PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32615095-11	2020	After the addition of AKT activator to cultures of Per2-overexpressed OSCC cells, reduced glucose uptake, lactic acid production, and cell proliferation, combined with increased apoptosis, were substantially reversed.	Lactic Acid	106-117	thymoma viral proto-oncogene 1	Mus musculus	22-25	
15794940-3	2005	Increased Akt protein expression was associated with reduced phospho-AMP-activated protein kinase abundance and with a fall in the phosphorylation of acetyl-CoA carboxylase, which in turn resulted in an increase in the content of muscular malonyl-CoA (2.4-fold, P<0.05) and lactate (1.4-fold, P<0.05).	Lactic Acid	277-284	thymoma viral proto-oncogene 1	Mus musculus	10-13	
35551947-7	2022	Intriguingly, a shift in glucose metabolism that restricts lactate production in Sertoli cells was induced upon Smtnl2 depletion, leading to the activation of downstream AMPK and AKT signaling.	Lactic Acid	59-66	thymoma viral proto-oncogene 1	Mus musculus	179-182	
30865888-5	2019	Elevation of lactate activates AKT and STAT3 signaling in the hypothalamic neurons, leading to increased expression of Pomc and suppression of Agrp.	Lactic Acid	13-20	thymoma viral proto-oncogene 1	Mus musculus	31-34	
31761722-5	2019	The endothelial PTEN/Akt pathway increases monocarboxylic acid transporter 1 (MCT1) expression to enhance lactate transport across the brain endothelium.	Lactic Acid	106-113	thymoma viral proto-oncogene 1	Mus musculus	21-24	
31761722-6	2019	Moreover, cerebrovascular overexpression of MCT1 or deletion of Akt1 restores MCT1 expression, decreases lactate levels, and normalizes hippocampal neurogenesis and cognitive function in PTEN mutant mice.	Lactic Acid	105-112	thymoma viral proto-oncogene 1	Mus musculus	64-68	
28978011-4	2017	In both cultured liver cancer cells and liver tissues in DEN-induced transgenic HCC model mice, we observed that AR overexpression-induced AKT/mTOR signaling tended to enhance lactate formation and hepatic inflammation to enhance hepatocarcinogenesis.	Lactic Acid	176-183	thymoma viral proto-oncogene 1	Mus musculus	139-142	
23886627-5	2013	On the other hand, subcellular distribution of the enzyme also depends on the stress and pro-survival signals mediated by the Akt and the p38 pathways and, in non-proliferating cells, on the availability of glucose and lactate.	Lactic Acid	219-226	thymoma viral proto-oncogene 1	Mus musculus	126-129	
26208479-4	2015	Furthermore, AKT1 silencing resulted in decreased expression of the lactate/H+ symporter MCT4 and its chaperone CD147/Basigin, and in the induction of estrogen receptor beta (ERbeta) expression.	Lactic Acid	68-75	thymoma viral proto-oncogene 1	Mus musculus	13-17