PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32667776-7	2020	Neurons, which express primarily MCT2, were able to export lactate and maintain an intracellular pH homeostasis under similar conditions.	Lactic Acid	59-66	solute carrier family 16 member 7	Homo sapiens	33-37	
31178678-6	2019	Systemic pharmacological blocking of monocarboxylate transporter 2 (MCT2), which transports L-lactate to the brain, prevented lactate-induced neurogenesis, while 3,5-dihydroxybenzoic acid (3,5-DHBA), an agonist for the lactate-receptor hydroxycarboxylic acid receptor 1 (HCAR1), did not affect adult neurogenesis.	Lactic Acid	94-101	solute carrier family 16 member 7	Homo sapiens	37-66	
31178678-6	2019	Systemic pharmacological blocking of monocarboxylate transporter 2 (MCT2), which transports L-lactate to the brain, prevented lactate-induced neurogenesis, while 3,5-dihydroxybenzoic acid (3,5-DHBA), an agonist for the lactate-receptor hydroxycarboxylic acid receptor 1 (HCAR1), did not affect adult neurogenesis.	Lactic Acid	94-101	solute carrier family 16 member 7	Homo sapiens	68-72	
30143583-3	2018	Monocarboxylate transporter-2-knockout, which blocked the lactate shuttle in neurons, showed a remarkable decrease in the length of axons and dendrites.	Lactic Acid	58-65	solute carrier family 16 member 7	Homo sapiens	0-29	
26765963-5	2016	Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4.	Lactic Acid	0-7	solute carrier family 16 member 7	Homo sapiens	161-165	
27559140-3	2016	We tested for the effects of alpha-cyano-4-hydroxycinnamic acid (4-CIN), which could interfere with energy metabolism by blocking monocarboxylate-transporter 2 (MCT2)-mediated neuronal lactate uptake, on evoked potentials, stimulus-induced changes in K+, Na+, Ca2+, and oxygen concentrations as well as on changes in flavin adenine dinucleotide (FAD) autofluorescence in the hippocampal area CA3.	Lactic Acid	185-192	solute carrier family 16 member 7	Homo sapiens	161-165	
28092823-3	2017	One isoform, MCT2, has the highest affinity for lactate and thus should have the ability to respond to microenvironment conditions such as hypoxia, lactate, and pH to help maintain high glycolytic flux in the tumor.	Lactic Acid	48-55	solute carrier family 16 member 7	Homo sapiens	13-17	
28092823-3	2017	One isoform, MCT2, has the highest affinity for lactate and thus should have the ability to respond to microenvironment conditions such as hypoxia, lactate, and pH to help maintain high glycolytic flux in the tumor.	Lactic Acid	148-155	solute carrier family 16 member 7	Homo sapiens	13-17	
28092823-8	2017	Reporter analysis of nested-promoter constructs indicated response of MCT2 to hypoxia, pH, lactate, and glucose, the major physiological "players" that facilitate a tumor"s growth and proliferation.	Lactic Acid	91-98	solute carrier family 16 member 7	Homo sapiens	70-74	
26384349-4	2015	Lactate export was substantially suppressed to induce death along with lowering intracellular pH in MM cells by blockade of all three MCT molecules with alpha-cyano-4-hydroxy cinnamate (CHC) or the MCT1 and MCT2 inhibitor AR-C155858 in combination with MCT4 knockdown, although only partially by knockdown of each MCT.	Lactic Acid	0-7	solute carrier family 16 member 7	Homo sapiens	207-211	
23192371-1	2013	BACKGROUND: Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate.	Lactic Acid	143-150	solute carrier family 16 member 7	Homo sapiens	12-41	
24799634-1	2014	Monocarboxylic acid transporter 2 (MCT2) transports pyruvate and lactate outside and inside of sperms, mainly as energy sources and plays roles in the regulation of spermatogenesis.	Lactic Acid	65-72	solute carrier family 16 member 7	Homo sapiens	0-33	
24799634-1	2014	Monocarboxylic acid transporter 2 (MCT2) transports pyruvate and lactate outside and inside of sperms, mainly as energy sources and plays roles in the regulation of spermatogenesis.	Lactic Acid	65-72	solute carrier family 16 member 7	Homo sapiens	35-39	
25300133-10	2014	Most recently the neuroplastins have been shown to chaperone and support the monocarboxylate transporter MCT2 in transporting lactate across the neuronal plasma membrane.	Lactic Acid	126-133	solute carrier family 16 member 7	Homo sapiens	105-109	
23192371-1	2013	BACKGROUND: Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate.	Lactic Acid	143-150	solute carrier family 16 member 7	Homo sapiens	43-47	
18598673-1	2008	The monocarboxylate transporter MCT2 belongs to a large family of membrane proteins involved in the transport of lactate, pyruvate and ketone bodies.	Lactic Acid	113-120	solute carrier family 16 member 7	Homo sapiens	32-36	
19404741-0	2009	Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2.	Lactic Acid	30-37	solute carrier family 16 member 7	Homo sapiens	120-124	
17579656-3	2007	Lactate, the glycolytic product of glucose metabolism, is transported into and out of neural cells by the monocarboxylate transporters (MCT): MCT1 in the BBB and astrocytes and MCT2 in neurons.	Lactic Acid	0-7	solute carrier family 16 member 7	Homo sapiens	177-181	
18093179-1	2008	MCT2 is the main neuronal monocarboxylate transporter essential for facilitating lactate and ketone body utilization as energy substrates.	Lactic Acid	81-88	solute carrier family 16 member 7	Homo sapiens	0-4	
15997097-10	2005	Accordingly, MCT2 or MCT4 is responsible for L-lactic acid efflux by RD cells.	Lactic Acid	45-58	solute carrier family 16 member 7	Homo sapiens	13-17	
16604139-17	2006	In conclusion, this study suggests that in skeletal muscle, as well as other tissues, lactate and pyruvate transport rates may not only involve MCT1 and -4, as other monocarboxylate transporters are also expressed in rat (MCT2, -5, -6) and human skeletal muscle (MCT2, -5, -6, -7).	Lactic Acid	86-93	solute carrier family 16 member 7	Homo sapiens	263-267	
15586354-10	2005	The predominant MCT in neurons is the high-affinity MCT2, which can only increase its activity to a limited extent in the face of an increased lactate gradient.	Lactic Acid	143-150	solute carrier family 16 member 7	Homo sapiens	52-56	
11291733-8	2001	The present data suggest that MCT2 has specific transport functions related to the synaptic cleft and that this transporter may allow an influx of lactate derived from perisynaptic glial processes.	Lactic Acid	147-154	solute carrier family 16 member 7	Homo sapiens	30-34	
15505343-6	2004	Because the K(m) for lactate increases approximately fivefold at each step, with MCT2<1<4, leukocytes must use the full range of lactate binding to survive in acidic and hypoxic environments.	Lactic Acid	21-28	solute carrier family 16 member 7	Homo sapiens	81-85	
10921872-2	2000	Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental role in metabolism, but not with MCT2.	Lactic Acid	181-188	solute carrier family 16 member 7	Homo sapiens	266-270	
10510291-4	1999	Direct demonstration of proton-linked lactate and pyruvate transport has been demonstrated for mammalian MCT1-MCT4, but only for MCT1 and MCT2 have detailed analyses of substrate and inhibitor kinetics been described following heterologous expression in Xenopus oocytes.	Lactic Acid	38-45	solute carrier family 16 member 7	Homo sapiens	138-142