PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24646266-6 2014 Glyoxalase II catalyses the hydrolysis of S-D-lactoylglutathione to D-lactate and glutathione. Lactic Acid 68-77 hydroxyacylglutathione hydrolase Homo sapiens 0-13 26594764-2 2015 GLO I catalyzes the reaction to transform hemimercaptal, a compound formed from methylglyoxal (MG) and reduced glutathione, into S-D-lactoylglutathione, which is then converted to D-lactic acid by glyoxalase II. Lactic Acid 180-193 hydroxyacylglutathione hydrolase Homo sapiens 197-210 24333633-3 2014 In this work we found that SLG (S-D-lactoylglutathione), an intermediate of the glyoxalase system, can enter the mitochondria and there be hydrolyzed from mitochondrial glyoxalase II enzyme to D-lactate and GSH. Lactic Acid 193-202 hydroxyacylglutathione hydrolase Homo sapiens 169-182 20387042-3 2010 Subsequently, SLG is converted to lactate by Gly II and one molecule of reduced glutathione is recycled back into the system. Lactic Acid 34-41 hydroxyacylglutathione hydrolase Homo sapiens 45-51 21310261-2 2011 In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6). Lactic Acid 147-156 hydroxyacylglutathione hydrolase Homo sapiens 250-254 24252591-6 2014 In addition, transduced Tat-GLO protein increased D-lactate in MG- and H2O2-treated cells whereas glycation end products (AGE) and MG levels were significantly reduced in the same cells. Lactic Acid 50-59 hydroxyacylglutathione hydrolase Homo sapiens 28-31 8504817-4 1993 The rate of hydrolysis of S-D-lactoylglutathione to reduced glutathione and D-lactate, catalysed by glyoxalase II, followed Michaelis-Menten kinetics where the Km and kcat values were 146 +/- 9 microM and 727 +/- 16 s-1, respectively in 50 mM Tris/HCl, pH 7.4 at 37 degrees C. Other S-2-hydroxyacylglutathione derivatives were also acceptable substrates. Lactic Acid 76-85 hydroxyacylglutathione hydrolase Homo sapiens 100-113 18533362-4 2008 Subsequently, glyoxalase II catalyzes the hydrolysis of this thiolester into D-lactic acid and free glutathione. Lactic Acid 77-90 hydroxyacylglutathione hydrolase Homo sapiens 14-27 18946510-1 2008 BACKGROUND: Glyoxalases (Glo1 and Glo2) are involved in the glycolytic pathway by detoxifying the reactive methylglyoxal (MGO) into D-lactate in a two-step reaction using glutathione (GSH) as cofactor. Lactic Acid 132-141 hydroxyacylglutathione hydrolase Homo sapiens 34-38 14976196-6 2004 Mono-(lactoyl)trypanothione and bis-(lactoyl)trypanothione are hydrolyzed by T. brucei glyoxalase II with k(cat)/K(m) values of 5 x 10(5) m(-1) s(-1) and 7 x 10(5) m(-1) s(-1), respectively, yielding d-lactate and regenerating trypanothione. Lactic Acid 200-209 hydroxyacylglutathione hydrolase Homo sapiens 87-100 10508780-1 1999 BACKGROUND: Glyoxalase II, the second of two enzymes in the glyoxalase system, is a thiolesterase that catalyses the hydrolysis of S-D-lactoylglutathione to form glutathione and D-lactic acid. Lactic Acid 178-191 hydroxyacylglutathione hydrolase Homo sapiens 12-25 2776650-2 1989 Glyoxalase I and glyoxalase II metabolise methylglyoxal to D-lactic acid, via the intermediate S-D-lactoylglutathione. Lactic Acid 59-72 hydroxyacylglutathione hydrolase Homo sapiens 17-30 259500-2 1978 Its metabolism to D-lactate (not the L-lactate of glycolysis) is catalysed by the mammalian enzymes glyoxalase I (S-lactoyl-glutathione methylglyoxal-lyase, isomerizing; EC 4.4.1.5) and glyoxalase II (S-2-hydroxyacylglutathione hydrolase; 3.1.2.6), with glutathione as a coenzyme. Lactic Acid 18-27 hydroxyacylglutathione hydrolase Homo sapiens 186-199 690442-1 1978 Glyoxalase I converts methylglyoxal and glutathione to S-lactoylglutathione and glyoxalase II converts this compound to D-lactic acid, regenerating glutathione in the process. Lactic Acid 120-133 hydroxyacylglutathione hydrolase Homo sapiens 80-93 30306863-2 2019 It is composed of Glyoxalase-I (Glo-I) and Glyoxalase- II which perform an essential metabolic process inside the cell by detoxifying endogenous harmful metabolites, mainly methylglyoxal (MG) into non-toxic D-lactic acid. Lactic Acid 207-220 hydroxyacylglutathione hydrolase Homo sapiens 43-57 31767537-5 2020 LGSH is hydrolyzed by glyoxalase 2 (GLO2), cycling glutathione and generating D-lactate. Lactic Acid 78-87 hydroxyacylglutathione hydrolase Homo sapiens 22-34 31767537-5 2020 LGSH is hydrolyzed by glyoxalase 2 (GLO2), cycling glutathione and generating D-lactate. Lactic Acid 78-87 hydroxyacylglutathione hydrolase Homo sapiens 36-40 28374736-2 2017 Upon the hydrolysis of the thioesters catalysed by glyoxalase II, inert (S)-alpha-hydroxy acids, that is, lactic acid, are then produced. Lactic Acid 106-117 hydroxyacylglutathione hydrolase Homo sapiens 51-64 29971290-1 2018 Glyoxalase II (GlxII) is an antioxidant glutathione-dependent enzyme, which catalyzes the hydrolysis of S-d-lactoylglutathione to form d-lactic acid and glutathione (GSH). Lactic Acid 135-148 hydroxyacylglutathione hydrolase Homo sapiens 0-13 29971290-1 2018 Glyoxalase II (GlxII) is an antioxidant glutathione-dependent enzyme, which catalyzes the hydrolysis of S-d-lactoylglutathione to form d-lactic acid and glutathione (GSH). Lactic Acid 135-148 hydroxyacylglutathione hydrolase Homo sapiens 15-20 28117708-3 2017 All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Lactic Acid 115-124 hydroxyacylglutathione hydrolase Homo sapiens 90-94 28358304-2 2017 It comprises two enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII), which act sequentially to convert MG into d-lactate, thereby helping living systems get rid of this otherwise cytotoxic byproduct of metabolism. Lactic Acid 115-124 hydroxyacylglutathione hydrolase Homo sapiens 50-63 28358304-2 2017 It comprises two enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII), which act sequentially to convert MG into d-lactate, thereby helping living systems get rid of this otherwise cytotoxic byproduct of metabolism. Lactic Acid 115-124 hydroxyacylglutathione hydrolase Homo sapiens 65-70 27935136-1 2016 Glyoxalase II, the second of 2 enzymes in the glyoxalase system, is a hydroxyacylglutathione hydrolase that catalyses the hydrolysis of S-d-lactoylglutathione to form d-lactic acid and glutathione, which is released from the active site. Lactic Acid 167-180 hydroxyacylglutathione hydrolase Homo sapiens 0-13