PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15496611-6 2004 IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p > 0.1). Lactic Acid 71-78 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 21934447-7 2011 The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL). Lactic Acid 59-70 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 21934447-8 2011 The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid. Lactic Acid 49-60 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 21934447-8 2011 The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid. Lactic Acid 120-131 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 21934447-8 2011 The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid. Lactic Acid 120-131 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 21300765-0 2011 Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Lactic Acid 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 21300765-4 2011 We found that lactate could enter endothelial cells through the monocarboxylate transporter MCT-1, trigger the phosphorylation/degradation of IkappaBalpha, and then stimulate an autocrine NF-kappaB/IL-8 (CXCL8) pathway driving cell migration and tube formation. Lactic Acid 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 198-202 21300765-4 2011 We found that lactate could enter endothelial cells through the monocarboxylate transporter MCT-1, trigger the phosphorylation/degradation of IkappaBalpha, and then stimulate an autocrine NF-kappaB/IL-8 (CXCL8) pathway driving cell migration and tube formation. Lactic Acid 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 204-209 21300765-7 2011 Finally, we documented in mouse xenograft models of human colorectal and breast cancer that lactate release from tumor cells through the MCT4 (and not MCT1) transporter is sufficient to stimulate IL-8-dependent angiogenesis and tumor growth. Lactic Acid 92-99 C-X-C motif chemokine ligand 8 Homo sapiens 196-200 21300765-8 2011 In conclusion, our findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-kappaB/IL-8 pathway as an important link between tumor metabolism and angiogenesis. Lactic Acid 110-117 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 16723241-1 2006 OBJECTIVE: Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines. Lactic Acid 11-18 C-X-C motif chemokine ligand 8 Homo sapiens 104-108 8124912-5 1993 However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose. Lactic Acid 76-83 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 9010051-4 1996 SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P < 0.001). Lactic Acid 44-51 C-X-C motif chemokine ligand 8 Homo sapiens 3-7 9010051-4 1996 SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P < 0.001). Lactic Acid 69-76 C-X-C motif chemokine ligand 8 Homo sapiens 3-7 34838662-8 2022 Long time to return of spontaneous circulation and high lactate level at admission were associated with increased complement activation (TCC and C3bc), pro-inflammatory cytokines (IL-6, IL-8) and endothelial injury (syndecan-1) at admission. Lactic Acid 56-63 C-X-C motif chemokine ligand 8 Homo sapiens 186-190 1612748-7 1992 IL-8 levels appeared to correlate significantly with lactate levels and inversely with leukocyte and platelet numbers and mean arterial pressure. Lactic Acid 53-60 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 33155332-9 2021 Moreover, L-lactic acid level was positively associated with serum CXCL8 level. Lactic Acid 10-23 C-X-C motif chemokine ligand 8 Homo sapiens 67-72 34459125-8 2021 Subsequently, TNF-alpha, IL-1beta, and lactate activated CAFs, and facilitated the secretion of IL-6, IL-7, IL-8, CCL5, and transforming growth factor-beta1 from CAFs. Lactic Acid 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 108-112 3123517-11 1988 Lactate, the principal product of resting neutrophil glucose catabolism, was demonstrable in cell-free supernatants after incubation at 37 degrees C. Lactate accumulation was inhibited by NaF and decreased temperature of incubation. Lactic Acid 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 188-191 707137-2 1978 In intact, sensitive cells, 6 mM NaF had no effect on glycolysis, whereas in homogenates, from both resistant and sensitive cells, lactate production was blocked by 6 mM NaF, indicating the cell membrane to be a barrier to fluoride. Lactic Acid 131-138 C-X-C motif chemokine ligand 8 Homo sapiens 170-173 35155394-4 2022 We engineered a model lactic acid bacterium, Lactococcus lactis, to co-display on its surface a protein ligand for tumor antigens (EpCAM-binding affitin; HER2-binding affibody) and a ligand for pro-inflammatory cytokines (IL-8-binding evasin; IL-6-binding affibody). Lactic Acid 22-33 C-X-C motif chemokine ligand 8 Homo sapiens 222-226 3123517-11 1988 Lactate, the principal product of resting neutrophil glucose catabolism, was demonstrable in cell-free supernatants after incubation at 37 degrees C. Lactate accumulation was inhibited by NaF and decreased temperature of incubation. Lactic Acid 150-157 C-X-C motif chemokine ligand 8 Homo sapiens 188-191 3857030-4 1985 Increasing the packing density of killed plaque residue of Streptococcus sanguis cells reduced D. Pre-incubation of plaque residue with sucrose or sucrose + NaF reduced D for lactate. Lactic Acid 175-182 C-X-C motif chemokine ligand 8 Homo sapiens 157-160 28736998-0 2017 Evasin-displaying lactic acid bacteria bind different chemokines and neutralize CXCL8 production in Caco-2 cells. Lactic Acid 18-29 C-X-C motif chemokine ligand 8 Homo sapiens 80-85 22473315-0 2012 Lactate-induced IL-8 pathway in endothelial cells--letter. Lactic Acid 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 23189959-4 2013 Lactate production, glucose uptake and the percentage of oocytes reaching metaphase II decreased in a dose-dependent manner in the presence of the pharmacological (NaF) or the physiological (ATP) inhibitors of glycolysis (p < 0.05). Lactic Acid 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 164-167 26558835-5 2016 The long-distance sculling intensity variables such as the average rating of perceived exertion, HR and blood lactate were correlated with changes in IL-8, IL-1alpha and IL-1beta levels (r=0.47 to r=0.59; P<0.05). Lactic Acid 110-117 C-X-C motif chemokine ligand 8 Homo sapiens 150-154 27262815-9 2016 The enhanced lactate contributed to TLR4 signaling activation, IL-6 and IL-8 generation, and cell viability promotion in MCF-7 cells. Lactic Acid 13-20 C-X-C motif chemokine ligand 8 Homo sapiens 72-76 23384547-12 2013 CONCLUSIONS: These findings suggest that decreased ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad1/5/8 in the presence of lactate. Lactic Acid 162-169 C-X-C motif chemokine ligand 8 Homo sapiens 69-72