PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14656049-4 2003 Insulin"s stimulation of pyruvate dehydrogenase as measured by lactate oxidation ([1-14C]-lactate --> 14CO2) in intact BC3H-1 myocytes reached a maximum at 15-30 min and returned to basal activity during the 60-90 min measurement interval. Lactic Acid 63-70 insulin Homo sapiens 0-7 14747280-14 2004 In conclusion, moderate exercise training at lactate threshold improves not only peripheral insulin sensitivity but also peripheral glucose effectiveness with no change in the effect of glucose and/or insulin to suppress EGP in healthy humans. Lactic Acid 45-52 insulin Homo sapiens 92-99 14686957-8 2004 A statistically significant increase (p<0.01), however, was observed for the "decremental" area of lactate in obese subjects with diabetes or FHD, which might probably contribute to the reduction of insulin resistance induced by the drug in these patients. Lactic Acid 102-109 insulin Homo sapiens 202-209 14656049-4 2003 Insulin"s stimulation of pyruvate dehydrogenase as measured by lactate oxidation ([1-14C]-lactate --> 14CO2) in intact BC3H-1 myocytes reached a maximum at 15-30 min and returned to basal activity during the 60-90 min measurement interval. Lactic Acid 90-97 insulin Homo sapiens 0-7 14711103-7 2003 Lactate release into the fetal effluent was significantly reduced in both insulin-treated GDM groups compared to the control group. Lactic Acid 0-7 insulin Homo sapiens 74-81 12502513-2 2003 The aim of the present study was to test the hypothesis that the increased levels of lactate and/or pyruvate during anaerobic exercise would trigger the aberrant insulin secretion in these patients. Lactic Acid 85-92 insulin Homo sapiens 162-169 11460573-5 2001 Studies examining insulin-stimulated glucose metabolism in skeletal muscle have suggested that, in the hyperthyroid state, it may be of primary importance to increase the rates of glycolysis and lactate formation relative to glucose oxidation in this tissue in order to provide substrate for gluconeogenesis (increase Cori cycle activity). Lactic Acid 195-202 insulin Homo sapiens 18-25 11889193-0 2002 Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics. Lactic Acid 90-97 insulin Homo sapiens 62-69 11158933-0 2001 Role of Na+-K+-ATPase in insulin-induced lactate release by skeletal muscle. Lactic Acid 41-48 insulin Homo sapiens 25-32 11158933-2 2001 Whereas it has been shown that aerobic glycolysis is linked to Na+-K+-ATPase activity, we hypothesized that stimulation by insulin of skeletal muscle Na+-K+-ATPase is responsible for increased muscle lactate production. Lactic Acid 200-207 insulin Homo sapiens 123-130 11158933-7 2001 These data indicate that insulin stimulates muscle lactate release by activating Na+-K+-ATPase in healthy humans. Lactic Acid 51-58 insulin Homo sapiens 25-32 11109972-7 2000 Insulin alone had no effect on progesterone release in any of the groups, but stimulated lactate formation in the PCOS-NIR and TF groups. Lactic Acid 89-96 insulin Homo sapiens 0-7 11109972-10 2000 We infer that the in vitro effect of insulin on progesterone and lactate release by granulosa-lutein cells is impaired in insulin resistant PCOS patients. Lactic Acid 65-72 insulin Homo sapiens 37-44 11007380-0 2000 Insulin efficacy with a new bicarbonate/lactate peritoneal dialysis solution. Lactic Acid 40-47 insulin Homo sapiens 0-7 11093297-12 2000 The significant increase in lactate levels in white obese women confirms that they are more insulin sensitive. Lactic Acid 28-35 insulin Homo sapiens 92-99 10484052-10 1999 We postulate that the insulin resistance induced by dex in first-degree relatives of type 2 diabetic patients is associated with a preferential channeling of glucose into the glycolytic pathway (increased glucose oxidation and lactate production), probably associated with a preexisting downregulation of the glycosen synthase pathway. Lactic Acid 227-234 insulin Homo sapiens 22-29 10935781-5 2000 Insulin(GIK) prevented lactate release during cardioplegia (1.5+/-15 vs -44+/-14 micromol/min, p = 0.04), and a significant extraction of lactate was induced shortly after declamping the aorta (15+/-3 vs 2+/-1%, p = 0.001). Lactic Acid 23-30 insulin Homo sapiens 0-12 10751195-7 2000 Insulin, which increases glucose uptake by these cells, increased the cell lactate content and the lactate-to-pyruvate ratio (LPR) by 81 and 97%, respectively (both P < 0.05), indicating that the hormone increased aerobic glycolysis and the redox potential. Lactic Acid 75-82 insulin Homo sapiens 0-7 10751195-7 2000 Insulin, which increases glucose uptake by these cells, increased the cell lactate content and the lactate-to-pyruvate ratio (LPR) by 81 and 97%, respectively (both P < 0.05), indicating that the hormone increased aerobic glycolysis and the redox potential. Lactic Acid 99-106 insulin Homo sapiens 0-7 10710341-9 2000 Coronary insulin infusion increased myocardial lactate extraction as well (from 20 +/- 10% to 29 +/- 9%, P < 0.05), suggesting the local action may include stimulation of a metabolic step distal to glucose transport and glycolysis. Lactic Acid 47-54 insulin Homo sapiens 9-16 10955370-6 2000 Insulin also increased myocardial uptake of glucose (from 6+/-1 to 17+/-6 mmol/min) and lactate (from 8+/-2 to 12+/-5 mmol/min), resulting in approximately 30% increase in total oxidative substrate uptake, but without increasing myocardial oxygen consumption (7.0+/-0.7 vs. 7.1+/-0.8 ml/min). Lactic Acid 88-95 insulin Homo sapiens 0-7 9731791-12 1998 Insulin increased the pyruvate dehydrogenase activity by 31% in cardiomyocytes and reduced extracellular lactate production by 40%. Lactic Acid 105-112 insulin Homo sapiens 0-7 10509803-2 1999 The role of cytosolic redox state has been assessed (as reflected by the lactate/pyruvate ratio) in nutrient- and non-nutrient-induced insulin release using a recently established glucose-sensitive clonal beta-cell line (BRIN-BD11). Lactic Acid 73-80 insulin Homo sapiens 135-142 9851784-2 1998 Furthermore, the influence of the plasma insulin concentration on the lactate concentration of sc adipose tissue was investigated during hyperglycemia. Lactic Acid 70-77 insulin Homo sapiens 41-48 10067662-12 1999 The significantly reduced plasma levels of lactate suggest that this effect might be exerted through the activation of pyruvate dehydrogenase, whose activity is depressed in the insulin resistant status. Lactic Acid 43-50 insulin Homo sapiens 178-185 9920088-11 1999 Only the close temporal relationship between insulin and lactate release persisted during nighttime. Lactic Acid 57-64 insulin Homo sapiens 45-52 9920088-12 1999 The temporal coupling and pattern synchrony between insulin and lactate were correlated inversely with insulin sensitivity, and positively with the degree of abdominal obesity. Lactic Acid 64-71 insulin Homo sapiens 103-110 9920088-13 1999 Our results suggest that: 1) the concentration of lactate, an indicator of cellular energy metabolism, fluctuates periodically in vivo; 2) the lactate concentrations fluctuate in synchrony with insulin pulses; and 3) such coupling is more pronounced in obese, insulin-resistant individuals. Lactic Acid 50-57 insulin Homo sapiens 194-201 9920088-13 1999 Our results suggest that: 1) the concentration of lactate, an indicator of cellular energy metabolism, fluctuates periodically in vivo; 2) the lactate concentrations fluctuate in synchrony with insulin pulses; and 3) such coupling is more pronounced in obese, insulin-resistant individuals. Lactic Acid 50-57 insulin Homo sapiens 260-267 9920088-13 1999 Our results suggest that: 1) the concentration of lactate, an indicator of cellular energy metabolism, fluctuates periodically in vivo; 2) the lactate concentrations fluctuate in synchrony with insulin pulses; and 3) such coupling is more pronounced in obese, insulin-resistant individuals. Lactic Acid 143-150 insulin Homo sapiens 194-201 9920088-13 1999 Our results suggest that: 1) the concentration of lactate, an indicator of cellular energy metabolism, fluctuates periodically in vivo; 2) the lactate concentrations fluctuate in synchrony with insulin pulses; and 3) such coupling is more pronounced in obese, insulin-resistant individuals. Lactic Acid 143-150 insulin Homo sapiens 260-267 9735234-14 1998 The insulin-stimulated HPAF cells also showed an enhanced glucose consumption and lactate production (P < 0.05). Lactic Acid 82-89 insulin Homo sapiens 4-11 8889439-6 1996 Furthermore, insulin infusion increased forearm lactate release and potassium uptake. Lactic Acid 48-55 insulin Homo sapiens 13-20 9436687-0 1997 Insulin stimulation of lactate accumulation in isolated human granulosa-luteal cells: a comparison between normal and polycystic ovaries. Lactic Acid 23-30 insulin Homo sapiens 0-7 9436687-3 1997 The aim was therefore to study the effect of insulin on lactate accumulation, an indicator of glucose metabolism, in granulosa-luteal cells from women with PCOS and from women with normal ovarian function. Lactic Acid 56-63 insulin Homo sapiens 45-52 9436687-10 1997 Insulin caused a dose-dependent increase in lactate in granulosa-luteal cells obtained from normal ovaries (control: 45.5 +/- 6.3; insulin 0.5 microg/ml: 77 +/- 10 nmol/microg protein). Lactic Acid 44-51 insulin Homo sapiens 0-7 9186311-6 1997 Insulin infusion with 250 microU/mL obtained half-maximal effects, causing a 2.8-fold increase in glucose uptake and a 1.5-fold increase in lactate and pyruvate release. Lactic Acid 140-147 insulin Homo sapiens 0-7 9178026-3 1997 We correlated these measures of carbohydrate metabolism with changes in free fatty acids and lactate levels both of which have been reported to be possible mediators of insulin sensitivity. Lactic Acid 93-100 insulin Homo sapiens 169-176 9339296-8 1997 Brain lactate levels were 4.3 +/- 1.0 mumol/g wet weight in the shams, 18.3 +/- 1.9 in the insulin group (p < 0.01 vs. sham), and 29.4 +/- 2.6 in the glucose group (p < 0.01 vs. insulin). Lactic Acid 6-13 insulin Homo sapiens 91-98 8944666-8 1996 Our data suggest that increased gluconeogenesis from lactate is associated with increased lipid oxidation and could contribute to the progressive development of insulin resistance and glucose intolerance in juvenile obesity. Lactic Acid 53-60 insulin Homo sapiens 161-168 9608544-7 1998 Conversely, the incremental areas of lactate were negatively correlated with total insulin (P < 0.05), NEFA (P < 0.05), and glucagon (P < 0.001) areas. Lactic Acid 37-44 insulin Homo sapiens 83-90 9449378-7 1997 Insulin produced by FTOInsm cells was biologically active because it blocked endogenous PEPCK gene expression and induced glucose uptake and lactate production. Lactic Acid 141-148 insulin Homo sapiens 0-7 9223392-4 1997 Pramlintide infusion in the insulin-treated patients resulted in statistically significant reductions in mean glucose, insulin, C-peptide, and lactate concentrations during the 4-h period after the Sustacal test meal. Lactic Acid 143-150 insulin Homo sapiens 28-35 9078265-3 1997 SNP stimulated the rate of 2-deoxyglucose transport and insulin-mediated (100 mu-units/ml) rates of both net and [14C]lactate release and the rate of glucose oxidation. Lactic Acid 118-125 insulin Homo sapiens 56-63 9078265-6 1997 SNP stimulated the insulin-stimulated rates of net and [14C]lactate release and glucose oxidation in a concentration-dependent manner. Lactic Acid 60-67 insulin Homo sapiens 19-26 8940617-0 1996 New aspects of lactate metabolism: IGF-I and insulin regulate mitochondrial function in cultured brain cells during normoxia and hypoxia. Lactic Acid 15-22 insulin Homo sapiens 45-52 8641378-4 1996 The inter-tissue cycle between glucose and lactate-the Cori cycle, which is influenced by insulin-may provide another novel mechanism for control of blood glucose. Lactic Acid 43-50 insulin Homo sapiens 90-97 8967027-15 1996 Amylin reduces in the muscle, probably by inhibition of glycogen synthase, the insulin stimulated non-oxidative utilization of glucose into muscle glycogen and conversely by stimulation of phosphorylase it stimulates glycogenolysis and thus also lactate production and gluconeogenesis in the liver which all are anti-insulin effects which intensify the insulin resistance of the main target tissues. Lactic Acid 246-253 insulin Homo sapiens 79-86 8672547-6 1996 Insulin stimulated rates of pyruvate or lactate release or of glycogen synthesis were unaffected by the addition of adenosine deaminase or GR79236 in human rectus abdominus muscle strips. Lactic Acid 40-47 insulin Homo sapiens 0-7 8621203-7 1996 Similarly, in the presence of physiological concentrations of glucose (5.5 mmol/L), insulin increased lactate production from 123 +/- 6 to 175 +/- 10 nmol/min (P < .01). Lactic Acid 102-109 insulin Homo sapiens 84-91 8940617-9 1996 Using [1-13C]glucose it could be demonstrated that production of lactate from mitochondrial precursors was, in the presence of insulin or IGF-I, down regulated in astrocytes but increased in neurons during normoxia. Lactic Acid 65-72 insulin Homo sapiens 127-134 8124481-11 1994 Insulin increased the muscle lactate content on the control day (6.50 +/- 0.95 vs 8.65 +/- 0.77 mmol/kg dry wt, p < 0.05), but not during Intralipid infusion. Lactic Acid 29-36 insulin Homo sapiens 0-7 7782904-6 1995 When subjects consumed the breads baked with sourdough, lactic acid and Na-propionate, their glucose and insulin responses were reduced compared with the wholemeal bread alone. Lactic Acid 56-67 insulin Homo sapiens 105-112 8205537-13 1994 In the U266 cells, insulin increased lactate production 62 +/- 9 and 101 +/- 12% (mean +/- SE) at concentrations of 2 nM and 200 nM, respectively. Lactic Acid 37-44 insulin Homo sapiens 19-26 8205537-15 1994 In the 8226 cells, insulin increased lactate production 4 +/- 4 and 36 +/- 15% at 2 and 200 nM, respectively. Lactic Acid 37-44 insulin Homo sapiens 19-26 8067287-0 1994 Metabolic alterations and lactate overproduction in insulin-resistant states. Lactic Acid 26-33 insulin Homo sapiens 52-59 7560063-8 1995 Glucose uptake and lactate release increased in the insulin- and IGF-I-infused forearms (P < 0.01) but did not change in the contralateral (aa alone) forearm in either study. Lactic Acid 19-26 insulin Homo sapiens 52-59 7576535-6 1995 Serum and insulin additions markedly enhanced the glucose consumption and lactate formation rates, a metabolic effect that was not coupled to the increase in mu. Lactic Acid 74-81 insulin Homo sapiens 10-17 7622002-0 1995 Insulin sensitivity accounts for glucose and lactate kinetics after intravenous glucose injection. Lactic Acid 45-52 insulin Homo sapiens 0-7 7612874-6 1995 Evidence is presented that IGF-I and insulin stimulate neurones to release factors affecting astrocytic lactate production. Lactic Acid 104-111 insulin Homo sapiens 37-44 1476187-8 1992 During insulin infusion lactate release (P < 0.05) [8.9 +/- 1.8 vs. 2.9 +/- 0.9 mumol.min-1.kg-1 (step I), 24.6 +/- 3.1 vs. 12.5 +/- 2.6 (step III)] and glycogen storage (P < 0.1) calculated by indirect calorimetry [6.7 +/- 2.3 vs. 5.0 +/- 1.7 mg.min-1.kg-1 (step I), 16.8 +/- 2.1 vs. 14.1 +/- 1.8 (step III)] were always higher in T than in UT legs. Lactic Acid 24-31 insulin Homo sapiens 7-14 7688386-12 1993 At 200 and 2 nM, insulin increased production of lactate by 33 +/- 9% and 19 +/- 11%, respectively. Lactic Acid 49-56 insulin Homo sapiens 17-24 8359587-7 1993 Plasma free insulin levels were lower after recombinant insulin-like growth factor I administration (31.9 +/- 2.7 compared with 67.9 +/- 16.0 mU/l; p = 0.001) but no significant differences in ketone or lactate levels were detected. Lactic Acid 203-210 insulin Homo sapiens 12-19 8422762-6 1993 CONCLUSIONS: This investigation demonstrated that the treatment of IDDM patients during early pregnancy by an open-loop insulin infusion system is sufficient to normalize their glucose-processing capability with respect to cellular oxidative and nonoxidative glucose metabolism in response to an oral glucose challenge, but some abnormalities in their blood profiles of glucose, lactate, and pyruvate persisted. Lactic Acid 379-386 insulin Homo sapiens 120-127 8457423-3 1993 The present experiments inhibited lactic acid production by lowering glucose availability using insulin-induced hypoglycemia. Lactic Acid 34-45 insulin Homo sapiens 96-103 8457423-6 1993 The results showed that insulin-induced hypoglycemia markedly inhibits production of lactic acid, but has no effect on brain pHi during ischemia. Lactic Acid 85-96 insulin Homo sapiens 24-31 1915515-6 1991 The absence of both ketosis and elevated levels of free fatty acids and lactate during hypoglycaemia, as observed in our patient, are important diagnostic clues since the insulin levels themselves may sometimes be only slightly elevated. Lactic Acid 72-79 insulin Homo sapiens 171-178 1425612-5 1992 The plasma concentrations of glucose and lactate increased from 5.2 +/- 0.4 to 13.7 +/- 1.3 mmol litre-1 and from 0.9 +/- 0.3 to 4.7 +/- 2.6 mmol litre-1, respectively, during the highest infusion rate without a significant increase in insulin concentration. Lactic Acid 41-48 insulin Homo sapiens 236-243 1430089-9 1992 Proinsulin caused significant net reductions in blood lactate levels compared to insulin at each infusion dose; (P1) -130 +/- 34, (I1) -32 +/- 30 mumol/L (P < 0.05) (P2) -139 +/- 76 (I2) +8 +/- 65 mumol/L (P < 0.05) (P3) 48 +/- 60 (I3) 230 +/- 64 mumol/L (P < 0.05). Lactic Acid 54-61 insulin Homo sapiens 0-10 1430089-9 1992 Proinsulin caused significant net reductions in blood lactate levels compared to insulin at each infusion dose; (P1) -130 +/- 34, (I1) -32 +/- 30 mumol/L (P < 0.05) (P2) -139 +/- 76 (I2) +8 +/- 65 mumol/L (P < 0.05) (P3) 48 +/- 60 (I3) 230 +/- 64 mumol/L (P < 0.05). Lactic Acid 54-61 insulin Homo sapiens 3-10 1587421-4 1992 Simultaneously, insulin-induced increases in glucose oxidation, plasma lactate levels, and lipogenesis were normal, whereas nonoxidative glucose metabolism was reduced (-82% and -47% of controls, respectively). Lactic Acid 71-78 insulin Homo sapiens 16-23 1538640-0 1992 Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Lactic Acid 64-71 insulin Homo sapiens 0-7 1538640-0 1992 Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Lactic Acid 94-101 insulin Homo sapiens 0-7 1538640-3 1992 In contrast, we have recently shown a marked decrease in the capacity for acute lactate generation in obese subjects following an oral glucose load, which we postulated might be linked to altered insulin sensitivity. Lactic Acid 80-87 insulin Homo sapiens 196-203 1538640-6 1992 Insulin sensitivity was more tightly associated with glucose, insulin, and lactate levels (both basal and integrated) than obesity per se. Lactic Acid 75-82 insulin Homo sapiens 0-7 1538640-11 1992 We conclude that elevations in basal lactate are associated with the development of insulin resistance. Lactic Acid 37-44 insulin Homo sapiens 84-91 1917388-3 1991 Insulin-mediated stimulation of glucose uptake and lactate production was decreased significantly in the RPE cells from diabetic donors compared with those from normal controls. Lactic Acid 51-58 insulin Homo sapiens 0-7 1406302-6 1992 Forearm lactate release was slightly increased by insulin alone, but rose markedly on addition of epinephrine (from 5.2 +/- 0.8 mumol.L-1.min-1 to 17 +/- 2; P less than .02). Lactic Acid 8-15 insulin Homo sapiens 50-57 1375219-6 1992 Thus, the stimulatory effects of vanadate and insulin on MeAIB and 3-O-methylglucose uptake were not additive; however, the effects of insulin and vanadate on lactate production were additive. Lactic Acid 159-166 insulin Homo sapiens 135-142 1625922-2 1992 Accumulation of lactate in the tissues and the development of acidosis probably play an important role in disturbance of the insulin-binding activity of the plasma membrane. Lactic Acid 16-23 insulin Homo sapiens 125-132 1752724-7 1991 Fasting concentrations of carbohydrate intermediaries were, however, better correlated with fasting plasma insulin: lactate (r = 0.29; P less than 0.01), pyruvate (r = 0.24; P less than 0.01) and alanine (r = 0.36; P less than 0.001). Lactic Acid 116-123 insulin Homo sapiens 107-114 2008651-0 1991 The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer cachexia. Lactic Acid 71-78 insulin Homo sapiens 30-37 2040382-11 1991 The lactate and pyruvate levels in subcutaneous tissue increased briefly after insulin replacement, whereas the lactate but not pyruvate levels in blood showed a similar increase. Lactic Acid 4-11 insulin Homo sapiens 79-86 2008471-5 1991 Lactate release was maintained throughout perfusion and was markedly increased by addition of insulin to the perfusate. Lactic Acid 0-7 insulin Homo sapiens 94-101 2008651-10 1991 Supraphysiologic insulin abolished this increased lactate efflux in patients. Lactic Acid 50-57 insulin Homo sapiens 17-24 2008651-13 1991 This impaired insulin action on peripheral glucose use was associated with an increase in peripheral lactate release in patients. Lactic Acid 101-108 insulin Homo sapiens 14-21 2032990-6 1991 At these insulin concentrations also, lactate release and glucose oxidation and glycogen storage estimated by indirect calorimetry were lower in the leg after bed rest. Lactic Acid 38-45 insulin Homo sapiens 9-16 20504586-5 1990 or intracerebrally (2 x 10(?4) M, via the microdialysis probe) 2 h before insulin injection, was able to reduce the decay of the perfusate levels of lactate induced by the insulin injection. Lactic Acid 149-156 insulin Homo sapiens 74-81 2113769-4 1990 Under conditions of insulin stimulation, 49 +/- 5% of leg glucose uptake was stored, 37 +/- 4% was oxidized, and 14 +/- 2% was released as lactate and alanine. Lactic Acid 139-146 insulin Homo sapiens 20-27 2269580-0 1990 Lactate generation following glucose ingestion: relation to obesity, carbohydrate tolerance and insulin sensitivity. Lactic Acid 0-7 insulin Homo sapiens 96-103 2269580-11 1990 Secondly, the inverse association between acute lactate generation following glucose ingestion and obesity, despite the increased sum of glucose in obese subjects, may reflect a decreased ability of adipose and/or extra-adipose tissues to convert glucose to lactate due to insulin resistance. Lactic Acid 48-55 insulin Homo sapiens 273-280 2198023-2 1990 The effects of synthetic human amylin on basal and insulin-stimulated (100 and 1000 microunits/ml) rates of lactate formation, glucose oxidation and glycogen synthesis were measured in the isolated rat soleus muscle preparation incubated in the presence of various concentrations of glucose (5, 11 and 22 mM). Lactic Acid 108-115 insulin Homo sapiens 51-58 2163613-5 1990 Fructose 2,6-bisphosphate (Fru-2,6-P2) levels, glucose consumption and lactate production are increased in a dose-dependent manner in HT29 cells treated with PMA or insulin. Lactic Acid 71-78 insulin Homo sapiens 165-172 2163613-9 1990 Furthermore, the effects of insulin and PMA on glucose consumption, lactate production, Fru-2,6-P2 levels and PFK2 activity are additive, and the effect of insulin on Fru-2,6-P2 production is not altered by pre-treatment of the cells with the phorbol ester. Lactic Acid 68-75 insulin Homo sapiens 28-35 20504586-5 1990 or intracerebrally (2 x 10(?4) M, via the microdialysis probe) 2 h before insulin injection, was able to reduce the decay of the perfusate levels of lactate induced by the insulin injection. Lactic Acid 149-156 insulin Homo sapiens 172-179 35014047-3 2022 Insulin (50 nM) promotes cell proliferation, 3 H-DG uptake and lactic acid production in both cell lines. Lactic Acid 63-74 insulin Homo sapiens 0-7 34779480-0 2022 Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport. Lactic Acid 38-45 insulin Homo sapiens 0-7 34779480-8 2022 Together, these data suggest that insulin drives adipocytes to secrete lactate, which then acts in a paracrine fashion to promote fatty acid uptake and transport across the neighboring endothelial barrier. Lactic Acid 71-78 insulin Homo sapiens 34-41 2673694-7 1989 Glucagon, alpha-amino acid nitrogen, and lactate concentrations were exquisitely sensitive to a rise in glucose and insulin concentrations. Lactic Acid 41-48 insulin Homo sapiens 116-123 35016146-7 2022 Oral lactate administration lowered plasma concentrations of acylated ghrelin (p = 0.02) and elevated glucagon like peptide-1 (GLP-1, p = 0.045), insulin (p < 0.001), and glucagon (p < 0.001) compared with iv administration. Lactic Acid 5-12 insulin Homo sapiens 146-153 35059257-8 2022 However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Lactic Acid 9-16 insulin Homo sapiens 185-192 2660587-0 1989 Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM. Lactic Acid 76-83 insulin Homo sapiens 0-7 2660587-2 1989 We examined whether insulin inhibits gluconeogenesis from lactate by altering the fate of lactate and/or by reducing lactate flux. Lactic Acid 58-65 insulin Homo sapiens 20-27 2660587-8 1989 We conclude that insulin inhibits overnight glucose Ra from lactate by decreasing the proportion of lactate diverted towards gluconeogenesis rather than by altering lactate availability or total flux. Lactic Acid 60-67 insulin Homo sapiens 17-24 2660587-8 1989 We conclude that insulin inhibits overnight glucose Ra from lactate by decreasing the proportion of lactate diverted towards gluconeogenesis rather than by altering lactate availability or total flux. Lactic Acid 100-107 insulin Homo sapiens 17-24 2660587-8 1989 We conclude that insulin inhibits overnight glucose Ra from lactate by decreasing the proportion of lactate diverted towards gluconeogenesis rather than by altering lactate availability or total flux. Lactic Acid 100-107 insulin Homo sapiens 17-24 2665059-8 1989 Myocardial lactate balance was also improved by insulin treatment, with fractional extraction increased from 6 to 21%. Lactic Acid 11-18 insulin Homo sapiens 48-55 2533112-2 1989 Insulin is able to stimulate lactate production and to enhance fructose 2,6-bisphosphate (Fru-2,6-P2) content in 3T3-L1 adipocytes. Lactic Acid 29-36 insulin Homo sapiens 0-7 3052595-6 1988 Glucose consumption increased from 0.33 +/- 0.03 mumol/mg protein per h to 0.49 +/- 0.05 mumol/mg protein per h and lactate production was augmented from 0.67 +/- 0.04 mumol/mg protein per h to 0.87 +/- 0.06 mumol/mg protein per h in response to 10(-7) to 10(-5) M insulin. Lactic Acid 116-123 insulin Homo sapiens 265-272 3068827-4 1988 A significant increase in arterial lactate concentration in both the control group (from 1.40 +/- 0.19 to 1.68 +/- 0.24 mmol/l p less than 0.01) and the insulin group (from 1.58 +/- 0.27 to 2.07 +/- 0.22 mmol/l, p less than 0.05) was observed. Lactic Acid 35-42 insulin Homo sapiens 153-160 3052595-9 1988 With the possible exception of glyceraldehyde, little lactate was produced from alternative substrates, including adenosine, inosine, ribose, deoxyribose, dihydroxyacetone, galactose and fructose either with or without insulin. Lactic Acid 54-61 insulin Homo sapiens 219-226 3310656-3 1987 In large fat cells from 8-mo-old rats, donor"s food restriction produced minimal changes in basal glucose metabolism and lactate production (already elevated at 37% of total) but caused insulin-stimulated lactate production to increase. Lactic Acid 205-212 insulin Homo sapiens 186-193 3609498-3 1987 The purpose of this study was to determine whether an increase in blood concentration patterns of ketone bodies and lactic acid, organic acids often elevated in poorly controlled insulin-dependent diabetes mellitus (IDDM), could contribute to increase glomerular filtration rate (GFR) and renal plasma flow (RPF) regardless of changes in circulating levels of glucose and insulin. Lactic Acid 116-127 insulin Homo sapiens 179-186 2879174-2 1987 Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon, molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the non-fentanyl than in the fentanyl group. Lactic Acid 250-257 insulin Homo sapiens 197-204 2969910-8 1987 Moreover, insulin pump treatment resulted in a significant reduction of two major intermediary metabolites, lactate and glycerol (p less than 0.05 and p less than 0.01, respectively). Lactic Acid 108-115 insulin Homo sapiens 10-17 3030131-7 1987 Insulin-stimulated lactate production and glucose transport without affecting the other parameters. Lactic Acid 19-26 insulin Homo sapiens 0-7 20928962-2 1987 Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon, molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the non-fentanyl than in the fentanyl group. Lactic Acid 250-257 insulin Homo sapiens 197-204 3517029-11 1986 The lactate turnover rate increased during the euglycemic clamp and was lower in IDDM than in N. We conclude that during euglycemic-multiple insulin clamp studies the greater lactate increase suggests that the flux of glycolysis is higher in N than in IDDM, tricarboxylic acid concentrations are comparable in N and IDDM, and FFA, glycerol, and branched chain amino acid decreases were less in IDDM than in N, suggesting that IDDM patients are resistant to insulin with regard to lipid and protein metabolism. Lactic Acid 4-11 insulin Homo sapiens 141-148 3026341-4 1986 At constant 5 mM-glucose and 2 mM-lactate concentrations insulin increased glucokinase flux by 35%; it decreased glucose-6-phosphatase flux from glycogen by 50%, from lactate by 15% and reverse flux from external glucose by 65%, i.e. overall by 40%. Lactic Acid 34-41 insulin Homo sapiens 57-64 3026341-4 1986 At constant 5 mM-glucose and 2 mM-lactate concentrations insulin increased glucokinase flux by 35%; it decreased glucose-6-phosphatase flux from glycogen by 50%, from lactate by 15% and reverse flux from external glucose by 65%, i.e. overall by 40%. Lactic Acid 167-174 insulin Homo sapiens 57-64 2874153-8 1986 Lactate concentrations rose significantly during hyperglycemia, but the rise in the presence of increased insulin concentrations (from 0.72 +/- 0.06 to 1.31 +/- 0.11 mmol/liter; P less than 0.001) considerably exceeded the increment (from 0.74 +/- 0.05 to 0.92 +/- 0.03 mmol/liter) with basal insulin levels. Lactic Acid 0-7 insulin Homo sapiens 293-300 3089579-6 1986 The number of high affinity cytochalasin B binding sites was 175,000 receptors/cell (about 0.6 pmol/mg protein) and Kd = 1 X 10(-7) M. Insulin increased glucose utilization and lactate production by about 70% and caused a 56% increase in transport without alterations in the Kd of the site. Lactic Acid 177-184 insulin Homo sapiens 135-142 3517029-11 1986 The lactate turnover rate increased during the euglycemic clamp and was lower in IDDM than in N. We conclude that during euglycemic-multiple insulin clamp studies the greater lactate increase suggests that the flux of glycolysis is higher in N than in IDDM, tricarboxylic acid concentrations are comparable in N and IDDM, and FFA, glycerol, and branched chain amino acid decreases were less in IDDM than in N, suggesting that IDDM patients are resistant to insulin with regard to lipid and protein metabolism. Lactic Acid 4-11 insulin Homo sapiens 457-464 3517029-11 1986 The lactate turnover rate increased during the euglycemic clamp and was lower in IDDM than in N. We conclude that during euglycemic-multiple insulin clamp studies the greater lactate increase suggests that the flux of glycolysis is higher in N than in IDDM, tricarboxylic acid concentrations are comparable in N and IDDM, and FFA, glycerol, and branched chain amino acid decreases were less in IDDM than in N, suggesting that IDDM patients are resistant to insulin with regard to lipid and protein metabolism. Lactic Acid 175-182 insulin Homo sapiens 141-148 3517029-11 1986 The lactate turnover rate increased during the euglycemic clamp and was lower in IDDM than in N. We conclude that during euglycemic-multiple insulin clamp studies the greater lactate increase suggests that the flux of glycolysis is higher in N than in IDDM, tricarboxylic acid concentrations are comparable in N and IDDM, and FFA, glycerol, and branched chain amino acid decreases were less in IDDM than in N, suggesting that IDDM patients are resistant to insulin with regard to lipid and protein metabolism. Lactic Acid 175-182 insulin Homo sapiens 457-464 3526480-3 1986 Significant lipogenic or lipolytic hormonal effects upon lactate metabolism were observed only in the presence of glucose, as insulin primarily increased lactate conversion to fatty acids while epinephrine promoted lactate oxidation. Lactic Acid 57-64 insulin Homo sapiens 126-133 3526480-3 1986 Significant lipogenic or lipolytic hormonal effects upon lactate metabolism were observed only in the presence of glucose, as insulin primarily increased lactate conversion to fatty acids while epinephrine promoted lactate oxidation. Lactic Acid 154-161 insulin Homo sapiens 126-133 3526480-3 1986 Significant lipogenic or lipolytic hormonal effects upon lactate metabolism were observed only in the presence of glucose, as insulin primarily increased lactate conversion to fatty acids while epinephrine promoted lactate oxidation. Lactic Acid 154-161 insulin Homo sapiens 126-133 3884627-7 1985 ADP and lactate levels were elevated after ischaemia and decreased after reperfusion in the insulin-group but not in the control-group. Lactic Acid 8-15 insulin Homo sapiens 92-99 3884965-6 1985 Maximum insulin-stimulated total glucose utilization rates by isolated adipocytes incubated at 5.5 mmol/L glucose were 63% greater after overfeeding, due to increases in lactate formation, triglyceride synthesis, and CO2 production. Lactic Acid 170-177 insulin Homo sapiens 8-15 3527516-6 1986 Basal lactate and pyruvate concentrations were significantly correlated with overnight insulin requirements (lactate, rs 0.62, p less than 0.05; pyruvate, rs 0.70, p less than 0.05) suggesting that the elevated basal concentrations resulted from the higher peripheral insulin delivery rates required to maintain overnight normoglycaemia in the brittle patients. Lactic Acid 6-13 insulin Homo sapiens 87-94 3518640-3 1986 Significantly higher 24h mean blood lactate concentrations and lower total ketone bodies and glycerol concentrations were observed during treatment with human insulin. Lactic Acid 36-43 insulin Homo sapiens 159-166 2861168-8 1985 Lactate (10 mmol/l) induced a 28% drop in cellular insulin binding at low pH. Lactic Acid 0-7 insulin Homo sapiens 51-58 6391212-0 1984 Insulin levels during lactate infusion. Lactic Acid 22-29 insulin Homo sapiens 0-7 3922347-4 1985 Insulin preferentially increases lactate formation, dichloroacetate only CO2 production. Lactic Acid 33-40 insulin Homo sapiens 0-7 6391212-1 1984 To determine whether the lactate-induced panic of patients with panic attacks results from hyperinsulinism balanced by epinephrine-enhanced gluconeogenesis, the authors measured 10 subjects" insulin levels exactly when the lactate-induced attacks began. Lactic Acid 25-32 insulin Homo sapiens 96-103 6398261-2 1984 When the insulin dose delivered is adjusted to achieve a near match of the peripheral plasma glucose profile, the 24 h profiles of free fatty acids, glycerol, lactate and beta-hydroxybutyrate and the hormones, insulin, glucagon, cortisol and catecholamines were identical. Lactic Acid 159-166 insulin Homo sapiens 9-16 6397293-4 1984 Mean individual 24 hr blood lactate concentrations correlated significantly with mean free insulin levels (r = 0.85, p less than 0.002), but inversely with prior out-patient diabetic control (r = 0.64, p less than 0.05). Lactic Acid 28-35 insulin Homo sapiens 91-98 6397293-5 1984 The shape of the 24 hr profiles of blood lactate and pyruvate changed between SC therapy and the GCIIS, corresponding in both studies to the form of the free insulin profile. Lactic Acid 41-48 insulin Homo sapiens 158-165 6395878-3 1984 Diagnosis of hyperinsulinism (HI) was made in a single blood sample by showing inappropriate plasma insulin levels (23 +/- 3 mU/l) for glycaemia (1.2 +/- 0.1 mmol/l), with low blood ketone body, lactate, alanine and glycerol levels. Lactic Acid 195-202 insulin Homo sapiens 18-25 6242422-4 1984 In McArdle disease, the augmentation in exercise-induced lactate production was also observed after administration of glucose, or glucose plus insulin, but it was neither observed after administration of insulin alone nor after arginine or epinephrine administration. Lactic Acid 57-64 insulin Homo sapiens 143-150 6235108-2 1984 Insulin increased lactic acid production; the maximal stimulation occurred at the concentrations above 250 ng/ml and the half-maximal dose was 50 ng/ml. Lactic Acid 18-29 insulin Homo sapiens 0-7 6235108-3 1984 This effect of insulin appeared as early as one hour, and lactic acid production in the presence of insulin linearly increased up to 4 h. The 24-h pretreatment with insulin exhibited no significant effect on the production by cells afterward incubated either with or without insulin. Lactic Acid 58-69 insulin Homo sapiens 100-107 6235108-3 1984 This effect of insulin appeared as early as one hour, and lactic acid production in the presence of insulin linearly increased up to 4 h. The 24-h pretreatment with insulin exhibited no significant effect on the production by cells afterward incubated either with or without insulin. Lactic Acid 58-69 insulin Homo sapiens 100-107 6235108-3 1984 This effect of insulin appeared as early as one hour, and lactic acid production in the presence of insulin linearly increased up to 4 h. The 24-h pretreatment with insulin exhibited no significant effect on the production by cells afterward incubated either with or without insulin. Lactic Acid 58-69 insulin Homo sapiens 100-107 6380895-4 1984 Both adrenaline and insulin infusions resulted in an increased lactate content of muscle and blood, indicating an enhanced glycolysis. Lactic Acid 63-70 insulin Homo sapiens 20-27 6376030-7 1984 On active treatment, insulin levels rose coincident with a fall in fasting blood glucose and an improvement in glucose tolerance and near-normalization of plasma lactate, pyruvate, free fatty acids, glycerol, and ketone bodies, all of which relapsed to initial values after placebo. Lactic Acid 162-169 insulin Homo sapiens 21-28 6354230-5 1983 In comparison with a control group of patients, the insulin infusion caused a marked decrease in circulating glucose, non-esterified fatty acids and beta-hydroxybutyrate concentrations, and an increase in blood lactate values. Lactic Acid 211-218 insulin Homo sapiens 52-59 7068289-1 1982 Administration of pyridoxine-alpha-ketoglutarate (PAK) to a group of insulin-independent non-ketotic diabetics decreased (p less than 0.01) the plasma concentration of lactate response to isometric exercise. Lactic Acid 168-175 insulin Homo sapiens 69-76 6756622-8 1982 In summary, (i) complete normalization of glycemia, glucose turnover, and the lactate response to postabsorptive exercise can be achieved by the intravenous infusion of insulin adjusted to obtain normoglycemia before the onset of exercise; (ii) this response was obtained with an associated elevation in circulating free insulin which probably reflects the peripheral intravenous route rather than the physiologic (portal) site of insulin administration. Lactic Acid 78-85 insulin Homo sapiens 169-176 7036751-1 1982 In a glucose-free bicarbonate Ringer (5% CO2 in N2), insulin increased intracellular pH (pHi), as determined by [14C]dimethadione, by 0.12 +/- 0.02 and stimulated glycolysis, as monitored by anaerobic lactate production, by 42.9 +/- 3.5% in paired frog sartorius muscles. Lactic Acid 201-208 insulin Homo sapiens 53-60 7034539-8 1982 Furthermore, these observations raise the possibility that decreased binding of insulin by placental insulin receptors, which is reported to occur in placentas from diabetic women, may be accompanied by a relatively decreased umbilical uptake of glucose for a given maternal concentration of glucose, but not of lactate. Lactic Acid 312-319 insulin Homo sapiens 80-87 6257679-6 1981 The addition to the medium of glucose, fructose, pyruvate, or lactate enhanced the insulin-induced increase in glucokinase, but only fructose, pyruvate, and lactate increased the activity of the enzyme in the absence of insulin. Lactic Acid 62-69 insulin Homo sapiens 83-90 7037586-4 1982 Blood lactate and pyruvate concentrations were elevated in cirrhotic patients, both fasting and post-glucose, while mean blood lactate correlated with mean serum insulin concentrations (rs 0.55, p less than). Lactic Acid 127-134 insulin Homo sapiens 162-169 7017343-7 1981 Plasma lactate concentrations at the completion of exercise with insulin infusion were higher than after exercise without insulin infusion. Lactic Acid 7-14 insulin Homo sapiens 65-72 6264944-8 1981 Insulin-induced changes in FFA, glycerol, 3-HB, cyclic AMP, and lactate were similar during and after pregnancy. Lactic Acid 64-71 insulin Homo sapiens 0-7 6918294-7 1982 Preperfusion with insulin enhanced the lactate production but resulted in the maintenance of ATP for a longer period during ischaemia, even though acidosis was enhanced. Lactic Acid 39-46 insulin Homo sapiens 18-25 7032981-0 1981 [Effect of glucose and lactic acid on the insulin-depositing function of erythrocytes]. Lactic Acid 23-34 insulin Homo sapiens 42-49 6257679-6 1981 The addition to the medium of glucose, fructose, pyruvate, or lactate enhanced the insulin-induced increase in glucokinase, but only fructose, pyruvate, and lactate increased the activity of the enzyme in the absence of insulin. Lactic Acid 157-164 insulin Homo sapiens 83-90 6257679-6 1981 The addition to the medium of glucose, fructose, pyruvate, or lactate enhanced the insulin-induced increase in glucokinase, but only fructose, pyruvate, and lactate increased the activity of the enzyme in the absence of insulin. Lactic Acid 157-164 insulin Homo sapiens 220-227 6257679-6 1981 The addition to the medium of glucose, fructose, pyruvate, or lactate enhanced the insulin-induced increase in glucokinase, but only fructose, pyruvate, and lactate increased the activity of the enzyme in the absence of insulin. Lactic Acid 62-69 insulin Homo sapiens 220-227 7020069-4 1981 Following addition of insulin a dose-related rise in ADCC, lactate release, and glucose uptake was observed. Lactic Acid 59-66 insulin Homo sapiens 22-29 7020069-6 1981 Most of the stimulation was seen within the physiological concentration range of insulin, and the insulin concentration resulting in 50% of the maximal effect was nearly the same for ADCC, lactate release, and glucose uptake (about 100 pM). Lactic Acid 189-196 insulin Homo sapiens 98-105 7020069-7 1981 The insulin stimulation of ADCC correlated with the stimulation of lactate release and glucose uptake. Lactic Acid 67-74 insulin Homo sapiens 4-11 582980-4 1979 The model is based on our clinical results on the change of blood glucose and blood lactate levels after application of insulin or tolbutamide, resp.: Concerning the blood glucose depressing effects equivalent concentrations of insulin and tolbutamide cause an increase of lactate and pyruvate to different extents in healthy subjects. Lactic Acid 84-91 insulin Homo sapiens 120-127 119646-4 1979 Free insulin and lactate or alanine were positively correlated in the C-peptide secreting group. Lactic Acid 17-24 insulin Homo sapiens 70-79 400427-0 1979 [Semi-automatic determination of blood lactate in the newborn infant of the insulin-dependent diabetic mother]. Lactic Acid 39-46 insulin Homo sapiens 76-83 582980-4 1979 The model is based on our clinical results on the change of blood glucose and blood lactate levels after application of insulin or tolbutamide, resp.: Concerning the blood glucose depressing effects equivalent concentrations of insulin and tolbutamide cause an increase of lactate and pyruvate to different extents in healthy subjects. Lactic Acid 273-280 insulin Homo sapiens 120-127 582980-4 1979 The model is based on our clinical results on the change of blood glucose and blood lactate levels after application of insulin or tolbutamide, resp.: Concerning the blood glucose depressing effects equivalent concentrations of insulin and tolbutamide cause an increase of lactate and pyruvate to different extents in healthy subjects. Lactic Acid 273-280 insulin Homo sapiens 228-235 582980-7 1979 Simply the different paths of insulin entrance--either evenly distributed in the blood or directly at liver entry--may cause the different increases of lactate levels. Lactic Acid 152-159 insulin Homo sapiens 30-37 396109-9 1979 However, the reduction in plasma lactate may be related to an acute enhancement of the exogenously administered insulin. Lactic Acid 33-40 insulin Homo sapiens 112-119 365176-0 1978 Stimulation of proinsulin biosynthesis and insulin release by pyruvate and lactate. Lactic Acid 75-82 insulin Homo sapiens 15-25 365176-0 1978 Stimulation of proinsulin biosynthesis and insulin release by pyruvate and lactate. Lactic Acid 75-82 insulin Homo sapiens 18-25 338101-4 1977 Acebutolol potentiated the hypoglycaemic effect of insulin in tablet-treated diabetics (mean difference of blood glucose concentration 0.7 mmol/l (12.6 mg/100 ml)) and this difference was maintained during the recovery phase4 the blood lactate response was also impaired. Lactic Acid 236-243 insulin Homo sapiens 51-58 171158-6 1975 An important fraction of the extra glucose consumed under the influence of insulin was recovered as neither glycogen nor lactate, nor was it oxidized in the Krebs cycle. Lactic Acid 121-128 insulin Homo sapiens 75-82 1204766-1 1975 Tryptophan (4-10 mM) reduces the stimulating effect of insulin on glucose uptake, CO2 output and lactate production by adipose tissue. Lactic Acid 97-104 insulin Homo sapiens 55-62 402275-3 1977 When Ringer"s lactate solution was infused into a control group of subjects during surgery, plasma levels of insulin did not change during and after the surgery while plasma levels of glucose and free fatty acids increased gradually during this period. Lactic Acid 14-21 insulin Homo sapiens 109-116 402275-6 1977 In the group which was given the glucose load during infusion of only Ringer"s lactate solution, plasma levels of insulin significantly increased soon after the glucose load and the gradually decreased. Lactic Acid 79-86 insulin Homo sapiens 114-121 402275-7 1977 In another group which was given the glucose load during infusion of Ringer"s lactate and phentolamine, plasma levels of insulin also increased significantly after the glucose load and remained elevated during surgery. Lactic Acid 78-85 insulin Homo sapiens 121-128 1080305-5 1975 In the excess of exogenous lactate and pyruvate, the degree of the insulin stimulated respiration did not change. Lactic Acid 27-34 insulin Homo sapiens 67-74 5444845-0 1970 On the effect of insulin on lactate permeability through the nuclear membrane. Lactic Acid 28-35 insulin Homo sapiens 17-24 5158898-2 1971 In epididymal adipose tissue synthesizing fatty acids from fructose in vitro, addition of insulin led to a moderate increase in fructose uptake, to a considerable increase in the flow of fructose carbon atoms to fatty acid, to a decrease in the steady-state concentration of lactate and pyruvate in the medium, and to net uptake of lactate and pyruvate from the medium. Lactic Acid 275-282 insulin Homo sapiens 90-97 5158898-2 1971 In epididymal adipose tissue synthesizing fatty acids from fructose in vitro, addition of insulin led to a moderate increase in fructose uptake, to a considerable increase in the flow of fructose carbon atoms to fatty acid, to a decrease in the steady-state concentration of lactate and pyruvate in the medium, and to net uptake of lactate and pyruvate from the medium. Lactic Acid 332-339 insulin Homo sapiens 90-97 1124146-5 1975 Insulin-induced increases in lactate and pyruvate were inhibited to a varying degree, namely 78% (61-93%) and 44% (0.94%) respectively. Lactic Acid 29-36 insulin Homo sapiens 0-7 1229805-1 1975 The effect of propranolol on adrenaline- and insulin-induced changes in blood glucose pyruvate, lactate, phosphorus and potassium were examined in 29 apparently healthy volunteers. Lactic Acid 96-103 insulin Homo sapiens 45-52 1229805-3 1975 There was no significant change in the blood glucose curve after insulin whereas insulin-induced increases in pyruvate and lactate were reduced by 44% +/- 17.7 (mean +/- SEM) and 78% +/- 5.4 respectively, and the fall in phosphorus by 48% +/- 3.1; the decrease in potassium, however, was not significantly modified. Lactic Acid 123-130 insulin Homo sapiens 81-88 1229805-4 1975 These findings suggest that changes in plasma pyruvate, lactate and inorganic phosphates induced by insulin, and regarded as espressions of its peripheral metabolism, are greatly dependent on the beta-adrenergic effect of the endogenous catecholamines released during the time when blood glucose values are low. Lactic Acid 56-63 insulin Homo sapiens 100-107 242159-1 1975 In a case of lethal poisoning due to insulin a significant low level of lactic acid and a corresponding high pH value in the brain tissue were detected. Lactic Acid 72-83 insulin Homo sapiens 37-44 6023775-5 1967 Both insulin and cyanide increased lactate production in the presence of glucose. Lactic Acid 35-42 insulin Homo sapiens 5-12 5791115-0 1969 Insulin-like effects of puromycin on lactate metabolism in frog skeletal muscle. Lactic Acid 37-44 insulin Homo sapiens 0-7 6039828-0 1967 Insulin stimulation of lactate oxidation and incorporation into glycogen in frog skeletal muscle. Lactic Acid 23-30 insulin Homo sapiens 0-7 13816486-0 1959 [Behavior of the blood sugar, blood pyruvate and blood lactic acid after insulin loading in a group of 10 elderly diabetics]. Lactic Acid 55-66 insulin Homo sapiens 73-80 14408192-1 1960 V. The effect of a growth hormone preparation and insulin on the oxygen consumption, glucose uptake, and lactic acid production. Lactic Acid 105-116 insulin Homo sapiens 50-57 13646515-0 1959 [Effect of insulin on variations of serum lactic acid in labor]. Lactic Acid 42-53 insulin Homo sapiens 11-18 13806320-1 1959 Lactic acid production following insulin administration. Lactic Acid 0-11 insulin Homo sapiens 33-40 33671767-5 2021 In this study, we found lactic acid accumulated during insulin stimulation in cells, however, cellular MG and S-d-lactoylglutathione also increased due to the massive flux of glycolytic intermediates. Lactic Acid 24-35 insulin Homo sapiens 55-62 33609419-9 2021 Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized 13 C pyruvate-to-lactate reaction. Lactic Acid 169-176 insulin Homo sapiens 5-12 33600878-9 2021 Another important and original aspect of the reported work is that revelation that the pH, lactate and glucose levels increased under the stress conditions and the changes tended to be more pronounced in diabetic rats (both untreated and long-acting insulin-treated) compared to normal rats. Lactic Acid 91-98 insulin Homo sapiens 250-257 33965350-4 2021 That error is probably caused by a dysmetabolic signal from the foregut, stimulated by food, that limits entry of 2-carbon fragments into the tricarboxylic acid cycle, the accumulation of lactate and, in turn, increases in glucose and insulin. Lactic Acid 188-195 insulin Homo sapiens 235-242 33378577-11 2021 CONCLUSIONS: In our selected homogenous group of patients with T1DM treated with personal insulin pumps, higher CF was associated with lower percentage of body fat, male gender, higher lactate level after the CF test, and the PSS10 score. Lactic Acid 185-192 insulin Homo sapiens 90-97 33573178-9 2021 Both of the polyphenols increased insulin-stimulated glycogen synthesis and reduced lactate production in human myotubes. Lactic Acid 84-91 insulin Homo sapiens 34-41 31690627-4 2020 Insulin treatment increased glucose uptake and conversion to lactate, with the latter responding more to insulin than did other metabolic fates of glucose. Lactic Acid 61-68 insulin Homo sapiens 0-7 33247734-6 2020 The main substrate for renal gluconeogenesis is lactate and the process is regulated by insulin and cellular glucose levels, but also by acidosis and stress hormones. Lactic Acid 48-55 insulin Homo sapiens 88-95 32873953-5 2020 The change in plasma lactate correlated significantly with the change in insulin resistance. Lactic Acid 21-28 insulin Homo sapiens 73-80 32060497-10 2020 Baseline lactate and alanine were associated with baseline and 1-y changes of homeostasis model assessment of insulin resistance. Lactic Acid 9-16 insulin Homo sapiens 110-117 31690627-4 2020 Insulin treatment increased glucose uptake and conversion to lactate, with the latter responding more to insulin than did other metabolic fates of glucose. Lactic Acid 61-68 insulin Homo sapiens 105-112 30199916-4 2019 RESULTS: The serum high-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment of insulin resistance (HOMA-IR) levels and odds ratios (ORs) for MS increased across the blood lactate or UA level tertiles (all P for trend<0.05). Lactic Acid 192-199 insulin Homo sapiens 100-107 31801490-7 2019 Partial least squares discriminant analysis showed a significant difference in the metabolic profile between the fasting and carbohydrate groups, compatible with the endocrine effects of insulin (i.e., increased serum-lactate and pyruvate and decreased ketone bodies and amino acids in the carbohydrate group). Lactic Acid 218-225 insulin Homo sapiens 187-194 30868510-8 2019 Fasting plasma lactate shows a significant association with a wide range of insulin sensitivity/resistance indexes based on fasting plasma samples (HOMA-S, adipose IR index, Revised-QUICKI, leptin-adiponectin ratio, TyG index, McAuley index and TG-to-HDL-C ratio), as well as OGTT-based measures such as the Matsuda index, the hepatic insulin resistance index, and the disposition index. Lactic Acid 15-22 insulin Homo sapiens 76-83 31311004-5 2019 When steady state was reached, insulin-stimulated mice were rapidly infused with hyperpolarized [1-13C]pyruvate for real-time tracking of the dynamic distribution of metabolic derivatives from pyruvate, such as [1-13C]lactate, [1-13C]alanine and [13C]bicarbonate. Lactic Acid 218-225 insulin Homo sapiens 31-38 31233407-4 2019 Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the nonfentanyl than in the fentanyl group. Lactic Acid 249-256 insulin Homo sapiens 197-204 31946576-1 2019 Blood lactate is an important biomarker that has been linked to morbidity and mortality of critically ill patients, acute ischemic stroke, septic shock, lung injuries, insulin resistance in diabetic patients, and cancer. Lactic Acid 6-13 insulin Homo sapiens 168-175 30107041-10 2018 CONCLUSIONS: Abnormal mitochondrial function in human white adipose tissue likely contributes to the secretion of lipid metabolites and lactate, which are linked to insulin resistance in peripheral tissues. Lactic Acid 136-143 insulin Homo sapiens 165-172 30913535-5 2019 We demonstrated that the glucose uptake in cultured GCs and lactate accumulation in the culture medium were stimulated by insulin, but the effects of insulin were attenuated by PA treatment. Lactic Acid 60-67 insulin Homo sapiens 122-129 30548433-7 2018 The increased lactate to pyruvate ratio over time showed an exponential correlation with insulin, glucagon and free fatty acids. Lactic Acid 14-21 insulin Homo sapiens 89-96 28120013-0 2017 Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria. Lactic Acid 114-125 insulin Homo sapiens 87-94 28899812-10 2017 Elevated insulin with low bioavailable glucose cross the BBB hyper-activating neurons to preserve brain function, thereby overloading the astrocyte-neuron lactate shuttle. Lactic Acid 155-162 insulin Homo sapiens 9-16 28208845-2 2016 Increased blood lactate concentration and alterations of substrate utilization are partly involved in development of insulin resistance in GDM. Lactic Acid 16-23 insulin Homo sapiens 117-124 28966262-6 2017 The insulin-containing LbL films can be prepared not only on the surface of flat substrates, such as quartz slides, but also on the surface of microparticles, such as poly(lactic acid) (PLA) microbeads. Lactic Acid 172-183 insulin Homo sapiens 4-11 26299332-12 2016 CONCLUSIONS: Mild metabolic acidosis, measured by plasma lactate, aligns with insulin resistance independent of obesity and is induced by short-term increases in energy and dietary acid load in healthy humans. Lactic Acid 57-64 insulin Homo sapiens 78-85 27060006-4 2016 The Akt phosphorylation and lactate production were increased after insulin treatment. Lactic Acid 28-35 insulin Homo sapiens 68-75 27060006-5 2016 Pre-treatment with PI3-K inhibitor attenuated insulin-induced phosphorylation of Akt and lactate accumulation. Lactic Acid 89-96 insulin Homo sapiens 46-53 27060006-6 2016 However, after treating GCs with different concentrations of testosterone for 5 days, insulin-induced phosphorylation of Akt and lactate production showed no significant change comparing with those of control cells. Lactic Acid 129-136 insulin Homo sapiens 86-93 27060006-8 2016 In conclusion, insulin activates PI3-K/Akt signaling pathway and promotes lactate production in ovarian GCs, but high androgen exerted no obvious influence on insulin signaling pathway and metabolic effect in GCs, suggesting that metabolic actions of insulin in ovarian GCs were unaffected by hyperandrogenism directly. Lactic Acid 74-81 insulin Homo sapiens 15-22 26122286-2 2015 Studies suggest a link between increased lactate levels and the manifestation and progression of insulin resistance. Lactic Acid 41-48 insulin Homo sapiens 97-104 28077918-4 2016 Conversely, high lactate contribute to a higher insulin resistant status and a more malignant phenotype of cancer cells, promoting diabetes and cancer development and progression. Lactic Acid 17-24 insulin Homo sapiens 48-55 27221120-4 2016 In response to insulin, plasma lactate was elevated in aged individuals when normalized to insulin action. Lactic Acid 31-38 insulin Homo sapiens 15-22 27221120-6 2016 Changes in insulin-stimulated PDH phosphorylation were positively related to changes in plasma lactate. Lactic Acid 95-102 insulin Homo sapiens 11-18 27221120-8 2016 Twelve weeks of endurance- or strength-oriented exercise training improved insulin-stimulated PDH dephosphorylation, which was related to a reduced lactate response. Lactic Acid 148-155 insulin Homo sapiens 75-82 25844530-1 2015 Chronic elevated lactate levels are associated with insulin resistance in patients with type 2 diabetes mellitus (T2DM). Lactic Acid 17-24 insulin Homo sapiens 52-59 23762265-3 2013 In this study, we showed that insulin decreased miR-99a expression levels, but induced glucose consumption and lactate production, and increased the expression of mTOR, HIF-1alpha and PKM2 in HepG2 and HL7702 cells. Lactic Acid 111-118 insulin Homo sapiens 30-37 24841383-6 2015 IGF-1 and insulin also rescued energy levels in HD peripheral cells, as evaluated by increased ATP and phosphocreatine, and decreased lactate levels. Lactic Acid 134-141 insulin Homo sapiens 10-17 26118086-5 2014 Excess of the formation lactate and pyruvate on background of the effect anty-insulin hormone prevalence and relative insufficiency of the insulin realizes the independent contribution to development hyperglicemia disorders. Lactic Acid 24-31 insulin Homo sapiens 78-85 24895527-0 2014 Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2. Lactic Acid 42-49 insulin Homo sapiens 0-7 24895527-5 2014 Furthermore, the knockdown of PKM2 expression also inhibited cancer cell growth and insulin-induced glucose consumption and lactate production, suggesting that PKM2 is a functional downstream effecter of insulin. Lactic Acid 124-131 insulin Homo sapiens 84-91 25439266-4 2015 Compared to baseline concentrations (at 0 min), insulin infusion decreased (P < 0.05) plasma concentrations of glucagon, non-esterified fatty acids (NEFA), lactate, nonessential amino acids (NEAA), branched-chain amino acids (BCAA), total amino acids (TAA) and urea nitrogen (UN). Lactic Acid 159-166 insulin Homo sapiens 48-55 25133511-9 2014 In addition, secretion of lactate, a byproduct of glycolysis, was shown to mediate insulin-dependent HSD11B2 downregulation. Lactic Acid 26-33 insulin Homo sapiens 83-90 25133511-10 2014 In summary, we demonstrate that insulin downregulates HSD11B2 through increased LIP expression and augmented lactate secretion. Lactic Acid 109-116 insulin Homo sapiens 32-39 24176820-6 2013 In Cox proportional hazards models, baseline plasma lactate (per 10 mg/dL) was significantly associated with diabetes (hazard ratio, 1.20; 95% confidence interval, 1.01-1.43), even after adjustment for diabetes risk factors, fasting glucose, and insulin. Lactic Acid 52-59 insulin Homo sapiens 246-253 23382451-8 2013 Changes in beta-hydroxybutyrate, isoleucine, lactate, and pyridoxate were blunted in those with insulin resistance. Lactic Acid 45-52 insulin Homo sapiens 96-103 23354340-4 2013 This technique is especially useful when combined with tasks designed to rely on specific brain regions and/or acute pharmacological manipulation; for example, hippocampal measurements during a spatial working memory task (spontaneous alternation) show a dip in extracellular glucose and rise in lactate that are suggestive of enhanced glycolysis, and intrahippocampal insulin administration both improves memory and increases hippocampal glycolysis. Lactic Acid 296-303 insulin Homo sapiens 369-376 23751582-8 2013 The insulin level on admission (41.47 +- 30.85) mU/L were positively correlated with lactic acid (2.29 +- 1.81) mmol/L and procalcitonin level (5.08 +- 6.70) ng/ml (r = 0.370, P = 0.000; r = 0.168, P = 0.002) (P < 0.01). Lactic Acid 85-96 insulin Homo sapiens 4-11 23510829-11 2013 Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate"s association with carotid atherosclerosis may be related to insulin resistance. Lactic Acid 121-128 insulin Homo sapiens 87-94 23510829-11 2013 Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate"s association with carotid atherosclerosis may be related to insulin resistance. Lactic Acid 121-128 insulin Homo sapiens 190-197 22146232-5 2012 RESULTS: Insulin deprivation resulted in decreased lactate production and in decrease of glucose consumption that was completely reverted after 6h. Lactic Acid 51-58 insulin Homo sapiens 9-16 23383072-10 2013 CONCLUSIONS: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Lactic Acid 13-20 insulin Homo sapiens 162-169 22146232-7 2012 In insulin-deprived cells, transcript levels of genes associated to lactate metabolism (LDHA and MCT4) were decreased. Lactic Acid 68-75 insulin Homo sapiens 3-10 22146232-9 2012 Insulin-deprived hSCs presented: 1) altered glucose consumption and lactate secretion; 2) altered expression of metabolism-associated genes involved in lactate production and export; 3) an adaptation of glucose uptake by modulating the expression of GLUT1 and GLUT3. Lactic Acid 68-75 insulin Homo sapiens 0-7 22146232-9 2012 Insulin-deprived hSCs presented: 1) altered glucose consumption and lactate secretion; 2) altered expression of metabolism-associated genes involved in lactate production and export; 3) an adaptation of glucose uptake by modulating the expression of GLUT1 and GLUT3. Lactic Acid 152-159 insulin Homo sapiens 0-7 21902860-4 2011 Lactate inhibits lipolysis in adipose tissue by mediating, through GPR81, the anti-lipolytic action of insulin. Lactic Acid 0-7 insulin Homo sapiens 103-110 21977308-11 2011 Lactate levels were 23.0 vs 23.4 in the insulin-metformin and insulin only groups when the study was started, respectively. Lactic Acid 0-7 insulin Homo sapiens 40-69 21262869-6 2011 Insulin was directly and significantly related to glycaemia (p = 0.0006), body mass index (BMI) (p = 0.00028) and lactate (p = 0.0096) In the early phase of STEMI without previously known diabetes the acute glucose dysmetabolism is quite complex, comprising increased glucose values and the development of acute insulin resistance. Lactic Acid 114-121 insulin Homo sapiens 0-7 21434616-9 2011 Finally, with these new values of log beta, the predicted percent distribution of an insulin-enhancing VO(2+) agent between the high molecular mass (hTf, HSA, and IgG) and low molecular mass (lactate) components of the blood serum at physiological conditions is calculated. Lactic Acid 192-199 insulin Homo sapiens 85-92 20634790-7 2010 Insulin administration was associated with significantly reduced cerebral glucose concentrations and significantly increased lactate-to-glucose ratios with arterial blood glucose levels <5 mM. Lactic Acid 125-132 insulin Homo sapiens 0-7 20634790-5 2010 RESULTS: The impact of different arterial blood glucose values and concomitant insulin administration on cerebral interstitial glucose and lactate levels was investigated. Lactic Acid 139-146 insulin Homo sapiens 79-86 20634790-8 2010 At arterial blood glucose levels >7 mM, insulin administration was associated with significantly increased interstitial glucose values, significantly decreased lactate concentrations, and markedly diminished lactate-to-glucose ratios. Lactic Acid 163-170 insulin Homo sapiens 43-50 20634790-8 2010 At arterial blood glucose levels >7 mM, insulin administration was associated with significantly increased interstitial glucose values, significantly decreased lactate concentrations, and markedly diminished lactate-to-glucose ratios. Lactic Acid 211-218 insulin Homo sapiens 43-50 20634790-11 2010 However, at arterial blood glucose levels >7-8 mM, insulin administration appears to be encouraged to increase extracellular glucose concentrations and decrease energetic impairment reflected by reduced interstitial brain lactate and decreased lactate-to-glucose ratios. Lactic Acid 225-232 insulin Homo sapiens 54-61 20634790-11 2010 However, at arterial blood glucose levels >7-8 mM, insulin administration appears to be encouraged to increase extracellular glucose concentrations and decrease energetic impairment reflected by reduced interstitial brain lactate and decreased lactate-to-glucose ratios. Lactic Acid 247-254 insulin Homo sapiens 54-61 20374952-1 2010 ): lactate involvement in insulin antilipolytic action. Lactic Acid 3-10 insulin Homo sapiens 26-33 19741411-11 2009 CONCLUSION: This data may indicate that exposure to bacterial cell wall components and insulin could create cellular environments that result in a build-up of lactate. Lactic Acid 159-166 insulin Homo sapiens 87-94 19264418-14 2009 Thus, we hypothesize that the combination of hypoglycaemia induced by insulin and concomitant lactate administration will selectively suppress cancers manifesting the Warburg effect, since such cancers will have great difficulty in metabolizing lactate. Lactic Acid 245-252 insulin Homo sapiens 70-77 18674921-4 2008 The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. Lactic Acid 95-102 insulin Homo sapiens 20-27 19001513-13 2009 A level of metformin (125 microm) insufficient for the stimulation of lactate output when used alone potentiated the effects of suboptimal doses of insulin on lactate production. Lactic Acid 159-166 insulin Homo sapiens 148-155 19001513-16 2009 Metformin also enhances the action of suboptimal insulin concentrations to stimulate lactate production. Lactic Acid 85-92 insulin Homo sapiens 49-56 18184925-0 2008 Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance. Lactic Acid 22-29 insulin Homo sapiens 109-116 18184925-3 2008 RESEARCH DESIGN AND METHODS: We performed intracerebroventricular (ICV) administration of lactate to enhance central lactate metabolism in 1) early-onset streptozotocin-induced uncontrolled diabetic rodents, 2) experimentally induced hypoinsulinemic normal rodents, and 3) early-onset diet-induced insulin-resistant rodents. Lactic Acid 90-97 insulin Homo sapiens 238-245 18184925-7 2008 Third, and finally, ICV lactate administration lowered glucose production in normal rodents with diet-induced insulin resistance. Lactic Acid 24-31 insulin Homo sapiens 110-117 18184925-8 2008 CONCLUSIONS: Central lactate metabolism lowered glucose production in uncontrolled diabetic and normal rodents with hypoinsulinemia and in rodents with diet-induced insulin resistance. Lactic Acid 21-28 insulin Homo sapiens 120-127 17244784-8 2007 Elevated intrafollicular insulin levels in overweight women (P=0.004) were accompanied by normal glucose and lactate levels. Lactic Acid 109-116 insulin Homo sapiens 25-32 17114876-15 2008 Its lower increase may be due, in addition to the characteristics of their chest walls, to insulin resistance which may limit the increase in lactic acid during effort, and to the hypertrophy of muscle fibers previously noted, which may be linked to a lower increase in plasma K(+) during physical exercise. Lactic Acid 142-153 insulin Homo sapiens 91-98 18036907-9 2007 The high-dose insulin therapy group had early extraction of lactate and higher oxygen extraction immediately postoperatively compared with the standard group. Lactic Acid 60-67 insulin Homo sapiens 14-21 18271251-0 2007 [Expression of human insulin in lactic acid bacteria and its oral administration in non-obese diabetic mice]. Lactic Acid 32-43 insulin Homo sapiens 21-28 17956836-0 2007 Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients. Lactic Acid 61-68 insulin Homo sapiens 0-7 17956836-7 2007 CONCLUSION: In HIV+NRTI+ patients, both resting and postexercise levels of lactate were related to insulin resistance rather than mtDNA alterations in skeletal muscle. Lactic Acid 75-82 insulin Homo sapiens 99-106 17339414-14 2007 Insulin did not increase conversion of glucose to CO(2), lactate, or total lipid in steers fed hay but caused an increase (per cell) of 97 to 110% in glucose conversion to CO(2), 46 to 54% in glucose conversion to lactate, and 65 to 160% in glucose conversion to total lipid content in adipose tissue from steers fed corn. Lactic Acid 214-221 insulin Homo sapiens 0-7 17077346-0 2007 Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women. Lactic Acid 0-7 insulin Homo sapiens 75-82 17321040-7 2007 Insulin treatment partially prevented the inhibitory effects of CLA on glucose uptake and induced a significant increase (P<0.05-0.01) in the percentage of glucose metabolized to lactate. Lactic Acid 182-189 insulin Homo sapiens 0-7 17077346-6 2007 During insulin infusion, lactate release in the controls increased to 1.92+/-0.26 in SM (P<0.005) and to 1.14+/-0.22 in AT (P<0.005) but remained unchanged in the obese women. Lactic Acid 25-32 insulin Homo sapiens 7-14 17077346-8 2007 The ability to increase lactate release in response to insulin is impaired in AT and SM in insulin-resistant obese women, involving defective insulin regulation of both tissue lactate metabolism and local blood flow. Lactic Acid 24-31 insulin Homo sapiens 55-62 17077346-8 2007 The ability to increase lactate release in response to insulin is impaired in AT and SM in insulin-resistant obese women, involving defective insulin regulation of both tissue lactate metabolism and local blood flow. Lactic Acid 24-31 insulin Homo sapiens 91-98 17077346-8 2007 The ability to increase lactate release in response to insulin is impaired in AT and SM in insulin-resistant obese women, involving defective insulin regulation of both tissue lactate metabolism and local blood flow. Lactic Acid 24-31 insulin Homo sapiens 91-98 17077346-8 2007 The ability to increase lactate release in response to insulin is impaired in AT and SM in insulin-resistant obese women, involving defective insulin regulation of both tissue lactate metabolism and local blood flow. Lactic Acid 176-183 insulin Homo sapiens 55-62 16943110-0 2006 [The effects of insulin given prior to release of cross-clamp on coronary sinus lactate levels in coronary artery surgery]. Lactic Acid 80-87 insulin Homo sapiens 16-23 16487595-9 2007 CONCLUSIONS: Fasting EGP, GOX and insulin resistance may be major determinants of fasting lactate levels in HIV-infected patients on HAART. Lactic Acid 90-97 insulin Homo sapiens 34-41 16505665-8 2006 However, intensive insulin therapy was associated with increased incidence of microdialysis markers of cellular distress, namely elevated glutamate (38+/-37% vs. 10+/-17%, p<.01), elevated lactate/pyruvate ratio (38+/-37% vs. 19+/-26%, p<.03) and low glucose (26+/-17% vs. 11+/-15%, p<.05, and increased global oxygen extraction fraction. Lactic Acid 192-199 insulin Homo sapiens 19-26 16494630-9 2006 CONCLUSION: Plasma triglyceride, alanine, glucagon, lactate and TNF-alpha may be associated with alterations in the first-phase prehepatic insulin secretion response to intravenous glucose in normoglycaemic lipodystrophic HIV-infected patients. Lactic Acid 52-59 insulin Homo sapiens 139-146 16567513-7 2006 This upregulation would potentially allow a similar twofold increase in the transport of other MCAs, including lactate, during insulin-induced hypoglycemia. Lactic Acid 111-118 insulin Homo sapiens 127-134 16494630-0 2006 Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy. Lactic Acid 112-119 insulin Homo sapiens 30-37 16505665-10 2006 CONCLUSIONS: Intensive insulin therapy results in a net reduction in microdialysis glucose and an increase in microdialysis glutamate and lactate/pyruvate without conveying a functional outcome advantage. Lactic Acid 138-145 insulin Homo sapiens 23-30 16039195-5 2005 RESULTS: The lactate clearance was faster (p = 0.046), and the lactate levels (p = 0.016), blood glucose levels (p < 0.001), and free fatty acid levels (p < 0.001) were lower in the insulin group postoperatively. Lactic Acid 13-20 insulin Homo sapiens 188-195 16206112-2 2005 We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance. Lactic Acid 185-192 insulin Homo sapiens 204-211 16206112-13 2005 These data raise the possibility that insulin resistance may be an additional mechanism through which NRTI therapy is related to lactate level. Lactic Acid 129-136 insulin Homo sapiens 38-45 16308838-9 2005 The hypothesis of abnormal transport or metabolism of lactate/pyruvate in the beta-cells of patients with EIHI was further supported by the parallel increase of lactate and insulin in this study elicited in particular by anaerobic exercise. Lactic Acid 54-61 insulin Homo sapiens 173-180 16102994-6 2005 Lactate production increased 56 and 173% in the presence of 10 and 100 nM insulin, respectively. Lactic Acid 0-7 insulin Homo sapiens 74-81 16039195-9 2005 CONCLUSIONS: The high-dose insulin treatment was associated with lower blood glucose levels, better preserved myocardial contractile function, and less need for inotropic support, and hence led to lower lactate levels postoperatively. Lactic Acid 203-210 insulin Homo sapiens 27-34 15769984-5 2005 Addition of human chorionic gonadotropin (hCG) (100 ng/ml) stimulated progesterone production (7.0-fold, P < 0.001 vs. control), whereas lactate was increased by hCG (1.6-fold, P < 0.001) and insulin (1.4-fold, P < 0.001; 1000 ng/ml). Lactic Acid 140-147 insulin Homo sapiens 198-205 16092062-1 2005 Increased blood lactate concentration and alterations of substrate utilization have been shown to be partly involved in development of insulin resistance in obese and type 2 diabetic patients. Lactic Acid 16-23 insulin Homo sapiens 135-142 15533600-3 2004 Insulin caused a marked increase of glucose consumption and lactate production by incubated slices of mammary gland but had no effect on both microregions of the tumor. Lactic Acid 60-67 insulin Homo sapiens 0-7 15539436-8 2005 Insulin and LH stimulated lactate production in a dose-dependent manner, but insulin-dependent lactate production was markedly impaired in granulosa-lutein cells from anovPCO compared with either normal (P=0.002) or ovPCO (P<0.0001). Lactic Acid 26-33 insulin Homo sapiens 0-7 15539436-8 2005 Insulin and LH stimulated lactate production in a dose-dependent manner, but insulin-dependent lactate production was markedly impaired in granulosa-lutein cells from anovPCO compared with either normal (P=0.002) or ovPCO (P<0.0001). Lactic Acid 95-102 insulin Homo sapiens 77-84 15070396-6 2004 Treatment with insulin quadrupled the lactate/pyruvate ratio during hypoxia, but did not change hypoxic vasodilation. Lactic Acid 38-45 insulin Homo sapiens 15-22