PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33933680-8 2021 We further showed that embigin associates with monocarboxylate transporter MCT1 in the OS plasma membrane, facilitating lactate transport through this cellular compartment. Lactic Acid 120-127 solute carrier family 16 member 1 Homo sapiens 75-79 33548088-5 2021 We further propose that lactate is then utilised symbiotically by neighbouring highly proliferative matrix keratinocytes to fuel oxidative metabolism via MCT1-mediated uptake. Lactic Acid 24-31 solute carrier family 16 member 1 Homo sapiens 154-158 33559958-3 2021 Monocarboxylate transporter 1 (MCT1) promotes transport for lactate and pyruvate, which are crucial for cell metabolism. Lactic Acid 60-67 solute carrier family 16 member 1 Homo sapiens 0-29 33559958-3 2021 Monocarboxylate transporter 1 (MCT1) promotes transport for lactate and pyruvate, which are crucial for cell metabolism. Lactic Acid 60-67 solute carrier family 16 member 1 Homo sapiens 31-35 34020698-9 2021 Addition of exogenous lactate (4 mM) in culture media induced expression of the lactate importer MCT1 and increased oxygen consumption rate by 50%, mitochondrial ATP-linked respiration by 30%, and collagen synthesis by 50% in AF cell cultures grown under physiologic oxygen (2-5% O2) and glucose concentration (1-5 mM). Lactic Acid 22-29 solute carrier family 16 member 1 Homo sapiens 97-101 34020698-9 2021 Addition of exogenous lactate (4 mM) in culture media induced expression of the lactate importer MCT1 and increased oxygen consumption rate by 50%, mitochondrial ATP-linked respiration by 30%, and collagen synthesis by 50% in AF cell cultures grown under physiologic oxygen (2-5% O2) and glucose concentration (1-5 mM). Lactic Acid 80-87 solute carrier family 16 member 1 Homo sapiens 97-101 34020698-10 2021 AF tissue highly expresses MCT1, LDH-H, an enzyme that preferentially converts lactate to pyruvate, and PDH, an enzyme that converts pyruvate to acetyl-coA. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 27-31 33221062-4 2021 Their cytotoxic activity has been tested against three cell lines high-expressing and low-expressing monocarboxylate transporter 1 (MCT1) which acts as the main carrier for lactate. Lactic Acid 173-180 solute carrier family 16 member 1 Homo sapiens 101-130 33614502-7 2020 Altogether, our study shows that inhibition of MCT1 or MCT4 impairs leukemic cell proliferation, suggesting that targeting lactate metabolism may be a new therapeutic strategy for AML, and points to MCT4 as a potential therapeutic target in AML patients and to syrosingopine as a new anti-proliferative drug and inducer of autophagy to be used in combination with conventional chemotherapeutic agents in AML treatment. Lactic Acid 123-130 solute carrier family 16 member 1 Homo sapiens 47-51 33401672-9 2021 Monocarboxylate transporters (MCTs) mediate metabolic symbiosis, by which lactate in cancer cells under hypoxia is exported through MCT4 and imported by MCT1 in less hypoxic regions, where it is used as an oxidative metabolite. Lactic Acid 74-81 solute carrier family 16 member 1 Homo sapiens 153-157 33486968-0 2021 Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Lactic Acid 35-42 solute carrier family 16 member 1 Homo sapiens 21-25 33486968-15 2021 Given that lactate is a major substrate for stress adaption both in the healthy and the diseased human heart, future studies of conserved McT1/Caveolin3 interactions may provide rationales to target this muscle-specific assembly function therapeutically. Lactic Acid 11-18 solute carrier family 16 member 1 Homo sapiens 138-142 33450176-3 2021 Targeting the MCT-mediated lactate/proton efflux makes MCTs a potentially interesting anticancer target. Lactic Acid 27-34 solute carrier family 16 member 1 Homo sapiens 14-17 33614502-0 2020 Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells. Lactic Acid 10-17 solute carrier family 16 member 1 Homo sapiens 43-47 33614502-3 2020 Understanding whether monocarboxylate transporters MCT1 and MCT4, which remove the excess of lactate produced by cancer cells, represent new hematological targets, and whether their respective inhibitors, AR-C155858 and syrosingopine, can be useful in leukemia therapy, may reveal a novel treatment strategy for patients with AML. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 51-55 33333023-2 2021 Here, we report five cryo-EM structures, at resolutions of 3.0-3.3 A, of human MCT1 bound to lactate or inhibitors in the presence of Basigin-2, a single transmembrane segment (TM)-containing chaperon. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 79-83 33333023-3 2021 MCT1 exhibits similar outward-open conformations when complexed with lactate or the inhibitors BAY-8002 and AZD3965. Lactic Acid 69-76 solute carrier family 16 member 1 Homo sapiens 0-4 33221062-4 2021 Their cytotoxic activity has been tested against three cell lines high-expressing and low-expressing monocarboxylate transporter 1 (MCT1) which acts as the main carrier for lactate. Lactic Acid 173-180 solute carrier family 16 member 1 Homo sapiens 132-136 33221062-8 2021 Additionally, compound 5o induced intracellular lactate accumulation and inhibited lactate uptake, which implied that it blocked lactate transport via MCT1. Lactic Acid 83-90 solute carrier family 16 member 1 Homo sapiens 151-155 33221062-8 2021 Additionally, compound 5o induced intracellular lactate accumulation and inhibited lactate uptake, which implied that it blocked lactate transport via MCT1. Lactic Acid 83-90 solute carrier family 16 member 1 Homo sapiens 151-155 33296645-0 2020 HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 6-10 33645520-7 2021 In particular, the registered changes reflect a violation of the paracrine intercellular interactions of two subpopulations of cells, one of which acts as a source of NAD+, and the second as a consumer of NAD+ to ensure the processes of intracellular signal transduction; a change in the mechanisms of lactate transport due to aberrant expression of the lactate transporter MCT1 in cells forming a pool of cells developing along the neuronal path of differentiation. Lactic Acid 302-309 solute carrier family 16 member 1 Homo sapiens 374-378 33296645-3 2020 Additionally, blocking the lactate uptake via hydroxycarboxylic acid receptor 1 (HCAR1)/MCT1 inhibition promotes ferroptosis by activating the AMPK to downregulate SCD1, which may synergize with its acyl-coenzyme A synthetase 4 (ACSL4)-promoting effect to amplify the ferroptotic susceptibility. Lactic Acid 27-34 solute carrier family 16 member 1 Homo sapiens 88-92 32839325-3 2020 By contrast, we find by cross-sectional analysis using genetic and pharmacological tools in mechanistic studies applied to well-defined genetically engineered cell lines and tumors that initial hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion rates as well as global conversion were highly dependent on and critically rate-limited by the transmembrane influx of [1-13C]pyruvate mediated predominately by monocarboxylate transporter-1 (MCT1). Lactic Acid 235-242 solute carrier family 16 member 1 Homo sapiens 415-444 33256802-11 2020 Moreover, over-produced lactic acid from hyperglycolytic HCC cells stimulated the ERK phosphorylation of co-cultured LX2 and THP1 non-tumor cells partially via NDRG3 and MCT1, which in turn promoted cell malignancy and stemness of HCC cells. Lactic Acid 24-35 solute carrier family 16 member 1 Homo sapiens 170-174 32717355-4 2020 The primary transporter for lactate in the nervous system, monocarboxylate transporter-1 (MCT1), has been shown to be critical for peripheral nerve regeneration and metabolic support to neurons/axons. Lactic Acid 28-35 solute carrier family 16 member 1 Homo sapiens 90-94 33178603-1 2020 Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Lactic Acid 70-77 solute carrier family 16 member 1 Homo sapiens 0-29 33178603-1 2020 Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Lactic Acid 70-77 solute carrier family 16 member 1 Homo sapiens 31-35 32667776-6 2020 However, persistent hypoxia, but not hypoglycemia, inhibited the function of MCT1 leading to an intracellular lactate accumulation and acidosis in OPCs. Lactic Acid 110-117 solute carrier family 16 member 1 Homo sapiens 77-81 32667776-8 2020 The results support that compromised lactate efflux resulting from hypoxia-induced dysfunction of MCT1 contributes to the high vulnerability of OPCs. Lactic Acid 37-44 solute carrier family 16 member 1 Homo sapiens 98-102 32650130-4 2020 To maintain the hyperglycolytic phenotype, cancer cells efficiently export lactate through the monocarboxylate transporters MCT1 and MCT4. Lactic Acid 75-82 solute carrier family 16 member 1 Homo sapiens 124-128 32942665-2 2020 Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a formate-nitrite transporter (plasmodium falciparum FNT, PfFNT) in the equilibrium transport state. Lactic Acid 39-50 solute carrier family 16 member 1 Homo sapiens 127-131 32942665-2 2020 Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a formate-nitrite transporter (plasmodium falciparum FNT, PfFNT) in the equilibrium transport state. Lactic Acid 39-50 solute carrier family 16 member 1 Homo sapiens 133-140 32942665-2 2020 Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a formate-nitrite transporter (plasmodium falciparum FNT, PfFNT) in the equilibrium transport state. Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 127-131 32942665-2 2020 Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a formate-nitrite transporter (plasmodium falciparum FNT, PfFNT) in the equilibrium transport state. Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 133-140 32839325-3 2020 By contrast, we find by cross-sectional analysis using genetic and pharmacological tools in mechanistic studies applied to well-defined genetically engineered cell lines and tumors that initial hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion rates as well as global conversion were highly dependent on and critically rate-limited by the transmembrane influx of [1-13C]pyruvate mediated predominately by monocarboxylate transporter-1 (MCT1). Lactic Acid 235-242 solute carrier family 16 member 1 Homo sapiens 446-450 32839325-4 2020 Specifically, in a cell-encapsulated alginate bead model, induced short hairpin (shRNA) knockdown or overexpression of MCT1 quantitatively inhibited or enhanced, respectively, unidirectional pyruvate influxes and [1-13C]pyruvate-to-[1-13C]lactate conversion rates, independent of glycolysis or LDHA activity. Lactic Acid 239-246 solute carrier family 16 member 1 Homo sapiens 119-123 32703414-3 2020 However, MCT1 also transports lactate and can be used by cancer cells to facilitate anaerobic glycolysis. Lactic Acid 30-37 solute carrier family 16 member 1 Homo sapiens 9-13 32633891-9 2020 Simultaneously, PDAC cells took up these glycolysis products (lactate) through up-regulated MCT1 to undergo OXPHOS, with down-regulated expression of glycolytic enzymes (HK-2, PFKP and PKM2) and up-regulated expression of OXPHOS enzymes (TOMM20 and NQO1). Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 92-96 32821126-10 2020 Furthermore, the conditioned medium of activated HSCs enhanced the lactate metabolism of hypoxic tumor cells by activating the IL-6/STAT3 pathway and upregulating the downstream MCT1 and LDHB, in order to confer the resistance of SN38, which is the active metabolite of irinotecan. Lactic Acid 67-74 solute carrier family 16 member 1 Homo sapiens 178-182 32163224-8 2020 In addition, decreased expression of monocarboxylate transporter member 1, a member of the solute carrier family (SLC16A1), which regulates lactate and H+ uptake, contributed to the high pHi of hiPSC-EC. Lactic Acid 140-147 solute carrier family 16 member 1 Homo sapiens 114-121 32637597-1 2020 Malignant glioma is a fatal brain tumor whose pathological progression is closely associated with glycolytic reprogramming, leading to the high expression of monocarboxylate transporter 1 (MCT1) and its ancillary protein, cluster of differentiation 147 (CD147) for enhancing lactate efflux. Lactic Acid 275-282 solute carrier family 16 member 1 Homo sapiens 158-187 32637597-1 2020 Malignant glioma is a fatal brain tumor whose pathological progression is closely associated with glycolytic reprogramming, leading to the high expression of monocarboxylate transporter 1 (MCT1) and its ancillary protein, cluster of differentiation 147 (CD147) for enhancing lactate efflux. Lactic Acid 275-282 solute carrier family 16 member 1 Homo sapiens 189-193 31395464-10 2020 MAJOR CONCLUSIONS: Lactate and MCTs, especially MCT1 and MCT4, are important contributors to tumor aggressiveness. Lactic Acid 19-26 solute carrier family 16 member 1 Homo sapiens 48-52 31945319-0 2020 Lactic acid promotes macrophage polarization through MCT-HIF1alpha signaling in gastric cancer. Lactic Acid 0-11 solute carrier family 16 member 1 Homo sapiens 53-56 31945319-10 2020 Collectively, our findings identify the lactate-MCT-HIF1alpha axis as a critical signaling cascade that couples metabolic reprogramming to macrophage polarization in gastric cancer. Lactic Acid 40-47 solute carrier family 16 member 1 Homo sapiens 48-51 32138176-5 2020 These lactate dependent effects on stemness properties are abrogated by the MCT1/lactate-uptake inhibitor 7ACC2 or MCT1 knock-down. Lactic Acid 6-13 solute carrier family 16 member 1 Homo sapiens 76-80 32138176-5 2020 These lactate dependent effects on stemness properties are abrogated by the MCT1/lactate-uptake inhibitor 7ACC2 or MCT1 knock-down. Lactic Acid 6-13 solute carrier family 16 member 1 Homo sapiens 115-119 32138176-5 2020 These lactate dependent effects on stemness properties are abrogated by the MCT1/lactate-uptake inhibitor 7ACC2 or MCT1 knock-down. Lactic Acid 81-88 solute carrier family 16 member 1 Homo sapiens 76-80 32138176-7 2020 In conclusion, the MCT1-dependent import of lactate supplies "reverse Warburg "PDAC cells with an efficient driver of metabostemness. Lactic Acid 44-51 solute carrier family 16 member 1 Homo sapiens 19-23 32492393-5 2020 Addition of lactate to pfkfb3-deficient ECs restored M2-like polarization in an MCT1-dependent fashion. Lactic Acid 12-19 solute carrier family 16 member 1 Homo sapiens 80-84 32037723-6 2020 Strikingly, higher mitochondrial activities were also found in these clones which might be attributed to the increase of PGC-1alpha stimulated by the lactate uptaken through the upregulated MCT-1. Lactic Acid 150-157 solute carrier family 16 member 1 Homo sapiens 190-195 31900520-4 2020 The transport function of MCT1 in A549 cells was examined using [3H]gamma-hydroxybutyrate (GHB) and [3H] lactic acid (LA) as substrates and alpha-cyano-4-hydroxycinnamate (CHC), lactic acid, phloretin, and AR-C155858 (AR) as inhibitors of MCT1. Lactic Acid 100-116 solute carrier family 16 member 1 Homo sapiens 26-30 31900520-4 2020 The transport function of MCT1 in A549 cells was examined using [3H]gamma-hydroxybutyrate (GHB) and [3H] lactic acid (LA) as substrates and alpha-cyano-4-hydroxycinnamate (CHC), lactic acid, phloretin, and AR-C155858 (AR) as inhibitors of MCT1. Lactic Acid 105-116 solute carrier family 16 member 1 Homo sapiens 26-30 31900520-8 2020 CHC, lactic acid, phloretin, and AR significantly inhibited the uptake of GHB in a concentration-dependent manner, suggesting that MCT1 is primarily responsible for transport of monocarboxylates such as GHB and LA in A549 cells. Lactic Acid 5-16 solute carrier family 16 member 1 Homo sapiens 131-135 32123312-4 2020 Treatment of neuroblastoma cells with the MCT1 inhibitor SR13800 increased intracellular lactate levels, disrupted the nicotinamide adenine dinucleotide (NADH/NAD+) ratio, and decreased intracellular glutathione levels. Lactic Acid 89-96 solute carrier family 16 member 1 Homo sapiens 42-46 32123312-9 2020 Co-treatment of neuroblastoma cells with inhibitors of MCT1 and LDHA, the enzyme responsible for lactate production, resulted in a large increase in intracellular pyruvate and was highly synergistic in decreasing neuroblastoma cell viability. Lactic Acid 97-104 solute carrier family 16 member 1 Homo sapiens 55-59 32257942-5 2020 Lactate transport is mediated by the monocarboxylate transporter (MCT) family, while another large family of G protein-coupled receptors (GPCRs), not yet fully characterized in the cancer context, is involved in lactate/acidosis signaling. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 37-64 32257942-5 2020 Lactate transport is mediated by the monocarboxylate transporter (MCT) family, while another large family of G protein-coupled receptors (GPCRs), not yet fully characterized in the cancer context, is involved in lactate/acidosis signaling. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 66-69 32257942-5 2020 Lactate transport is mediated by the monocarboxylate transporter (MCT) family, while another large family of G protein-coupled receptors (GPCRs), not yet fully characterized in the cancer context, is involved in lactate/acidosis signaling. Lactic Acid 212-219 solute carrier family 16 member 1 Homo sapiens 37-64 32257942-5 2020 Lactate transport is mediated by the monocarboxylate transporter (MCT) family, while another large family of G protein-coupled receptors (GPCRs), not yet fully characterized in the cancer context, is involved in lactate/acidosis signaling. Lactic Acid 212-219 solute carrier family 16 member 1 Homo sapiens 66-69 32138176-0 2020 Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells . Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 14-43 32138176-0 2020 Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells . Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 45-49 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 82-111 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 113-117 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 187-191 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 187-191 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 136-143 solute carrier family 16 member 1 Homo sapiens 82-111 32138176-3 2020 We now show that PDAC cells (BxPc3, A818-6, T3M4) expressing the lactate-importer monocarboxylate transporter-1 (MCT1) are protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells (Panc1, Capan2). Lactic Acid 136-143 solute carrier family 16 member 1 Homo sapiens 113-117 32111097-7 2020 Reduced levels of MCT1 were associated with significant intracellular lactate accumulation. Lactic Acid 70-77 solute carrier family 16 member 1 Homo sapiens 18-22 31936895-5 2020 Concurrently, we found the predominant expression of monocarboxylate transporter 1 (MCT-1) in the TKI-resistant NSCLC cells was strongly increased in those cells that oxidized lactate. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 53-82 31964840-4 2020 Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 188-192 31964840-9 2020 Imaging of hyperpolarized [1-13C]pyruvate metabolism in breast cancer is feasible and demonstrated significant intertumoral and intratumoral metabolic heterogeneity, where lactate labeling correlated with MCT1 expression and hypoxia. Lactic Acid 172-179 solute carrier family 16 member 1 Homo sapiens 205-209 31936895-5 2020 Concurrently, we found the predominant expression of monocarboxylate transporter 1 (MCT-1) in the TKI-resistant NSCLC cells was strongly increased in those cells that oxidized lactate. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 84-89 31678436-0 2020 The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1). Lactic Acid 43-50 solute carrier family 16 member 1 Homo sapiens 65-72 31564440-0 2020 Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 97-126 29852858-4 2020 Inhibitors of glycolysis like 2-deoxy-D-glucose (2-DG; a hexokinase inhibitor), dichloroacetate and small molecule inhibitors of lactate transport (MCT-1) are some of the metabolic modifiers investigated for their therapeutic as well as adjuvant potential. Lactic Acid 129-136 solute carrier family 16 member 1 Homo sapiens 148-153 31678436-0 2020 The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1). Lactic Acid 43-50 solute carrier family 16 member 1 Homo sapiens 74-78 31678436-5 2020 We found that SLC2A1 and SLC16A1 were, respectively, the most abundantly expressed glucose and lactate (monocarboxylate) transporters. Lactic Acid 95-102 solute carrier family 16 member 1 Homo sapiens 25-32 31678436-13 2020 Pearson"s r revealed that the concentration gradients (Api - BL) of glucose and lactate correlated with the gene expression of respective SLC2A1 and SLC16A1 transporters. Lactic Acid 80-87 solute carrier family 16 member 1 Homo sapiens 149-156 31853067-4 2020 Efficient metastasizers had higher levels of MCT1, and inhibition of MCT1 reduced lactate uptake. Lactic Acid 82-89 solute carrier family 16 member 1 Homo sapiens 69-73 31797891-3 2019 Further, candidate compounds exhibit several-fold more potent MCT1 inhibition properties as determined by lactate-uptake studies, and these studies are supported by MCT homology modeling and computational inhibitor-docking studies. Lactic Acid 106-113 solute carrier family 16 member 1 Homo sapiens 62-66 31797891-3 2019 Further, candidate compounds exhibit several-fold more potent MCT1 inhibition properties as determined by lactate-uptake studies, and these studies are supported by MCT homology modeling and computational inhibitor-docking studies. Lactic Acid 106-113 solute carrier family 16 member 1 Homo sapiens 62-65 31367191-0 2019 Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition. Lactic Acid 21-28 solute carrier family 16 member 1 Homo sapiens 146-150 31532712-4 2019 The monocarboxylate transporter protein 1 (MCT1) is a passive transporter of lactate and has gained significant attention for its role(s) in cancer progression; moreover, upregulation of MCT1 connotes poor patient outcome and survival. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 4-41 31532712-4 2019 The monocarboxylate transporter protein 1 (MCT1) is a passive transporter of lactate and has gained significant attention for its role(s) in cancer progression; moreover, upregulation of MCT1 connotes poor patient outcome and survival. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 43-47 31532712-4 2019 The monocarboxylate transporter protein 1 (MCT1) is a passive transporter of lactate and has gained significant attention for its role(s) in cancer progression; moreover, upregulation of MCT1 connotes poor patient outcome and survival. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 187-191 31367191-4 2019 Materials and methods: In this study, Human breast cancer cells, BT474, SKBR3 and MCF7 were used to study the causal relationship between the lactate exporter, MCT1 (SLC16A1)-modulated glucose metabolism and Taxol resistance of breast cancer cells. Lactic Acid 142-149 solute carrier family 16 member 1 Homo sapiens 160-164 31367191-4 2019 Materials and methods: In this study, Human breast cancer cells, BT474, SKBR3 and MCF7 were used to study the causal relationship between the lactate exporter, MCT1 (SLC16A1)-modulated glucose metabolism and Taxol resistance of breast cancer cells. Lactic Acid 142-149 solute carrier family 16 member 1 Homo sapiens 166-173 31380330-1 2019 The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Lactic Acid 158-165 solute carrier family 16 member 1 Homo sapiens 4-37 31380330-1 2019 The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Lactic Acid 158-165 solute carrier family 16 member 1 Homo sapiens 39-46 31380330-1 2019 The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Lactic Acid 158-165 solute carrier family 16 member 1 Homo sapiens 65-94 31380330-1 2019 The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Lactic Acid 158-165 solute carrier family 16 member 1 Homo sapiens 96-100 31380330-3 2019 In the brain where MCT1 is highly localized around axons and oligodendrocytes, glucose is the most crucial energy substrate while lactate is an alternative substrate. Lactic Acid 130-137 solute carrier family 16 member 1 Homo sapiens 19-23 30790227-9 2019 In addition, we found that AZD3965-mediated disruption of MCT1 activity led to inhibited NHL cell viability and extracellular lactate accumulation, while increasing apoptotic cell death. Lactic Acid 126-133 solute carrier family 16 member 1 Homo sapiens 58-62 31209810-8 2019 Moreover, silencing monocarboxylate transporter 1 (MCT1), the prominent path for lactate uptake in human tumor with siRNA significantly impaired organoid forming capacity of OSCC cells. Lactic Acid 81-88 solute carrier family 16 member 1 Homo sapiens 20-49 31209810-8 2019 Moreover, silencing monocarboxylate transporter 1 (MCT1), the prominent path for lactate uptake in human tumor with siRNA significantly impaired organoid forming capacity of OSCC cells. Lactic Acid 81-88 solute carrier family 16 member 1 Homo sapiens 51-55 31171526-6 2019 Such exchange is catalyzed by MCT transporters, which cotransport lactate and protons (H+). Lactic Acid 66-73 solute carrier family 16 member 1 Homo sapiens 30-33 31297034-2 2019 We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential transporters of lactate, in renal cancer progression during cancer-endothelial cell co-culturing. Lactic Acid 109-116 solute carrier family 16 member 1 Homo sapiens 32-61 30540938-2 2018 We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher potency on MCT4) that prevents lactate and H+ efflux. Lactic Acid 143-150 solute carrier family 16 member 1 Homo sapiens 67-71 30923124-6 2019 Interestingly, monocarboxylate transporter 1 was the major lactate transporter in hepatoma cells, and its expression was essential for PDH phosphorylation by modulating intracellular lactate levels. Lactic Acid 59-66 solute carrier family 16 member 1 Homo sapiens 15-44 30540938-1 2018 Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). Lactic Acid 108-115 solute carrier family 16 member 1 Homo sapiens 131-161 30550949-8 2019 These results indicate that lactate flux through MCT1 between the body and the brain could be upregulated in children with ADHD. Lactic Acid 28-35 solute carrier family 16 member 1 Homo sapiens 49-53 29985759-0 2018 An unexpected world population variation of MCT1 polymorphism 1470T > A involved in lactate transport. Lactic Acid 87-94 solute carrier family 16 member 1 Homo sapiens 44-48 30540938-1 2018 Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). Lactic Acid 108-115 solute carrier family 16 member 1 Homo sapiens 163-167 29985759-1 2018 A common missense mutation (1470T > A) in gene SLC16A1 responsible for an amino acid substitution in protein MCT1 has been associated with differential lactate transport and hence, differences in physical performance and muscle injuries in relation to physical exercise. Lactic Acid 155-162 solute carrier family 16 member 1 Homo sapiens 50-57 29985759-1 2018 A common missense mutation (1470T > A) in gene SLC16A1 responsible for an amino acid substitution in protein MCT1 has been associated with differential lactate transport and hence, differences in physical performance and muscle injuries in relation to physical exercise. Lactic Acid 155-162 solute carrier family 16 member 1 Homo sapiens 112-116 30125826-8 2018 These results showed that AMPK reduces heat-induced lactate secretion by decreasing the expression levels of GLUT3, LDHA and MCT1. Lactic Acid 52-59 solute carrier family 16 member 1 Homo sapiens 125-129 30464343-7 2018 SLC16A1 was upregulated after corpse uptake, increasing the release of lactate, a natural by-product of aerobic glycolysis3. Lactic Acid 71-78 solute carrier family 16 member 1 Homo sapiens 0-7 30464343-8 2018 Whereas glycolysis within phagocytes contributed to actin polymerization and the continued uptake of corpses, lactate released via SLC16A1 promoted the establishment of an anti-inflammatory tissue environment. Lactic Acid 110-117 solute carrier family 16 member 1 Homo sapiens 131-138 30115664-2 2018 In a cell-based screen, we identified a novel class of MCT1 inhibitors, including BAY-8002, which potently suppress bidirectional lactate transport. Lactic Acid 130-137 solute carrier family 16 member 1 Homo sapiens 55-59 30189359-5 2018 Furthermore, we show that AXL-dependent peripheral distribution of lysosomes and cell invasion are mediated by extracellular acidification, which is potentiated by AXL-induced secretion of lactate through AKT-NF-kappaB-dependent MCT-1 regulation. Lactic Acid 189-196 solute carrier family 16 member 1 Homo sapiens 229-234 30177396-2 2018 MCT1 and MCT4 transport pH-related monocarboxylates, such as lactate and pyruvate. Lactic Acid 61-68 solute carrier family 16 member 1 Homo sapiens 0-4 30115973-6 2018 Bioinformatic and functional analyses revealed that miR-342-3p directly targets the monocarboxylate transporter 1 (MCT1), which promotes lactate and glucose fluxes alteration, thus disrupting the metabolic homeostasis of tumor cells. Lactic Acid 137-144 solute carrier family 16 member 1 Homo sapiens 84-113 29913143-6 2018 Using inhibitors for MCT-1 reveales that lactate effects are MCT-1 independent. Lactic Acid 41-48 solute carrier family 16 member 1 Homo sapiens 21-26 29913143-6 2018 Using inhibitors for MCT-1 reveales that lactate effects are MCT-1 independent. Lactic Acid 41-48 solute carrier family 16 member 1 Homo sapiens 61-66 30115973-6 2018 Bioinformatic and functional analyses revealed that miR-342-3p directly targets the monocarboxylate transporter 1 (MCT1), which promotes lactate and glucose fluxes alteration, thus disrupting the metabolic homeostasis of tumor cells. Lactic Acid 137-144 solute carrier family 16 member 1 Homo sapiens 115-119 29483215-1 2018 Monocarboxylate transporters (MCT) are transmembrane proteins that control the lactate metabolism and are associated with poor prognosis in solid tumors, including colorectal cancer. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 30-33 30026847-1 2018 Background: Monocarboxylate transporter isoform 1 (MCT1) is an important molecule in mediating lactate transportation. Lactic Acid 95-102 solute carrier family 16 member 1 Homo sapiens 12-49 30026847-1 2018 Background: Monocarboxylate transporter isoform 1 (MCT1) is an important molecule in mediating lactate transportation. Lactic Acid 95-102 solute carrier family 16 member 1 Homo sapiens 51-55 30026847-11 2018 Downregulation of MCT1 decreased lactate levels in cell medium, as well as HK2, GLUT1 and LDHB expression. Lactic Acid 33-40 solute carrier family 16 member 1 Homo sapiens 18-22 29695106-2 2018 Basigin (BSG, CD147) controls lactate export through the monocarboxylic acid transporter 1 (MCT1, SLC16A1) and supports MM survival and proliferation. Lactic Acid 30-37 solute carrier family 16 member 1 Homo sapiens 92-96 29809145-2 2018 In the present study, we show that proton-driven lactate flux is enhanced by the intracellular carbonic anhydrase CAII, which is colocalized with the monocarboxylate transporter MCT1 in MCF-7 breast cancer cells. Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 178-182 29351758-4 2018 Monocarboxylate transporter 1 (MCT1) plays an important role in lactic acid transport and H+ clearance in cancer cells, and Wnt/beta-catenin signaling can increase cancer cell glycolysis. Lactic Acid 64-75 solute carrier family 16 member 1 Homo sapiens 0-29 29572438-2 2018 Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. Lactic Acid 9-16 solute carrier family 16 member 1 Homo sapiens 32-61 29572438-2 2018 Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. Lactic Acid 9-16 solute carrier family 16 member 1 Homo sapiens 63-67 29351758-4 2018 Monocarboxylate transporter 1 (MCT1) plays an important role in lactic acid transport and H+ clearance in cancer cells, and Wnt/beta-catenin signaling can increase cancer cell glycolysis. Lactic Acid 64-75 solute carrier family 16 member 1 Homo sapiens 31-35 28827372-4 2017 Monocarboxylate transporter MCT1 is a passive transporter of lactic acid that has attracted interest as a target for small-molecule drugs to prevent metastasis. Lactic Acid 61-72 solute carrier family 16 member 1 Homo sapiens 28-32 28846107-10 2018 Depending on MCT1-mediated lactate uptake, Nrf2 conferred protection from TRAIL-induced apoptosis in NCM460 and HCT15 cells. Lactic Acid 27-34 solute carrier family 16 member 1 Homo sapiens 13-17 28846107-11 2018 Moreover, metabolism-dependent clonal growth of HCT15 cells was induced by Nrf2-dependent activation of MCT1-driven lactate exchange. Lactic Acid 116-123 solute carrier family 16 member 1 Homo sapiens 104-108 30355947-9 2018 Inhibition of MCT1 affected lactate metabolism, resulting in a higher intracellular pH and less proliferation of PANC-1 cells. Lactic Acid 28-35 solute carrier family 16 member 1 Homo sapiens 14-18 29299023-5 2017 The aim of this study was to evaluate the expression of the lactate/proton monocarboxylate transporters MCT1 and MCT4 and their chaperone CD147 in EC, with the ultimate aim of directing future drug development. Lactic Acid 60-67 solute carrier family 16 member 1 Homo sapiens 104-108 28762551-7 2017 Here, we demonstrate a role for MCT1 as a mediator of lactate signaling between glioma cells and brain ECs. Lactic Acid 54-61 solute carrier family 16 member 1 Homo sapiens 32-36 28923861-3 2017 In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo Exposing human lymphoma and colon carcinoma cells to AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux. Lactic Acid 231-238 solute carrier family 16 member 1 Homo sapiens 45-49 30355947-13 2018 CONCLUSION: miR-124 inhibits the progression of PANC-1 by targeting MCT1 in the lactate metabolic pathway. Lactic Acid 80-87 solute carrier family 16 member 1 Homo sapiens 68-72 28866133-7 2017 The passive transport of lactate into osteoclasts was mediated by MCT1: MCT1 expression is significantly upregulated during osteoclast differentiation and Type I collagen resorption is significantly impaired when osteoclasts are treated with 7-(N-benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid, an MCT-1 inhibitor. Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 66-70 28866133-7 2017 The passive transport of lactate into osteoclasts was mediated by MCT1: MCT1 expression is significantly upregulated during osteoclast differentiation and Type I collagen resorption is significantly impaired when osteoclasts are treated with 7-(N-benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid, an MCT-1 inhibitor. Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 72-76 28866133-7 2017 The passive transport of lactate into osteoclasts was mediated by MCT1: MCT1 expression is significantly upregulated during osteoclast differentiation and Type I collagen resorption is significantly impaired when osteoclasts are treated with 7-(N-benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid, an MCT-1 inhibitor. Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 309-314 28866133-8 2017 Together, these data demonstrate that lactate released by glycolytic breast carcinoma cells in the bone microenvironment promotes the formation of osteolytic lesions, and provide the rationale for further studies on the use of MCT1 targeting as a novel therapeutic approach in advanced cancer patients with BM. Lactic Acid 38-45 solute carrier family 16 member 1 Homo sapiens 227-231 28827372-5 2017 In this study, we present evidence of a function for MCT1 in metastasis beyond its role as a transporter of lactic acid. Lactic Acid 108-119 solute carrier family 16 member 1 Homo sapiens 53-57 28827372-8 2017 Our findings raise the possibility that pharmacologic inhibitors of MCT1-mediated lactic acid transport may not effectively prevent metastatic dissemination of cancer cells. Lactic Acid 82-93 solute carrier family 16 member 1 Homo sapiens 68-72 29248133-13 2017 Monocarboxylate transporter 1 (MCT1) is the main importer of lactate into cells and is a marker of OXPHOS. Lactic Acid 61-68 solute carrier family 16 member 1 Homo sapiens 0-29 28994701-3 2017 Previous studies have shown that statins and loratadine have the potential to inhibit l-lactic acid efflux by MCTs (MCT1 and 4). Lactic Acid 86-99 solute carrier family 16 member 1 Homo sapiens 116-126 28392448-4 2017 Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. Lactic Acid 75-82 solute carrier family 16 member 1 Homo sapiens 26-55 28392448-4 2017 Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. Lactic Acid 75-82 solute carrier family 16 member 1 Homo sapiens 57-61 28392448-4 2017 Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. Lactic Acid 75-82 solute carrier family 16 member 1 Homo sapiens 139-143 28392448-4 2017 Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. Lactic Acid 192-199 solute carrier family 16 member 1 Homo sapiens 26-55 28392448-4 2017 Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. Lactic Acid 192-199 solute carrier family 16 member 1 Homo sapiens 57-61 28536031-4 2017 This osteoblast differentiation-inducing effect of lactate can be inhibited by blocking its entry into cells with MCT1 siRNA or inhibitors, and by interfering with its metabolism by using specific siRNAs for LDHB and PDH. Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 114-118 29050199-8 2017 Inhibition of MCT1 by AZD3965 inhibited lactate efflux and resulted in accumulation of glycolytic intermediates. Lactic Acid 40-47 solute carrier family 16 member 1 Homo sapiens 14-18 29248133-13 2017 Monocarboxylate transporter 1 (MCT1) is the main importer of lactate into cells and is a marker of OXPHOS. Lactic Acid 61-68 solute carrier family 16 member 1 Homo sapiens 31-35 29069720-7 2017 Overall, we demonstrated that WNT5A signaling (via a beta-catenin-PFKP axis) reduces lactate production and lowers the expression of MCT1, a carrier mediating the uptake of lactate from the tumor microenvironment. Lactic Acid 173-180 solute carrier family 16 member 1 Homo sapiens 133-137 28148492-6 2017 Finally, our data support intracellular lactate as a signaling molecule for inducing MCT1 expression, but neither lactate nor H+ accumulation appears to be important signaling factors in MCT4 regulation. Lactic Acid 40-47 solute carrier family 16 member 1 Homo sapiens 85-89 29069720-5 2017 To also explore the effect of non-tumor cell-derived lactate, we added exogenous lactate to the cells and noted an increase in migration that was significantly impaired by recombinant WNT5A in parallel with a down-regulation of the lactate transporter monocarboxylate transporter 1 (MCT1). Lactic Acid 81-88 solute carrier family 16 member 1 Homo sapiens 252-281 29069720-5 2017 To also explore the effect of non-tumor cell-derived lactate, we added exogenous lactate to the cells and noted an increase in migration that was significantly impaired by recombinant WNT5A in parallel with a down-regulation of the lactate transporter monocarboxylate transporter 1 (MCT1). Lactic Acid 81-88 solute carrier family 16 member 1 Homo sapiens 283-287 28107190-0 2017 Radiosynthesis and validation of (+-)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. Lactic Acid 139-146 solute carrier family 16 member 1 Homo sapiens 124-128 28107190-5 2017 MCT4 is the main facilitator of lactate export by glycolytic cancer cells, and MCT1 is adapted for lactate uptake by oxidative cancer cells. Lactic Acid 99-106 solute carrier family 16 member 1 Homo sapiens 79-83 28107190-6 2017 While MCT1 inhibitor AZD3965 is currently tested in phase I clinical trials and other inhibitors of lactate metabolism have been developed for anticancer therapy, predicting and monitoring a response to the inhibition of lactate uptake is still an unmet clinical need. Lactic Acid 221-228 solute carrier family 16 member 1 Homo sapiens 6-10 28107190-8 2017 [18F]-FLac offers the possibility to monitor MCT1-dependent lactate uptake and inhibition in tumors in vivo. Lactic Acid 60-67 solute carrier family 16 member 1 Homo sapiens 45-49 26944480-3 2016 The reversible H(+)/lactate(-) symporters MCT1 and 4 cotransport lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. Lactic Acid 20-27 solute carrier family 16 member 1 Homo sapiens 42-52 27957817-0 2017 Monocarboxylate Transporter-1 Mediates the Protective Effects of Neutral-pH Bicarbonate/Lactate-Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis. Lactic Acid 88-95 solute carrier family 16 member 1 Homo sapiens 0-29 27957817-2 2017 MCT-1 transports lactate into cells. Lactic Acid 17-24 solute carrier family 16 member 1 Homo sapiens 0-5 27751602-9 2017 These findings indicated that HS-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3, LDHA, and SLC16A1, which suggests that HS-induced autophagy may enhance lactate secretion by SCs. Lactic Acid 61-68 solute carrier family 16 member 1 Homo sapiens 174-181 27765851-7 2016 Further, the reduction in MCT1 expression observed led to inhibition of hyperpolarized 13C-pyruvate-lactate exchange, a parameter that is translatable to in vivo imaging studies, in live WM266.4 cells. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 26-30 27729975-8 2016 MCT-1 can export lactate, the byproduct of Warburg metabolism, and it is the essential transporter of pyruvate as well as a glycolysis-targeting cancer drug, 3-bromopyruvate (3-BP). Lactic Acid 17-24 solute carrier family 16 member 1 Homo sapiens 0-5 28421181-1 2017 Introduction: Monocarboxylate transporter 1 (MCT1) is an importer of monocarboxylates such as lactate and pyruvate and a marker of mitochondrial metabolism. Lactic Acid 94-101 solute carrier family 16 member 1 Homo sapiens 14-43 28421181-1 2017 Introduction: Monocarboxylate transporter 1 (MCT1) is an importer of monocarboxylates such as lactate and pyruvate and a marker of mitochondrial metabolism. Lactic Acid 94-101 solute carrier family 16 member 1 Homo sapiens 45-49 29521223-0 2017 Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4. Lactic Acid 39-52 solute carrier family 16 member 1 Homo sapiens 99-103 29521223-7 2017 The efflux transport was next examined: loratadine (IC50: 10 and 61 microM) and atorvastatin (IC50: 78 and 41 microM) demonstrated the greatest potency for inhibition of L-lactic acid efflux by MCT1 and MCT4, respectively. Lactic Acid 170-183 solute carrier family 16 member 1 Homo sapiens 194-198 27813046-8 2017 The AA genotype of the MCT1 T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s WAnT and during intermittent sprint tests in Japanese wrestlers. Lactic Acid 139-146 solute carrier family 16 member 1 Homo sapiens 23-27 27514365-7 2016 The uptake of [14 C] l-lactic acid, a typical MCT substrate, in Caco-2 cells was saturable with relatively high affinity for MCT. Lactic Acid 21-34 solute carrier family 16 member 1 Homo sapiens 46-49 27514365-7 2016 The uptake of [14 C] l-lactic acid, a typical MCT substrate, in Caco-2 cells was saturable with relatively high affinity for MCT. Lactic Acid 21-34 solute carrier family 16 member 1 Homo sapiens 125-128 26944480-3 2016 The reversible H(+)/lactate(-) symporters MCT1 and 4 cotransport lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 42-52 26944480-3 2016 The reversible H(+)/lactate(-) symporters MCT1 and 4 cotransport lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. Lactic Acid 117-128 solute carrier family 16 member 1 Homo sapiens 42-52 27331625-10 2016 CONCLUSION: Hypoxia-induced MCT1 supports GBM glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness. Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 28-32 26765963-5 2016 Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 156-160 26765963-5 2016 Lactate influx capacity was highest in AsPC-1 cells and lowest in HPDE cells and was inhibited by the MCT inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 204-208 26765963-8 2016 CONCLUSIONS: Human PDAC cells exhibit robust MCT1 and MCT4 expression and partially MCT1- and MCT4-dependent lactate flux. Lactic Acid 109-116 solute carrier family 16 member 1 Homo sapiens 84-88 27677351-3 2016 Monocarboxylate transporter 1 (MCT1) is the main isoform expressed by tanycytes, which could facilitate lactate release to hypothalamic AN neurons. Lactic Acid 104-111 solute carrier family 16 member 1 Homo sapiens 0-29 27677351-3 2016 Monocarboxylate transporter 1 (MCT1) is the main isoform expressed by tanycytes, which could facilitate lactate release to hypothalamic AN neurons. Lactic Acid 104-111 solute carrier family 16 member 1 Homo sapiens 31-35 27342420-11 2016 Lactate concentrations seem to correlate with MCT1 (spearman rank correlation rho = 0.624, 0.05 > p > 0.025), but not with MCT4 (spearman rank correlation rho = 0.018, p > 0.1). Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 46-50 27331625-8 2016 Additionally, treatment with CHC and downregulation of MCT1 in glioma cells decreased lactate production, cell proliferation and invasion under hypoxia. Lactic Acid 86-93 solute carrier family 16 member 1 Homo sapiens 55-59 27294876-4 2016 This process allows for the formation and activation of the CD147-MCT1 transmembrane complex, which promotes various biological functions, including angiogenesis, proliferation, invasion and lactate export. Lactic Acid 191-198 solute carrier family 16 member 1 Homo sapiens 66-70 27375499-1 2016 The purpose of this study was to test if the lactate exchange (gamma1) and removal (gamma2) abilities during recovery following short all-out supramaximal exercise correlate with the muscle content of MCT1 and MCT4, the two isoforms of the monocarboxylate transporters family involved in lactate and H(+) co-transport in skeletal muscle. Lactic Acid 45-52 solute carrier family 16 member 1 Homo sapiens 201-205 27437179-5 2016 In particular, mutant IDH1 gliomas are associated with low levels of lactate dehydrogenase A (LDHA) and monocarboxylate transporters 1 and 4 (MCT1, MCT4), three proteins involved in pyruvate metabolism to lactate. Lactic Acid 69-76 solute carrier family 16 member 1 Homo sapiens 142-146 27375499-1 2016 The purpose of this study was to test if the lactate exchange (gamma1) and removal (gamma2) abilities during recovery following short all-out supramaximal exercise correlate with the muscle content of MCT1 and MCT4, the two isoforms of the monocarboxylate transporters family involved in lactate and H(+) co-transport in skeletal muscle. Lactic Acid 288-295 solute carrier family 16 member 1 Homo sapiens 201-205 27347360-0 2016 Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors. Lactic Acid 72-79 solute carrier family 16 member 1 Homo sapiens 107-111 27375499-10 2016 These findings suggest that the lactate exchange ability is highly dependent on the milieu so that the importance of the muscle MCT1 and MCT4 content in gamma1 was hidden in the present study. Lactic Acid 32-39 solute carrier family 16 member 1 Homo sapiens 128-132 27144334-9 2016 Collectively, our findings indicated that lower MCT expression was a key contributor to lower hyperpolarized lactate production in NHAIDHmut cells. Lactic Acid 109-116 solute carrier family 16 member 1 Homo sapiens 48-51 27134168-6 2016 Moreover, tumors establish metabolic symbiosis, illustrated by the differential expression of MCT1 and MCT4, monocarboxylate transporters active in lactate exchange in glycolytic tumors. Lactic Acid 148-155 solute carrier family 16 member 1 Homo sapiens 94-98 27026015-0 2016 Role of the monocarboxylate transporter MCT1 in the uptake of lactate during active recovery. Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 40-44 27026015-1 2016 PURPOSE: We assessed the role of monocarboxylate transporter 1 (MCT1) on lactate clearance during an active recovery after high-intensity exercise, by comparing genetic groups based on the T1470A (rs1049434) MCT1 polymorphism, whose influence on lactate transport has been proven. Lactic Acid 73-80 solute carrier family 16 member 1 Homo sapiens 33-62 27026015-1 2016 PURPOSE: We assessed the role of monocarboxylate transporter 1 (MCT1) on lactate clearance during an active recovery after high-intensity exercise, by comparing genetic groups based on the T1470A (rs1049434) MCT1 polymorphism, whose influence on lactate transport has been proven. Lactic Acid 73-80 solute carrier family 16 member 1 Homo sapiens 64-68 27026015-1 2016 PURPOSE: We assessed the role of monocarboxylate transporter 1 (MCT1) on lactate clearance during an active recovery after high-intensity exercise, by comparing genetic groups based on the T1470A (rs1049434) MCT1 polymorphism, whose influence on lactate transport has been proven. Lactic Acid 246-253 solute carrier family 16 member 1 Homo sapiens 64-68 27026015-10 2016 CONCLUSIONS: These differences according to the polymorphic variant T1470A suggest that MCT1 affects the plasma lactate decrease during a crucial period of active recovery, where the maximal lactate amount is cleared (i.e. 10-20 min period). Lactic Acid 112-119 solute carrier family 16 member 1 Homo sapiens 88-92 27026015-10 2016 CONCLUSIONS: These differences according to the polymorphic variant T1470A suggest that MCT1 affects the plasma lactate decrease during a crucial period of active recovery, where the maximal lactate amount is cleared (i.e. 10-20 min period). Lactic Acid 191-198 solute carrier family 16 member 1 Homo sapiens 88-92 26636483-10 2016 First, inhibitors of lactate uptake targeting MCT1 are currently entering clinical trials. Lactic Acid 21-28 solute carrier family 16 member 1 Homo sapiens 46-50 26563366-0 2016 STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 16-20 26563366-6 2016 MCT1 is a key factor, allowing lactate consumption and being regulated in vitro by lactate through the FOXM1:STAT3 pathway. Lactic Acid 31-38 solute carrier family 16 member 1 Homo sapiens 0-4 26563366-6 2016 MCT1 is a key factor, allowing lactate consumption and being regulated in vitro by lactate through the FOXM1:STAT3 pathway. Lactic Acid 83-90 solute carrier family 16 member 1 Homo sapiens 0-4 26876179-1 2016 Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth through disruption of lactate transport and glycolysis. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 0-29 26876179-1 2016 Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth through disruption of lactate transport and glycolysis. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 31-35 26876179-2 2016 Here, we show MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export. Lactic Acid 153-160 solute carrier family 16 member 1 Homo sapiens 14-18 26636483-6 2016 It depends on the uptake of extracellular lactate by monocarboxylate transporter 1 (MCT1). Lactic Acid 42-49 solute carrier family 16 member 1 Homo sapiens 53-82 26636483-6 2016 It depends on the uptake of extracellular lactate by monocarboxylate transporter 1 (MCT1). Lactic Acid 42-49 solute carrier family 16 member 1 Homo sapiens 84-88 26384349-4 2015 Lactate export was substantially suppressed to induce death along with lowering intracellular pH in MM cells by blockade of all three MCT molecules with alpha-cyano-4-hydroxy cinnamate (CHC) or the MCT1 and MCT2 inhibitor AR-C155858 in combination with MCT4 knockdown, although only partially by knockdown of each MCT. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 198-202 26615135-5 2015 Metabolic characterization of melanoma cells revealed that, with development of hypercalcemia, there was high expression of monocarboxylate transporter 1 (MCT1), which is the main importer of lactate and ketone bodies into cells. Lactic Acid 192-199 solute carrier family 16 member 1 Homo sapiens 124-153 26615135-5 2015 Metabolic characterization of melanoma cells revealed that, with development of hypercalcemia, there was high expression of monocarboxylate transporter 1 (MCT1), which is the main importer of lactate and ketone bodies into cells. Lactic Acid 192-199 solute carrier family 16 member 1 Homo sapiens 155-159 25938544-4 2015 We found that human THP-1 monocytes took up lactate secreted from tumor cells through monocarboxylate transporter 1. Lactic Acid 44-51 solute carrier family 16 member 1 Homo sapiens 86-115 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 31-38 solute carrier family 16 member 1 Homo sapiens 145-174 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 31-38 solute carrier family 16 member 1 Homo sapiens 176-180 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 145-174 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 176-180 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 145-174 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 176-180 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 145-174 26528183-4 2015 These protumoral activities of lactate depend on lactate uptake, a process primarily facilitated by the inward, passive lactate-proton symporter monocarboxylate transporter 1 (MCT1); the conversion of lactate and NAD(+) to pyruvate, NADH and H(+) by lactate dehydrogenase-1 (LDH-1); and a competition between pyruvate and alpha-ketoglutarate that inhibits prolylhydroxylases (PHDs). Lactic Acid 49-56 solute carrier family 16 member 1 Homo sapiens 176-180 26194608-6 2015 Moreover, XH appeared to decrease cellular uptake of lactate due to inhibition of the monocarboxylate transporter 1. Lactic Acid 53-60 solute carrier family 16 member 1 Homo sapiens 86-115 26284589-2 2015 BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. Lactic Acid 76-87 solute carrier family 16 member 1 Homo sapiens 140-144 26066969-1 2015 BACKGROUND: Lactate import or export over cell membranes is facilitated by monocarboxylate transporters (MCTs) 1 and 4. Lactic Acid 12-19 solute carrier family 16 member 1 Homo sapiens 75-118 24708341-3 2015 Lactate transport is mediated by proton-linked monocarboxylate transporter (MCT1). Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 76-80 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 28-35 solute carrier family 16 member 1 Homo sapiens 40-67 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 28-35 solute carrier family 16 member 1 Homo sapiens 69-72 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 40-67 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 69-72 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 40-67 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 69-72 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 40-67 25844530-3 2015 Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blood from lactate-producing to lactate-consuming organs. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 69-72 24708341-4 2015 The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. Lactic Acid 60-67 solute carrier family 16 member 1 Homo sapiens 39-43 24708341-4 2015 The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. Lactic Acid 122-129 solute carrier family 16 member 1 Homo sapiens 39-43 24708341-4 2015 The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. Lactic Acid 122-129 solute carrier family 16 member 1 Homo sapiens 39-43 25747963-6 2015 Lactate use by ATII mitochondria is dependent on monocarboxylate transporter (MCT)-mediated import, and ATII cells express MCT1, the isoform that mediates lactate import by cells in other lactate-consuming tissues. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 49-76 25747963-6 2015 Lactate use by ATII mitochondria is dependent on monocarboxylate transporter (MCT)-mediated import, and ATII cells express MCT1, the isoform that mediates lactate import by cells in other lactate-consuming tissues. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 78-81 25747963-6 2015 Lactate use by ATII mitochondria is dependent on monocarboxylate transporter (MCT)-mediated import, and ATII cells express MCT1, the isoform that mediates lactate import by cells in other lactate-consuming tissues. Lactic Acid 155-162 solute carrier family 16 member 1 Homo sapiens 123-127 25747963-6 2015 Lactate use by ATII mitochondria is dependent on monocarboxylate transporter (MCT)-mediated import, and ATII cells express MCT1, the isoform that mediates lactate import by cells in other lactate-consuming tissues. Lactic Acid 188-195 solute carrier family 16 member 1 Homo sapiens 123-127 25750919-10 2015 Immunohistochemistry demonstrated increased astrocytic expression of a key lactate generating enzyme in MS lesions as well as profound vascular expression of monocarboxylate transporter-1, which is involved in lactate transport. Lactic Acid 210-217 solute carrier family 16 member 1 Homo sapiens 158-187 25909034-14 2015 Suppression of lactate incorporation by targeting MCT1 may provide a novel therapeutic strategy for MM which may be applicable for other B-cell neoplasms. Lactic Acid 15-22 solute carrier family 16 member 1 Homo sapiens 50-54 25909034-10 2015 Inhibition of MCT1 by using CHC or MCT1-targeting siRNA reduced lactate incorporation and caused apoptosis in MM cells. Lactic Acid 64-71 solute carrier family 16 member 1 Homo sapiens 14-18 25909034-10 2015 Inhibition of MCT1 by using CHC or MCT1-targeting siRNA reduced lactate incorporation and caused apoptosis in MM cells. Lactic Acid 64-71 solute carrier family 16 member 1 Homo sapiens 35-39 25371203-8 2015 In this study, the polymorphism caused an observable change in 5-oxoproline and lactate transport via SLC16A1. Lactic Acid 80-87 solute carrier family 16 member 1 Homo sapiens 102-109 25456395-0 2015 Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 36-40 25403912-4 2015 Second, we demonstrated that knockout of BSG leads to a decrease in lactate transport activity of MCT1 and MCT4 by 10- and 6-fold, respectively. Lactic Acid 68-75 solute carrier family 16 member 1 Homo sapiens 98-102 25719685-7 2015 Finally, exposure of cells to kaempferol (30 microM) induced an increase in extracellular lactate levels over time (to 731 +- 32% of control after a 24 h exposure), due to inhibition of MCT1-mediated lactate cellular uptake. Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 186-190 25755717-3 2015 CD147 play a crucial role in tumorigenicity, invasion and metastasis; and CD147 also interacts strongly and specifically with monocarboxylate transporter1 (MCT1) that mediates the transport of lactate. Lactic Acid 193-200 solute carrier family 16 member 1 Homo sapiens 126-154 25755717-3 2015 CD147 play a crucial role in tumorigenicity, invasion and metastasis; and CD147 also interacts strongly and specifically with monocarboxylate transporter1 (MCT1) that mediates the transport of lactate. Lactic Acid 193-200 solute carrier family 16 member 1 Homo sapiens 156-160 25755717-4 2015 The objective of this study was to determine whether CD147 is involved, via its association with MCT1 to transport lactate, in glycolysis, contributing to the progression of thyroid carcinoma. Lactic Acid 115-122 solute carrier family 16 member 1 Homo sapiens 97-101 24485392-1 2015 OBJECTIVES: The A1470T polymorphism (rs1049434) in the monocarboxylate (lactate/pyruvate) transporter 1 gene (MCT1) has been suggested to influence athletic performance in the general population. Lactic Acid 72-79 solute carrier family 16 member 1 Homo sapiens 110-114 25719685-7 2015 Finally, exposure of cells to kaempferol (30 microM) induced an increase in extracellular lactate levels over time (to 731 +- 32% of control after a 24 h exposure), due to inhibition of MCT1-mediated lactate cellular uptake. Lactic Acid 200-207 solute carrier family 16 member 1 Homo sapiens 186-190 25009968-2 2014 Monocarboxylate transporter (MCT) proteins transfer lactate molecules through cellular membranes. Lactic Acid 52-59 solute carrier family 16 member 1 Homo sapiens 0-27 25320343-10 2014 Extent of lactate-coupled proton export indicates that MCT1 is already working on a high level even under unstimulated conditions. Lactic Acid 10-17 solute carrier family 16 member 1 Homo sapiens 55-59 25009968-2 2014 Monocarboxylate transporter (MCT) proteins transfer lactate molecules through cellular membranes. Lactic Acid 52-59 solute carrier family 16 member 1 Homo sapiens 29-32 25009968-3 2014 MCT-1 and MCT-4 are the main protein isoforms expressed in human skeletal muscle, with MCT-1 showing a higher affinity (lower Km) for lactate than MCT-4. Lactic Acid 134-141 solute carrier family 16 member 1 Homo sapiens 0-5 25009968-3 2014 MCT-1 and MCT-4 are the main protein isoforms expressed in human skeletal muscle, with MCT-1 showing a higher affinity (lower Km) for lactate than MCT-4. Lactic Acid 134-141 solute carrier family 16 member 1 Homo sapiens 87-92 25009968-10 2014 The question of whether the training-induced up-regulation of intracellular MCT-1 leads to an improved lactate transport (and clearance) in T2DM patients requires further research. Lactic Acid 103-110 solute carrier family 16 member 1 Homo sapiens 76-81 25281618-0 2014 Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 14-43 25123669-9 2014 The expression of lactate transporter MCT-1 and multidrug resistance regulating protein MRP-1 got inhibited along with hampered uptake of glucose and lactate production in SITS-treated DL cells. Lactic Acid 18-25 solute carrier family 16 member 1 Homo sapiens 38-43 25281618-0 2014 Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 45-49 25241983-10 2014 Moreover, alpha-cyano-4-hydroxycinnamate (CHC; a specific blocker of MCT) blocked the lactate-induced pHi changes. Lactic Acid 86-93 solute carrier family 16 member 1 Homo sapiens 69-72 24285728-0 2014 Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Lactic Acid 9-16 solute carrier family 16 member 1 Homo sapiens 53-57 25277190-5 2014 By real time PCR and immunofluorescence, in MSC we detected the expression of MCT-4, the transporter for lactate efflux, whereas MCT-1, responsible for lactate uptake, was expressed in OS cells. Lactic Acid 152-159 solute carrier family 16 member 1 Homo sapiens 129-134 24166504-2 2014 Its activities primarily depend on its uptake, a process facilitated by the lactate-proton symporter monocarboxylate transporter 1 (MCT1). Lactic Acid 76-83 solute carrier family 16 member 1 Homo sapiens 101-130 24166504-2 2014 Its activities primarily depend on its uptake, a process facilitated by the lactate-proton symporter monocarboxylate transporter 1 (MCT1). Lactic Acid 76-83 solute carrier family 16 member 1 Homo sapiens 132-136 24857275-0 2014 Prognostic significance of lactate/proton symporters MCT1, MCT4, and their chaperone CD147 expressions in urothelial carcinoma of the bladder. Lactic Acid 27-34 solute carrier family 16 member 1 Homo sapiens 53-57 24853433-8 2014 We also found that radiation increased the expression of monocarboxylate transporter 1 (MCT1) that facilitates the export of lactate into the extracellular environment. Lactic Acid 125-132 solute carrier family 16 member 1 Homo sapiens 57-86 24853433-8 2014 We also found that radiation increased the expression of monocarboxylate transporter 1 (MCT1) that facilitates the export of lactate into the extracellular environment. Lactic Acid 125-132 solute carrier family 16 member 1 Homo sapiens 88-92 24102496-7 2014 MCT substrates such as salicylic acid, ofloxacin and L-lactic acid significantly inhibited the uptake of moxifloxacin. Lactic Acid 53-66 solute carrier family 16 member 1 Homo sapiens 0-3 24285728-3 2014 Notably, disrupting MCT1 function leads to an accumulation of intracellular lactate that rapidly disables tumor cell growth and glycolysis, provoking marked alterations in glycolytic intermediates, reductions in glucose transport, and in levels of ATP, NADPH, and ultimately, glutathione (GSH). Lactic Acid 76-83 solute carrier family 16 member 1 Homo sapiens 20-24 24483274-4 2014 We explored whether mutations in the genes encoding the other major glucose (GLUT3) or lactate (MCT1/2/3/4) transporters involved in cerebral energy metabolism also cause generalized epilepsies. Lactic Acid 87-94 solute carrier family 16 member 1 Homo sapiens 96-106 24013424-9 2013 Specific siRNA-mediated downregulation of MCT1 but not MCT4 resulted in decreased HMCL proliferation, decreased lactate export, and increased cellular media pH. Lactic Acid 112-119 solute carrier family 16 member 1 Homo sapiens 42-46 23628675-1 2014 PURPOSE: In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. Lactic Acid 86-93 solute carrier family 16 member 1 Homo sapiens 33-62 23628675-1 2014 PURPOSE: In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. Lactic Acid 86-93 solute carrier family 16 member 1 Homo sapiens 64-68 23628675-2 2014 The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human skeletal muscles. Lactic Acid 85-92 solute carrier family 16 member 1 Homo sapiens 43-47 23628675-8 2014 CONCLUSIONS: MCT1 gene A1470T polymorphism is associated with endurance athlete status and blood lactate level after intensive exercise. Lactic Acid 97-104 solute carrier family 16 member 1 Homo sapiens 13-17 24094633-6 2013 Myelinating oligodendrocytes release lactate through the monocarboxylate transporter MCT1. Lactic Acid 37-44 solute carrier family 16 member 1 Homo sapiens 85-89 22360558-8 2012 The monocarboxylate transporters MCT1 and MCT4 have now been confirmed as prominent facilitators of lactate exchanges between cancer cells with different metabolic behaviors and between cancer and stromal cells. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 33-37 24265240-8 2013 Regulation of MCT activity involves both transcriptional and posttranscriptional mechanisms, examples being upregulation of MCT1 by chronic exercise in red muscle (which oxidizes lactate) and in T-lymphocytes upon stimulation. Lactic Acid 179-186 solute carrier family 16 member 1 Homo sapiens 124-128 22895074-8 2012 Monocarboxylate transporter-1 (MCT-1)-the main facilitator of lactate uptake in tumor cells, was expressed exclusively in prostate cancer cells and related directly to LDH-5 overexpression. Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 0-29 22895074-8 2012 Monocarboxylate transporter-1 (MCT-1)-the main facilitator of lactate uptake in tumor cells, was expressed exclusively in prostate cancer cells and related directly to LDH-5 overexpression. Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 31-36 22850421-6 2012 Conversely, prostate cancer cells, upon contact with CAFs, were reprogrammed toward aerobic metabolism, with a decrease in GLUT1 expression and an increase in lactate upload via the lactate transporter MCT1. Lactic Acid 159-166 solute carrier family 16 member 1 Homo sapiens 202-206 22850421-9 2012 In agreement, pharmacologic inhibition of MCT1-mediated lactate upload dramatically affected prostate cancer cell survival and tumor outgrowth. Lactic Acid 56-63 solute carrier family 16 member 1 Homo sapiens 42-46 22473315-1 2012 Vegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. Lactic Acid 52-59 solute carrier family 16 member 1 Homo sapiens 146-150 22178238-4 2012 The mRNA and protein expression of functional MCT1 in hMSCs is increased in response to lactate exposure. Lactic Acid 88-95 solute carrier family 16 member 1 Homo sapiens 46-50 23177990-3 2012 The focus of this review is on MCTs 1-4 because their role in lactate transport is intrinsically linked to cellular metabolism in various biological systems, including skeletal muscle, brain, retina, and testis. Lactic Acid 62-69 solute carrier family 16 member 1 Homo sapiens 31-39 23177990-4 2012 Although MCTs 1-4 all transport lactate, they differ in their transport kinetics and vary in tissue and subcellular distribution, where they facilitate "lactate-shuttling" between glycolytic and oxidative cells within tissues and across blood-tissue barriers. Lactic Acid 32-39 solute carrier family 16 member 1 Homo sapiens 9-17 23177990-4 2012 Although MCTs 1-4 all transport lactate, they differ in their transport kinetics and vary in tissue and subcellular distribution, where they facilitate "lactate-shuttling" between glycolytic and oxidative cells within tissues and across blood-tissue barriers. Lactic Acid 153-160 solute carrier family 16 member 1 Homo sapiens 9-17 24455478-5 2013 The accumulation of lactic acids in cancer cells provokes upregulation of several transport machineries (MCT-1, NHE-1, CA IX and H(+) pump V-ATPase) resulting in reinforced efflux of proton into extracellular fluid. Lactic Acid 20-32 solute carrier family 16 member 1 Homo sapiens 105-110 22516692-0 2012 Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women. Lactic Acid 63-70 solute carrier family 16 member 1 Homo sapiens 17-21 22516692-1 2012 OBJECTIVES: To analyze the effect of the MCT1 T1470A polymorphism (rs1049434) on venous blood lactate levels in men and women, during three different circuit weight training protocols. Lactic Acid 94-101 solute carrier family 16 member 1 Homo sapiens 41-45 22516692-9 2012 CONCLUSIONS: Our data suggest an influence of the MCT1 polymorphism on lactate transport across sarcolemma in males. Lactic Acid 71-78 solute carrier family 16 member 1 Homo sapiens 50-54 22184616-0 2012 Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 14-41 22184616-0 2012 Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 42-46 22184616-1 2012 The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Lactic Acid 71-78 solute carrier family 16 member 1 Homo sapiens 4-31 22184616-1 2012 The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Lactic Acid 71-78 solute carrier family 16 member 1 Homo sapiens 33-36 22184616-1 2012 The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Lactic Acid 71-78 solute carrier family 16 member 1 Homo sapiens 52-56 22184616-2 2012 Whereas most oxidative cancer cells import lactate through MCT1 to fuel mitochondrial respiration, the role of MCT1 in glycolysis-derived lactate efflux remains less clear. Lactic Acid 43-50 solute carrier family 16 member 1 Homo sapiens 59-63 22184616-2 2012 Whereas most oxidative cancer cells import lactate through MCT1 to fuel mitochondrial respiration, the role of MCT1 in glycolysis-derived lactate efflux remains less clear. Lactic Acid 138-145 solute carrier family 16 member 1 Homo sapiens 111-115 22184616-7 2012 Following glucose deprivation, upregulated MCT1 in p53(-/-) cells promoted lactate import and favored cell proliferation by fuelling mitochondrial respiration. Lactic Acid 75-82 solute carrier family 16 member 1 Homo sapiens 43-47 22184616-9 2012 Together, our findings identify MCT1 as a target for p53 repression and they suggest that MCT1 elevation in p53-deficient tumors allows them to adapt to metabolic needs by facilitating lactate export or import depending on the glucose availability. Lactic Acid 185-192 solute carrier family 16 member 1 Homo sapiens 90-94 22407107-2 2012 MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. Lactic Acid 88-95 solute carrier family 16 member 1 Homo sapiens 0-4 22012699-9 2012 Regulation of skeletal muscle MCT1 and MCT4 content by a variety of stimuli inducing an elevation of lactate level (exercise, hypoxia, nutrition, metabolic perturbations) has been demonstrated. Lactic Acid 101-108 solute carrier family 16 member 1 Homo sapiens 30-34 22240841-1 2012 MCT4 (SLC16A3) is the third member of the monocarboxylate transporter (MCT) family and is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 173-180 solute carrier family 16 member 1 Homo sapiens 42-69 22240841-1 2012 MCT4 (SLC16A3) is the third member of the monocarboxylate transporter (MCT) family and is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 173-180 solute carrier family 16 member 1 Homo sapiens 0-3 23082126-8 2012 Lactate activates HIF-1 and triggers tumor angiogenesis and tumor growth in vivo, an activity that we found to be under the specific upstream control of the lactate transporter monocarboxylate transporter 1 (MCT1) expressed in tumor cells. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 177-206 21856423-1 2012 Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes. Lactic Acid 89-96 solute carrier family 16 member 1 Homo sapiens 0-29 21856423-1 2012 Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes. Lactic Acid 89-96 solute carrier family 16 member 1 Homo sapiens 31-35 23082126-8 2012 Lactate activates HIF-1 and triggers tumor angiogenesis and tumor growth in vivo, an activity that we found to be under the specific upstream control of the lactate transporter monocarboxylate transporter 1 (MCT1) expressed in tumor cells. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 208-212 23082126-9 2012 Because MCT1 also gates lactate-fueled tumor cell respiration and mediates pro-angiogenic lactate signaling in endothelial cells, MCT1 inhibition is confirmed as an attractive anticancer strategy in which a single drug may target multiple tumor-promoting pathways. Lactic Acid 24-31 solute carrier family 16 member 1 Homo sapiens 8-12 23082126-9 2012 Because MCT1 also gates lactate-fueled tumor cell respiration and mediates pro-angiogenic lactate signaling in endothelial cells, MCT1 inhibition is confirmed as an attractive anticancer strategy in which a single drug may target multiple tumor-promoting pathways. Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 8-12 22428047-0 2012 Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 34-38 22428047-5 2012 In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. Lactic Acid 155-162 solute carrier family 16 member 1 Homo sapiens 58-87 22428047-5 2012 In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. Lactic Acid 155-162 solute carrier family 16 member 1 Homo sapiens 89-93 22428047-9 2012 Together with the previous demonstration of MCT1 being a key regulator of lactate exchange between tumor cells, the current study identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities. Lactic Acid 74-81 solute carrier family 16 member 1 Homo sapiens 44-48 21930917-0 2011 CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Lactic Acid 17-24 solute carrier family 16 member 1 Homo sapiens 39-43 21036377-1 2011 Polymorphisms in human lactate transporter proteins (monocarboxylate transporters; MCTs), especially the MCT1 isoform, can affect lactate transport activity and cause signs of exercise-induced myopathy. Lactic Acid 23-30 solute carrier family 16 member 1 Homo sapiens 105-109 22065843-5 2011 In tumors, MCT4 is largely involved in hypoxia-driven lactate release, whereas the uptake of lactate into both tumor cells and tumor endothelial cells occurs via MCT1. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 162-166 21930917-2 2011 Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. Lactic Acid 0-11 solute carrier family 16 member 1 Homo sapiens 66-70 21930917-2 2011 Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. Lactic Acid 46-53 solute carrier family 16 member 1 Homo sapiens 66-70 21081165-1 2011 Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood-brain barrier. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 0-29 21856924-5 2011 The lactate, acting through monocarboxylate transporter 1 (MCT1), initiated neuronal nitric oxide (NO) synthase (nNOS) and catalyzed production of NO for the vasodilation. Lactic Acid 4-11 solute carrier family 16 member 1 Homo sapiens 28-57 21856924-5 2011 The lactate, acting through monocarboxylate transporter 1 (MCT1), initiated neuronal nitric oxide (NO) synthase (nNOS) and catalyzed production of NO for the vasodilation. Lactic Acid 4-11 solute carrier family 16 member 1 Homo sapiens 59-63 21558814-8 2011 In contrast to our results with MCT4, we see that MCT1, a transporter involved in lactate uptake, is specifically upregulated in MCF7 breast cancer cells when co-cultured with fibroblasts. Lactic Acid 82-89 solute carrier family 16 member 1 Homo sapiens 50-54 21300765-0 2011 Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 72-76 21282642-7 2011 Our results show that His64 is essential for the enhancement of lactate transport via MCT1/4, because a mutation of this residue to alanine (CAII-H64A) abolishes the CAII-induced increase in MCT1/4 activity. Lactic Acid 64-71 solute carrier family 16 member 1 Homo sapiens 86-90 21081165-1 2011 Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood-brain barrier. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 31-35 19850519-1 2010 Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. Lactic Acid 84-91 solute carrier family 16 member 1 Homo sapiens 0-29 21076380-1 2010 BACKGROUND: Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Lactic Acid 120-127 solute carrier family 16 member 1 Homo sapiens 12-47 19850519-1 2010 Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. Lactic Acid 84-91 solute carrier family 16 member 1 Homo sapiens 31-35 19850519-3 2010 We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Lactic Acid 73-80 solute carrier family 16 member 1 Homo sapiens 33-37 20823576-2 2010 Monocarboxylate transporter (MCT) 1 has been suggested to play a major role in influx of L-lactic acid for oxidation. Lactic Acid 89-102 solute carrier family 16 member 1 Homo sapiens 0-35 19876643-2 2010 This study has examined the effect of hypoxia on lactate release from adipocytes and whether the monocarboxylate transporters that mediate lactate transport (MCTs1-4) are expressed in human adipocytes and are induced by low O(2) tension. Lactic Acid 139-146 solute carrier family 16 member 1 Homo sapiens 158-165 20021214-0 2010 Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Lactic Acid 20-27 solute carrier family 16 member 1 Homo sapiens 73-76 19905008-0 2010 The involvement of intracellular calcium in the MCT-mediated uptake of lactic acid by HeLa cells. Lactic Acid 71-82 solute carrier family 16 member 1 Homo sapiens 48-51 19905008-3 2010 The changes in intracellular pH (pH(in)) and MCT mediated uptake rates of L-lactic acid by HeLa cells, a human cervical adenocarcinoma cell line, were evaluated under the conditions, whose [Ca2+](in) concentrations were altered by various calcium modulators, such as EGTA-AM (a chelator), nifedipine (a Ca2+ channel antagonist) and A23187 (an ionophore). Lactic Acid 74-87 solute carrier family 16 member 1 Homo sapiens 45-48 20823576-4 2010 The uptake of L-lactic acid via MCT1 was studied in the presence of various intracellular regulatory pathways, including pathways mediated by protein kinases A, C and G (PKA, PKC and PKG), protein tyrosine kinase (PTK), and Ca2+/calmodulin modulators. Lactic Acid 14-27 solute carrier family 16 member 1 Homo sapiens 32-36 20823576-10 2010 Parallel to the decrease in Vmax of L-lactic acid uptake, the level of MCT1 expression was decreased in response to incubation with 8-Br-cAMP. Lactic Acid 36-49 solute carrier family 16 member 1 Homo sapiens 71-75 19505879-5 2009 MCT1 and MCT4 are the natural transporters of lactate, and MiaPaCa2 cells exhibited a high rate of lactate production, which is characteristic for the Warburg effect, an early hallmark of cancer that confers a significant growth advantage. Lactic Acid 46-53 solute carrier family 16 member 1 Homo sapiens 0-4 19741037-6 2009 Finally, the function of one ubiquitously expressed transporter, MCT1/SLC16A1, was investigated using [(14)C]lactic acid as a substrate. Lactic Acid 109-120 solute carrier family 16 member 1 Homo sapiens 65-69 19741037-6 2009 Finally, the function of one ubiquitously expressed transporter, MCT1/SLC16A1, was investigated using [(14)C]lactic acid as a substrate. Lactic Acid 109-120 solute carrier family 16 member 1 Homo sapiens 70-77 19805739-8 2009 In vitro lactate accumulation upregulates expression of MCT1 and genes coding for other components of the mitochondrial reticulum in skeletal muscle. Lactic Acid 9-16 solute carrier family 16 member 1 Homo sapiens 56-60 19826085-4 2009 Transport was found to be the rate-limiting process for the conversion of extracellular pyruvate to lactate with K(m) = 2.14 +/- 0.03 mM, typical of the monocarboxylate transporter 1 (MCT1), and a V(max) = 27.6 +/- 1.1 fmolxmin(-1).cell(-1), in agreement with the high expression level of this transporter. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 153-182 19826085-4 2009 Transport was found to be the rate-limiting process for the conversion of extracellular pyruvate to lactate with K(m) = 2.14 +/- 0.03 mM, typical of the monocarboxylate transporter 1 (MCT1), and a V(max) = 27.6 +/- 1.1 fmolxmin(-1).cell(-1), in agreement with the high expression level of this transporter. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 184-188 19826085-5 2009 Modulation of the environment to hypoxic conditions as well as suppression of cells" perfusion enhanced the rate of pyruvate-to-lactate conversion, presumably by up-regulation of the MCT1. Lactic Acid 128-135 solute carrier family 16 member 1 Homo sapiens 183-187 19826085-6 2009 Conversely, the addition of quercetin, a flavonoidal MCT1 inhibitor, markedly reduces the apparent rate of pyruvate-to-lactate conversion. Lactic Acid 119-126 solute carrier family 16 member 1 Homo sapiens 53-57 19505879-6 2009 Further induction of lactate production by sodium azide in MiaPaCa2 cells increased MCT1 as well as MCT4 expression. Lactic Acid 21-28 solute carrier family 16 member 1 Homo sapiens 84-88 19404741-0 2009 Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2. Lactic Acid 30-37 solute carrier family 16 member 1 Homo sapiens 111-115 19604494-1 2009 AIMS: Lactate is transported by stereo-specific, pH-dependent monocarboxylate transporters (MCTs), of which MCT1 is expressed in abundance in rodent and human hearts. Lactic Acid 6-13 solute carrier family 16 member 1 Homo sapiens 108-112 19427019-9 2009 SLC16A1 functions to efflux lactic acid during aerobic glycolysis. Lactic Acid 28-39 solute carrier family 16 member 1 Homo sapiens 0-7 19604589-10 2009 Monocarboxylate transporter 1 regulates the entry of lactate into oxidative tumor cells. Lactic Acid 53-60 solute carrier family 16 member 1 Homo sapiens 0-29 18778892-3 2009 Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been implicated in a specific and strong interaction with monocarboxylate transporters (MCT) 1 and 4 that mediate the transport of lactate. Lactic Acid 306-313 solute carrier family 16 member 1 Homo sapiens 233-275 17218064-4 2007 Lactate is then taken up and oxidized by the oxidative slow twitch muscle fibers, which express MCT1. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 96-100 19881260-1 2009 MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT) and its family is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 0-4 19881260-1 2009 MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT) and its family is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 5-12 19881260-1 2009 MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT) and its family is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 41-68 19881260-1 2009 MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT) and its family is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. Lactic Acid 176-183 solute carrier family 16 member 1 Homo sapiens 0-3 19033652-3 2008 show that human cancer cells cultured under hypoxic conditions convert glucose to lactate and extrude it, whereas aerobic cancer cells take up lactate via monocarboxylate transporter 1 (MCT1) and utilize it for oxidative phosphorylation (see the related article beginning on page 3930). Lactic Acid 143-150 solute carrier family 16 member 1 Homo sapiens 155-184 19033652-3 2008 show that human cancer cells cultured under hypoxic conditions convert glucose to lactate and extrude it, whereas aerobic cancer cells take up lactate via monocarboxylate transporter 1 (MCT1) and utilize it for oxidative phosphorylation (see the related article beginning on page 3930). Lactic Acid 143-150 solute carrier family 16 member 1 Homo sapiens 186-190 19033652-4 2008 When MCT1 is inhibited, aerobic cancer cells take up glucose rather than lactate, and hypoxic cancer cells die due to glucose deprivation. Lactic Acid 73-80 solute carrier family 16 member 1 Homo sapiens 5-9 18668440-2 2008 The monocarboxylate transporter (MCT, SLC16) family comprises 14 members, of which to date only MCT1-4 have been shown to carry monocarboxylates, transporting important metabolic compounds such as lactate, pyruvate and ketone bodies in a proton-coupled manner. Lactic Acid 197-204 solute carrier family 16 member 1 Homo sapiens 4-31 18668440-2 2008 The monocarboxylate transporter (MCT, SLC16) family comprises 14 members, of which to date only MCT1-4 have been shown to carry monocarboxylates, transporting important metabolic compounds such as lactate, pyruvate and ketone bodies in a proton-coupled manner. Lactic Acid 197-204 solute carrier family 16 member 1 Homo sapiens 33-36 18379211-7 2008 Lactate is capable of upregulating MCT1 and COX gene and protein expression. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 35-39 18379211-8 2008 Current findings allow us to understand how lactate production during exercise represents a physiological signal for the activation of a vast transcription network affecting MCT1 protein expression and mitochondrial biogenesis, thereby explaining how training increases the capacity for lactate clearance via oxidation. Lactic Acid 44-51 solute carrier family 16 member 1 Homo sapiens 174-178 18379211-8 2008 Current findings allow us to understand how lactate production during exercise represents a physiological signal for the activation of a vast transcription network affecting MCT1 protein expression and mitochondrial biogenesis, thereby explaining how training increases the capacity for lactate clearance via oxidation. Lactic Acid 287-294 solute carrier family 16 member 1 Homo sapiens 174-178 17579656-3 2007 Lactate, the glycolytic product of glucose metabolism, is transported into and out of neural cells by the monocarboxylate transporters (MCT): MCT1 in the BBB and astrocytes and MCT2 in neurons. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 142-146 17395833-5 2007 Specifically, lactate increased monocarboxylate transporter-1 (MCT1) mRNA and protein expression within 1 h and cytochrome c oxidase (COX) mRNA and protein expression in 6 h. Increases in COX coincided with increases in peroxisome proliferator activated-receptor gamma coactivator-1alpha (PGC1alpha) expression and the DNA binding activity of nuclear respiratory factor (NRF)-2. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 32-61 17395833-5 2007 Specifically, lactate increased monocarboxylate transporter-1 (MCT1) mRNA and protein expression within 1 h and cytochrome c oxidase (COX) mRNA and protein expression in 6 h. Increases in COX coincided with increases in peroxisome proliferator activated-receptor gamma coactivator-1alpha (PGC1alpha) expression and the DNA binding activity of nuclear respiratory factor (NRF)-2. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 63-67 17606506-3 2007 Monocarboxylate transporter 1 (MCT1) is a major proton transporter in mammalian cells that transports monocarboxylates, such as lactate and pyruvate, together with a proton across the plasma membrane. Lactic Acid 128-135 solute carrier family 16 member 1 Homo sapiens 0-29 17606506-3 2007 Monocarboxylate transporter 1 (MCT1) is a major proton transporter in mammalian cells that transports monocarboxylates, such as lactate and pyruvate, together with a proton across the plasma membrane. Lactic Acid 128-135 solute carrier family 16 member 1 Homo sapiens 31-35 19033663-6 2008 We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 14-43 19033663-6 2008 We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 45-49 19033663-6 2008 We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. Lactic Acid 168-175 solute carrier family 16 member 1 Homo sapiens 14-43 19033663-6 2008 We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. Lactic Acid 168-175 solute carrier family 16 member 1 Homo sapiens 45-49 19033663-7 2008 Inhibiting MCT1 with alpha-cyano-4-hydroxycinnamate (CHC) or siRNA in these cells induced a switch from lactate-fueled respiration to glycolysis. Lactic Acid 104-111 solute carrier family 16 member 1 Homo sapiens 11-15 18761711-6 2008 Basal lactate uptake and release were significantly reduced by MCT1 knockdown, even more so than with basigin knockdown, whereas glutamate-driven or sodium azide-induced enhancement of lactate release was not inhibited by either MCT1, 2, or 4 small interfering RNAs. Lactic Acid 6-13 solute carrier family 16 member 1 Homo sapiens 63-67 18761711-7 2008 In conclusion, MCT1 plays a pivotal role in the control of basal proton-driven lactate flux in astrocytes while basigin is only partly involved, most likely via its interaction with MCT1. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 15-19 17255361-8 2007 Export by monocarboxylate transporter-1 (MCT-1) depends on a gradient between cytoplasmic and extracellular lactic acid concentrations and consequently, blockade of MCT-1 resulted in impaired CTL function. Lactic Acid 108-119 solute carrier family 16 member 1 Homo sapiens 10-39 17255361-8 2007 Export by monocarboxylate transporter-1 (MCT-1) depends on a gradient between cytoplasmic and extracellular lactic acid concentrations and consequently, blockade of MCT-1 resulted in impaired CTL function. Lactic Acid 108-119 solute carrier family 16 member 1 Homo sapiens 41-46 17255361-8 2007 Export by monocarboxylate transporter-1 (MCT-1) depends on a gradient between cytoplasmic and extracellular lactic acid concentrations and consequently, blockade of MCT-1 resulted in impaired CTL function. Lactic Acid 108-119 solute carrier family 16 member 1 Homo sapiens 165-170 16604139-15 2006 The differences in transport kinetics for lactate and pyruvate are only known for MCT1, -2 and -4. Lactic Acid 42-49 solute carrier family 16 member 1 Homo sapiens 82-97 17140255-8 2006 The uptake of D-lactate and butyrate by HK-2 cells significantly decreased after transfection with small-interference RNA for MCT1. Lactic Acid 14-23 solute carrier family 16 member 1 Homo sapiens 126-130 17402440-4 2006 Mutations of human MCT1 have been described that appear to impair lactate transport in muscles and cause exertional rhabdomyolysis. Lactic Acid 66-73 solute carrier family 16 member 1 Homo sapiens 19-23 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 23-30 solute carrier family 16 member 1 Homo sapiens 139-143 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 139-143 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 139-143 16873599-8 2006 Since the transport of lactate across the sarcolemma is mediated mainly by the lactate-H+ cotransport via the monocarboxylate transporters MCT1 and MCT4, an elevated lactate transport capacity delays both muscle lactate accumulation and intracellular pH decrease and seems to favor muscle activity. Lactic Acid 79-86 solute carrier family 16 member 1 Homo sapiens 139-143 16239612-6 2006 Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [14C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). Lactic Acid 88-95 solute carrier family 16 member 1 Homo sapiens 72-77 16239612-6 2006 Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [14C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). Lactic Acid 88-95 solute carrier family 16 member 1 Homo sapiens 72-77 16239612-8 2006 Total lactate influx and lactate influx via the MCT-1 pathway were significantly higher in AS compared with AA at 1.6, 41, and 81.1 mM. Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 48-53 16239612-9 2006 The maximal lactate transport capacity for MCT-1 was higher in AS than in AA. Lactic Acid 12-19 solute carrier family 16 member 1 Homo sapiens 43-48 16239612-11 2006 The higher MCT-1 maximal lactate transport capacity found in AS suggests greater content or greater activity of MCT-1 in AS RBC membranes. Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 11-16 16260747-1 2005 Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis. Lactic Acid 228-235 solute carrier family 16 member 1 Homo sapiens 45-48 16441976-1 2005 Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 188-193 16441976-1 2005 Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 349-354 16326938-9 2005 It has been clearly demonstrated that lactate is capable of entering cells via the monocarboxylate transporter (MCT) protein shuttle system and that conversion of lactate to and from pyruvate is governed by specific lactate dehydrogenase isoforms, thereby forming a highly adaptable metabolic intermediate system. Lactic Acid 38-45 solute carrier family 16 member 1 Homo sapiens 83-110 16326938-9 2005 It has been clearly demonstrated that lactate is capable of entering cells via the monocarboxylate transporter (MCT) protein shuttle system and that conversion of lactate to and from pyruvate is governed by specific lactate dehydrogenase isoforms, thereby forming a highly adaptable metabolic intermediate system. Lactic Acid 38-45 solute carrier family 16 member 1 Homo sapiens 112-115 16326938-9 2005 It has been clearly demonstrated that lactate is capable of entering cells via the monocarboxylate transporter (MCT) protein shuttle system and that conversion of lactate to and from pyruvate is governed by specific lactate dehydrogenase isoforms, thereby forming a highly adaptable metabolic intermediate system. Lactic Acid 163-170 solute carrier family 16 member 1 Homo sapiens 83-110 16326938-9 2005 It has been clearly demonstrated that lactate is capable of entering cells via the monocarboxylate transporter (MCT) protein shuttle system and that conversion of lactate to and from pyruvate is governed by specific lactate dehydrogenase isoforms, thereby forming a highly adaptable metabolic intermediate system. Lactic Acid 163-170 solute carrier family 16 member 1 Homo sapiens 112-115 16260747-1 2005 Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis. Lactic Acid 228-235 solute carrier family 16 member 1 Homo sapiens 50-54 16260747-2 2005 In the parenchymal epithelia of kidney, thyroid, and liver, MCT/CD147 heterocomplexes are localized in the basolateral membrane where they transport lactate out of or into the cell depending on metabolic conditions. Lactic Acid 149-156 solute carrier family 16 member 1 Homo sapiens 60-63 15997097-8 2005 Therefore, MCT1 most probably acts on L-lactic acid uptake at RD cells. Lactic Acid 38-51 solute carrier family 16 member 1 Homo sapiens 11-15 16105239-5 2005 Furthermore, the cellular accumulation of ketoprofen was significantly reduced in the presence of benzoic acid and L-lactic acid, two known substrates of monocarboxylic acid transporter 1 (MCT1). Lactic Acid 115-128 solute carrier family 16 member 1 Homo sapiens 189-193 15997097-9 2005 [14C] L-Lactic acid efflux in RD cells was inhibited by alpha-cyano-4-hydroxycinnamate (CHC) but not by butyric acid, a substrate of MCT1. Lactic Acid 8-19 solute carrier family 16 member 1 Homo sapiens 133-137 15997097-12 2005 We conclude that MCT1 is responsible for L-lactic acid uptake and L-lactic acid efflux is mediated by MCT4 in RD cells. Lactic Acid 41-54 solute carrier family 16 member 1 Homo sapiens 17-21 15548847-7 2004 These results suggest that an MCT participates in the uptake of L-lactic acid by L6 cells. Lactic Acid 64-77 solute carrier family 16 member 1 Homo sapiens 30-33 15452831-6 2005 The lactate-sensitive part of fluorescein transport was completely blocked by p-chloromercuribenzenesulfonic acid (pCMBS), a specific inhibitor of the monocarboxylate transporter-1 (MCT-1) that by Western blotting and immunofluorescence was identified in mitochondria of HT-29 cells. Lactic Acid 4-11 solute carrier family 16 member 1 Homo sapiens 151-180 15452831-6 2005 The lactate-sensitive part of fluorescein transport was completely blocked by p-chloromercuribenzenesulfonic acid (pCMBS), a specific inhibitor of the monocarboxylate transporter-1 (MCT-1) that by Western blotting and immunofluorescence was identified in mitochondria of HT-29 cells. Lactic Acid 4-11 solute carrier family 16 member 1 Homo sapiens 182-187 15531559-8 2005 However, greater MCT1 and MCT4 contents were negatively related with a reduction of blood lactate concentration at the end of 1-min all-out exercise (r = -0.56, and r = -0.61, P < 0.05, respectively). Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 17-21 15531559-12 2005 It is proposed that MCT1 expression may be important for blood lactate removal after supramaximal exercise based on the existence of lactate shuttles and, in turn, in favor of a better tolerance to muscle fatigue. Lactic Acid 63-70 solute carrier family 16 member 1 Homo sapiens 20-24 15586354-8 2005 Lactate uptake is fast in astrocytes, which express powerful, low-affinity MCTs, i.e., MCT1 and MCT4. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 87-91 15586354-10 2005 The predominant MCT in neurons is the high-affinity MCT2, which can only increase its activity to a limited extent in the face of an increased lactate gradient. Lactic Acid 143-150 solute carrier family 16 member 1 Homo sapiens 16-19 15574223-8 2004 Small interfering ribonucleic acid specific for MCT 1 and 2 reduced expression of these isoforms in U-87 MG cells to barely detectable levels and reduced lactate efflux by 30% individually and 85% in combination, with a concomitant decrease of intracellular pH by 0.6 units (a fourfold increase in intracellular H(+)). Lactic Acid 154-161 solute carrier family 16 member 1 Homo sapiens 48-59 15548847-11 2004 These results suggest that [(14)C] L-lactic acid efflux in L6 cells is mediated by MCT other than MCT1. Lactic Acid 37-48 solute carrier family 16 member 1 Homo sapiens 83-86 15548847-11 2004 These results suggest that [(14)C] L-lactic acid efflux in L6 cells is mediated by MCT other than MCT1. Lactic Acid 37-48 solute carrier family 16 member 1 Homo sapiens 98-102 15121747-10 2004 The results showed higher monocarboxylate transporter-1-mediated lactate influx in the EIH subjects and suggested that EIH could modify lactate influx into erythrocyte. Lactic Acid 136-143 solute carrier family 16 member 1 Homo sapiens 26-55 15135232-5 2004 Inhibition of lactate uptake in both MVM and BM by 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS), an inhibitor of monocarboxylate transporter (MCT) activity, indicated MCT-mediated mechanisms across both membranes. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 126-153 15121747-7 2004 Monocarboxylate transporter-1-mediated lactate influx was also higher in EIH at 8.1 mM (P < 0.05) and 41 mM (P < 0.01). Lactic Acid 39-46 solute carrier family 16 member 1 Homo sapiens 0-29 15121747-10 2004 The results showed higher monocarboxylate transporter-1-mediated lactate influx in the EIH subjects and suggested that EIH could modify lactate influx into erythrocyte. Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 26-55 14966016-3 2004 This study aimed to evaluate the effect of recombinant human erythropoietin (rHuEPO) injections on lactate transport into erythrocytes via band 3 and H(+)-monocarboxylate transporter MCT-1, two proteins involved in lactate exchange. Lactic Acid 99-106 solute carrier family 16 member 1 Homo sapiens 183-188 14966016-3 2004 This study aimed to evaluate the effect of recombinant human erythropoietin (rHuEPO) injections on lactate transport into erythrocytes via band 3 and H(+)-monocarboxylate transporter MCT-1, two proteins involved in lactate exchange. Lactic Acid 215-222 solute carrier family 16 member 1 Homo sapiens 183-188 14966016-7 2004 After treatment, MCT-1 lactate uptake was increased at 1.6, 41 (P < 0.01), and 81.1 mM lactate concentration (P < 0.001) although lactate uptake via band 3 and nonionic diffusion were unchanged. Lactic Acid 23-30 solute carrier family 16 member 1 Homo sapiens 17-22 14966016-7 2004 After treatment, MCT-1 lactate uptake was increased at 1.6, 41 (P < 0.01), and 81.1 mM lactate concentration (P < 0.001) although lactate uptake via band 3 and nonionic diffusion were unchanged. Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 17-22 14966016-7 2004 After treatment, MCT-1 lactate uptake was increased at 1.6, 41 (P < 0.01), and 81.1 mM lactate concentration (P < 0.001) although lactate uptake via band 3 and nonionic diffusion were unchanged. Lactic Acid 90-97 solute carrier family 16 member 1 Homo sapiens 17-22 14966016-9 2004 Our results show that rHuEPO injections increased MCT-1 lactate influx at low and high lactate concentrations. Lactic Acid 56-63 solute carrier family 16 member 1 Homo sapiens 50-55 14966016-9 2004 Our results show that rHuEPO injections increased MCT-1 lactate influx at low and high lactate concentrations. Lactic Acid 87-94 solute carrier family 16 member 1 Homo sapiens 50-55 15135232-5 2004 Inhibition of lactate uptake in both MVM and BM by 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS), an inhibitor of monocarboxylate transporter (MCT) activity, indicated MCT-mediated mechanisms across both membranes. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 155-158 15135232-5 2004 Inhibition of lactate uptake in both MVM and BM by 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS), an inhibitor of monocarboxylate transporter (MCT) activity, indicated MCT-mediated mechanisms across both membranes. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 180-183 12949353-5 2003 Efflux of biotin from PBMC was stimulated by extracellular lactate (a known substrate for MCT), consistent with countertransport of the two substrates by the same transporter. Lactic Acid 59-66 solute carrier family 16 member 1 Homo sapiens 90-93 14724187-1 2004 UNLABELLED: Lactate is released from skeletal muscle in proportion to glucose uptake rates, and it leaves the cells via simple diffusion and two monocarboxylate transporter proteins, MCT1 and MCT4. Lactic Acid 12-19 solute carrier family 16 member 1 Homo sapiens 183-187 15124918-12 2004 The pressure stress increased MCT1 in the membrane fraction in the presence of extracellular lactate. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 30-34 15124918-15 2004 The increased membranous MCT1 may transport lactate for energy metabolism in cells. Lactic Acid 44-51 solute carrier family 16 member 1 Homo sapiens 25-29 12739169-1 2004 The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1-MCT4) have been demonstrated experimentally to catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies. Lactic Acid 244-251 solute carrier family 16 member 1 Homo sapiens 103-107 10921872-2 2000 Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental role in metabolism, but not with MCT2. Lactic Acid 181-188 solute carrier family 16 member 1 Homo sapiens 116-120 12634113-3 2003 This study investigates by means of a non-invasive technique the mechanism of coupling between transport of H(+), lactate ion, and water in the monocarboxylate transporter (MCT1) located in the apical (retinal) membrane of a mammalian RPE. Lactic Acid 114-121 solute carrier family 16 member 1 Homo sapiens 173-177 12634113-11 2003 The data suggest that H(2)O is cotransported along with H(+) and lactate ions in MCT1 localized to the retinal membrane. Lactic Acid 65-72 solute carrier family 16 member 1 Homo sapiens 81-85 11683677-13 2001 Finally, MCT1 may be important for releasing lactate to the blood during long-lasting exercise. Lactic Acid 45-52 solute carrier family 16 member 1 Homo sapiens 9-13 11353425-5 2001 Lactate import into oxidative skeletal muscle appears to be catalyzed by MCT1, whereas its extrusion from glycolytic fibers may be mediated by MCT4. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 73-77 11052969-9 2000 This increase in MCT1 alone was sufficient to increase lactate uptake from the circulation. Lactic Acid 55-62 solute carrier family 16 member 1 Homo sapiens 17-21 12870677-6 2003 However, GST-MCT1-immobilized column showed specific convex curve from fraction approximately 3 mM of lactate and demonstrated wash out delay compared to Sepharose 4B and GST-immobilized column. Lactic Acid 102-109 solute carrier family 16 member 1 Homo sapiens 13-17 12870677-8 2003 The studies on MCT1-fusion protein suggested possible functional properties of a 44-kDa protein as a lactate buffer by holding and unhand a lactate according to the lactate concentration in human blood. Lactic Acid 101-108 solute carrier family 16 member 1 Homo sapiens 15-19 12870677-8 2003 The studies on MCT1-fusion protein suggested possible functional properties of a 44-kDa protein as a lactate buffer by holding and unhand a lactate according to the lactate concentration in human blood. Lactic Acid 140-147 solute carrier family 16 member 1 Homo sapiens 15-19 12870677-8 2003 The studies on MCT1-fusion protein suggested possible functional properties of a 44-kDa protein as a lactate buffer by holding and unhand a lactate according to the lactate concentration in human blood. Lactic Acid 140-147 solute carrier family 16 member 1 Homo sapiens 15-19 12705896-4 2003 Here we present evidence that purified peroxisomal membranes contain both monocarboxylate transporter 1 (MCT 1) and MCT 2 and that along with peroxisomal lactate dehydrogenase (pLDH) form a Peroxisomal Lactate Shuttle. Lactic Acid 202-209 solute carrier family 16 member 1 Homo sapiens 105-110 11943706-5 2002 MCT1 is one of a family of widely expressed proton-linked transporters for monocarboxylates such as lactate and pyruvate. Lactic Acid 100-107 solute carrier family 16 member 1 Homo sapiens 0-4 11820315-2 2001 The release and uptake of lactate both involve transmembrane transport, which is mediated mainly by a membrane protein called the monocarboxylate transporter (MCT). Lactic Acid 26-33 solute carrier family 16 member 1 Homo sapiens 130-157 11820315-2 2001 The release and uptake of lactate both involve transmembrane transport, which is mediated mainly by a membrane protein called the monocarboxylate transporter (MCT). Lactic Acid 26-33 solute carrier family 16 member 1 Homo sapiens 159-162 16136905-1 2001 OBJECTIVE: To study the influence of the first subtype of monocarboxylate transporter (MCT1) gene on pHi regulation, lactate transport and cell growth in tumor cells. Lactic Acid 117-124 solute carrier family 16 member 1 Homo sapiens 87-91 16136905-9 2001 (2) Intracellular pH and lactate were remarkably decreased in the cells transfected pLXSN-MCT1, comparing to A549 cells without transfection (P < 0.001). Lactic Acid 25-32 solute carrier family 16 member 1 Homo sapiens 90-94 16136905-11 2001 CONCLUSION: MCT1 gene could play an important role in pHi regulation, lactate transport and cell growth in tumor cells. Lactic Acid 70-77 solute carrier family 16 member 1 Homo sapiens 12-16 8124722-8 1994 By exporting lactate from intestine and erythrocytes, MCT1 participates in the Cori cycle. Lactic Acid 13-20 solute carrier family 16 member 1 Homo sapiens 54-58 10776895-9 2000 Endurance training improves muscle capacity for lactate utilization and increases membrane transport of lactate probably via an increase in Type I monocarboxylate transport protein (MCT1) and perhaps other MCT isoforms as well. Lactic Acid 104-111 solute carrier family 16 member 1 Homo sapiens 182-186 10776897-6 2000 MCT1 and MCT3-M/MCT4 are present in rat and human muscles, and MCT1 expression is highly correlated with the oxidative capacity of skeletal muscles and with their capacity to take up lactate from the circulation. Lactic Acid 183-190 solute carrier family 16 member 1 Homo sapiens 63-67 10776897-9 2000 In humans, the training-induced increases in MCT1 are associated with an increased lactate efflux out of muscle. Lactic Acid 83-90 solute carrier family 16 member 1 Homo sapiens 45-49 9415827-3 1997 The MCT1 expression patterns in metabolically heterogeneous skeletal suggests that a primary role of this lactate transporter is to take up lactate into the oxidative muscle fibers where it may be used as a fuel in mitochondrial oxidation. Lactic Acid 106-113 solute carrier family 16 member 1 Homo sapiens 4-8 10751188-7 2000 Mitochondrial MCT1 content was negatively correlated to net leg lactate release at rest (r = -0.85, P < 0.02). Lactic Acid 64-71 solute carrier family 16 member 1 Homo sapiens 14-18 10751188-8 2000 Sarcolemmal MCT1 and MCT4 contents correlated positively to net leg lactate release at 5 min of exercise at 65% VO(2 peak) (r = 0.76, P < 0.03 and r = 0. Lactic Acid 68-75 solute carrier family 16 member 1 Homo sapiens 12-16 10751188-10 2000 Results support the conclusions that 1) endurance training increases expression of MCT1 in muscle because of insertion of MCT1 into both sarcolemmal and mitochondrial membranes, 2) training has variable effects on sarcolemmal MCT4, and 3) both MCT1 and MCT4 participate in the cell-cell lactate shuttle, whereas MCT1 facilitates operation of the intracellular lactate shuttle. Lactic Acid 287-294 solute carrier family 16 member 1 Homo sapiens 83-87 10751188-10 2000 Results support the conclusions that 1) endurance training increases expression of MCT1 in muscle because of insertion of MCT1 into both sarcolemmal and mitochondrial membranes, 2) training has variable effects on sarcolemmal MCT4, and 3) both MCT1 and MCT4 participate in the cell-cell lactate shuttle, whereas MCT1 facilitates operation of the intracellular lactate shuttle. Lactic Acid 360-367 solute carrier family 16 member 1 Homo sapiens 83-87 10590411-0 2000 Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. Lactic Acid 66-73 solute carrier family 16 member 1 Homo sapiens 13-17 10510291-4 1999 Direct demonstration of proton-linked lactate and pyruvate transport has been demonstrated for mammalian MCT1-MCT4, but only for MCT1 and MCT2 have detailed analyses of substrate and inhibitor kinetics been described following heterologous expression in Xenopus oocytes. Lactic Acid 38-45 solute carrier family 16 member 1 Homo sapiens 105-109 10510291-5 1999 MCT1 is ubiquitously expressed, but is especially prominent in heart and red muscle, where it is up-regulated in response to increased work, suggesting a special role in lactic acid oxidation. Lactic Acid 170-181 solute carrier family 16 member 1 Homo sapiens 0-4 10471310-1 1999 Transport of lactate, pyruvate, and the ketone bodies, acetoacetate and beta-hydroxybutyrate, is mediated in many mammalian cells by the monocarboxylate transporter MCT1. Lactic Acid 13-20 solute carrier family 16 member 1 Homo sapiens 165-169 10440131-8 1999 CONCLUSION/INTERPRETATION: The explant model provides evidence for the involvement of macrophages and glial fibrillary acidic protein activation in human retinal angiogenesis and for the expression of monocarboxylate transporter type 1, which is likely to be important in the use of lactate in the hypoxic retina. Lactic Acid 283-290 solute carrier family 16 member 1 Homo sapiens 201-235 9458754-1 1998 We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Lactic Acid 46-53 solute carrier family 16 member 1 Homo sapiens 75-104 9458754-1 1998 We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Lactic Acid 46-53 solute carrier family 16 member 1 Homo sapiens 106-110 9458754-9 1998 These results suggest that lactate extrusion from exercising muscles is increased after training, and this may be associated with the increase in skeletal muscle MCT1. Lactic Acid 27-34 solute carrier family 16 member 1 Homo sapiens 162-166 34843897-1 2022 Glucose transported to the brain is metabolized to lactate in astrocytes and supplied to neuronal cells via a monocarboxylic acid transporter (MCT). Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 110-141 34843897-1 2022 Glucose transported to the brain is metabolized to lactate in astrocytes and supplied to neuronal cells via a monocarboxylic acid transporter (MCT). Lactic Acid 51-58 solute carrier family 16 member 1 Homo sapiens 143-146 34843897-6 2022 Under physiological conditions, lactate production and release by astrocytes are regulated by changes in lactate dehydrogenase (LDH) and MCT expression. Lactic Acid 32-39 solute carrier family 16 member 1 Homo sapiens 137-140 34606041-4 2022 Cancer cells absorb lactate by mono-carboxylate transporter 1 (MCT1) and convert lactate to pyruvate via intracellular lactate dehydrogenase B (LDH-B) to maintain their growth and metabolism. Lactic Acid 20-27 solute carrier family 16 member 1 Homo sapiens 31-61 34606041-4 2022 Cancer cells absorb lactate by mono-carboxylate transporter 1 (MCT1) and convert lactate to pyruvate via intracellular lactate dehydrogenase B (LDH-B) to maintain their growth and metabolism. Lactic Acid 20-27 solute carrier family 16 member 1 Homo sapiens 63-67 34625424-5 2021 This ratio correlated with gene expression of the pyruvate transporter MCT1, and lactate dehydrogenase A (LDHA), the enzyme catalyzing label exchange between pyruvate and lactate. Lactic Acid 171-178 solute carrier family 16 member 1 Homo sapiens 71-75 34472101-5 2022 Interestingly, blockade of lactate transporters, monocarboxylate transporter-1 and -4 (MCT1 and MCT4), attenuated the intracellular level of GO6983, and its inhibitory effect on PKC activity, suggesting that lactic acid promotes the resistance to PKC inhibitors by competing for the uptake through these transporters rather than by activating its receptor, GPR81. Lactic Acid 208-219 solute carrier family 16 member 1 Homo sapiens 49-85 34472101-5 2022 Interestingly, blockade of lactate transporters, monocarboxylate transporter-1 and -4 (MCT1 and MCT4), attenuated the intracellular level of GO6983, and its inhibitory effect on PKC activity, suggesting that lactic acid promotes the resistance to PKC inhibitors by competing for the uptake through these transporters rather than by activating its receptor, GPR81. Lactic Acid 208-219 solute carrier family 16 member 1 Homo sapiens 87-91 34586586-9 2022 In addition, gene expressions of monocarboxylate transporter (MCT) 1, MCT-2 and activity-regulated cytoskeleton-associated protein were significantly higher in brain samples treated with alpha-MSH, suggesting this peptide may have role in neuron survival by an involvement of lactate metabolism. Lactic Acid 276-283 solute carrier family 16 member 1 Homo sapiens 33-68 34254872-5 2021 SLC16A1 is a member of the SLC family, participating in the transport of lactate, pyruvate, amino acids, ketone bodies, etc. Lactic Acid 73-80 solute carrier family 16 member 1 Homo sapiens 0-7 34649623-4 2021 Expression of the monocarboxylate transporter 1 (MCT1), which is responsible for the bidirectional transport of lactate, correlates with an aggressive phenotype and poor outcome in several cancer types, including breast cancer. Lactic Acid 112-119 solute carrier family 16 member 1 Homo sapiens 18-47 34649623-4 2021 Expression of the monocarboxylate transporter 1 (MCT1), which is responsible for the bidirectional transport of lactate, correlates with an aggressive phenotype and poor outcome in several cancer types, including breast cancer. Lactic Acid 112-119 solute carrier family 16 member 1 Homo sapiens 49-53 34649623-5 2021 In this study, 3-bromopyruvate (3BP), a lactate/pyruvate analog, was used to selectively target TNBC cells that express MCT1. Lactic Acid 40-47 solute carrier family 16 member 1 Homo sapiens 120-124 34773210-4 2021 There is also increasing evidence that other sources of energy, particularly monocarboxylates such as lactate that are transported primarily by monocarboxylate transporters 1 and 2 in peripheral nerves, can be efficiently utilized by peripheral nerves. Lactic Acid 102-109 solute carrier family 16 member 1 Homo sapiens 144-180 34298681-7 2021 Functionally, in U251 GBM cells, MCT1 stable knockdown decreased glucose consumption and lactate efflux, compromising the response to the MCT1 inhibitors CHC and AR-C155858. Lactic Acid 89-96 solute carrier family 16 member 1 Homo sapiens 33-37 34475628-0 2021 The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake. Lactic Acid 106-113 solute carrier family 16 member 1 Homo sapiens 4-8 35574309-0 2022 Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma. Lactic Acid 0-7 solute carrier family 16 member 1 Homo sapiens 35-39 34471053-2 2021 Monocarboxylate transporters (MCTs), especially MCT1 and MCT4, play a critical role in maintaining an appropriate pH environment through lactate transport, and their high expression is associated with poor prognosis in breast cancer. Lactic Acid 137-144 solute carrier family 16 member 1 Homo sapiens 48-52 35574309-8 2022 We also showed that lactate increased the expressions of MCT1 and HCAR1. Lactic Acid 20-27 solute carrier family 16 member 1 Homo sapiens 57-61 35054026-1 2022 Basigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters (MCTs) such as MCT1. Lactic Acid 106-113 solute carrier family 16 member 1 Homo sapiens 197-201 35547368-0 2022 Monocarboxylate Transporter 1 May Benefit Cerebral Ischemia via Facilitating Lactate Transport From Glial Cells to Neurons. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 0-29 35547368-5 2022 In this review, it provides a novel insight that MCT1 may protect brain from I/R injury via facilitating lactate transport from glial cells (such as, astrocytes and OLs) to neurons. Lactic Acid 105-112 solute carrier family 16 member 1 Homo sapiens 49-53 35547368-6 2022 It extensively discusses (1) the structure and localization of MCT1; (2) the regulation of MCT1 in lactate transport among astrocytes, OLs, and neurons; and (3) the regulation of MCT1 in the cellular response of lactate accumulation under ischemic attack. Lactic Acid 99-106 solute carrier family 16 member 1 Homo sapiens 91-95 35547368-6 2022 It extensively discusses (1) the structure and localization of MCT1; (2) the regulation of MCT1 in lactate transport among astrocytes, OLs, and neurons; and (3) the regulation of MCT1 in the cellular response of lactate accumulation under ischemic attack. Lactic Acid 212-219 solute carrier family 16 member 1 Homo sapiens 91-95 35547368-6 2022 It extensively discusses (1) the structure and localization of MCT1; (2) the regulation of MCT1 in lactate transport among astrocytes, OLs, and neurons; and (3) the regulation of MCT1 in the cellular response of lactate accumulation under ischemic attack. Lactic Acid 212-219 solute carrier family 16 member 1 Homo sapiens 179-183 35547368-7 2022 At last, this review concludes that MCT1, in cerebral ischemia, may improve lactate transport from glial cells to neurons, which subsequently alleviates cellular damage induced by lactate accumulation (mostly in glial cells), and meets the energy metabolism of neurons. Lactic Acid 76-83 solute carrier family 16 member 1 Homo sapiens 36-40 35547368-7 2022 At last, this review concludes that MCT1, in cerebral ischemia, may improve lactate transport from glial cells to neurons, which subsequently alleviates cellular damage induced by lactate accumulation (mostly in glial cells), and meets the energy metabolism of neurons. Lactic Acid 180-187 solute carrier family 16 member 1 Homo sapiens 36-40 35239073-2 2022 Monocarboxylate transporter 1 (MCT1) and 4 (MCT4) are critical symporters mediating lactate efflux and preventing intracellular acidification during tumor growth. Lactic Acid 84-91 solute carrier family 16 member 1 Homo sapiens 0-29 35239073-2 2022 Monocarboxylate transporter 1 (MCT1) and 4 (MCT4) are critical symporters mediating lactate efflux and preventing intracellular acidification during tumor growth. Lactic Acid 84-91 solute carrier family 16 member 1 Homo sapiens 31-35 35054513-3 2022 (2) Methods: We expressed AQP9 and human monocarboxylate transporter 1 (MCT1) in yeast to determine the uptake rates and accumulation of radiolabeled l-lactate/l-lactic acid in different external pH conditions. Lactic Acid 160-173 solute carrier family 16 member 1 Homo sapiens 41-70 35054513-5 2022 At a pH corresponding to the pKa of l-lactic acid, uptake via AQP9 was faster than via MCT1. Lactic Acid 36-49 solute carrier family 16 member 1 Homo sapiens 87-91 35440568-6 2022 Inhibition of lactate transport by blocking Monocarboxylic Acid Transporter 1 (MCT1) strongly enhances sensitivity to ETC complex II inhibition in vitro as well as in vivo. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 44-77 35440568-6 2022 Inhibition of lactate transport by blocking Monocarboxylic Acid Transporter 1 (MCT1) strongly enhances sensitivity to ETC complex II inhibition in vitro as well as in vivo. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 79-83 35406740-4 2022 BACH1 suppresses the transcriptional expression of monocarboxylate transporter 1 (MCT1) and lactate dehydrogenase B, inhibiting lactate-mediated mitochondrial metabolism. Lactic Acid 128-135 solute carrier family 16 member 1 Homo sapiens 51-80 35406740-4 2022 BACH1 suppresses the transcriptional expression of monocarboxylate transporter 1 (MCT1) and lactate dehydrogenase B, inhibiting lactate-mediated mitochondrial metabolism. Lactic Acid 128-135 solute carrier family 16 member 1 Homo sapiens 82-86 35406740-5 2022 In our studies, the depletion of BACH1 either genetically or pharmacologically increased the lactate use of TNBC cells, increasing their sensitivity to MCT1 inhibition. Lactic Acid 93-100 solute carrier family 16 member 1 Homo sapiens 152-156 35406740-7 2022 Particularly, hemin treatment degrading BACH1 proteins induced lactate catabolism in TNBC cells, generating synthetic lethality with MCT1 inhibition. Lactic Acid 63-70 solute carrier family 16 member 1 Homo sapiens 133-137 35188217-0 2022 Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. Lactic Acid 39-46 solute carrier family 16 member 1 Homo sapiens 0-29 35188217-8 2022 Inhibition of lactate influx by the monocarboxylate transporter (MCT)-1 inhibitor, AZD3965, reversed the effect of lactate on GAG accumulation and MMP3 expression and further improved NP cell degeneration in the NPD model. Lactic Acid 14-21 solute carrier family 16 member 1 Homo sapiens 36-71 34619707-4 2022 To investigate the metabolic phenotype of malignant lymphoma associated with lactate transport, we analyzed immunohistochemical expressions of MCT1, MCT4, and CD147 in 247 cases of various malignant lymphomas. Lactic Acid 77-84 solute carrier family 16 member 1 Homo sapiens 143-147 35102189-4 2022 Multiple linear regression revealed that phosphofructokinase, monocarboxylate transporter (MCT)1, MCT4, and citrate synthase equally contribute to the lactate production volume at high-intensity exercise within physiological adaptations, such as EX, not PGC-1alpha OE. Lactic Acid 151-158 solute carrier family 16 member 1 Homo sapiens 62-96 35173374-4 2022 Therefore, genetic variants associated with swimming performance are not necessarily related to metabolic pathways, but rather to blood lactate transport (MCT1), muscle functioning (IGF1 axis), muscle damage (IL6) and others. Lactic Acid 136-143 solute carrier family 16 member 1 Homo sapiens 155-159