PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9593038-3	1998	The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6.	Lactic Acid	27-34	interleukin 1 beta	Homo sapiens	66-88	
9041915-11	1997	The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability.	Lactic Acid	261-268	interleukin 1 beta	Homo sapiens	26-35	
8163567-1	1994	Addition of human, recombinant interleukin-1 beta (hrIL-1 beta) to cultures of lapine articular chondrocytes provoked a delayed increase in the production of both nitric oxide (NO) and lactate.	Lactic Acid	185-192	interleukin 1 beta	Homo sapiens	31-49	
29207019-0	2018	Stromal-epithelial lactate shuttle induced by tumor-derived interleukin-1beta promotes cell proliferation in oral squamous cell carcinoma.	Lactic Acid	19-26	interleukin 1 beta	Homo sapiens	60-77	
33481676-4	2021	We have recently reported that in carcinoma Caco-2/pRS26 cells (shRNA for CFTR) or CF lung epithelial IB3-1 cells, the CFTR failure decreased mitochondrial Complex I activity due to an autocrine IL1B loop, and increased lactic acid production.	Lactic Acid	220-231	interleukin 1 beta	Homo sapiens	195-199	
29108965-6	2018	Furthermore, administration of IL-1beta into the airways stimulated lactate production and expression of glycolytic enzymes, with notable expression of lactate dehydrogenase A occurring in the airway epithelium.	Lactic Acid	68-75	interleukin 1 beta	Homo sapiens	31-39	
29108965-13	2018	A positive correlation was observed between sputum lactate and IL-1beta levels, and lactate content correlated negatively with lung function.	Lactic Acid	51-58	interleukin 1 beta	Homo sapiens	63-71	
2787856-5	1989	In CSF2 the mean IL-1 beta concentration was 135 +/- 343 pg/ml, and IL-1 beta concentrations correlated significantly with CSF2 leukocyte count, with glucose, lactate, protein, and tumor necrosis factor concentrations, and with neurologic sequelae.	Lactic Acid	159-166	interleukin 1 beta	Homo sapiens	68-77	
29207019-3	2018	In the present study, anaerobic glycolysis of cancer-associated fibroblasts (CAFs) was evaluated and the role of IL-1beta in regulating stromal-epithelial lactate shuttle was determined.	Lactic Acid	155-162	interleukin 1 beta	Homo sapiens	113-121	
29207019-11	2018	These results indicate that tumor-derived IL-1beta enhanced stromal glycolysis and induced one-way lactate flow from the tumor mesenchyme to transformed epithelium, which promotes OSCC proliferation.	Lactic Acid	99-106	interleukin 1 beta	Homo sapiens	42-50	
26363456-5	2015	HG and IL-1beta decrease MCT4 and its location on plasma membrane, as well as increase lactic acid accumulation and apoptosis in HUVECs.	Lactic Acid	87-98	interleukin 1 beta	Homo sapiens	7-15	
19019580-9	2009	CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta.	Lactic Acid	4-11	interleukin 1 beta	Homo sapiens	54-62	
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	49-60	interleukin 1 beta	Homo sapiens	71-79	
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	interleukin 1 beta	Homo sapiens	71-79	
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	interleukin 1 beta	Homo sapiens	71-79	
21131367-10	2011	IL-1beta also increased IL-17A expression; however, IL-1beta, CARD9 and MyD88 signaling pathways activated by known intrinsic inflammatory mediators were hardly required for the enhanced activity induced by lactic acid.	Lactic Acid	207-218	interleukin 1 beta	Homo sapiens	0-8	
22924724-8	2012	At 0 hours, IL-1beta expression was correlated with plasma fibrinogen concentration in healthy foals and with the neutrophil-to-lymphocyte ratio in foals with sepsis; IL-8 expression was correlated with monocyte count in foals with sepsis and with arterial pH, plasma fibrinogen concentration, and plasma lactate concentration in foals with peripartum asphyxia syndrome.	Lactic Acid	305-312	interleukin 1 beta	Homo sapiens	12-20	
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Lactic Acid	59-70	interleukin 1 beta	Homo sapiens	145-153	
14749204-6	2004	Although both IL-1beta and TGF-beta1 enhance glucose transport in chondrocytes to a similar magnitude, IL-1beta induces significantly higher levels of lactate.	Lactic Acid	151-158	interleukin 1 beta	Homo sapiens	103-111	
16123165-1	2005	In testicular Sertoli cells, IL-1beta regulates steroid, lactate, and transferrin secretion; although each influences germ cell development and spermatogenesis, little is known about the signaling mechanisms involved.	Lactic Acid	57-64	interleukin 1 beta	Homo sapiens	29-37	
15496611-6	2004	IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p > 0.1).	Lactic Acid	71-78	interleukin 1 beta	Homo sapiens	0-9	
15934951-0	2005	Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures.	Lactic Acid	0-7	interleukin 1 beta	Homo sapiens	64-81	
12115742-10	2002	IL-1beta increased glucose consumption and lactate production throughout the treatment.	Lactic Acid	43-50	interleukin 1 beta	Homo sapiens	0-8	
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Lactic Acid	95-102	interleukin 1 beta	Homo sapiens	44-52