PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8940617-0 1996 New aspects of lactate metabolism: IGF-I and insulin regulate mitochondrial function in cultured brain cells during normoxia and hypoxia. Lactic Acid 15-22 insulin like growth factor 1 Homo sapiens 35-40 11774666-4 1998 (2) IGF1 increases lactate production of PDL cells, which can be negated by 2-DG. Lactic Acid 19-26 insulin like growth factor 1 Homo sapiens 4-8 11774666-7 1998 CONCLUSION: IGF1 stimulates collagen synthesis of PDL cells through inhibiting PADPR synthesis by acting at increasing lactate production which lowers intracellular NAD+ level and at suppressing PADPR synthetase activity. Lactic Acid 119-126 insulin like growth factor 1 Homo sapiens 12-16 8940617-9 1996 Using [1-13C]glucose it could be demonstrated that production of lactate from mitochondrial precursors was, in the presence of insulin or IGF-I, down regulated in astrocytes but increased in neurons during normoxia. Lactic Acid 65-72 insulin like growth factor 1 Homo sapiens 138-143 7928875-1 1994 An acute insulin-like growth factor I (IGF-I) response to 10 min of above-lactate threshold cycle ergometer exercise was studied in 10 subjects (age 22-35 yr). Lactic Acid 74-81 insulin like growth factor 1 Homo sapiens 9-37 7560063-8 1995 Glucose uptake and lactate release increased in the insulin- and IGF-I-infused forearms (P < 0.01) but did not change in the contralateral (aa alone) forearm in either study. Lactic Acid 19-26 insulin like growth factor 1 Homo sapiens 65-70 7612874-6 1995 Evidence is presented that IGF-I and insulin stimulate neurones to release factors affecting astrocytic lactate production. Lactic Acid 104-111 insulin like growth factor 1 Homo sapiens 27-32 7828554-3 1995 IGF-I gene expression is also stimulated by lactate, suggesting that the stimulatory effect is mediated by a product of glycolysis. Lactic Acid 44-51 insulin like growth factor 1 Homo sapiens 0-5 7928875-1 1994 An acute insulin-like growth factor I (IGF-I) response to 10 min of above-lactate threshold cycle ergometer exercise was studied in 10 subjects (age 22-35 yr). Lactic Acid 74-81 insulin like growth factor 1 Homo sapiens 39-44 24841383-6 2015 IGF-1 and insulin also rescued energy levels in HD peripheral cells, as evaluated by increased ATP and phosphocreatine, and decreased lactate levels. Lactic Acid 134-141 insulin like growth factor 1 Homo sapiens 0-5 7688386-13 1993 IGF-1 increased lactate production 47 +/- 3% and 23 +/- 3% at identical hormone concentrations. Lactic Acid 16-23 insulin like growth factor 1 Homo sapiens 0-5 22365501-5 2012 The enhancement of IGF-1 on lactate production was also taken into account in the theoretical model. Lactic Acid 28-35 insulin like growth factor 1 Homo sapiens 19-24 22365501-8 2012 It was also found that the IGF-1 injection can reduce glucose concentration and increase lactate accumulation (i.e., lower pH) in the IVD and these influences were regulated by the IGF-1 binding reactions. Lactic Acid 89-96 insulin like growth factor 1 Homo sapiens 27-32 22365501-8 2012 It was also found that the IGF-1 injection can reduce glucose concentration and increase lactate accumulation (i.e., lower pH) in the IVD and these influences were regulated by the IGF-1 binding reactions. Lactic Acid 89-96 insulin like growth factor 1 Homo sapiens 181-186 21058741-7 2011 Increases in the expression of glycolysis proteins leading to lactic acid production were observed common to IGF-1-stimulated MCF-7 cells and the invasive MDA-MB-231 cell line. Lactic Acid 62-73 insulin like growth factor 1 Homo sapiens 109-114 15682328-4 2005 We observed in vitro a close linear relationship (r = 0.86, P < 0.0005) between the recoveries of lactate (RecLac) and of IGF-I (RecIGF-I), giving access to the measurement of IGF-I with the same accuracy as the one previously found for lactate and glucose. Lactic Acid 101-108 insulin like growth factor 1 Homo sapiens 125-130 15682328-4 2005 We observed in vitro a close linear relationship (r = 0.86, P < 0.0005) between the recoveries of lactate (RecLac) and of IGF-I (RecIGF-I), giving access to the measurement of IGF-I with the same accuracy as the one previously found for lactate and glucose. Lactic Acid 101-108 insulin like growth factor 1 Homo sapiens 135-140 15682328-4 2005 We observed in vitro a close linear relationship (r = 0.86, P < 0.0005) between the recoveries of lactate (RecLac) and of IGF-I (RecIGF-I), giving access to the measurement of IGF-I with the same accuracy as the one previously found for lactate and glucose. Lactic Acid 240-247 insulin like growth factor 1 Homo sapiens 125-130 15682328-4 2005 We observed in vitro a close linear relationship (r = 0.86, P < 0.0005) between the recoveries of lactate (RecLac) and of IGF-I (RecIGF-I), giving access to the measurement of IGF-I with the same accuracy as the one previously found for lactate and glucose. Lactic Acid 240-247 insulin like growth factor 1 Homo sapiens 135-140