insignificantly altered.	Lactic Acid	81-88	insulin	Canis lupus familiaris	7-14	
829734-4	1976	Responses to haemorrhage during infusion of glucos-saline + insulin showed reduced blood sugar, blood lactate, pyruvate, and L/P ratios, plasma inorganic phosphate and FFA were diminished while, mean arterial blood pressure (MABP) changes were significantly higher than the glucose-saline group.	Lactic Acid	102-109	insulin	Canis lupus familiaris	60-67	
34009199-11	2020	Within 20 minutes post injection of insulin, glucose uptake was negative while lactate uptake increased.	Lactic Acid	79-86	insulin	Canis lupus familiaris	36-43