PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15145917-3 2004 In our study, we investigated the liberation of POMC derivatives from peripheral tissues under a state of acidosis achieved by tourniquet-induced ischemia, alteration of lactate concentration, and base excess. Lactic Acid 170-177 proopiomelanocortin Homo sapiens 48-52 4321810-1 1970 Effects of ACTH and adenosine-3",5"-monophosphate (cyclic AMP) on corticosteroid and lactic acid production in vitro. Lactic Acid 85-96 proopiomelanocortin Homo sapiens 11-15 22797365-8 2012 This increase in lactate concentrations during stress was associated with an increase in epinephrine (R(2) = 0.221, p = 0.02) and ACTH concentrations (R(2) = 0.460, p < 0.001). Lactic Acid 17-24 proopiomelanocortin Homo sapiens 130-134 4322666-4 1971 ACTH-induced paralysis was preceded by rising serum inorganic P, and associated with increased plasma glucose, blood lactate, and serum creatine phosphokinase concentrations. Lactic Acid 117-124 proopiomelanocortin Homo sapiens 0-4 16998458-6 2006 The correlation analyses showed significant positive relationships between lactate peak values and percentages of change for ACTH (r2 = 0.16, P < 0.05), salivary cortisol (r2 = 0.42, P < 0.01), and serum cortisol (r2 = 0.56, P < 0.001). Lactic Acid 75-82 proopiomelanocortin Homo sapiens 125-129 8775570-1 1996 It has been recently suggested that high and sustained lactate levels may elicit increases in peripheral B-EN concentrations (16). Lactic Acid 55-62 proopiomelanocortin Homo sapiens 105-109 11071055-4 2000 In agreement with reports from the literature ACTH and beta-endorphin-IRM concentrations in the plasma rose upon anaerobic exercise in all 23 subjects; this increase in the ACTH and beta-endorphin IRM levels was significantly correlated with the increase of lactate levels observed upon anaerobic exercise. Lactic Acid 258-265 proopiomelanocortin Homo sapiens 173-177 11071055-4 2000 In agreement with reports from the literature ACTH and beta-endorphin-IRM concentrations in the plasma rose upon anaerobic exercise in all 23 subjects; this increase in the ACTH and beta-endorphin IRM levels was significantly correlated with the increase of lactate levels observed upon anaerobic exercise. Lactic Acid 258-265 proopiomelanocortin Homo sapiens 182-196 9761001-4 1998 ACTH therapy significantly elevated the levels of lactate and pyruvate in the CSF and serum. Lactic Acid 50-57 proopiomelanocortin Homo sapiens 0-4 9435765-0 1998 Nonresponse of adrenocorticotropic hormone in first-ever lactate-induced panic attacks in healthy volunteers. Lactic Acid 57-64 proopiomelanocortin Homo sapiens 15-42 9257407-8 1997 Additionally, some of the possible mechanisms which may induce beta-endorphin changes in the circulation include analgesia, lactate or base excess, and metabolic factors. Lactic Acid 124-131 proopiomelanocortin Homo sapiens 63-77 1592064-9 1992 The changes in concentration in beta-endorphin were significantly related to the changes in cortisol (r = 0.78; P less than 0.01) and to the changes in plasma lactic acid (r = 0.58; P less than 0.05). Lactic Acid 159-170 proopiomelanocortin Homo sapiens 32-46 1320581-10 1992 Plasma lactate levels increased approximately 107% by 1.5 hr after ACTH infusion and then decreased to approximately 22% greater than the initial levels by 12 hr. Lactic Acid 7-14 proopiomelanocortin Homo sapiens 67-71 1320581-11 1992 Lactate levels increased after the second ACTH infusion and remained approximately 58% greater than the initial levels when sampling ended at 96 hr. Lactic Acid 0-7 proopiomelanocortin Homo sapiens 42-46 7653695-1 1995 OBJECTIVE: This study investigated whether lactate-induced panic attacks in patients with panic disorder would activate atrial natriuretic hormone, which could explain the missing ACTH and cortisol response found in this kind of experimentally induced panic. Lactic Acid 43-50 proopiomelanocortin Homo sapiens 180-184 8444727-5 1993 Within the H10/1 protocol, lactate concentrations were correlated (r = 0.82, P < 0.05) with plasma beta-EP concentrations. Lactic Acid 27-34 proopiomelanocortin Homo sapiens 102-109 8444727-9 1993 Furthermore the H10/1 protocol"s significant challenge to the acid-base status of the blood, due to marked increases in whole blood lactate, may be associated with mechanisms modulating peripheral blood concentrations of beta-EP and cortisol. Lactic Acid 132-139 proopiomelanocortin Homo sapiens 221-228 2141380-12 1990 Lactate showed a mild correlation with B-EP (r = 0.43) at 80% VO2max. Lactic Acid 0-7 proopiomelanocortin Homo sapiens 39-43 1553453-3 1992 Published studies reveal that incremental graded and short term anaerobic exercise lead to an increase in beta-endorphin levels, the extent correlating with the lactate concentration. Lactic Acid 161-168 proopiomelanocortin Homo sapiens 106-120 1553453-4 1992 During incremental graded exercise beta-endorphin levels increase when the anaerobic threshold has been exceeded or at the point of an overproportionate increase in lactate. Lactic Acid 165-172 proopiomelanocortin Homo sapiens 35-49 1553453-5 1992 In endurance exercise performed at a steady-state between lactate production and elimination, blood beta-endorphin levels do not increase until exercise duration exceeds approximately 1 hour, with the increase being exponential thereafter. Lactic Acid 58-65 proopiomelanocortin Homo sapiens 100-114 2141380-13 1990 A significant correlation (r = 0.78) between lactate and B-EP did occur with the VO2max test. Lactic Acid 45-52 proopiomelanocortin Homo sapiens 57-61 34847565-1 2021 INTRODUCTION: Exercise becomes a stress when performed at an intensity above the lactate threshold (LT) because at that point the plasma adrenocorticotropic hormone (ACTH), a marker of stress response, increases. Lactic Acid 81-88 proopiomelanocortin Homo sapiens 137-164 2178088-8 1990 Both in AnT and ST there was a relationship between the maximum concentrations of beta-E and lactate (r = 0.63 and 0.71; each P less than 0.05). Lactic Acid 93-100 proopiomelanocortin Homo sapiens 82-88 2178088-9 1990 We therefore conclude that physical exercise with increasing or mostly anaerobic components leads to an increase in [beta-E], the extent correlating with the degree of lactate concentration. Lactic Acid 168-175 proopiomelanocortin Homo sapiens 117-123 34847565-1 2021 INTRODUCTION: Exercise becomes a stress when performed at an intensity above the lactate threshold (LT) because at that point the plasma adrenocorticotropic hormone (ACTH), a marker of stress response, increases. Lactic Acid 81-88 proopiomelanocortin Homo sapiens 166-170 34737351-4 2021 We used a conditional genetic approach to label POMC neurons and evaluated their sensitivity to lactate using patch-clamp recordings. Lactic Acid 96-103 proopiomelanocortin Homo sapiens 48-52 34737351-6 2021 In addition, the depolarization of a subset of POMC neurons was sensitive to alpha-cyano-4-hydroxycinnamate (4-CIN), a lactate transporter blocker, suggesting that the depolarization induced by L-lactate can also occur by direct intracellular action. Lactic Acid 119-126 proopiomelanocortin Homo sapiens 47-51 34737351-0 2021 Lactate activates hypothalamic POMC neurons by intercellular signaling. Lactic Acid 0-7 proopiomelanocortin Homo sapiens 31-35 34324439-0 2021 Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons. Lactic Acid 53-60 proopiomelanocortin Homo sapiens 84-88 34737351-1 2021 Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. Lactic Acid 153-160 proopiomelanocortin Homo sapiens 60-64 2847736-2 1988 ACTH caused a sustained increase in the liberation of lactate as well as a stimulation of both basal and glucose-induced fructose 2,6-bisphosphate content. Lactic Acid 54-61 proopiomelanocortin Homo sapiens 0-4 35198055-9 2022 In line with these findings, the excitability of POMC neurons was enhanced by lactate and decreased in the presence of betaHB. Lactic Acid 78-85 proopiomelanocortin Homo sapiens 49-53 2540392-11 1989 Lactate was significantly correlated with beta-EP (r = 0.72), ACTH (r = 0.70), and cortisol (r = 0.64). Lactic Acid 0-7 proopiomelanocortin Homo sapiens 42-49 2540392-11 1989 Lactate was significantly correlated with beta-EP (r = 0.72), ACTH (r = 0.70), and cortisol (r = 0.64). Lactic Acid 0-7 proopiomelanocortin Homo sapiens 62-66 2522799-0 1989 Plasma beta-endorphin response to lactate infusion. Lactic Acid 34-41 proopiomelanocortin Homo sapiens 7-21 2841552-7 1988 Increases in the plasma levels of beta-E + beta-LPH and ACTH were always accompanied by an increase in the blood lactate level. Lactic Acid 113-120 proopiomelanocortin Homo sapiens 43-51 3009176-6 1986 A rise in lactic acid levels above the anaerobic threshold always preceded the exercise-induced rise in beta-End and ACTH. Lactic Acid 10-21 proopiomelanocortin Homo sapiens 104-112 2952498-3 1987 The change in beta-endorphin with exercise was significantly related to the change in cortisol (r = 0.68; p less than 0.001) and to the change in plasma lactic acid (r = 0.60; p less than 0.001). Lactic Acid 153-164 proopiomelanocortin Homo sapiens 14-28 3009176-6 1986 A rise in lactic acid levels above the anaerobic threshold always preceded the exercise-induced rise in beta-End and ACTH. Lactic Acid 10-21 proopiomelanocortin Homo sapiens 117-121 6315651-7 1983 Both the change in ACTH with exercise and its postrun concentration were significantly related to the change in plasma lactic acid (r = 0.65, P less than 0.05) and the postrun plasma lactic acid (r = 0.64, P less than 0.05). Lactic Acid 119-130 proopiomelanocortin Homo sapiens 19-23 6315651-7 1983 Both the change in ACTH with exercise and its postrun concentration were significantly related to the change in plasma lactic acid (r = 0.65, P less than 0.05) and the postrun plasma lactic acid (r = 0.64, P less than 0.05). Lactic Acid 183-194 proopiomelanocortin Homo sapiens 19-23 6315651-9 1983 Our observations also suggest that plasma lactic acid may influence ACTH release during exercise. Lactic Acid 42-53 proopiomelanocortin Homo sapiens 68-72