PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35543151-6	2022	The results revealed that TRAP1 was involved in regulating hypoxia-induced HIF-1alpha stabilization and glycolytic metabolism and that glucose transporter 1 expression, glucose uptake and lactate production were partially impaired in TRAP1-silenced CRC cells under hypoxic conditions.	Lactic Acid	188-195	TNF receptor associated protein 1	Homo sapiens	234-239	
33025742-7	2020	By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production.	Lactic Acid	141-148	TNF receptor associated protein 1	Homo sapiens	13-18	
33025742-7	2020	By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production.	Lactic Acid	141-148	TNF receptor associated protein 1	Homo sapiens	103-108	
33025742-5	2020	Consistently, TRAP1 enhances GLUT1 expression, glucose uptake and lactate production and downregulates OXPHOS in CRC patient-derived spheroids and cell lines.	Lactic Acid	66-73	TNF receptor associated protein 1	Homo sapiens	14-19	
33025742-6	2020	Mechanistically, TRAP1 maximizes lactate production to balance low OXPHOS through the regulation of the glycolytic enzyme phosphofructokinase-1 (PFK1); this depends on the interaction between TRAP1 and PFK1, which favors PFK1 glycolytic activity and prevents its ubiquitination/degradation.	Lactic Acid	33-40	TNF receptor associated protein 1	Homo sapiens	17-22